Abstract：
:Chronic myeloid leukemia (CML) has been a "model disease" with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission after targeted therapies, we describe here the journey of CML, focusing on molecular pathways relating to signaling, metabolism and the bone marrow microenvironment. We highlight current strategies for combination therapies aimed at eradicating the CML stem cell; hopefully the final destination of this long voyage.
journal_name
Cellsjournal_title
Cellsauthors
Minciacchi VR,Kumar R,Krause DSdoi
10.3390/cells10010117subject
Has Abstractpub_date
2021-01-10 00:00:00issue
1issn
2073-4409pii
cells10010117journal_volume
10pub_type
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