Abstract：
:Cell plasticity, defined as the ability to undergo phenotypical transformation in a reversible manner, is a physiological process that also exerts important roles in disease progression. Two forms of cellular plasticity are epithelial-mesenchymal transition (EMT) and its inverse process, mesenchymal-epithelial transition (MET). These processes have been correlated to the poor outcome of different types of neoplasias as well as drug resistance development. Since EMT/MET are transitional processes, we generated and validated a reporter cell line. Specifically, a far-red fluorescent protein was knocked-in in-frame with the mesenchymal gene marker VIMENTIN (VIM) in H2170 lung cancer cells. The vimentin reporter cells (VRCs) are a reliable model for studying EMT and MET showing cellular plasticity upon a series of stimulations. These cells are a robust platform to dissect the molecular mechanisms of these processes, and for drug discovery in vitro and in vivo in the future.
journal_name
Cellsjournal_title
Cellsauthors
Kiełbus M,Czapiński J,Kałafut J,Woś J,Stepulak A,Rivero-Müller Adoi
10.3390/cells8121644subject
Has Abstractpub_date
2019-12-15 00:00:00issue
12issn
2073-4409pii
cells8121644journal_volume
8pub_type
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