Abstract:
:Telomere dysfunction has been strongly implicated in the initiation of genomic instability and is suspected to be an early event in the carcinogenesis of human solid tumors. Recent findings have established the presence of telomere fusions in human breast and prostate malignancies; however, the onset of this genomic instability mechanism during progression of other solid cancers is not well understood. Herein, we explored telomere dynamics in patient-derived epithelial ovarian cancers (OC), a malignancy characterized by multiple distinct subtypes, extensive molecular heterogeneity, and widespread genomic instability. We discovered a high frequency of telomere fusions in ovarian tumor tissues; however, limited telomere fusions were detected in normal adjacent tissues or benign ovarian samples. In addition, we found relatively high levels of both telomerase activity and hTERT expression, along with anaphase bridges in tumor tissues, which were notably absent in adjacent normal ovarian tissues and benign lesions. These results suggest that telomere dysfunction may occur early in ovarian carcinogenesis and, importantly, that it may play a critical role in the initiation and progression of the disease. Recognizing telomere dysfunction as a pervasive feature of this heterogeneous malignancy may facilitate the future development of novel diagnostic tools and improved methods of disease monitoring and treatment.
journal_name
Cellsjournal_title
Cellsauthors
Huda N,Xu Y,Bates AM,Rankin DA,Kannan N,Gilley Ddoi
10.3390/cells8050414subject
Has Abstractpub_date
2019-05-04 00:00:00issue
5issn
2073-4409pii
cells8050414journal_volume
8pub_type
杂志文章相关文献
Cells文献大全abstract::The multifunctional HSP70 co-chaperone BAG3 (BCL-2-associated athanogene 3) represents a key player in the quality control of the cellular proteostasis network. In response to stress, BAG3 specifically targets aggregation-prone proteins to the perinuclear aggresome and promotes their degradation via BAG3-mediated sele...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9112416
更新日期:2020-11-04 00:00:00
abstract::Several decades after its discovery, the hepatitis B virus (HBV) still displays one of the most successful pathogens in human populations worldwide. The identification and characterization of interactions between cellular and pathogenic components are essential for the development of antiviral treatments. Due to its s...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9081889
更新日期:2020-08-12 00:00:00
abstract::Cancer cells perform a metabolic rewiring to sustain an increased growth rate and compensate for the redox stress caused by augmented energy metabolism. The metabolic changes are not the same in all cancers. Some features, however, are considered hallmarks of this disease. As an example, all cancer cells rewire the am...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9092028
更新日期:2020-09-03 00:00:00
abstract::Chemotherapeutic targeting of microtubules has been the standard of care in treating a variety of malignancies for decades. During mitosis, increased microtubule dynamics are necessary for mitotic spindle formation and successful chromosomal segregation. Microtubule targeting agents (MTAs) disrupt the dynamics necessa...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8040346
更新日期:2019-04-12 00:00:00
abstract::Disseminated metastatic cancer cells represent one of the most relevant causes of disease relapse and associated death for cancer patients, and a therapeutic target of the highest priority. Still, our understanding of how disseminated cancer cells survive in the foreign metastatic environment, and eventually cause met...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9010250
更新日期:2020-01-19 00:00:00
abstract::Radiotherapy is one of the major cancer treatment strategies. Exposure to penetrating radiation causes cellular stress, directly or indirectly, due to the generation of reactive oxygen species, DNA damage, and subcellular organelle damage and autophagy. These radiation-induced damage responses cooperatively contribute...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8091105
更新日期:2019-09-18 00:00:00
abstract::Patient-derived tumor organoids (PDOs) represent a promising preclinical cancer model that better replicates disease, compared with traditional cell culture models. We have established PDOs from various human tumors to accurately and efficiently recapitulate the tissue architecture and function. Molecular targeted the...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8050481
更新日期:2019-05-20 00:00:00
abstract::Autophagy is a key cellular process that involves constituent degradation and recycling during cellular development and homeostasis. Autophagy also plays key roles in antimicrobial host defense and numerous pathogenic organisms have developed strategies to take advantage of and/or modulate cellular autophagy. Several ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9040805
更新日期:2020-03-26 00:00:00
abstract::Nuclear transport receptors of the karyopherin superfamily of proteins transport macromolecules from one compartment to the other and are critical for both cell physiology and pathophysiology. The nuclear transport machinery is tightly regulated and essential to a number of key cellular processes since the spatiotempo...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells7110221
更新日期:2018-11-21 00:00:00
abstract::Ion channels (IChs) are transmembrane proteins that selectively drive ions across membranes. The function of IChs partially relies on their abundance and proper location in the cell, fine-tuned by the delicate balance between secretory, endocytic, and degradative pathways. The disruption of this balance is associated ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9081833
更新日期:2020-08-04 00:00:00
abstract::Adipose tissue accumulation is an independent and modifiable risk factor for cardiovascular disease (CVD). The recent CVD European Guidelines strongly recommend regular physical exercise (PE) as a management strategy for prevention and treatment of CVD associated with metabolic disorders and obesity. Although mutation...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8080875
更新日期:2019-08-11 00:00:00
abstract::Osteoarthritis (OA) is a degenerative and inflammatory joint disorder with cartilage loss. Dental pulp stem cells (DPSCs) can undergo chondrogenic differentiation and secrete growth factors associated with tissue repair and immunomodulation. Leukocyte- and platelet-rich fibrin (L-PRF) emerges in regenerative medicine ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9040980
更新日期:2020-04-15 00:00:00
abstract::Although G protein-coupled receptor kinases (GRKs) have long been known to regulate G protein-coupled receptor (GPCR) desensitization, their more recently characterized functions as scaffolds and signalling adapters underscore that this small family of proteins governs a larger array of physiological functions than or...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10010075
更新日期:2021-01-05 00:00:00
abstract::The third isotype of beta-adrenoreceptors (β3-AR) has recently come (back) into focus after the observation of its expression in white and beige human adipocytes and its implication in metabolic regulation. This coincides with the recent development and marketing of agonists at the human receptor with superior specifi...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9122584
更新日期:2020-12-02 00:00:00
abstract::Parkinson's disease (PD) is currently the world's fastest-growing neurological disorder. It is characterized by motor and non-motor symptoms which progressively lead to significant clinical impairment, causing a high burden of disease. In addition to pharmacological therapies, various non-pharmacological treatment opt...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8020151
更新日期:2019-02-11 00:00:00
abstract::The pathogenesis of inflammatory bowel disease (IBD) is not well-understood; however, increased and persistent intestinal inflammation, due to inappropriate immune responses that are caused by interactions between genetic factors, gut microbiota, and environmental factors, are thought to lead to IBD. Various studies h...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8050404
更新日期:2019-05-01 00:00:00
abstract::Autophagy is an intracellular catabolic system that delivers cytoplasmic constituents and organelles in the vacuole. This degradative process is mediated by a group of proteins coded by autophagy-related (ATG) genes that are widely conserved from yeasts to plants and mammals. Homologs of ATG genes have been also ident...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells6040036
更新日期:2017-10-22 00:00:00
abstract::Detachment and the formation of spheroids under microgravity conditions can be observed with various types of intrinsically adherent human cells. In particular, for cancer cells this process mimics metastasis and may provide insights into cancer biology and progression that can be used to identify new drug/target comb...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9020367
更新日期:2020-02-05 00:00:00
abstract::Sars-Cov-2 infection causes fever and cough that may rapidly lead to acute respiratory distress syndrome (ARDS). Few biomarkers have been identified but, unfortunately, these are individually poorly specific, and novel biomarkers are needed to better predict patient outcome. The aim of this study was to evaluate the d...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010085
更新日期:2021-01-07 00:00:00
abstract::Metastasis is the leading cause of cancer death worldwide. Circulating tumor cells (CTCs) are a critical step in the metastatic cascade and a good tool to study this process. We isolated CTCs from a syngeneic mouse model of hepatocellular carcinoma (HCC) and a human xenograft mouse model of castration-resistant prosta...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8060618
更新日期:2019-06-20 00:00:00
abstract:OBJECTIVES:Synovial fluids of rheumatoid arthritis (RA) patients commonly contain high concentrations of soluble CD14 (sCD14). To investigate its potential role in RA pathogenesis, we tested whether sCD14 binding transmits a signal to fibroblast-like synoviocytes from RA patients (RA-FLS). METHODS:The induction of pro...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9071689
更新日期:2020-07-14 00:00:00
abstract::Actin remodeling is frequently regulated by antagonistic activities driving protrusion and contraction downstream of Rac and Rho small GTPases, respectively. WAVE regulatory complex (WRC), which primarily operates downstream of Rac, plays pivotal roles in neuronal morphogenesis. Recently, two independent studies descr...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9061355
更新日期:2020-05-29 00:00:00
abstract::Mast cells have been associated with arteriogenesis and collateral formation. In advanced human atherosclerotic plaques, mast cells have been shown to colocalize with plaque neovessels, and mast cells have also been associated with tumor vascularization. Based on these associations, we hypothesize that mast cells prom...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9030701
更新日期:2020-03-12 00:00:00
abstract::Defects in membrane repair contribute to the development of some muscular dystrophies, highlighting the importance to decipher the membrane repair mechanisms in human skeletal muscle. In murine myofibers, the formation of a cap subdomain composed notably by annexins (Anx) is critical for membrane repair. We applied me...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9071742
更新日期:2020-07-21 00:00:00
abstract::The administration of adipose tissue-derived mesenchymal stem cells (ADMSCs) represents a promising therapeutic option after myocardial ischemia or myocardial infarction. However, their potential is reduced due to the high post-transplant cell mortality probably caused by oxidative stress and mitogen-deficient microen...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9102298
更新日期:2020-10-15 00:00:00
abstract::Grade IV astrocytomas, or glioblastomas (GBMs), are the most common malignant primary brain tumor in adults. The median GBM patient survival of 12-15 months has remained stagnant, in spite of treatment strategies, making GBMs a tremendous challenge clinically. This is at least in part due to the complex interaction of...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8101203
更新日期:2019-10-05 00:00:00
abstract::Stromal immune cells constitute the tumor microenvironment. These immune cell subsets include myeloid cells, the so-called tumor-associated myeloid cells (TAMCs), which are of two types: tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs). Breast tumors, particularly those in human epiderm...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9081785
更新日期:2020-07-27 00:00:00
abstract::Blood vessel formation or angiogenesis is a key process for successful tooth regeneration. Bone marrow-derived mesenchymal stromal cells (BM-MSCs) possess paracrine proangiogenic properties, which are, at least partially, induced by their extracellular vesicles (EVs). However, the isolation of BM-MSCs is associated wi...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9020312
更新日期:2020-01-28 00:00:00
abstract::The Epithelial Cell Adhesion Molecule or EpCAM is a well-known marker highly expressed in carcinomas and showing a strong correlation with poor cancer prognosis. While its name relates to its proposed function as a cell adhesion molecule, EpCAM has been shown to have various signalling functions. In particular, it has...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9092128
更新日期:2020-09-19 00:00:00
abstract::Background: Insulin resistance (IR), considered a hallmark of diabetes at the cellular level, is implicated in pre-diabetes, results in type 2 diabetes, and negatively affects mitochondrial function. Diabetes is increasingly associated with enhanced risk of developing Parkinson's disease (PD); however, the underlying ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9030740
更新日期:2020-03-17 00:00:00