Regulation of Oncogenic Targets by miR-99a-3p (Passenger Strand of miR-99a-Duplex) in Head and Neck Squamous Cell Carcinoma.

abstract：:Blood-derived microRNA signatures have emerged as powerful biomarkers for predicting and diagnosing cardiovascular disease, cancer, and metabolic disorders. Platelets and platelet-derived microvesicles are a major source of microRNAs. We have previously shown that the inappropriate anticoagulation and storage of blood...

journal_title：Cells

authors： Mussbacher M,Krammer TL,Heber S,Schrottmaier WC,Zeibig S,Holthoff HP,Pereyra D,Starlinger P,Hackl M,Assinger A

更新日期：2020-08-18 00:00:00

abstract：:In this study we report the functional comparison of T cell receptor (TCR)-engineered major histocompatibility complex (MHC) class I-restricted CD4+ versus CD8+ T cells targeting a peptide from six transmembrane epithelial antigen of the prostate 1 (STEAP1) in the context of HLA-A*02:01. STEAP1 is a tumor-associated a...

journal_title：Cells

authors： Schober SJ,Thiede M,Gassmann H,Prexler C,Xue B,Schirmer D,Wohlleber D,Stein S,Grünewald TGP,Busch DH,Richter GHS,Burdach SEG,Thiel U

更新日期：2020-06-29 00:00:00

abstract：:Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcriptio...

journal_title：Cells

authors： Liang S,Hu L,Wu Z,Chen Z,Liu S,Xu X,Qian A

更新日期：2020-06-18 00:00:00

abstract：:Lamins are important filaments forming the inner nuclear membrane. Lamin A is processed by zinc metalloproteinase (ZMPSTE24). Failure to cleave a truncated form of prelamin A-also called progerin-causes Hutchinson-Gilford progeria syndrome a well-known premature aging disease. Minor levels of progerin are readily expr...

journal_title：Cells

authors： Messner M,Ghadge SK,Maurer T,Graber M,Staggl S,Christine Maier S,Pölzl G,Zaruba MM

更新日期：2020-08-28 00:00:00

abstract：:The complex nature and structure of the human immunodeficiency virus has rendered the cure for HIV infections elusive. The advances in antiretroviral treatment regimes and the development of highly advanced anti-retroviral therapy, which primarily targets the HIV enzymes, have dramatically changed the face of the HIV ...

journal_title：Cells

authors： Shukla E,Chauhan R

更新日期：2019-09-27 00:00:00

abstract：:Multipolar divisions of heated cells has long been thought to stem from centrosome aberrations of cells directly caused by heat stress. In this paper, through long-term live-cell imaging, we provide direct cellular evidences to demonstrate that heat stress can promote multiple multipolar divisions of MGC-803 and MCF-7...

journal_title：Cells

authors： Chen S,Liu M,Huang H,Li B,Zhao H,Feng XQ,Zhao HP

更新日期：2019-08-13 00:00:00

abstract：:(1) Aim: In the present paper we analyzed the transcriptome of CSCs (Cancer Stem Cells), in order to find defining molecular processes of breast cancer. (2) Methods: We performed RNA-Seq from CSCs isolated from the basal cell line MDA-MB-468. Enriched processes and networks were studied using the IPA (Ingenuity Pathwa...

journal_title：Cells

authors： Schwarz-Cruz Y Celis A,Ceballos-Cancino G,Vazquez-Santillan K,Espinosa M,Zampedri C,Bahena I,Ruiz V,Maldonado V,Melendez-Zajgla J

更新日期：2020-03-13 00:00:00

abstract：:Cell division cycle 42 (CDC42), a small Rho GTPase, plays a critical role in many cellular processes, including cell proliferation and survival. CDC42 interacts with the CRIB (Cdc42- and Rac-interactive binding) domain of CDC42SE1, a small effector protein of 9 kDa. We found that the expression of CDC42SE1 was reduced...

journal_title：Cells

authors： Kalailingam P,Tan HB,Pan JY,Tan SH,Thanabalu T

更新日期：2019-02-02 00:00:00

abstract：:Vesicle fusion is a fundamental cell biological process similar from yeasts to humans. For secretory vesicles, swelling is considered a step required for the expulsion of intravesicular content. Here this concept is revisited providing evidence that it may instead represent a general mechanism. We report the first exa...

journal_title：Cells

authors： Centrone M,De Santo MP,Nicotera I,Labate C,Ranieri M,Di Mise A,Mola MG,Mastrodonato M,Elliani R,Barberi R,Formoso V,Tamma G,Valenti G

更新日期：2018-12-19 00:00:00

abstract：:As the lung develops, epithelial-mesenchymal crosstalk is essential for the developmental processes that drive cell proliferation, differentiation, and extracellular matrix (ECM) production within the lung epithelial-mesenchymal trophic unit (EMTU). In asthma, a number of the lung EMTU developmental signals have been ...

journal_title：Cells

authors： Osei ET,Booth S,Hackett TL

更新日期：2020-07-15 00:00:00

abstract：:For decades, cardiovascular disease (CVD) has been the leading cause of death throughout most developed countries. Several studies relate RNA splicing, and more recently also circular RNAs (circRNAs), to CVD. CircRNAs originate from linear transcripts and have been shown to exhibit tissue-specific expression profiles....

journal_title：Cells

authors： Jakobi T,Siede D,Eschenbach J,Heumüller AW,Busch M,Nietsch R,Meder B,Most P,Dimmeler S,Backs J,Katus HA,Dieterich C

更新日期：2020-07-04 00:00:00

abstract：:Small guanosine triphosphatases (GTPases) gathered in the Rat sarcoma (Ras) superfamily represent a large family of proteins involved in several key cellular mechanisms. Within the Ras superfamily, the Ras homolog (Rho) family is specialized in the regulation of actin cytoskeleton-based mechanisms. These proteins swit...

journal_title：Cells

authors： Héraud C,Pinault M,Lagrée V,Moreau V

更新日期：2019-04-12 00:00:00

abstract：:EGFR and some of the cognate ligands extensively traffic in extracellular vesicles (EVs) from different biogenesis pathways. EGFR belongs to a family of four homologous tyrosine kinase receptors (TKRs). This family are one of the major drivers of cancer and is involved in several of the most frequent malignancies such...

journal_title：Cells

authors： Zanetti-Domingues LC,Bonner SE,Martin-Fernandez ML,Huber V

更新日期：2020-11-19 00:00:00

abstract：:YRNAs are a class of non-coding RNAs that are components of the Ro60 ribonucleoprotein particle and are essential for initiation of DNA replication. Ro60 ribonucleoprotein particle is a target of autoimmune antibodies in patients suffering from systemic lupus erythematosus and Sjögren's syndrome. Deregulation of YRNAs...

journal_title：Cells

authors： Guglas K,Kolenda T,Stasiak M,Kopczyńska M,Teresiak A,Ibbs M,Bliźniak R,Lamperska K

更新日期：2020-05-21 00:00:00

abstract：:T cells play an essential role in the pathogenesis of both human rheumatoid arthritis (RA) and its murine models. A key molecule in T cell activation is ZAP-70, therefore we aimed to investigate the effects of partial ZAP-70 deficiency on the pathogenesis of recombinant human G1(rhG1)-induced arthritis (GIA), a well-e...

journal_title：Cells

authors： Kugyelka R,Prenek L,Olasz K,Kohl Z,Botz B,Glant TT,Berki T,Boldizsár F

更新日期：2019-05-24 00:00:00

abstract：:The transient receptor potential cation channel subfamily M member 4 (TRPM4) channel influences calcium homeostasis during many physiological activities such as insulin secretion, immune response, respiratory reaction, and cerebral vasoconstriction. This calcium-activated, monovalent, selective cation channel also pla...

journal_title：Cells

authors： Wang C,Naruse K,Takahashi K

更新日期：2018-06-15 00:00:00

abstract：:Host immune responses play an important role in the outcome of infection with hepatitis C virus (HCV). They can lead to viral clearance and a positive outcome, or progression and severity of chronic disease. Extensive research in the past >25 years into understanding the immune responses against HCV have still resulte...

journal_title：Cells

authors： Agrawal B,Gupta N,Vedi S,Singh S,Li W,Garg S,Li J,Kumar R

更新日期：2019-05-26 00:00:00

abstract：:Innate lymphoid cells (ILCs) are tissue-resident sentinels of the immune system that function to protect local tissue microenvironments against pathogens and maintain homeostasis. However, because ILCs are sensitively tuned to perturbations within tissues, they can also contribute to host pathology when critical activ...

journal_title：Cells

authors： Rolot M,O'Sullivan TE

更新日期：2020-02-01 00:00:00

abstract：:Anchoring of heterochromatin to the nuclear envelope appears to be an important process ensuring the spatial organization of the chromatin structure and genome function in eukaryotic nuclei. Proteins of the inner nuclear membrane (INM) mediating these interactions are able to recognize lamina-associated heterochromati...

journal_title：Cells

authors： Lukášová E,Kovařík A,Kozubek S

更新日期：2018-02-06 00:00:00

abstract：:The calcium (Ca2+)-dependent membrane-binding Annexin A6 (AnxA6), is a multifunctional, predominantly intracellular scaffolding protein, now known to play relevant roles in different cancer types through diverse, often cell-type-specific mechanisms. AnxA6 is differentially expressed in various stages/subtypes of sever...

journal_title：Cells

authors： Korolkova OY,Widatalla SE,Williams SD,Whalen DS,Beasley HK,Ochieng J,Grewal T,Sakwe AM

更新日期：2020-08-07 00:00:00

abstract：:Hypertensive pregnancy has been associated with reduced nitric oxide (NO), bioavailability, and increased activity of matrix metalloproteinases (MMPs). However, it is unclear if MMPs activation is regulated by NO during pregnancy. To this end, we examined activity of MMP-2 and MMP-9 in plasma, placenta, uterus and aor...

journal_title：Cells

authors： Nascimento RA,Possomato-Vieira JS,Bonacio GF,Rizzi E,Dias-Junior CA

更新日期：2019-11-07 00:00:00

abstract：:Although thousands of long noncoding RNAs (lncRNAs) have been identified in porcine growth and development, the regulation mechanisms of functional lncRNAs have not been well explored. In this study, using 5'- and 3'-rapid amplification of cDNA ends (RACE) assays, we obtained two different variants of lncRNA maternall...

journal_title：Cells

authors： Cheng X,Li L,Shi G,Chen L,Fang C,Li M,Li C

更新日期：2020-02-15 00:00:00

abstract：:Receptor tyrosine kinases (RTKs) play essential roles in cellular processes, including metabolism, cell-cycle control, survival, proliferation, motility and differentiation. RTKs are all synthesized as single-pass transmembrane proteins and bind polypeptide ligands, mainly growth factors. It has long been thought that...

journal_title：Cells

authors： Maruyama IN

更新日期：2014-04-22 00:00:00

abstract：:The aim of this study was to compare the acute effects of thrombin and brain-derived neurotrophic factor (BDNF) on spontaneous miniature endplate potentials (MEPPs) and multiquantal evoked endplate potentials (EPPs) in mouse neuromuscular junctions (NMJs) of m. diaphragma and m. EDL. Intracellular microelectrode recor...

journal_title：Cells

authors： Gaydukov A,Bogacheva P,Tarasova E,Molchanova A,Miteva A,Pravdivceva E,Balezina O

更新日期：2019-07-22 00:00:00

abstract：:Metastatic spread is mainly sustained by cancer stem cells (CSC), a subpopulation of cancer cells that displays stemness features. CSC are thought to be derived from cancer cells that undergo epithelial to mesenchymal transition (EMT), thus acquiring resistance to anoikis and anti-cancer drugs. After detachment from t...

journal_title：Cells

authors： Paolillo M,Colombo R,Serra M,Belvisi L,Papetti A,Ciusani E,Comincini S,Schinelli S

更新日期：2019-11-13 00:00:00

abstract：:Almost 25 years ago, the first mammalian transient receptor potential (TRP) channel, now named TRPC1, was cloned and published (reviewed in [...]. ...

journal_title：Cells

authors： Dietrich A

更新日期：2019-05-04 00:00:00

abstract：:Stroke is a leading cause of death and disability globally and is associated with a number of co-morbidities including sepsis and sickle cell disease (SCD). Despite thrombo-inflammation underlying these co-morbidities, its pathogenesis remains complicated and drug discovery programs aimed at reducing and resolving the...

journal_title：Cells

authors： Vital SA,Senchenkova EY,Ansari J,Gavins FNE

更新日期：2020-11-13 00:00:00

abstract：:(1) Background: Refractory acute graft-versus-host disease (R-aGvHD) remains a leading cause of death after allogeneic stem cell transplantation. Survival rates of 15% after four years are currently achieved; deaths are only in part due to aGvHD itself, but mostly due to adverse effects of R-aGvHD treatment with immun...

journal_title：Cells

authors： Bonig H,Kuçi Z,Kuçi S,Bakhtiar S,Basu O,Bug G,Dennis M,Greil J,Barta A,Kállay KM,Lang P,Lucchini G,Pol R,Schulz A,Sykora KW,Teichert von Luettichau I,Herter-Sprie G,Ashab Uddin M,Jenkin P,Alsultan A,Buechner J,S

更新日期：2019-12-05 00:00:00

abstract：:The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenan...

journal_title：Cells

authors： Laronha H,Caldeira J

更新日期：2020-04-26 00:00:00

abstract：:Detachment and the formation of spheroids under microgravity conditions can be observed with various types of intrinsically adherent human cells. In particular, for cancer cells this process mimics metastasis and may provide insights into cancer biology and progression that can be used to identify new drug/target comb...

journal_title：Cells

authors： Melnik D,Sahana J,Corydon TJ,Kopp S,Nassef MZ,Wehland M,Infanger M,Grimm D,Krüger M

更新日期：2020-02-05 00:00:00