Activation of Cryptic 3' Splice-Sites by SRSF2 Contributes to Cassette Exon Skipping.

abstract：:Aging is characterized by the gradual loss of tissue function and integrity. Activation of inflammatory responses accelerates the deterioration of cells and tissues. Many studies have shown that alteration of the components of the nuclear lamina is associated with inflammation, both in vivo and in vitro. However, the ...

journal_title：Cells

authors： Kristiani L,Kim M,Kim Y

更新日期：2020-03-14 00:00:00

abstract：:Adipose tissue accumulation is an independent and modifiable risk factor for cardiovascular disease (CVD). The recent CVD European Guidelines strongly recommend regular physical exercise (PE) as a management strategy for prevention and treatment of CVD associated with metabolic disorders and obesity. Although mutation...

journal_title：Cells

authors： Sandrini L,Ieraci A,Amadio P,Zarà M,Mitro N,Lee FS,Tremoli E,Barbieri SS

更新日期：2019-08-11 00:00:00

abstract：:In mammal myocytes, endothelial cells and inner ear cells, ferlins are proteins involved in membrane processes such as fusion, recycling, endo- and exocytosis. They harbour several C2 domains allowing their interaction with phospholipids. The expression of several Ferlin genes was described as altered in several tumou...

journal_title：Cells

authors： Peulen O,Rademaker G,Anania S,Turtoi A,Bellahcène A,Castronovo V

更新日期：2019-08-22 00:00:00

abstract：:Stromal immune cells constitute the tumor microenvironment. These immune cell subsets include myeloid cells, the so-called tumor-associated myeloid cells (TAMCs), which are of two types: tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs). Breast tumors, particularly those in human epiderm...

journal_title：Cells

authors： Cha YJ,Koo JS

更新日期：2020-07-27 00:00:00

abstract：:CCN1 and CCN2 are members of the CCN family and play essential roles in the regulation of multiple female reproductive functions, including ovulation. Cyclooxygenase-2 (COX2) is a critical mediator of ovulation and can be induced by sphingosine-1-phosphate (S1P) through the S1P1/3-mediated Yes-associated protein (YAP)...

journal_title：Cells

authors： Hu LL,Chang HM,Yi Y,Liu Y,Taylor EL,Zheng LP,Leung PCK

更新日期：2019-11-15 00:00:00

abstract：:Histones are constitutive components of nucleosomes and key regulators of chromatin structure. We previously observed that an extrachromosomal histone H2B (ecH2B) localizes at the intercellular bridge (ICB) connecting the two daughter cells during cytokinesis independently of DNA and RNA. Here, we show that ecH2B bind...

journal_title：Cells

authors： Monteonofrio L,Valente D,Rinaldo C,Soddu S

更新日期：2019-11-05 00:00:00

abstract：:Schizophrenia is a severe psychiatric disorder with a complex array of signs and symptoms that causes very significant disability in young people. While schizophrenia has a strong genetic component, with heritability around 80%, there is also a very significant range of environmental exposures and stressors that have ...

journal_title：Cells

authors： Khavari B,Cairns MJ

更新日期：2020-08-05 00:00:00

abstract：:Lupus flares when genetically predisposed people encounter exogenous agents such as infections and sun exposure and drugs such as procainamide and hydralazine, but the mechanisms by which these agents trigger the flares has been unclear. Current evidence indicates that procainamide and hydralazine, as well as inflamma...

journal_title：Cells

authors： Richardson B

更新日期：2019-02-05 00:00:00

abstract：:During the development of hypertrophic cardiomyopathy, the heart returns to fetal energy metabolism where cells utilize more glucose instead of fatty acids as a source of energy. Metabolism of glucose can increase synthesis of the extracellular glycosaminoglycan hyaluronan, which has been shown to be involved in the d...

journal_title：Cells

authors： Lorén CE,Dahl CP,Do L,Almaas VM,Geiran OR,Mörner S,Hellman U

更新日期：2019-01-29 00:00:00

abstract：:Pancreatic beta-cell apoptosis is an important feature of islets in type 2 diabetes. Apoptosis can occur through two major pathways, the extrinsic or death receptor mediated pathway, and the intrinsic or Bcl-2-regulated pathway. Hyperglycaemia, hyperlipidaemia and islet amyloid poly-peptide (IAPP) represent important ...

journal_title：Cells

authors： Wali JA,Masters SL,Thomas HE

更新日期：2013-04-26 00:00:00

abstract：:More than 50 years after the first description of Bronchopulmonary dysplasia (BPD) by Northway, this chronic lung disease affecting many preterm infants is still poorly understood. Additonally, approximately 40% of preterm infants suffering from severe BPD also suffer from Bronchopulmonary dysplasia-associated pulmona...

journal_title：Cells

authors： Chao CM,Chong L,Chu X,Shrestha A,Behnke J,Ehrhardt H,Zhang J,Chen C,Bellusci S

更新日期：2020-08-11 00:00:00

abstract：:Hspb8 is a member of the small heat shock protein (sHSP) family. Its expression is known to be upregulated under heat shock. This protein interacts with different partners and can, therefore, be involved in various processes relevant to tissue integrity and functioning. In humans, mutations in the gene encoding Hspb8 ...

journal_title：Cells

authors： Dubińska-Magiera M,Niedbalska-Tarnowska J,Migocka-Patrzałek M,Posyniak E,Daczewska M

更新日期：2020-06-26 00:00:00

abstract：:While high levels of saturated fatty acids are associated with impairment of cardiovascular functions, n-3 polyunsaturated fatty acids (PUFAs) have been shown to exert protective effects. However the molecular mechanisms underlying this evidence are not completely understood. In the present study we have used rat H9c2...

journal_title：Cells

authors： Cetrullo S,D'Adamo S,Panichi V,Borzì RM,Pignatti C,Flamigni F

更新日期：2020-02-26 00:00:00

abstract：:The mitochondrial genetic disorder, Leber's hereditary optic neuropathy (LHON), is caused by a mutation in MT-ND4 gene, encoding NADH dehydrogenase subunit 4. It leads to the progressive death of retinal ganglion cells (RGCs) and causes visual impairment or even blindness. However, the precise mechanisms of LHON disea...

journal_title：Cells

authors： Yang YP,Nguyen PNN,Lin TC,Yarmishyn AA,Chen WS,Hwang DK,Chiou GY,Lin TW,Chien CS,Tsai CY,Chiou SH,Chen SJ,Peng CH,Hsu CC

更新日期：2019-06-21 00:00:00

abstract：:Microautophagy is a type of autophagy. It is characterized by direct enclosing with the vacuolar/lysosomal membrane, which completes the isolation and uptake of cell components in the vacuole. Several publications present evidence that plants exhibit microautophagy. Plant microautophagy is involved in anthocyanin accu...

journal_title：Cells

authors： Sieńko K,Poormassalehgoo A,Yamada K,Goto-Yamada S

更新日期：2020-04-04 00:00:00

abstract：:Inborn errors of metabolism and diabetes share common derangements in analytes of metabolic networks that are tested for in newborn screening, usually performed 48-72 h after birth. There is limited research examining the metabolic imprint of diabetes on newborn screening results. This paper aims to demonstrate the li...

journal_title：Cells

authors： Estrella JFGL,Immanuel J,Wiley V,Simmons D

更新日期：2020-10-15 00:00:00

abstract：:Commonly, circulating tumor cells (CTCs) are described as source of metastasis in cancer patients. However, in this process cancer cells of the primary tumor site need to survive the physical and biological challenges in the blood stream before leaving the circulation to become the seed of a new metastatic site in dis...

journal_title：Cells

authors： Heeke S,Mograbi B,Alix-Panabières C,Hofman P

更新日期：2019-07-13 00:00:00

abstract：:The chronic factor of the Hepatitis B Virus (HBV), specifically the covalently closed circular DNA (cccDNA), is a highly stable and active viral episomal genome established in the livers of chronic hepatitis B patients as a constant source of disease. Being able to target and eliminate cccDNA is the end goal for a gen...

journal_title：Cells

authors： Marchetti AL,Guo H

更新日期：2020-11-06 00:00:00

abstract：:Spermatogonial stem cells (SSCs) are the only adult stem cells capable of passing genes onto the next generation. SSCs also have the potential to provide important knowledge about stem cells in general and to offer critical in vitro and in vivo applications in assisted reproductive technologies. After century-long res...

journal_title：Cells

authors： Ibtisham F,Honaramooz A

更新日期：2020-03-18 00:00:00

abstract：:Ovulation denotes the discharge of fertilizable oocytes from ovarian follicles. Follicle rupture during ovulation requires extracellular matrix (ECM) degradation at the apex of the follicle. In the teleost medaka, an excellent model for vertebrate ovulation studies, LH-inducible matrix metalloproteinase 15 (Mmp15) pla...

journal_title：Cells

authors： Ogiwara K,Takahashi T

更新日期：2019-03-04 00:00:00

abstract：:Telomeres with G-rich repetitive DNA and particular proteins as special heterochromatin structures at the termini of eukaryotic chromosomes are tightly maintained to safeguard genetic integrity and functionality. Telomerase as a specialized reverse transcriptase uses its intrinsic RNA template to lengthen telomeric G-...

journal_title：Cells

authors： Liu J,Wang L,Wang Z,Liu JP

更新日期：2019-01-15 00:00:00

abstract：:Signaling via the Wnt-related receptor tyrosine kinase-like orphan receptor 1 (ROR1) triggers tumorigenic features associated with cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT), while aberrant expression of ROR1 is strongly linked to advanced disease progression and chemoresistance. Several rece...

journal_title：Cells

authors： Karvonen H,Barker H,Kaleva L,Niininen W,Ungureanu D

更新日期：2019-08-02 00:00:00

abstract：:Extracellular vesicles (EVs) contribute to a variety of signaling processes and the overall physiological and pathological states of stem cells and tissues. Human induced pluripotent stem cells (hiPSCs) have unique characteristics that can mimic embryonic tissue development. There is growing interest in the use of EVs...

journal_title：Cells

authors： Marzano M,Bejoy J,Cheerathodi MR,Sun L,York SB,Zhao J,Kanekiyo T,Bu G,Meckes DG Jr,Li Y

更新日期：2019-08-28 00:00:00

abstract：:Endoscopic submucosal dissection (ESD) is an effective treatment of early esophageal adenocarcinomas (EACs). The decision of ESD over esophagectomy is based on clinical evaluation of tumor depth and invasion. On a molecular level, tumor invasion is strongly associated with epithelial-to-mesenchymal transition (EMT). H...

journal_title：Cells

authors： Neureiter D,Mayr C,Winkelmann P,Neumayer B,Klieser E,Wagner A,Hufnagl C,Emmanuel K,Holzinger J,Koch O,Kiesslich T,Varga M

更新日期：2020-02-20 00:00:00

abstract：:Mammalian Pumilio (PUM) proteins are sequence-specific, RNA-binding proteins (RBPs) with wide-ranging roles. They are involved in germ cell development, which has functional implications in development and fertility. Although human PUM1 and PUM2 are closely related to each other and recognize the same RNA binding moti...

journal_title：Cells

authors： Smialek MJ,Ilaslan E,Sajek MP,Swiercz A,Janecki DM,Kusz-Zamelczyk K,Wozniak T,Kotecki M,Handschuh L,Figlerowicz M,Jaruzelska J

更新日期：2020-04-16 00:00:00

abstract：:The third isotype of beta-adrenoreceptors (β3-AR) has recently come (back) into focus after the observation of its expression in white and beige human adipocytes and its implication in metabolic regulation. This coincides with the recent development and marketing of agonists at the human receptor with superior specifi...

journal_title：Cells

authors： Michel LYM,Farah C,Balligand JL

更新日期：2020-12-02 00:00:00

abstract：:Approximately 3 × 1017 DNA damage events take place per hour in the human body. Within clustered DNA lesions, they pose a serious problem for repair proteins, especially for iron-sulfur glycosylases (MutyH), which can recognize them by the electron-transfer process. It has been found that the presence of both 5',8-cyc...

journal_title：Cells

authors： Karwowski BT

更新日期：2020-02-12 00:00:00

abstract：:Podoplanin and CD44 are transmembrane glycoproteins involved in inflammation and cancer. In this paper, we report that podoplanin is coordinately expressed with the CD44 standard (CD44s) and variant (CD44v) isoforms in vivo-in hyperplastic skin after a pro-inflammatory stimulus with 12-O-tetradecanoylphorbol-13-acetat...

journal_title：Cells

authors： Montero-Montero L,Renart J,Ramírez A,Ramos C,Shamhood M,Jarcovsky R,Quintanilla M,Martín-Villar E

更新日期：2020-09-29 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver diseases with an increasing prevalence due to rising rates of obesity, metabolic syndrome and type II diabetes. Untreated NAFLD may progress to steatohepatitis (NASH) and ultimately liver cirrhosis. NAFLD is characterized by lipid accumulatio...

journal_title：Cells

authors： Asimakopoulou A,Engel KM,Gassler N,Bracht T,Sitek B,Buhl EM,Kalampoka S,Pinoé-Schmidt M,van Helden J,Schiller J,Weiskirchen R

更新日期：2020-05-28 00:00:00

abstract：:Autophagy is a highly regulated bulk degradation process that plays a key role in the maintenance of cellular homeostasis. During autophagy, a double membrane-bound compartment termed the autophagosome is formed through de novo nucleation and assembly of membrane sources to engulf unwanted cytoplasmic components and t...

journal_title：Cells

authors： Lai LTF,Ye H,Zhang W,Jiang L,Lau WCY

更新日期：2019-12-12 00:00:00