Clustered DNA Damage: Electronic Properties and Their Influence on Charge Transfer. 7,8-Dihydro-8-Oxo-2'-Deoxyguaosine Versus 5',8-Cyclo-2'-Deoxyadenosines: A Theoretical Approach.

Abstract:

:Approximately 3 × 1017 DNA damage events take place per hour in the human body. Within clustered DNA lesions, they pose a serious problem for repair proteins, especially for iron-sulfur glycosylases (MutyH), which can recognize them by the electron-transfer process. It has been found that the presence of both 5',8-cyclo-2'-deoxyadenosine (cdA) diastereomers in the ds-DNA structure, as part of a clustered lesion, can influence vertical radical cation distribution within the proximal part of the double helix, i.e., d[~oxoGcAoxoG~] (7,8-dihydro-8-oxo-2'-deoxyguaosine - oxodG). Here, the influence of cdA, "the simplest tandem lesion", on the charge transfer through ds-DNA was taken into theoretical consideration at the M062x/6-31+G** level of theory in the aqueous phase. It was shown that the presence of (5'S)- or (5'R)-cdA leads to a slowdown in the hole transfer by one order of magnitude between the neighboring dGoxodG in comparison to "native" ds-DNA. Therefore, it can be concluded that such clustered lesions can lead to defective damage recognition with a subsequent slowing down of the DNA repair process, giving rise to an increase in mutations. As a result, the unrepaired, oxodG: dA base pair prior to genetic information replication can finally result in GC TA or ATCG transversion. This type of mutation is commonly observed in human cancer cells. Moreover, because local multiple damage sites (LMSD) are effectively produced as a result of ionization factors, the presented data in this article might be useful in developing a new scheme of radiotherapy treatment against the background of DNA repair efficiency.

journal_name

Cells

journal_title

Cells

authors

Karwowski BT

doi

10.3390/cells9020424

subject

Has Abstract

pub_date

2020-02-12 00:00:00

issue

2

issn

2073-4409

pii

cells9020424

journal_volume

9

pub_type

杂志文章

相关文献

Cells文献大全
  • Physical Exercise Affects Adipose Tissue Profile and Prevents Arterial Thrombosis in BDNF Val66Met Mice.

    abstract::Adipose tissue accumulation is an independent and modifiable risk factor for cardiovascular disease (CVD). The recent CVD European Guidelines strongly recommend regular physical exercise (PE) as a management strategy for prevention and treatment of CVD associated with metabolic disorders and obesity. Although mutation...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells8080875

    authors: Sandrini L,Ieraci A,Amadio P,Zarà M,Mitro N,Lee FS,Tremoli E,Barbieri SS

    更新日期:2019-08-11 00:00:00

  • Alterations in Progesterone Receptor Isoform Balance in Normal and Neoplastic Breast Cells Modulates the Stem Cell Population.

    abstract::To investigate the role of PR isoforms on the homeostasis of stem cells in the normal and neoplastic mammary gland, we used PRA and PRB transgenic mice and the T47D human breast cancer cell line and its derivatives, T47D YA and YB (manipulated to express only PRA or PRB, respectively). Flow cytometry and mammosphere a...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9092074

    authors: Recouvreux MS,Diaz Bessone MI,Taruselli A,Todaro L,Lago Huvelle MA,Sampayo RG,Bissell MJ,Simian M

    更新日期:2020-09-11 00:00:00

  • ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA.

    abstract::Lamins are important filaments forming the inner nuclear membrane. Lamin A is processed by zinc metalloproteinase (ZMPSTE24). Failure to cleave a truncated form of prelamin A-also called progerin-causes Hutchinson-Gilford progeria syndrome a well-known premature aging disease. Minor levels of progerin are readily expr...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9091981

    authors: Messner M,Ghadge SK,Maurer T,Graber M,Staggl S,Christine Maier S,Pölzl G,Zaruba MM

    更新日期:2020-08-28 00:00:00

  • Evaluation of the Effectiveness of Mesenchymal Stem Cells of the Placenta and Their Conditioned Medium in Local Radiation Injuries.

    abstract:BACKGROUND:The search for an effective therapy for local radiation injuries (LRI) is urgent; one option is mesenchymal stem cells (MSC) derived from the placenta and their conditioned medium for the regenerative processes of the skin. METHODS:We used 80 animals, randomly assigned to four groups: control (C) animals th...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9122558

    authors: Brunchukov V,Astrelina T,Usupzhanova D,Rastorgueva A,Kobzeva I,Nikitina V,Lishchuk S,Dubova E,Pavlov K,Brumberg V,Benderitter M,Samoylov A

    更新日期:2020-11-29 00:00:00

  • Nevoid Basal Cell Carcinoma Syndrome: PTCH1 Mutation Profile and Expression of Genes Involved in the Hedgehog Pathway in Argentinian Patients.

    abstract::Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder characterized by multiple basal cell carcinomas (BCC), mainly caused by PTCH1 gene mutations. Our current study aimed to establish (1) PTCH1 germinal and somatic mutational status, (2) component and Hedgehog (HH) pathway targets gene expres...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells8020144

    authors: Martinez MF,Romano MV,Martinez AP,González A,Muchnik C,Stengel FM,Mazzuoccolo LD,Azurmendi PJ

    更新日期:2019-02-11 00:00:00

  • Structural Biology and Electron Microscopy of the Autophagy Molecular Machinery.

    abstract::Autophagy is a highly regulated bulk degradation process that plays a key role in the maintenance of cellular homeostasis. During autophagy, a double membrane-bound compartment termed the autophagosome is formed through de novo nucleation and assembly of membrane sources to engulf unwanted cytoplasmic components and t...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells8121627

    authors: Lai LTF,Ye H,Zhang W,Jiang L,Lau WCY

    更新日期:2019-12-12 00:00:00

  • Melatonin's Antineoplastic Potential Against Glioblastoma.

    abstract::Glioblastoma (GBM) is one of the most intransigent and aggressive brain tumors, and its treatment is extremely challenging and ineffective. To improve patients' expectancy and quality of life, new therapeutic approaches were investigated. Melatonin is an endogenous indoleamine with an incredible variety of properties....

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9030599

    authors: Moretti E,Favero G,Rodella LF,Rezzani R

    更新日期:2020-03-03 00:00:00

  • Controversy in the Use of CD38 Antibody for Treatment of Myeloma: Is High CD38 Expression Good or Bad?

    abstract::During a time span of just a few years, the CD38 antibody, daratumumab, has been established as one of the most important new drugs for the treatment of multiple myeloma, both in the relapsed/refractory setting and, more recently, as a first-line treatment. Although much is known about the pleiotropic modes of action ...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9020378

    authors: Plesner T,van de Donk N,Richardson PG

    更新日期:2020-02-06 00:00:00

  • Methods to Monitor and Quantify Autophagy in the Social Amoeba Dictyostelium discoideum.

    abstract::Autophagy is a eukaryotic catabolic pathway that degrades and recycles cellular components to maintain homeostasis. It can target protein aggregates, superfluous biomolecular complexes, dysfunctional and damaged organelles, as well as pathogenic intracellular microbes. Autophagy is a dynamic process in which the diffe...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells6030018

    authors: Domínguez-Martín E,Cardenal-Muñoz E,King JS,Soldati T,Coria R,Escalante R

    更新日期:2017-07-03 00:00:00

  • The Rebirth of Matrix Metalloproteinase Inhibitors: Moving Beyond the Dogma.

    abstract::The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three decades ago. Initial clinical trials were disappointing, resulting in a negative view of MMPs as therapeutic targets. As a better understanding of MMP biology and inhibitor pharmacokinetic properties emerged, it became clear that init...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells8090984

    authors: Fields GB

    更新日期:2019-08-27 00:00:00

  • Dexamethasone Inhibits Spheroid Formation of Thyroid Cancer Cells Exposed to Simulated Microgravity.

    abstract::Detachment and the formation of spheroids under microgravity conditions can be observed with various types of intrinsically adherent human cells. In particular, for cancer cells this process mimics metastasis and may provide insights into cancer biology and progression that can be used to identify new drug/target comb...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9020367

    authors: Melnik D,Sahana J,Corydon TJ,Kopp S,Nassef MZ,Wehland M,Infanger M,Grimm D,Krüger M

    更新日期:2020-02-05 00:00:00

  • A New Highlight of Ephedra alata Decne Properties as Potential Adjuvant in Combination with Cisplatin to Induce Cell Death of 4T1 Breast Cancer Cells In Vitro and In Vivo.

    abstract::Despite major advances in the last 10 years, whether in terms of prevention or treatment, the 5 year survival rate remains relatively low for a large number of cancers. These therapeutic failures can be the consequence of several factors associated with the cellular modifications or with the host by itself, especially...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9020362

    authors: Sioud F,Amor S,Toumia IB,Lahmar A,Aires V,Chekir-Ghedira L,Delmas D

    更新日期:2020-02-04 00:00:00

  • Altered Expression of Mitoferrin and Frataxin, Larger Labile Iron Pool and Greater Mitochondrial DNA Damage in the Skeletal Muscle of Older Adults.

    abstract::Mitochondrial dysfunction and iron (Fe) dyshomeostasis are invoked among the mechanisms contributing to muscle aging, possibly via a detrimental mitochondrial-iron feed-forward loop. We quantified the labile Fe pool, Fe isotopes, and the expression of mitochondrial Fe handling proteins in muscle biopsies obtained from...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9122579

    authors: Picca A,Saini SK,Mankowski RT,Kamenov G,Anton SD,Manini TM,Buford TW,Wohlgemuth SE,Xiao R,Calvani R,Coelho-Júnior HJ,Landi F,Bernabei R,Hood DA,Marzetti E,Leeuwenburgh C

    更新日期:2020-12-02 00:00:00

  • Trifolium Repens Blocks Proliferation in Chronic Myelogenous Leukemia via the BCR-ABL/STAT5 Pathway.

    abstract::Some species of clover are reported to have beneficial effects in human diseases. However, little is known about the activity of the forage plant Trifolium repens, or white clover, which has been recently found to exert a hepatoprotective action. Scientific interest is increasingly focused on identifying new drugs, es...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9020379

    authors: Sarno F,Pepe G,Termolino P,Carafa V,Massaro C,Merciai F,Campiglia P,Nebbioso A,Altucci L

    更新日期:2020-02-06 00:00:00

  • Cannabinoid-Induced Autophagy and Heme Oxygenase-1 Determine the Fate of Adipose Tissue-Derived Mesenchymal Stem Cells under Stressful Conditions.

    abstract::The administration of adipose tissue-derived mesenchymal stem cells (ADMSCs) represents a promising therapeutic option after myocardial ischemia or myocardial infarction. However, their potential is reduced due to the high post-transplant cell mortality probably caused by oxidative stress and mitogen-deficient microen...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9102298

    authors: Bublitz K,Böckmann S,Peters K,Hinz B

    更新日期:2020-10-15 00:00:00

  • The Emerging Role and Promise of Circular RNAs in Obesity and Related Metabolic Disorders.

    abstract::Circular RNAs (circRNAs) are genome transcripts that are produced from back-splicing of specific regions of pre-mRNA. These single-stranded RNA molecules are widely expressed across diverse phyla and many of them are stable and evolutionary conserved between species. Growing evidence suggests that many circRNAs functi...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9061473

    authors: Zaiou M

    更新日期:2020-06-16 00:00:00

  • Newborn Screening Samples for Diabetes Research: An Underused Resource.

    abstract::Inborn errors of metabolism and diabetes share common derangements in analytes of metabolic networks that are tested for in newborn screening, usually performed 48-72 h after birth. There is limited research examining the metabolic imprint of diabetes on newborn screening results. This paper aims to demonstrate the li...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9102299

    authors: Estrella JFGL,Immanuel J,Wiley V,Simmons D

    更新日期:2020-10-15 00:00:00

  • Receptor Tyrosine Kinase Ubiquitination and De-Ubiquitination in Signal Transduction and Receptor Trafficking.

    abstract::Receptor tyrosine kinases (RTKs) are membrane-based sensors that enable rapid communication between cells and their environment. Evidence is now emerging that interdependent regulatory mechanisms, such as membrane trafficking, ubiquitination, proteolysis and gene expression, have substantial effects on RTK signal tran...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells7030022

    authors: Critchley WR,Pellet-Many C,Ringham-Terry B,Harrison MA,Zachary IC,Ponnambalam S

    更新日期:2018-03-15 00:00:00

  • A Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope.

    abstract::The ongoing threat of viral infections and the emergence of antiviral drug resistance warrants a ceaseless search for new antiviral compounds. Broadly-inhibiting compounds that act on elements shared by many viruses are promising antiviral candidates. Here, we identify a peptide derived from the cowpox virus protein C...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9091989

    authors: Luteijn RD,Praest P,Thiele F,Sadasivam SM,Singethan K,Drijfhout JW,Bach C,de Boer SM,Lebbink RJ,Tao S,Helfer M,Bach NC,Protzer U,Costa AI,Killian JA,Drexler I,Wiertz EJHJ

    更新日期:2020-08-29 00:00:00

  • Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology.

    abstract::Angiopoietins 1-4 (Ang1-4) represent an important family of growth factors, whose activities are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized are angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2). Ang1 is a potent angiogenic growth factor signaling through Tie2, whereas Ang2 was ...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells8050471

    authors: Akwii RG,Sajib MS,Zahra FT,Mikelis CM

    更新日期:2019-05-17 00:00:00

  • p190RhoGAPs, the ARHGAP35- and ARHGAP5-Encoded Proteins, in Health and Disease.

    abstract::Small guanosine triphosphatases (GTPases) gathered in the Rat sarcoma (Ras) superfamily represent a large family of proteins involved in several key cellular mechanisms. Within the Ras superfamily, the Ras homolog (Rho) family is specialized in the regulation of actin cytoskeleton-based mechanisms. These proteins swit...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells8040351

    authors: Héraud C,Pinault M,Lagrée V,Moreau V

    更新日期:2019-04-12 00:00:00

  • Special Issue on "Disease and the Hippo Pathway".

    abstract::The Hippo pathway is a cellular signalling network, which plays major roles in organ homeostasis and development[...]. ...

    journal_title:Cells

    pub_type: 社论

    doi:10.3390/cells8101179

    authors: Hansen CG

    更新日期:2019-09-30 00:00:00

  • Notch Signaling in Breast Cancer: A Role in Drug Resistance.

    abstract::Breast cancer is a heterogeneous disease that can be subdivided into unique molecular subtypes based on protein expression of the Estrogen Receptor, Progesterone Receptor, and/or the Human Epidermal Growth Factor Receptor 2. Therapeutic approaches are designed to inhibit these overexpressed receptors either by endocri...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9102204

    authors: BeLow M,Osipo C

    更新日期:2020-09-29 00:00:00

  • Yeast to Study Human Purine Metabolism Diseases.

    abstract::Purine nucleotides are involved in a multitude of cellular processes, and the dysfunction of purine metabolism has drastic physiological and pathological consequences. Accordingly, several genetic disorders associated with defective purine metabolism have been reported. The etiology of these diseases is poorly underst...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells8010067

    authors: Daignan-Fornier B,Pinson B

    更新日期:2019-01-17 00:00:00

  • Animal, Fungi, and Plant Genome Sequences Harbor Different Non-Canonical Splice Sites.

    abstract::Most protein-encoding genes in eukaryotes contain introns, which are interwoven with exons. Introns need to be removed from initial transcripts in order to generate the final messenger RNA (mRNA), which can be translated into an amino acid sequence. Precise excision of introns by the spliceosome requires conserved din...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells9020458

    authors: Frey K,Pucker B

    更新日期:2020-02-18 00:00:00

  • Interplay between Hormones and Several Abiotic Stress Conditions on Arabidopsis thaliana Primary Root Development.

    abstract::As sessile organisms, plants must adjust their growth to withstand several environmental conditions. The root is a crucial organ for plant survival as it is responsible for water and nutrient acquisition from the soil and has high phenotypic plasticity in response to a lack or excess of them. How plants sense and tran...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9122576

    authors: López-Ruiz BA,Zluhan-Martínez E,Sánchez MP,Álvarez-Buylla ER,Garay-Arroyo A

    更新日期:2020-12-01 00:00:00

  • An Immediate and Long-Term Complication of COVID-19 May Be Type 2 Diabetes Mellitus: The Central Role of β-Cell Dysfunction, Apoptosis and Exploration of Possible Mechanisms.

    abstract::The novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was declared a pandemic by the WHO on 19 March 2020. This pandemic is associated with markedly elevated blood glucose levels and a remarkable degree of insulin resistance, which suggests pancreatic ...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9112475

    authors: Hayden MR

    更新日期:2020-11-13 00:00:00

  • An Intricate Connection between Alternative Splicing and Phenotypic Plasticity in Development and Cancer.

    abstract::During tumor progression, hypoxia, nutrient deprivation or changes in the extracellular environment (i.e., induced by anti-cancer drugs) elicit adaptive responses in cancer cells. Cellular plasticity increases the chance that tumor cells may survive in a challenging microenvironment, acquire new mechanisms of resistan...

    journal_title:Cells

    pub_type: 杂志文章,评审

    doi:10.3390/cells9010034

    authors: Biamonti G,Infantino L,Gaglio D,Amato A

    更新日期:2019-12-21 00:00:00

  • Characterization of Brassica rapa RAP2.4-Related Proteins in Stress Response and as CUL3-Dependent E3 Ligase Substrates.

    abstract::The turnip Brassica rapa has important economic value and represents a good model system to study gene function in crop plants. ERF/AP2 transcription factors are a major group of proteins that are often involved in regulating stress-responses and developmental programs. Some ERF/AP2 proteins are targets of CULLIN3-bas...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells8040336

    authors: Mooney S,Al-Saharin R,Choi CM,Tucker K,Beathard C,Hellmann HA

    更新日期:2019-04-10 00:00:00

  • Subcutaneous Maturation of Neural Stem Cell-Loaded Hydrogels Forms Region-Specific Neuroepithelium.

    abstract::A combinatorial approach integrating stem cells and capable of exploiting available cues is likely needed to regenerate lost neural tissues and ultimately restore neurologic functions. This study investigates the effects of the subcutaneous maturation of adult-derived neural stem cell (aNSCs) seeded into biomaterial c...

    journal_title:Cells

    pub_type: 杂志文章

    doi:10.3390/cells7100173

    authors: Farrag M,Leipzig ND

    更新日期:2018-10-17 00:00:00