Abstract:
:Stromal immune cells constitute the tumor microenvironment. These immune cell subsets include myeloid cells, the so-called tumor-associated myeloid cells (TAMCs), which are of two types: tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs). Breast tumors, particularly those in human epidermal growth factor receptor 2 (HER-2)-positive breast cancer and triple-negative breast cancer, are solid tumors containing immune cell stroma. TAMCs drive breast cancer progression via immune mediated, nonimmune-mediated, and metabolic interactions, thus serving as a potential therapeutic target for breast cancer. TAMC-associated breast cancer treatment approaches potentially involve the inhibition of TAM recruitment, modulation of TAM polarization/differentiation, reduction of TAM products, elimination of MDSCs, and reduction of MDSC products. Furthermore, TAMCs can enhance or restore immune responses during cancer immunotherapy. This review describes the role of TAMs and MDSCs in breast cancer and elucidates the clinical implications of TAMs and MDSCs as potential targets for breast cancer treatment.
journal_name
Cellsjournal_title
Cellsauthors
Cha YJ,Koo JSdoi
10.3390/cells9081785subject
Has Abstractpub_date
2020-07-27 00:00:00issue
8issn
2073-4409pii
cells9081785journal_volume
9pub_type
杂志文章,评审相关文献
Cells文献大全abstract::We have previously postulated that unconventional myosin VI (MVI) could be involved in myoblast differentiation. Here, we addressed the mechanism(s) of its involvement using primary myoblast culture derived from the hindlimb muscles of Snell's waltzer mice, the natural MVI knockouts (MVI-KO). We observed that MVI-KO m...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9071673
更新日期:2020-07-11 00:00:00
abstract::Through the combined action of ubiquitinating and deubiquitinating enzymes, conjugation of ubiquitin to a target protein acts as a reversible post-translational modification functionally similar to phosphorylation. Indeed, ubiquitination is more and more recognized as a central process for the fine regulation of many ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells3020386
更新日期:2014-05-06 00:00:00
abstract::Human Toll-like receptor (TLR) signaling plays a vital role in intestinal inflammation by activating the NF-B pathway. By querying GENT2 datasets, we identified the gene expression level of TLR2 and TLR4 as being substantially increased in colorectal cancer. Introduction of shRNAs for TLR4 but not TLR2 dramatically re...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9020397
更新日期:2020-02-09 00:00:00
abstract::Centrosomes and primary cilia are usually considered as distinct organelles, although both are assembled with the same evolutionary conserved, microtubule-based templates, the centrioles. Centrosomes serve as major microtubule- and actin cytoskeleton-organizing centers and are involved in a variety of intracellular pr...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8070701
更新日期:2019-07-10 00:00:00
abstract::The γ-aminobutyric acid type A receptor-associated protein (GABARAP) and its close paralogs GABARAPL1 and GABARAPL2 constitute a subfamily of the autophagy-related 8 (Atg8) protein family. Being associated with a variety of dynamic membranous structures of autophagic and non-autophagic origin, Atg8 proteins functional...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9051296
更新日期:2020-05-22 00:00:00
abstract::Mutations in the LMNA gene, encoding the nuclear envelope A-type lamins, are responsible for muscular dystrophies, the most severe form being the LMNA-related congenital muscular dystrophy (L-CMD), with severe defects in myonucleus integrity. We previously reported that L-CMD mutations compromise the ability of muscle...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9040816
更新日期:2020-03-27 00:00:00
abstract::The insulin-like growth factor (IGF) system regulates metabolic and mitogenic signaling through an intricate network of related receptors and hormones. IGF-II is one of several hormones within this system that primarily regulates mitogenic functions and is especially important during fetal growth and development. IGF-...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9102276
更新日期:2020-10-12 00:00:00
abstract::Innate lymphoid cells (ILCs) are tissue-resident sentinels of the immune system that function to protect local tissue microenvironments against pathogens and maintain homeostasis. However, because ILCs are sensitively tuned to perturbations within tissues, they can also contribute to host pathology when critical activ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9020334
更新日期:2020-02-01 00:00:00
abstract::Parkinson's disease (PD) is the second most common neurodegenerative disease. PD patients exhibit motor symptoms such as akinesia/bradykinesia, tremor, rigidity, and postural instability due to a loss of nigrostriatal dopaminergic neurons. Although the pathogenesis in sporadic PD remains unknown, there is a consensus ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9122623
更新日期:2020-12-07 00:00:00
abstract::Tumor-infiltrating lymphocytes are known to be critical in controlling tumor progression. While the role of T lymphocytes has been extensively studied, the function of B cells in this context is still ill-defined. In this review, we propose to explore the role of B cells in tumor immunity. First of all we define their...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8050449
更新日期:2019-05-13 00:00:00
abstract::This review briefly summarizes the single cell application of classical chemical dyes used to visualize cardiomyocyte physiology and their undesirable toxicities which have the potential to confound experimental observations. We will discuss, in detail, the more recent iterative development of fluorescent and biolumin...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells7060051
更新日期:2018-05-31 00:00:00
abstract::There is growing evidence that mesenchymal stem cell (MSC)-based immunosuppression was mainly attributed to the effects of MSC-derived extracellular vesicles (MSC-EVs). MSC-EVs are enriched with MSC-sourced bioactive molecules (messenger RNA (mRNA), microRNAs (miRNAs), cytokines, chemokines, immunomodulatory factors) ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8121605
更新日期:2019-12-11 00:00:00
abstract::Neurodegenerative diseases (NDs) are a broad class of pathologies characterized by the progressive loss of neurons in the central nervous system. The main problem in the study of NDs is the lack of an adequate realistic experimental model to study the pathogenic mechanisms. Induced pluripotent stem cells (iPSCs) parti...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8080830
更新日期:2019-08-05 00:00:00
abstract::Signaling via the Wnt-related receptor tyrosine kinase-like orphan receptor 1 (ROR1) triggers tumorigenic features associated with cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT), while aberrant expression of ROR1 is strongly linked to advanced disease progression and chemoresistance. Several rece...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8080812
更新日期:2019-08-02 00:00:00
abstract::RhoBTB proteins constitute a subfamily of atypical Rho GTPases represented in mammals by RhoBTB1, RhoBTB2, and RhoBTB3. Their characteristic feature is a carboxyl terminal extension that harbors two BTB domains capable of assembling cullin 3-dependent ubiquitin ligase complexes. The expression of all three RHOBTB gene...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells5020028
更新日期:2016-06-14 00:00:00
abstract::The mechanism of intercellular transmission of pathological agents in neurodegenerative diseases has received much recent attention. Huntington's disease (HD) is caused by a monogenic mutation in the gene encoding Huntingtin (HTT). Mutant HTT (mHTT) harbors a CAG repeat extension which encodes an abnormally long polyg...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells7060059
更新日期:2018-06-14 00:00:00
abstract::Blood vessel formation or angiogenesis is a key process for successful tooth regeneration. Bone marrow-derived mesenchymal stromal cells (BM-MSCs) possess paracrine proangiogenic properties, which are, at least partially, induced by their extracellular vesicles (EVs). However, the isolation of BM-MSCs is associated wi...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9020312
更新日期:2020-01-28 00:00:00
abstract::Evaluation of myelin by magnetic resonance imaging (MRI) is a difficult challenge, but holds promise in demyelinating diseases, such as multiple sclerosis (MS). Although multiple techniques have been developed, no gold standard has been established. This study aims to evaluate the correlation between synthetic MRI mye...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9020393
更新日期:2020-02-08 00:00:00
abstract::Mitochondrial DNA (mtDNA) replication is thought to be an integral part of exercise-training-induced mitochondrial adaptations. Thus, mtDNA level is often used as an index of mitochondrial adaptations in training studies. We investigated the hypothesis that endurance exercise training-induced mitochondrial enzymatic c...
journal_title:Cells
pub_type: 临床试验,杂志文章
doi:10.3390/cells8030237
更新日期:2019-03-12 00:00:00
abstract::Peripherin 2 (Prph2) is a photoreceptor-specific tetraspanin protein present in the outer segment (OS) rims of rod and cone photoreceptors. It shares many common features with other tetraspanins, including a large intradiscal loop which contains several cysteines. This loop enables Prph2 to associate with itself to fo...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9030784
更新日期:2020-03-24 00:00:00
abstract::Extracellular vesicles (EVs) are involved in intercellular communication during carcinogenesis, and cancer cells are able to secrete EVs, in particular exosomes containing molecules, that can be transferred to recipient cells to induce pathological processes and significant modifications, as metastasis, increase of pr...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8080777
更新日期:2019-07-25 00:00:00
abstract::Network-based systems biology has become an important method for analyzing high-throughput gene expression data and gene function mining. Escherichia coli (E. coli) has long been a popular model organism for basic biological research. In this paper, weighted gene co-expression network analysis (WGCNA) algorithm was ap...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells7030019
更新日期:2018-03-08 00:00:00
abstract::Telomere dysfunction has been strongly implicated in the initiation of genomic instability and is suspected to be an early event in the carcinogenesis of human solid tumors. Recent findings have established the presence of telomere fusions in human breast and prostate malignancies; however, the onset of this genomic i...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8050414
更新日期:2019-05-04 00:00:00
abstract::BAG3, a multifunctional HSP70 co-chaperone and anti-apoptotic protein that interacts with the ATPase domain of HSP70 through its C-terminal BAG domain plays a key physiological role in cellular proteostasis. The HSP70/BAG3 complex determines the levels of a large number of selective client proteins by regulating their...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9030574
更新日期:2020-02-28 00:00:00
abstract::Metabolic remodelling of the tumour microenvironment is a major mechanism by which cancer cells survive and resist treatment. The pro-oncogenic inflammatory cascade released by adipose tissue promotes oncogenic transformation, proliferation, angiogenesis, metastasis and evasion of apoptosis. STAT3 has emerged as an im...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9041043
更新日期:2020-04-22 00:00:00
abstract::Myeloid cells, including macrophages and dendritic cells, represent an important first line of defense against infections. Upon recognition of pathogens, these cells undergo a metabolic reprogramming that supports their activation and ability to respond to the invading pathogens. An important metabolic regulator of th...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9010161
更新日期:2020-01-09 00:00:00
abstract::This study was aimed to investigate the role of SHP2 (Src-homology-2-containing phosphotyrosine phosphatase) in intricate signaling networks invoked by bovine oocyte to achieve maturation and blastocyst development. PTPN11 (Protein Tyrosine Phosphatase, non-receptor type 11) encoding protein SHP2, a positive transduce...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8101272
更新日期:2019-10-18 00:00:00
abstract::Cancer cells rely on aberrant transcription for growth and survival. Cyclin-dependent kinases (CDKs) play critical roles in regulating gene transcription by modulating the activity of RNA polymerase II (RNAPII). THZ1, a selective covalent inhibitor of CDK7, has antitumor effects in several human cancers. In this study...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8111469
更新日期:2019-11-19 00:00:00
abstract::L-Ascorbate (Asc) plays important roles in cell growth and plant development, and its de novo biosynthesis was catalyzed by the first rate-limiting enzyme VTC1. However, the function and regulatory mechanism of VTC1 involved in cell development is obscure in Gossypium hirsutum. Herein, the Asc content and AsA/DHA rati...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8091039
更新日期:2019-09-05 00:00:00
abstract::Blood-derived microRNA signatures have emerged as powerful biomarkers for predicting and diagnosing cardiovascular disease, cancer, and metabolic disorders. Platelets and platelet-derived microvesicles are a major source of microRNAs. We have previously shown that the inappropriate anticoagulation and storage of blood...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9081915
更新日期:2020-08-18 00:00:00