Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases.

abstract：:Extracellular matrix (ECM) remodeling is required for many physiological and pathological processes. Metalloproteinases (MMPs) are endopeptidases which are able to degrade different components of the ECM and nucleus matrix and to cleave numerous non-ECM proteins. Among pathological processes, MMPs are involved in adip...

journal_title：Cells

authors： Berg G,Barchuk M,Miksztowicz V

更新日期：2019-02-14 00:00:00

abstract：:We developed tumor-targeting Salmonella typhimurium (S. typhimurium) A1-R, a facultative anaerobe that is an auxotroph of leucine and arginine. The tumor-targeting efficacy of S. typhimurium A1-R was demonstrated in vivo and vitro using several malignant cell lines including melanoma, sarcoma, glioma, breast, pancreat...

journal_title：Cells

authors： Murakami T,Hiroshima Y,Miyake K,Kiyuna T,Endo I,Zhao M,Hoffman RM

更新日期：2019-06-16 00:00:00

abstract：:Fatty acids are the main respiratory substrates important for cardiac function, and their oxidation is altered during various chronic disorders. We investigated the mechanism of fatty acid-oxidation-induced changes and their relations with mitochondrial morphology and ADP/ATP carrier conformation on the kinetics of th...

journal_title：Cells

authors： Toleikis A,Trumbeckaite S,Liobikas J,Pauziene N,Kursvietiene L,Kopustinskiene DM

更新日期：2020-02-01 00:00:00

abstract：:The transient receptor potential cation channel subfamily M member 4 (TRPM4) channel influences calcium homeostasis during many physiological activities such as insulin secretion, immune response, respiratory reaction, and cerebral vasoconstriction. This calcium-activated, monovalent, selective cation channel also pla...

journal_title：Cells

authors： Wang C,Naruse K,Takahashi K

更新日期：2018-06-15 00:00:00

abstract：:The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three decades ago. Initial clinical trials were disappointing, resulting in a negative view of MMPs as therapeutic targets. As a better understanding of MMP biology and inhibitor pharmacokinetic properties emerged, it became clear that init...

journal_title：Cells

authors： Fields GB

更新日期：2019-08-27 00:00:00

abstract：:Gene editing permits changing specific DNA sequences within the vast genomes of human cells. Stem cells are particularly attractive targets for gene editing interventions as their self-renewal and differentiation capabilities consent studying cellular differentiation processes, screening small-molecule drugs, modeling...

journal_title：Cells

authors： Tasca F,Wang Q,Gonçalves MAFV

更新日期：2020-04-13 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by memory loss and multiple cognitive impairments. Several decades of intense research have revealed that multiple cellular changes are implicated in the development and progression of AD, including mitochondrial damage, synaptic dysfunc...

journal_title：Cells

authors： Reddy PH,Oliver DM

更新日期：2019-05-22 00:00:00

abstract：:Compartmentalization of diverse types of signaling molecules contributes to the precise coordination of signal propagation. The primary cilium fulfills this function by acting as a spatiotemporally confined sensory signaling platform. For the integrity of ciliary signaling, it is mandatory that the ciliary signaling p...

journal_title：Cells

authors： Tschaikner P,Enzler F,Torres-Quesada O,Aanstad P,Stefan E

更新日期：2020-01-03 00:00:00

abstract：:The xCELLigence real-time cell analysis (RTCA) system has the potential to detect cellular proliferation, migration, cytotoxicity, adherence, and remodeling. Although the RTCA system is widely recognized as a noninvasive and efficient tool for real-time monitoring of cellular fate, it cannot describe detailed cell mor...

journal_title：Cells

authors： Zhang L,Ye Y,Dhar R,Deng J,Tang H

更新日期：2019-10-21 00:00:00

abstract：:More than 50 years after the first description of Bronchopulmonary dysplasia (BPD) by Northway, this chronic lung disease affecting many preterm infants is still poorly understood. Additonally, approximately 40% of preterm infants suffering from severe BPD also suffer from Bronchopulmonary dysplasia-associated pulmona...

journal_title：Cells

authors： Chao CM,Chong L,Chu X,Shrestha A,Behnke J,Ehrhardt H,Zhang J,Chen C,Bellusci S

更新日期：2020-08-11 00:00:00

abstract：:Many life activities and key functions in organisms are maintained by different types of protein⁻protein interactions (PPIs). In order to accelerate the discovery of PPIs for different species, many computational methods have been developed. Unfortunately, even though computational methods are constantly evolving, eff...

journal_title：Cells

authors： Wang Y,You ZH,Yang S,Li X,Jiang TH,Zhou X

更新日期：2019-02-03 00:00:00

abstract：:The blood-brain barrier (BBB) is one of the most complex and selective barriers in the human organism. Its role is to protect the brain and preserve the homeostasis of the central nervous system (CNS). The central elements of this physical and physiological barrier are the endothelial cells that form a monolayer of ti...

journal_title：Cells

authors： Saint-Pol J,Gosselet F,Duban-Deweer S,Pottiez G,Karamanos Y

更新日期：2020-04-01 00:00:00

abstract：:RhoBTB proteins constitute a subfamily of atypical Rho GTPases represented in mammals by RhoBTB1, RhoBTB2, and RhoBTB3. Their characteristic feature is a carboxyl terminal extension that harbors two BTB domains capable of assembling cullin 3-dependent ubiquitin ligase complexes. The expression of all three RHOBTB gene...

journal_title：Cells

authors： Ji W,Rivero F

更新日期：2016-06-14 00:00:00

abstract：:Therapies intended to mitigate cardiovascular complications cannot be applied in practice without detailed knowledge of molecular mechanisms. Mitochondria, as the end-effector of cardioprotection, represent one of the possible therapeutic approaches. The present review provides an overview of factors affecting the reg...

journal_title：Cells

authors： Ferko M,Andelová N,Szeiffová Bačová B,Jašová M

更新日期：2019-11-17 00:00:00

abstract：:Endoscopic submucosal dissection (ESD) is an effective treatment of early esophageal adenocarcinomas (EACs). The decision of ESD over esophagectomy is based on clinical evaluation of tumor depth and invasion. On a molecular level, tumor invasion is strongly associated with epithelial-to-mesenchymal transition (EMT). H...

journal_title：Cells

authors： Neureiter D,Mayr C,Winkelmann P,Neumayer B,Klieser E,Wagner A,Hufnagl C,Emmanuel K,Holzinger J,Koch O,Kiesslich T,Varga M

更新日期：2020-02-20 00:00:00

abstract：:(1) Background: Hyperglycemia leads to several biochemical and physiological consequences, such as the generation of advanced glycation end products (AGEs) and reactive oxygen species (ROS), which are involved in the development of several human diseases. Intestinal cells are continuously exposed to pro-oxidants and l...

journal_title：Cells

authors： Morresi C,Cianfruglia L,Sartini D,Cecati M,Fumarola S,Emanuelli M,Armeni T,Ferretti G,Bacchetti T

更新日期：2019-12-11 00:00:00

abstract：:During tumor progression, hypoxia, nutrient deprivation or changes in the extracellular environment (i.e., induced by anti-cancer drugs) elicit adaptive responses in cancer cells. Cellular plasticity increases the chance that tumor cells may survive in a challenging microenvironment, acquire new mechanisms of resistan...

journal_title：Cells

authors： Biamonti G,Infantino L,Gaglio D,Amato A

更新日期：2019-12-21 00:00:00

abstract：:We have previously discovered that HDAC6 regulates the DNA damage response (DDR) via modulating the homeostasis of a DNA mismatch repair protein, MSH2, through HDAC6's ubiquitin E3 ligase activity. Here, we have reported HDAC6's second potential E3 ligase substrate, a critical cell cycle checkpoint protein, Chk1. We h...

journal_title：Cells

authors： Moses N,Zhang M,Wu JY,Hu C,Xiang S,Geng X,Chen Y,Bai W,Zhang YW,Bepler G,Zhang XM

更新日期：2020-10-04 00:00:00

abstract：:The hypoxia-inducible transcription factors (HIF)-1/2α are the main oxygen sensors which regulate the adaptation to intratumoral hypoxia. The aim of this study was to assess the role of the HIF proteins in regulating the radiation response of a non-small cell lung cancer (NSCLC) in vitro model. To directly assess the ...

journal_title：Cells

authors： Moreno Roig E,Groot AJ,Yaromina A,Hendrickx TC,Barbeau LMO,Giuranno L,Dams G,Ient J,Olivo Pimentel V,van Gisbergen MW,Dubois LJ,Vooijs MA

更新日期：2019-01-12 00:00:00

abstract：:Schizophrenia is a severe psychiatric disorder with a complex array of signs and symptoms that causes very significant disability in young people. While schizophrenia has a strong genetic component, with heritability around 80%, there is also a very significant range of environmental exposures and stressors that have ...

journal_title：Cells

authors： Khavari B,Cairns MJ

更新日期：2020-08-05 00:00:00

abstract：:Ovulation denotes the discharge of fertilizable oocytes from ovarian follicles. Follicle rupture during ovulation requires extracellular matrix (ECM) degradation at the apex of the follicle. In the teleost medaka, an excellent model for vertebrate ovulation studies, LH-inducible matrix metalloproteinase 15 (Mmp15) pla...

journal_title：Cells

authors： Ogiwara K,Takahashi T

更新日期：2019-03-04 00:00:00

abstract：:For years, moderate hypothermia (32 °C) has been proposed as an unorthodox therapy for liver injuries, with proven hepatoprotective potential. Yet, limited mechanistic understanding has largely denied its acceptance over conventional pharmaceuticals for hepatoprotection. Today, facing a high prevalence of acetaminophe...

journal_title：Cells

authors： Tan YL,Ho HK

更新日期：2020-10-26 00:00:00

abstract：:Blood vessel formation or angiogenesis is a key process for successful tooth regeneration. Bone marrow-derived mesenchymal stromal cells (BM-MSCs) possess paracrine proangiogenic properties, which are, at least partially, induced by their extracellular vesicles (EVs). However, the isolation of BM-MSCs is associated wi...

journal_title：Cells

authors： Merckx G,Hosseinkhani B,Kuypers S,Deville S,Irobi J,Nelissen I,Michiels L,Lambrichts I,Bronckaers A

更新日期：2020-01-28 00:00:00

abstract：:Angiogenesis is defined as the formation of new blood vessels and is a key phenomenon manifested in a host of cancers during which tyrosine kinases play a crucial role. Vascular endothelial growth factor receptor-2 (VEGFR-2) is pivotal in cancer angiogenesis, which warrants the urgency of discovering new anti-angiogen...

journal_title：Cells

authors： Rampogu S,Baek A,Park C,Parate S,Parameswaran S,Park Y,Shaik B,Kim JH,Park SJ,Lee KW

更新日期：2019-03-21 00:00:00

abstract：:Parkinson's Disease (PD) is typically classified as a neurodegenerative disease affecting the motor system. Recent evidence, however, has uncovered the presence of Lewy bodies in locations outside the CNS, in direct contact with the external environment, including the olfactory bulbs and the enteric nervous system. Th...

journal_title：Cells

authors： Miraglia F,Colla E

更新日期：2019-03-07 00:00:00

abstract：:Autophagy is a highly regulated bulk degradation process that plays a key role in the maintenance of cellular homeostasis. During autophagy, a double membrane-bound compartment termed the autophagosome is formed through de novo nucleation and assembly of membrane sources to engulf unwanted cytoplasmic components and t...

journal_title：Cells

authors： Lai LTF,Ye H,Zhang W,Jiang L,Lau WCY

更新日期：2019-12-12 00:00:00

abstract：:Blood-derived microRNA signatures have emerged as powerful biomarkers for predicting and diagnosing cardiovascular disease, cancer, and metabolic disorders. Platelets and platelet-derived microvesicles are a major source of microRNAs. We have previously shown that the inappropriate anticoagulation and storage of blood...

journal_title：Cells

authors： Mussbacher M,Krammer TL,Heber S,Schrottmaier WC,Zeibig S,Holthoff HP,Pereyra D,Starlinger P,Hackl M,Assinger A

更新日期：2020-08-18 00:00:00

abstract：:Mutations in the LMNA gene, encoding the nuclear envelope A-type lamins, are responsible for muscular dystrophies, the most severe form being the LMNA-related congenital muscular dystrophy (L-CMD), with severe defects in myonucleus integrity. We previously reported that L-CMD mutations compromise the ability of muscle...

journal_title：Cells

authors： Owens DJ,Fischer M,Jabre S,Moog S,Mamchaoui K,Butler-Browne G,Coirault C

更新日期：2020-03-27 00:00:00

abstract：:Circular RNAs (circRNAs) are genome transcripts that are produced from back-splicing of specific regions of pre-mRNA. These single-stranded RNA molecules are widely expressed across diverse phyla and many of them are stable and evolutionary conserved between species. Growing evidence suggests that many circRNAs functi...

journal_title：Cells

authors： Zaiou M

更新日期：2020-06-16 00:00:00

abstract：:For decades, cardiovascular disease (CVD) has been the leading cause of death throughout most developed countries. Several studies relate RNA splicing, and more recently also circular RNAs (circRNAs), to CVD. CircRNAs originate from linear transcripts and have been shown to exhibit tissue-specific expression profiles....

journal_title：Cells

authors： Jakobi T,Siede D,Eschenbach J,Heumüller AW,Busch M,Nietsch R,Meder B,Most P,Dimmeler S,Backs J,Katus HA,Dieterich C

更新日期：2020-07-04 00:00:00