Abstract：
:Compartmentalization of diverse types of signaling molecules contributes to the precise coordination of signal propagation. The primary cilium fulfills this function by acting as a spatiotemporally confined sensory signaling platform. For the integrity of ciliary signaling, it is mandatory that the ciliary signaling pathways are constantly attuned by alterations in both oscillating small molecules and the presence or absence of their sensor/effector proteins. In this context, ciliary G protein-coupled receptor (GPCR) pathways participate in coordinating the mobilization of the diffusible second messenger molecule 3',5'-cyclic adenosine monophosphate (cAMP). cAMP fluxes in the cilium are primarily sensed by protein kinase A (PKA) complexes, which are essential for the basal repression of Hedgehog (Hh) signaling. Here, we describe the dynamic properties of underlying signaling circuits, as well as strategies for second messenger compartmentalization. As an example, we summarize how receptor-guided cAMP-effector pathways control the off state of Hh signaling. We discuss the evidence that a macromolecular, ciliary-localized signaling complex, composed of the orphan GPCR Gpr161 and type I PKA holoenzymes, is involved in antagonizing Hh functions. Finally, we outline how ciliary cAMP-linked receptor pathways and cAMP-sensing signalosomes may become targets for more efficient combinatory therapy approaches to counteract dysregulation of Hh signaling.
journal_name
Cellsjournal_title
Cellsauthors
Tschaikner P,Enzler F,Torres-Quesada O,Aanstad P,Stefan Edoi
10.3390/cells9010118subject
Has Abstractpub_date
2020-01-03 00:00:00issue
1issn
2073-4409pii
cells9010118journal_volume
9pub_type
杂志文章,评审相关文献
Cells文献大全abstract：:During tumor progression, hypoxia, nutrient deprivation or changes in the extracellular environment (i.e., induced by anti-cancer drugs) elicit adaptive responses in cancer cells. Cellular plasticity increases the chance that tumor cells may survive in a challenging microenvironment, acquire new mechanisms of resistan...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9010034
更新日期：2019-12-21 00:00:00
abstract：:Langerhans cells (LC) are the resident antigen presenting cells of the mucosal epithelium and play an essential role in initiating immune responses. LC are the only cells in the body to contain Birbeck granules (BG), which are unique cytoplasmic organelles comprised of c-type lectin langerin. Studies of BG have histor...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9040974
更新日期：2020-04-15 00:00:00
abstract：:Obesity and its comorbidities like diabetes, hypertension and other cardiovascular disorders are the leading causes of death and disability worldwide. Metabolic diseases cause vascular dysfunction and loss of capillaries termed capillary rarefaction. Interestingly, obesity seems to affect capillary beds in an organ-sp...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9122683
更新日期：2020-12-14 00:00:00
abstract：:The important role of microRNAs (miRNAs) in the formation, development, diagnosis, and treatment of diseases has attracted much attention among researchers recently. In this study, we present an unsupervised deep learning model of the variational autoencoder for MiRNA-disease association prediction (VAEMDA). Through c...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8091040
更新日期：2019-09-06 00:00:00
abstract：:Evolutionarily conserved Notch plays a critical role in embryonic development and cellular self-renewal. It has both tumour suppressor and oncogenic activity, the latter of which is widely described. Notch-activating mutations are associated with haematological malignancies and several solid tumours including breast, ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9061503
更新日期：2020-06-20 00:00:00
abstract：:Transient receptor potential classical or canonical 4 (TRPC4) and TRPC5 channels are members of the classical or canonical transient receptor potential (TRPC) channel family of non-selective cation channels. TRPC4 and TRPC5 channels are widely accepted as receptor-operated cation channels that are activated in a phosp...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7110218
更新日期：2018-11-20 00:00:00
abstract：:The nucleolus has emerged as a cellular stress sensor and key regulator of p53-dependent and -independent stress responses. A variety of abnormal metabolic conditions, cytotoxic compounds, and physical insults induce alterations in nucleolar structure and function, a situation known as nucleolar or ribosomal stress. R...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells1040774
更新日期：2012-10-15 00:00:00
abstract：:Angiopoietins 1-4 (Ang1-4) represent an important family of growth factors, whose activities are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized are angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2). Ang1 is a potent angiogenic growth factor signaling through Tie2, whereas Ang2 was ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8050471
更新日期：2019-05-17 00:00:00
abstract：:The bioactive lipid sphingosine-1-phosphate (S1P), along with its receptors, modulates lymphocyte trafficking and immune responses to regulate skin inflammation. Macrophages are important in the pathogenesis of psoriasiform skin inflammation and express various S1P receptors. How they respond to S1P in skin inflammati...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8080785
更新日期：2019-07-28 00:00:00
abstract：:Background: The evidence on high-dose ifosfamide (HD-IFO) use in patients with relapsed osteosarcoma is limited. We performed a retrospective study to analyze HD-IFO activity. Methods: Patients with osteosarcoma relapsed after standard treatment [methotrexate, doxorubicin, cisplatin +/- ifosfamide (MAP+/-I)] with meas...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9112389
更新日期：2020-10-31 00:00:00
abstract：:Inhibitors of Apoptosis (IAPs) are a family of proteins with various biological functions including regulation of innate immunity and inflammation, cell proliferation, cell migration and apoptosis. They are characterized by the presence of at least one N-terminal baculoviral IAP repeat (BIR) domain involved in protein...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells2010163
更新日期：2013-03-14 00:00:00
abstract：:Second-generation antipsychotics (SGAs) are the cornerstone of treatment for schizophrenia because of their high clinical efficacy. However, SGA treatment is associated with severe metabolic alterations and body weight gain, which can increase the risk of type 2 diabetes and cardiovascular disease, and greatly acceler...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8111336
更新日期：2019-10-29 00:00:00
abstract：:Alternative splicing leads to the secretion of multiple forms of vascular endothelial growth factor-A (VEGF-A) that differ in their activity profiles with respect to neovascularization. FSAP (factor VII activating protease) is the zymogen form of a plasma protease that is activated (FSAPa) upon tissue injury via the r...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8111396
更新日期：2019-11-06 00:00:00
abstract：:Host immune responses play an important role in the outcome of infection with hepatitis C virus (HCV). They can lead to viral clearance and a positive outcome, or progression and severity of chronic disease. Extensive research in the past >25 years into understanding the immune responses against HCV have still resulte...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8050507
更新日期：2019-05-26 00:00:00
abstract：:Human embryonic stem cells (hESCs) have important roles in regenerative medicine, but only a few studies have investigated the cytokines secreted by hESCs. We screened and identified chemokine (C-X-C motif) ligand 14 (CXCL14), which plays crucial roles in hESC renewal. CXCL14, a C-X-C motif chemokine, is also named as...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9071706
更新日期：2020-07-16 00:00:00
abstract：:Dietary restriction (DR) is one of the most efficient approaches ameliorating the severity of different pathological conditions including aging. We investigated the protective potential of short-term DR in the model of acute kidney injury (AKI) in young and old rats. In kidney tissue, the levels of autophagy and mitop...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells7100178
更新日期：2018-10-22 00:00:00
abstract：:Breast cancer is a heterogeneous disease that can be subdivided into unique molecular subtypes based on protein expression of the Estrogen Receptor, Progesterone Receptor, and/or the Human Epidermal Growth Factor Receptor 2. Therapeutic approaches are designed to inhibit these overexpressed receptors either by endocri...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9102204
更新日期：2020-09-29 00:00:00
abstract：:Characterisation of animal models of diabetic cardiomyopathy may help unravel new molecular targets for therapy. Long-living individuals are protected from the adverse influence of diabetes on the heart, and the transfer of a longevity-associated variant (LAV) of the human BPIFB4 gene protects cardiac function in the ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9051283
更新日期：2020-05-21 00:00:00
abstract：:Oral cavity cancer is the most frequent malignancy of the head and neck. Unfortunately, despite educational interventions for prevention and early diagnosis, oral cancer patients are often diagnosed in advanced stages associated with poor prognosis and life expectancy. Therefore, there is an urgent need to find noninv...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8121653
更新日期：2019-12-17 00:00:00
abstract：:Epidermal growth factor receptor (EGFR) is the first discovered member of the receptor tyrosine kinase superfamily and plays a fundamental role during embryogenesis and in adult tissues, being involved in growth, differentiation, maintenance and repair of various tissues and organs. The role of EGFR in the regulation ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9081887
更新日期：2020-08-12 00:00:00
abstract：:Osteoarthritis (OA) is a degenerative disease of the hyaline articular cartilage. This disease is progressive and may lead to disability. Researchers proposed many regenerative approaches to treat osteoarthritis, including stem cells. Trans-differentiation of a fully differentiated cell state directly into another dif...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9010191
更新日期：2020-01-11 00:00:00
abstract：:Chronic myeloid leukemia (CML) has been a "model disease" with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission after targeted therapies, we describe here the journey of CML, focusing...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells10010117
更新日期：2021-01-10 00:00:00
abstract：:Neuroinflammation and cell death are among the common symptoms of many central nervous system diseases and injuries. Neuroinflammation and programmed cell death of the various cell types in the brain appear to be part of these disorders, and characteristic for each cell type, including neurons and glia cells. Concerni...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9040870
更新日期：2020-04-02 00:00:00
abstract：:The multifunctional HSP70 co-chaperone BAG3 (BCL-2-associated athanogene 3) represents a key player in the quality control of the cellular proteostasis network. In response to stress, BAG3 specifically targets aggregation-prone proteins to the perinuclear aggresome and promotes their degradation via BAG3-mediated sele...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9112416
更新日期：2020-11-04 00:00:00
abstract：:Stem cell therapy represents a promising approach in the treatment of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). The beneficial effect of stem cells is exerted by paracrine mediators, as exosomes, suggesting a possible potential use of these extracellular vesicles as non-cell b...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8091087
更新日期：2019-09-14 00:00:00
abstract：:It is well known that fibroblast growth factor receptor 2 (FGFR2) interacts with its ligand of fibroblast growth factor (FGF) therefore exerting biological functions on cell proliferation and differentiation. In this study, we first reported that the FGFR2 gene could generate a circular RNA of circFGFR2, which regulat...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells7110199
更新日期：2018-11-06 00:00:00
abstract：:MicroRNAs (miRNAs) have emerged as key players in tumor angiogenesis. Interleukin-17C (IL-17C) was identified to promote colorectal cancer (CRC) progression. Therefore, we aimed to investigate the effect of IL-17C on tumor angiogenesis, the involvement of miR-23a-3p in IL-17C signaling, and the direct target gene of m...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9061363
更新日期：2020-06-01 00:00:00
abstract：:Endocytosis and autophagy are evolutionarily conserved degradative processes in all eukaryotes. Both pathways converge to the lysosome where cargo is degraded. Improper lysosomal degradation is observed in many human pathologies, so its regulatory mechanisms are important to understand. Sec20/BNIP1 (BCL2/adenovirus E1...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8080768
更新日期：2019-07-24 00:00:00
abstract：:Neurodegenerative diseases (NDs) are a broad class of pathologies characterized by the progressive loss of neurons in the central nervous system. The main problem in the study of NDs is the lack of an adequate realistic experimental model to study the pathogenic mechanisms. Induced pluripotent stem cells (iPSCs) parti...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8080830
更新日期：2019-08-05 00:00:00
abstract：:Stroke is a leading cause of death and disability globally and is associated with a number of co-morbidities including sepsis and sickle cell disease (SCD). Despite thrombo-inflammation underlying these co-morbidities, its pathogenesis remains complicated and drug discovery programs aimed at reducing and resolving the...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9112473
更新日期：2020-11-13 00:00:00
