Role of the TRPM4 Channel in Cardiovascular Physiology and Pathophysiology.

abstract：:Xanthohumol (XN), a prenylated chalcone from hops, has been reported to exhibit a variety of health-beneficial effects. However, poor bioavailability may limit its application in the prevention and therapy of diseases. The objective of this study was to determine whether a micellar solubilization of xanthohumol could ...

journal_title：Cells

authors： Mahli A,Seitz T,Freese K,Frank J,Weiskirchen R,Abdel-Tawab M,Behnam D,Hellerbrand C

更新日期：2019-04-17 00:00:00

abstract：:The γ-aminobutyric acid type A receptor-associated protein (GABARAP) and its close paralogs GABARAPL1 and GABARAPL2 constitute a subfamily of the autophagy-related 8 (Atg8) protein family. Being associated with a variety of dynamic membranous structures of autophagic and non-autophagic origin, Atg8 proteins functional...

journal_title：Cells

authors： Dobner J,Simons IM,Rufinatscha K,Hänsch S,Schwarten M,Weiergräber OH,Abdollahzadeh I,Gensch T,Bode JG,Hoffmann S,Willbold D

更新日期：2020-05-22 00:00:00

abstract：:Autophagy is a conserved bulk degradation and recycling process that plays important roles in multiple biological functions, including inflammatory responses. As an important component of the innate immune system, macrophages are involved in defending cells from invading pathogens, clearing cellular debris, and regula...

journal_title：Cells

authors： Wu MY,Lu JH

更新日期：2019-12-27 00:00:00

abstract：:Neurodegenerative diseases (NDs) are a broad class of pathologies characterized by the progressive loss of neurons in the central nervous system. The main problem in the study of NDs is the lack of an adequate realistic experimental model to study the pathogenic mechanisms. Induced pluripotent stem cells (iPSCs) parti...

journal_title：Cells

authors： Fantini V,Bordoni M,Scocozza F,Conti M,Scarian E,Carelli S,Di Giulio AM,Marconi S,Pansarasa O,Auricchio F,Cereda C

更新日期：2019-08-05 00:00:00

abstract：:Innate immune cells monitor invading pathogens and pose the first-line inflammatory response to coordinate with adaptive immunity for infection removal. Innate immunity also plays pivotal roles in injury-induced tissue remodeling and the maintenance of tissue homeostasis in physiological and pathological conditions. L...

journal_title：Cells

authors： Tzeng HT,Chyuan IT,Chen WY

更新日期：2019-12-13 00:00:00

abstract：:One of the crucial challenges in the clinical management of cancer is resistance to chemotherapeutics. Multidrug resistance (MDR) has been intensively studied, and one of the most prominent mechanisms underlying MDR is overexpression of adenosine triphosphate (ATP)-binding cassette (ABC) transporters. Despite research...

journal_title：Cells

authors： Hasanovic A,Mus-Veteau I

更新日期：2018-08-14 00:00:00

abstract：:Xeroderma Pigmentosum (XP) is a DNA repair disease characterized by nucleotide excision repair (NER) malfunction, leading to photosensitivity and increased incidence of skin malignancies. The role of XP-A in NER pathways has been well studied while discrepancies associated with ROS levels and the role of radical speci...

journal_title：Cells

authors： Krokidis MG,Parlanti E,D'Errico M,Pascucci B,Pino A,Alimonti A,Pietraforte D,Masi A,Ferreri C,Chatgilialoglu C

更新日期：2019-11-01 00:00:00

abstract：:A combinatorial approach integrating stem cells and capable of exploiting available cues is likely needed to regenerate lost neural tissues and ultimately restore neurologic functions. This study investigates the effects of the subcutaneous maturation of adult-derived neural stem cell (aNSCs) seeded into biomaterial c...

journal_title：Cells

authors： Farrag M,Leipzig ND

更新日期：2018-10-17 00:00:00

abstract：:Lyme Borreliosis is an infectious disease caused by the spirochete Borrelia burgdorferi that is transmitted through the bite of infected ticks. Both B cell-mediated humoral immunity and T cell immunity develop during natural Borrelia infection. However, compared with humoral immunity, the T cell response to Borrelia i...

journal_title：Cells

authors： Jin C,Roen DR,Lehmann PV,Kellermann GH

更新日期：2013-09-13 00:00:00

abstract：:Invariant chain (Ii/CD74) has been identified as a surface receptor for migration inhibitory factor (MIF). Most cells that express Ii also synthesize major histocompatibility complex class II (MHC II) molecules, which depend on Ii as a chaperone and a targeting factor. The assembly of nonameric complexes consisting of...

journal_title：Cells

authors： Lindner R

更新日期：2017-02-10 00:00:00

abstract：:Apoptosis, a form of programmed cell death, is a highly regulated process critical for tissue development, homeostasis, and pathogenesis of various diseases [...]. ...

journal_title：Cells

authors： Ladokhin AS

更新日期：2020-09-18 00:00:00

abstract：:Type 2 diabetes (T2D) is a growing pandemic associated with metabolic dysregulation and chronic inflammation. Meteorin-like hormone (METRNL) is an adipomyokine that is linked to T2D. Our objective was to evaluate the changes in METRNL levels in T2D and obesity and assess the association of METRNL levels with irisin. O...

journal_title：Cells

authors： AlKhairi I,Cherian P,Abu-Farha M,Madhoun AA,Nizam R,Melhem M,Jamal M,Al-Sabah S,Ali H,Tuomilehto J,Al-Mulla F,Abubaker J

更新日期：2019-10-19 00:00:00

abstract：BACKGROUND:The search for an effective therapy for local radiation injuries (LRI) is urgent; one option is mesenchymal stem cells (MSC) derived from the placenta and their conditioned medium for the regenerative processes of the skin. METHODS:We used 80 animals, randomly assigned to four groups: control (C) animals th...

journal_title：Cells

authors： Brunchukov V,Astrelina T,Usupzhanova D,Rastorgueva A,Kobzeva I,Nikitina V,Lishchuk S,Dubova E,Pavlov K,Brumberg V,Benderitter M,Samoylov A

更新日期：2020-11-29 00:00:00

abstract：:The nucleolus is a prominent, membraneless compartment found within the nucleus of eukaryotic cells. It forms around ribosomal RNA (rRNA) genes, where it coordinates the transcription, processing, and packaging of rRNA to produce ribosomal subunits. Recent efforts to characterize the biophysical properties of the nucl...

journal_title：Cells

authors： Stochaj U,Weber SC

更新日期：2020-02-25 00:00:00

abstract：:Detachment and the formation of spheroids under microgravity conditions can be observed with various types of intrinsically adherent human cells. In particular, for cancer cells this process mimics metastasis and may provide insights into cancer biology and progression that can be used to identify new drug/target comb...

journal_title：Cells

authors： Melnik D,Sahana J,Corydon TJ,Kopp S,Nassef MZ,Wehland M,Infanger M,Grimm D,Krüger M

更新日期：2020-02-05 00:00:00

abstract：:A critically ill polytrauma patient is one of the most complex cases to be admitted to the intensive care unit, due to both the primary traumatic complications and the secondary post-traumatic interactions. From a molecular, genetic, and epigenetic point of view, numerous biochemical interactions are responsible for t...

journal_title：Cells

authors： Rogobete AF,Sandesc D,Bedreag OH,Papurica M,Popovici SE,Bratu T,Popoiu CM,Nitu R,Dragomir T,AAbed HIM,Ivan MV

更新日期：2018-12-13 00:00:00

abstract：:As the lung develops, epithelial-mesenchymal crosstalk is essential for the developmental processes that drive cell proliferation, differentiation, and extracellular matrix (ECM) production within the lung epithelial-mesenchymal trophic unit (EMTU). In asthma, a number of the lung EMTU developmental signals have been ...

journal_title：Cells

authors： Osei ET,Booth S,Hackett TL

更新日期：2020-07-15 00:00:00

abstract：:Filamins are large dimeric F-actin cross-linking proteins, crucial for the mechanosensitive properties of a number of cell types. Due to their interaction with a variety of different proteins, they exert important regulatory functions. However, in the human testis the role of filamins has been insufficiently explored....

journal_title：Cells

authors： Welter H,Herrmann C,Fröhlich T,Flenkenthaler F,Eubler K,Schorle H,Nettersheim D,Mayerhofer A,Müller-Taubenberger A

更新日期：2020-11-30 00:00:00

abstract：:Osteoarthritis (OA) is a degenerative disease of the hyaline articular cartilage. This disease is progressive and may lead to disability. Researchers proposed many regenerative approaches to treat osteoarthritis, including stem cells. Trans-differentiation of a fully differentiated cell state directly into another dif...

journal_title：Cells

authors： Cota P,Helmi SA,Hsu C,Rancourt DE

更新日期：2020-01-11 00:00:00

abstract：:Stage I epithelial ovarian cancer (EOC) represents about 10% of all EOCs. It is characterized by a complex histopathological and molecular heterogeneity, and it is composed of five main histological subtypes (mucinous, endometrioid, clear cell and high, and low grade serous), which have peculiar genetic, molecular, an...

journal_title：Cells

authors： Calura E,Ciciani M,Sambugaro A,Paracchini L,Benvenuto G,Milite S,Martini P,Beltrame L,Zane F,Fruscio R,Marchette MD,Borella F,Tognon G,Ravaggi A,Katsaros D,Bignotti E,Odicino F,D'Incalci M,Marchini S,Romualdi C

更新日期：2019-12-01 00:00:00

abstract：:Depression is a very common psychiatric disorder affecting approximately 300 million people worldwide with the prevalence being twice as high in women as in men. Despite intense research efforts in recent decades, the neurobiological basis underlying depression remains incompletely understood. However, the exposure to...

journal_title：Cells

authors： Berger S,Gureczny S,Reisinger SN,Horvath O,Pollak DD

更新日期：2019-09-01 00:00:00

abstract：:Vesicle fusion is a fundamental cell biological process similar from yeasts to humans. For secretory vesicles, swelling is considered a step required for the expulsion of intravesicular content. Here this concept is revisited providing evidence that it may instead represent a general mechanism. We report the first exa...

journal_title：Cells

authors： Centrone M,De Santo MP,Nicotera I,Labate C,Ranieri M,Di Mise A,Mola MG,Mastrodonato M,Elliani R,Barberi R,Formoso V,Tamma G,Valenti G

更新日期：2018-12-19 00:00:00

abstract：:Large tumor-derived Extracellular Vesicles (tdEVs) detected in blood of metastatic prostate, breast, colorectal, and non-small cell lung cancer patients after enrichment for Epithelial Cell Adhesion Molecule (EpCAM) expression and labeling with 4',6-diamidino-2-phenylindole (DAPI), phycoerythrin-conjugated antibodies ...

journal_title：Cells

authors： Nanou A,Zeune LL,Terstappen LWMM

更新日期：2019-08-20 00:00:00

abstract：:(1) Background: Hyperglycemia leads to several biochemical and physiological consequences, such as the generation of advanced glycation end products (AGEs) and reactive oxygen species (ROS), which are involved in the development of several human diseases. Intestinal cells are continuously exposed to pro-oxidants and l...

journal_title：Cells

authors： Morresi C,Cianfruglia L,Sartini D,Cecati M,Fumarola S,Emanuelli M,Armeni T,Ferretti G,Bacchetti T

更新日期：2019-12-11 00:00:00

abstract：:To investigate the role of PR isoforms on the homeostasis of stem cells in the normal and neoplastic mammary gland, we used PRA and PRB transgenic mice and the T47D human breast cancer cell line and its derivatives, T47D YA and YB (manipulated to express only PRA or PRB, respectively). Flow cytometry and mammosphere a...

journal_title：Cells

authors： Recouvreux MS,Diaz Bessone MI,Taruselli A,Todaro L,Lago Huvelle MA,Sampayo RG,Bissell MJ,Simian M

更新日期：2020-09-11 00:00:00

abstract：:Angiogenesis is defined as the formation of new blood vessels and is a key phenomenon manifested in a host of cancers during which tyrosine kinases play a crucial role. Vascular endothelial growth factor receptor-2 (VEGFR-2) is pivotal in cancer angiogenesis, which warrants the urgency of discovering new anti-angiogen...

journal_title：Cells

authors： Rampogu S,Baek A,Park C,Parate S,Parameswaran S,Park Y,Shaik B,Kim JH,Park SJ,Lee KW

更新日期：2019-03-21 00:00:00

abstract：:For years, moderate hypothermia (32 °C) has been proposed as an unorthodox therapy for liver injuries, with proven hepatoprotective potential. Yet, limited mechanistic understanding has largely denied its acceptance over conventional pharmaceuticals for hepatoprotection. Today, facing a high prevalence of acetaminophe...

journal_title：Cells

authors： Tan YL,Ho HK

更新日期：2020-10-26 00:00:00

abstract：:To identify novel oncogenic targets in head and neck squamous cell carcinoma (HNSCC), we have analyzed antitumor microRNAs (miRNAs) and their controlled molecular networks in HNSCC cells. Based on our miRNA signature in HNSCC, both strands of the miR-99a-duplex (miR-99a-5p: the guide strand, and miR-99a-3p: the passen...

journal_title：Cells

authors： Okada R,Koshizuka K,Yamada Y,Moriya S,Kikkawa N,Kinoshita T,Hanazawa T,Seki N

更新日期：2019-11-28 00:00:00

abstract：:Tuberous sclerosis complex (TSC) is a genetic disease affecting the brain. Neurological symptoms like epilepsy and neurodevelopmental issues cause a significant burden on patients. Both neurons and glial cells are affected by TSC mutations. Previous studies have shown changes in the excitation/inhibition balance (E/I ...

journal_title：Cells

authors： Dooves S,van Velthoven AJH,Suciati LG,Heine VM

更新日期：2021-01-12 00:00:00

abstract：:TROP1 (EpCAM) and TROP2 are homologous cell surface proteins that are widely expressed, and often co-expressed, in developing and adult epithelia. Various functions have been ascribed to EpCAM and TROP2, but responsible mechanisms are incompletely characterized and functional equivalence has not been examined. Adult i...

journal_title：Cells

authors： Nakato G,Morimura S,Lu M,Feng X,Wu C,Udey MC

更新日期：2020-08-06 00:00:00