Regulation of Apoptosis by the Bcl-2 Family of Proteins: Field on a Brink.

abstract：:CircRNA is a type of closed circular non-coding RNA formed by reverse splicing and plays an important role in regulating the growth and development of plants and animals. To investigate the function of circ-FoxO3 in mouse myoblast cells' (C2C12) differentiation and proliferation, we used RT-qPCR to detect the expressi...

journal_title：Cells

authors： Li X,Li C,Liu Z,Ni W,Yao R,Xu Y,Quan R,Zhang M,Li H,Liu L,Hu S

更新日期：2019-06-19 00:00:00

abstract：:Ribosomopathies are congenital diseases with defects in ribosome assembly and are characterized by elevated cancer risks. Additionally, somatic mutations in ribosomal proteins have recently been linked to a variety of cancers. Despite a clear correlation between ribosome defects and cancer, the molecular mechanisms by...

journal_title：Cells

authors： Sulima SO,Kampen KR,De Keersmaecker K

更新日期：2019-03-11 00:00:00

abstract：:Osteoarthritis (OA) is a degenerative disease of the hyaline articular cartilage. This disease is progressive and may lead to disability. Researchers proposed many regenerative approaches to treat osteoarthritis, including stem cells. Trans-differentiation of a fully differentiated cell state directly into another dif...

journal_title：Cells

authors： Cota P,Helmi SA,Hsu C,Rancourt DE

更新日期：2020-01-11 00:00:00

abstract：:Respiratory syncytial virus (RSV) infection affects the lives of neonates throughout the globe, causing a high rate of mortality upon hospital admission. Yet, therapeutic options to deal with this pulmonary pathogen are currently limited. Helminth therapy has been well received for its immunomodulatory role in hosts, ...

journal_title：Cells

authors： Chu KB,Lee HA,Kang HJ,Moon EK,Quan FS

更新日期：2020-05-25 00:00:00

abstract：:Chronic hyperglycemia has been associated with an increased prevalence of pathological conditions including cardiovascular disease, cancer, or various disorders of the immune system. In some cases, these associations may be traced back to a common underlying cause, but more often, hyperglycemia and the disturbance in ...

journal_title：Cells

authors： Nagy T,Fisi V,Frank D,Kátai E,Nagy Z,Miseta A

更新日期：2019-08-28 00:00:00

abstract：:One third of all human proteins are either transmembrane or soluble secretory proteins that first target the endoplasmic reticulum (ER). These proteins subsequently leave the ER and enter the Golgi apparatus via ER-Golgi intermediate vesicular structures. Live-cell imaging of cargos fused to fluorescent proteins (FPs)...

journal_title：Cells

authors： Rauter T,Burgstaller S,Gottschalk B,Ramadani-Muja J,Bischof H,Hay JC,Graier WF,Malli R

更新日期：2020-10-17 00:00:00

abstract：:Host immune responses play an important role in the outcome of infection with hepatitis C virus (HCV). They can lead to viral clearance and a positive outcome, or progression and severity of chronic disease. Extensive research in the past >25 years into understanding the immune responses against HCV have still resulte...

journal_title：Cells

authors： Agrawal B,Gupta N,Vedi S,Singh S,Li W,Garg S,Li J,Kumar R

更新日期：2019-05-26 00:00:00

abstract：:Preeclampsia (PE) is a pregnancy-specific disorder associated with hypertension and proteinuria. Since there is no proven method to treat PE, early prediction and accurate diagnosis are essential for appropriate management of the disease. Thus, reliable biomarkers for diagnosing PE need to be identified and evaluated....

journal_title：Cells

authors： Kim S,Park M,Kim JY,Kim T,Hwang JY,Ha KS,Won MH,Ryoo S,Kwon YG,Kim YM

更新日期：2020-08-31 00:00:00

abstract：:Leptin is one of the main adipokines secreted in breast tissue. Leptin promotes epithelial-mesenchymal transition (EMT), cell migration and invasion in epithelial breast cells, leading to tumor progression. Although, the molecular mechanisms that underlie these events are not fully understood, the activation of differ...

journal_title：Cells

authors： Olea-Flores M,Zuñiga-Eulogio M,Tacuba-Saavedra A,Bueno-Salgado M,Sánchez-Carvajal A,Vargas-Santiago Y,Mendoza-Catalán MA,Pérez Salazar E,García-Hernández A,Padilla-Benavides T,Navarro-Tito N

更新日期：2019-09-24 00:00:00

abstract：:Peripherin 2 (Prph2) is a photoreceptor-specific tetraspanin protein present in the outer segment (OS) rims of rod and cone photoreceptors. It shares many common features with other tetraspanins, including a large intradiscal loop which contains several cysteines. This loop enables Prph2 to associate with itself to fo...

journal_title：Cells

authors： Tebbe L,Kakakhel M,Makia MS,Al-Ubaidi MR,Naash MI

更新日期：2020-03-24 00:00:00

abstract：:Carnosine (β-alanyl-L-histidine), a dipeptide, is an endogenous antioxidant widely distributed in excitable tissues like muscles and the brain. Carnosine is involved in cellular defense mechanisms against oxidative stress, including the inhibition of amyloid-beta (Aβ) aggregation and the scavenging of reactive species...

journal_title：Cells

authors： Caruso G,Fresta CG,Musso N,Giambirtone M,Grasso M,Spampinato SF,Merlo S,Drago F,Lazzarino G,Sortino MA,Lunte SM,Caraci F

更新日期：2019-01-17 00:00:00

abstract：:Tuberous sclerosis complex (TSC) is a genetic disease affecting the brain. Neurological symptoms like epilepsy and neurodevelopmental issues cause a significant burden on patients. Both neurons and glial cells are affected by TSC mutations. Previous studies have shown changes in the excitation/inhibition balance (E/I ...

journal_title：Cells

authors： Dooves S,van Velthoven AJH,Suciati LG,Heine VM

更新日期：2021-01-12 00:00:00

abstract：:Patient-derived xenograft (PDX) models have been recognized as being more suitable for predicting therapeutic efficacy than cell-culture models. However, there are several limitations in applying PDX models in preclinical studies, including their availability-especially for cancers such as gastric cancer-that are not ...

journal_title：Cells

authors： Kuwata T,Yanagihara K,Iino Y,Komatsu T,Ochiai A,Sekine S,Taniguchi H,Katai H,Kinoshita T,Ohtsu A

更新日期：2019-06-14 00:00:00

abstract：:Cancer cells perform a metabolic rewiring to sustain an increased growth rate and compensate for the redox stress caused by augmented energy metabolism. The metabolic changes are not the same in all cancers. Some features, however, are considered hallmarks of this disease. As an example, all cancer cells rewire the am...

journal_title：Cells

authors： Scalise M,Console L,Rovella F,Galluccio M,Pochini L,Indiveri C

更新日期：2020-09-03 00:00:00

abstract：:Autophagy is a eukaryotic catabolic pathway that degrades and recycles cellular components to maintain homeostasis. It can target protein aggregates, superfluous biomolecular complexes, dysfunctional and damaged organelles, as well as pathogenic intracellular microbes. Autophagy is a dynamic process in which the diffe...

journal_title：Cells

authors： Domínguez-Martín E,Cardenal-Muñoz E,King JS,Soldati T,Coria R,Escalante R

更新日期：2017-07-03 00:00:00

abstract：:The aim of this review is to outline emerging biomarkers that can serve as early diagnostic tools to identify patients with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) and, among them, the subgroup of best candidates for clinical trials on emerging compounds. Regarding possible pre...

journal_title：Cells

authors： Piazzolla VA,Mangia A

更新日期：2020-04-17 00:00:00

abstract：:Macroautophagy (hereafter referred to as autophagy, a word derived from Greek meaning "auto-digestion") is a lysosome-dependent quality control process to degrade and turnover damaged or senescent organelles and proteins for cellular renewal [...]. ...

journal_title：Cells

authors： Lin PH

更新日期：2019-07-19 00:00:00

abstract：:The generation of new ribosomes is a coordinated process essential to sustain cell growth. As such, it is tightly regulated according to cell needs. As cancer cells require intense protein translation to ensure their enhanced growth rate, they exploit various mechanisms to boost ribosome biogenesis. In this review, we...

journal_title：Cells

authors： Gaviraghi M,Vivori C,Tonon G

更新日期：2019-09-17 00:00:00

abstract：:The xCELLigence real-time cell analysis (RTCA) system has the potential to detect cellular proliferation, migration, cytotoxicity, adherence, and remodeling. Although the RTCA system is widely recognized as a noninvasive and efficient tool for real-time monitoring of cellular fate, it cannot describe detailed cell mor...

journal_title：Cells

authors： Zhang L,Ye Y,Dhar R,Deng J,Tang H

更新日期：2019-10-21 00:00:00

abstract：:The knowledge about the molecular alterations which are found in head and neck squamous cell carcinomas (HNSCC) has much increased in recent years. However, we are still awaiting the translation of this knowledge to new diagnostic and therapeutic options. Among the many molecular changes that are detected in head and ...

journal_title：Cells

authors： Paluszczak J

更新日期：2020-03-15 00:00:00

abstract：:The mitochondrial genetic disorder, Leber's hereditary optic neuropathy (LHON), is caused by a mutation in MT-ND4 gene, encoding NADH dehydrogenase subunit 4. It leads to the progressive death of retinal ganglion cells (RGCs) and causes visual impairment or even blindness. However, the precise mechanisms of LHON disea...

journal_title：Cells

authors： Yang YP,Nguyen PNN,Lin TC,Yarmishyn AA,Chen WS,Hwang DK,Chiou GY,Lin TW,Chien CS,Tsai CY,Chiou SH,Chen SJ,Peng CH,Hsu CC

更新日期：2019-06-21 00:00:00

abstract：:We have previously shown that the combination of radiotherapy with human umbilical-cord-derived mesenchymal stromal/stem cells (MSCs) cell therapy significantly reduces the size of the xenotumors in mice, both in the directly irradiated tumor and in the distant nonirradiated tumor or its metastasis. We have also shown...

journal_title：Cells

authors： Tovar I,Guerrero R,López-Peñalver JJ,Expósito J,Ruiz de Almodóvar JM

更新日期：2020-09-02 00:00:00

abstract：:One key issue in the post-genomic era is how to systematically describe the associations between small molecule transcripts or translations inside cells. With the rapid development of high-throughput "omics" technologies, the achieved ability to detect and characterize molecules with other molecule targets opens the p...

journal_title：Cells

authors： Guo ZH,Yi HC,You ZH

更新日期：2019-08-09 00:00:00

abstract：:In order to provide a sufficient number of cells for clinical use, mesenchymal stem cells (MSCs) must be cultured for long-term expansion, which inevitably triggers cellular senescence. Although the small size of MSCs is known as a critical determinant of their fate, the main regulators of stem cell senescence and the...

journal_title：Cells

authors： Kwon JH,Kim M,Um S,Lee HJ,Bae YK,Choi SJ,Hwang HH,Oh W,Jin HJ

更新日期：2021-01-03 00:00:00

abstract：:High-throughput transcriptomic profiling approaches have revealed that circular RNAs (circRNAs) are important transcriptional gene products, identified across a broad range of organisms throughout the eukaryotic tree of life. In the nervous system, they are particularly abundant, developmentally regulated, region-spec...

journal_title：Cells

authors： Gasparini S,Licursi V,Presutti C,Mannironi C

更新日期：2020-07-31 00:00:00

abstract：:Inhibitors of Apoptosis (IAPs) are a family of proteins with various biological functions including regulation of innate immunity and inflammation, cell proliferation, cell migration and apoptosis. They are characterized by the presence of at least one N-terminal baculoviral IAP repeat (BIR) domain involved in protein...

journal_title：Cells

authors： Berthelet J,Dubrez L

更新日期：2013-03-14 00:00:00

abstract：:Rac1 is a small GTPase that belongs to the Rho family. The Rho family of small GTPases is a subfamily of the Ras superfamily. The Rho family of GTPases mediate a plethora of cellular effects, including regulation of cytoarchitecture, cell size, cell adhesion, cell polarity, cell motility, proliferation, apoptosis/surv...

journal_title：Cells

authors： Abdrabou A,Wang Z

更新日期：2018-12-11 00:00:00

abstract：:Mammarenaviruses are a diverse genus of emerging viruses that include several causative agents of severe viral hemorrhagic fevers with high mortality in humans. Although these viruses share many similarities, important differences with regard to pathogenicity, type of immune response, and molecular mechanisms during v...

journal_title：Cells

authors： Fernandes J,Miranda RL,de Lemos ERS,Guterres A

更新日期：2020-11-23 00:00:00

abstract：:Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder characterized by multiple basal cell carcinomas (BCC), mainly caused by PTCH1 gene mutations. Our current study aimed to establish (1) PTCH1 germinal and somatic mutational status, (2) component and Hedgehog (HH) pathway targets gene expres...

journal_title：Cells

authors： Martinez MF,Romano MV,Martinez AP,González A,Muchnik C,Stengel FM,Mazzuoccolo LD,Azurmendi PJ

更新日期：2019-02-11 00:00:00

abstract：:Nuclear mRNA export plays an important role in gene expression. We describe the mechanisms of mRNA export including the importance of mRNP assembly, docking with the nuclear basket of the nuclear pore complex (NPC), transit through the central channel of the NPC and cytoplasmic release. We describe multiple mechanisms...

journal_title：Cells

authors： Delaleau M,Borden KL

更新日期：2015-08-28 00:00:00