Implications of Selective Autophagy Dysfunction for ALS Pathology.

abstract：:Background: In retinitis pigmentosa (RP), inherited rod death is followed by cone loss and blindness. Why cones die is still a matter of consideration. Here, we investigate the pathogenic role of the sympathetic transmission in the rd10 mouse model of RP. Methods: Retinal levels of beta adrenergic receptor (BAR) 2 and...

journal_title：Cells

authors： Cammalleri M,Dal Monte M,Amato R,Lapi D,Bagnoli P

更新日期：2020-09-09 00:00:00

abstract：:The plant circadian clock controls a large number of internal processes, including growth and metabolism. Scent emission displays a circadian pattern in many species such as the snapdragon. Here we show that knocking down LATE ELONGATED HYPOCOTYL in Antirrhinum majus affects growth and scent emission. In order to gain...

journal_title：Cells

authors： Terry MI,Pérez-Sanz F,Navarro PJ,Weiss J,Egea-Cortines M

更新日期：2019-08-17 00:00:00

abstract：:Sarcopenia, a syndrome commonly seen in elderly populations, is often characterized by a gradual loss of skeletal muscle, leading to the decline of muscle strength and physical performance. Growing evidence suggests that the prevalence of sarcopenia increases in patients with heart failure (HF), which is a dominant pa...

journal_title：Cells

authors： Cho J,Choi Y,Sajgalik P,No MH,Lee SH,Kim S,Heo JW,Cho EJ,Chang E,Kang JH,Kwak HB,Park DH

更新日期：2020-10-13 00:00:00

abstract：:The third isotype of beta-adrenoreceptors (β3-AR) has recently come (back) into focus after the observation of its expression in white and beige human adipocytes and its implication in metabolic regulation. This coincides with the recent development and marketing of agonists at the human receptor with superior specifi...

journal_title：Cells

authors： Michel LYM,Farah C,Balligand JL

更新日期：2020-12-02 00:00:00

abstract：:Hepatitis E virus (HEV) infection is one of the most common causes of acute hepatitis in the world. HEV is an enterically transmitted positive-strand RNA virus found as a non-enveloped particle in bile as well as stool and as a quasi-enveloped particle in blood. Current understanding of the molecular mechanisms and ho...

journal_title：Cells

authors： Oechslin N,Moradpour D,Gouttenoire J

更新日期：2020-05-22 00:00:00

abstract：:The transient receptor potential cation channel subfamily M member 4 (TRPM4) channel influences calcium homeostasis during many physiological activities such as insulin secretion, immune response, respiratory reaction, and cerebral vasoconstriction. This calcium-activated, monovalent, selective cation channel also pla...

journal_title：Cells

authors： Wang C,Naruse K,Takahashi K

更新日期：2018-06-15 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver diseases with an increasing prevalence due to rising rates of obesity, metabolic syndrome and type II diabetes. Untreated NAFLD may progress to steatohepatitis (NASH) and ultimately liver cirrhosis. NAFLD is characterized by lipid accumulatio...

journal_title：Cells

authors： Asimakopoulou A,Engel KM,Gassler N,Bracht T,Sitek B,Buhl EM,Kalampoka S,Pinoé-Schmidt M,van Helden J,Schiller J,Weiskirchen R

更新日期：2020-05-28 00:00:00

abstract：:T cells play an essential role in the pathogenesis of both human rheumatoid arthritis (RA) and its murine models. A key molecule in T cell activation is ZAP-70, therefore we aimed to investigate the effects of partial ZAP-70 deficiency on the pathogenesis of recombinant human G1(rhG1)-induced arthritis (GIA), a well-e...

journal_title：Cells

authors： Kugyelka R,Prenek L,Olasz K,Kohl Z,Botz B,Glant TT,Berki T,Boldizsár F

更新日期：2019-05-24 00:00:00

abstract：:The crosstalk between human gut microbiota and intestinal wall is essential for the organ's homeostasis and immune tolerance. The gut microbiota plays a role in healthy and pathological conditions mediated by inflammatory processes or by the gut-brain axes, both involving a possible role for S100B protein as a diffusi...

journal_title：Cells

authors： Orsini M,Di Liddo R,Valeriani F,Mancin M,D'Incà R,Castagnetti A,Aceti A,Parnigotto PP,Romano Spica V,Michetti F

更新日期：2020-07-15 00:00:00

abstract：:ELISpot is one of the most commonly used immune monitoring assays, which allows the functional assessment of the immune system at the single cell level. With its outstanding sensitivity and ease of performance, the assay has recently advanced from the mere single function cell analysis to multifunctional analysis by i...

journal_title：Cells

authors： Janetzki S,Rueger M,Dillenbeck T

更新日期：2014-11-27 00:00:00

abstract：:We have previously discovered that HDAC6 regulates the DNA damage response (DDR) via modulating the homeostasis of a DNA mismatch repair protein, MSH2, through HDAC6's ubiquitin E3 ligase activity. Here, we have reported HDAC6's second potential E3 ligase substrate, a critical cell cycle checkpoint protein, Chk1. We h...

journal_title：Cells

authors： Moses N,Zhang M,Wu JY,Hu C,Xiang S,Geng X,Chen Y,Bai W,Zhang YW,Bepler G,Zhang XM

更新日期：2020-10-04 00:00:00

abstract：:Approximately 3 × 1017 DNA damage events take place per hour in the human body. Within clustered DNA lesions, they pose a serious problem for repair proteins, especially for iron-sulfur glycosylases (MutyH), which can recognize them by the electron-transfer process. It has been found that the presence of both 5',8-cyc...

journal_title：Cells

authors： Karwowski BT

更新日期：2020-02-12 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a deadly malignant tumor of the liver. It is a significant health problem in Thailand. The critical obstacles of CCA diagnosis and treatment are the high heterogeneity of disease and considerable resistance to treatment. Recent multi-omics studies revealed the promising targets for CCA trea...

journal_title：Cells

authors： Vaeteewoottacharn K,Pairojkul C,Kariya R,Muisuk K,Imtawil K,Chamgramol Y,Bhudhisawasdi V,Khuntikeo N,Pugkhem A,Saeseow OT,Silsirivanit A,Wongkham C,Wongkham S,Okada S

更新日期：2019-05-23 00:00:00

abstract：:Podoplanin and CD44 are transmembrane glycoproteins involved in inflammation and cancer. In this paper, we report that podoplanin is coordinately expressed with the CD44 standard (CD44s) and variant (CD44v) isoforms in vivo-in hyperplastic skin after a pro-inflammatory stimulus with 12-O-tetradecanoylphorbol-13-acetat...

journal_title：Cells

authors： Montero-Montero L,Renart J,Ramírez A,Ramos C,Shamhood M,Jarcovsky R,Quintanilla M,Martín-Villar E

更新日期：2020-09-29 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries with almost 25% affected adults worldwide. The growing public health burden is getting evident when considering that NAFLD-related liver transplantations are predicted to almost double within the next 20 years. Typic...

journal_title：Cells

authors： Drescher HK,Weiskirchen S,Weiskirchen R

更新日期：2019-08-07 00:00:00

abstract：:Insect adipokinetic hormones (AKHs) are short peptides produced in the corpora cardiaca and are responsible for mobilizing energy stores from the fat body to the hemolymph. Three related peptides, AKH1, AKH2, and AKH/corazonin-related peptide (ACP) as well as three AKH receptors have been reported in Bombyx mori. AKH1...

journal_title：Cells

authors： Sehadova H,Takasu Y,Zaloudikova A,Lin YH,Sauman I,Sezutsu H,Rouhova L,Kodrik D,Zurovec M

更新日期：2020-12-11 00:00:00

abstract：:In liver transplantation (LT), organ shortage has led to the use of steatotic and non-steatotic grafts from donors after cardiocirculatory death (DCD). However, these grafts, especially those with steatosis, exhibit poor post-operative outcomes. To address this problem, we investigated the roles of gut-derived glucago...

journal_title：Cells

authors： Avalos-de León CG,Jiménez-Castro MB,Cornide-Petronio ME,Casillas-Ramírez A,Peralta C

更新日期：2019-12-09 00:00:00

abstract：:Endoscopic submucosal dissection (ESD) is an effective treatment of early esophageal adenocarcinomas (EACs). The decision of ESD over esophagectomy is based on clinical evaluation of tumor depth and invasion. On a molecular level, tumor invasion is strongly associated with epithelial-to-mesenchymal transition (EMT). H...

journal_title：Cells

authors： Neureiter D,Mayr C,Winkelmann P,Neumayer B,Klieser E,Wagner A,Hufnagl C,Emmanuel K,Holzinger J,Koch O,Kiesslich T,Varga M

更新日期：2020-02-20 00:00:00

abstract：:Almost 25 years ago, the first mammalian transient receptor potential (TRP) channel, now named TRPC1, was cloned and published (reviewed in [...]. ...

journal_title：Cells

authors： Dietrich A

更新日期：2019-05-04 00:00:00

abstract：:Extracellular vesicles (EVs) are involved in intercellular communication during carcinogenesis, and cancer cells are able to secrete EVs, in particular exosomes containing molecules, that can be transferred to recipient cells to induce pathological processes and significant modifications, as metastasis, increase of pr...

journal_title：Cells

authors： Scavo MP,Depalo N,Rizzi F,Ingrosso C,Fanizza E,Chieti A,Messa C,Denora N,Laquintana V,Striccoli M,Curri ML,Giannelli G

更新日期：2019-07-25 00:00:00

abstract：:Inhibitors of Apoptosis (IAPs) are a family of proteins with various biological functions including regulation of innate immunity and inflammation, cell proliferation, cell migration and apoptosis. They are characterized by the presence of at least one N-terminal baculoviral IAP repeat (BIR) domain involved in protein...

journal_title：Cells

authors： Berthelet J,Dubrez L

更新日期：2013-03-14 00:00:00

abstract：:Cancer cells rely on aberrant transcription for growth and survival. Cyclin-dependent kinases (CDKs) play critical roles in regulating gene transcription by modulating the activity of RNA polymerase II (RNAPII). THZ1, a selective covalent inhibitor of CDK7, has antitumor effects in several human cancers. In this study...

journal_title：Cells

authors： Shi CS,Kuo KL,Chen MS,Chow PM,Liu SH,Chang YW,Lin WC,Liao SM,Hsu CH,Hsu FS,Chang HC,Huang KH

更新日期：2019-11-19 00:00:00

abstract：:YRNAs are a class of non-coding RNAs that are components of the Ro60 ribonucleoprotein particle and are essential for initiation of DNA replication. Ro60 ribonucleoprotein particle is a target of autoimmune antibodies in patients suffering from systemic lupus erythematosus and Sjögren's syndrome. Deregulation of YRNAs...

journal_title：Cells

authors： Guglas K,Kolenda T,Stasiak M,Kopczyńska M,Teresiak A,Ibbs M,Bliźniak R,Lamperska K

更新日期：2020-05-21 00:00:00

abstract：:Hypertensive pregnancy has been associated with reduced nitric oxide (NO), bioavailability, and increased activity of matrix metalloproteinases (MMPs). However, it is unclear if MMPs activation is regulated by NO during pregnancy. To this end, we examined activity of MMP-2 and MMP-9 in plasma, placenta, uterus and aor...

journal_title：Cells

authors： Nascimento RA,Possomato-Vieira JS,Bonacio GF,Rizzi E,Dias-Junior CA

更新日期：2019-11-07 00:00:00

abstract：:Identification of patients with activation of the immune system which indicates the presence of infection is essential, especially in the times of the global coronavirus 2019 (COVID-19) pandemic. The aim of the present study was to evaluate the reactive lymphocytes (RE-LYMP) parameter in COVID-19 and to correlate it w...

journal_title：Cells

authors： Rutkowska E,Kwiecień I,Kulik K,Chełstowska B,Kłos K,Rzepecki P,Chciałowski A

更新日期：2021-01-06 00:00:00

abstract：:The longevity of people with HIV/AIDS has been prolonged with the use of antiretroviral therapy (ART). The age-related complications, especially cognitive deficits, rise as HIV patients live longer. Deposition of beta-amyloid (Aβ), a hallmark of Alzheimer's disease (AD), has been observed in subjects with HIV-associat...

journal_title：Cells

authors： Kodidela S,Gerth K,Haque S,Gong Y,Ismael S,Singh A,Tauheed I,Kumar S

更新日期：2019-08-24 00:00:00

abstract：:The second messenger 3',5'-cyclic adenosine monophosphate (cAMP) is one of the most important signalling molecules in the heart as it regulates many physiological and pathophysiological processes. In addition to the classical protein kinase A (PKA) signalling route, the exchange proteins directly activated by cAMP (Ep...

journal_title：Cells

authors： Bouvet M,Blondeau JP,Lezoualc'h F

更新日期：2019-11-29 00:00:00

abstract：:Obesity is a well-known risk factor for insulin resistance syndrome (IRS). Nevertheless, limited data are available regarding the effects of physical activity (PA) intensity on the ability to modulate IRS. The study aim was to investigate the beneficial effects of the longer duration of light PA vs. a single bout of t...

journal_title：Cells

authors： Al-Rashed F,Alghaith A,Azim R,AlMekhled D,Thomas R,Sindhu S,Ahmad R

更新日期：2020-05-11 00:00:00

abstract：:Lyme Borreliosis is an infectious disease caused by the spirochete Borrelia burgdorferi that is transmitted through the bite of infected ticks. Both B cell-mediated humoral immunity and T cell immunity develop during natural Borrelia infection. However, compared with humoral immunity, the T cell response to Borrelia i...

journal_title：Cells

authors： Jin C,Roen DR,Lehmann PV,Kellermann GH

更新日期：2013-09-13 00:00:00

abstract：:Alcohol use disorder is associated with a wide array of hepatic pathologies ranging from steatosis to alcoholic-related cirrhosis (AC), alcoholic hepatitis (AH), or hepatocellular carcinoma (HCC). Biomarkers are categorized into two main categories: biomarkers associated with alcohol consumption and biomarkers of alco...

journal_title：Cells

authors： Gala KS,Vatsalya V

更新日期：2020-02-25 00:00:00