Abstract：
:Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play crucial roles in various cellular processes by regulating cell cycle and gene transcription. Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcription, RNA splicing, translation, DNA damage response (DDR), cell cycle progression and cell proliferation. Recently, increasing evidence demonstrates the important role of CDK12 in various human cancers, illustrating it as both a biomarker of cancer and a potential target for cancer therapy. Here, we summarize the current knowledge of CDK12, and review the research advances of CDK12's biological functions, especially its role in human cancers and as a potential target and biomarker for cancer therapy.
journal_name
Cellsjournal_title
Cellsauthors
Liang S,Hu L,Wu Z,Chen Z,Liu S,Xu X,Qian Adoi
10.3390/cells9061483subject
Has Abstractpub_date
2020-06-18 00:00:00issue
6issn
2073-4409pii
cells9061483journal_volume
9pub_type
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