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Ubiquitin signaling: extreme conservation as a source of diversity.

Abstract：

:Around 2 × 103-2.5 × 103 million years ago, a unicellular organism with radically novel features, ancestor of all eukaryotes, dwelt the earth. This organism, commonly referred as the last eukaryotic common ancestor, contained in its proteome the same functionally capable ubiquitin molecule that all eukaryotic species contain today. The fact that ubiquitin protein has virtually not changed during all eukaryotic evolution contrasts with the high expansion of the ubiquitin system, constituted by hundreds of enzymes, ubiquitin-interacting proteins, protein complexes, and cofactors. Interestingly, the simplest genetic arrangement encoding a fully-equipped ubiquitin signaling system is constituted by five genes organized in an operon-like cluster, and is found in archaea. How did ubiquitin achieve the status of central element in eukaryotic physiology? We analyze here the features of the ubiquitin molecule and the network that it conforms, and propose notions to explain the complexity of the ubiquitin signaling system in eukaryotic cells.

journal_name

Cells

journal_title

Cells

authors

Zuin A,Isasa M,Crosas B

doi

10.3390/cells3030690

subject

Has Abstract

pub_date

2014-07-10 00:00:00

pages

690-701

issue

3

issn

2073-4409

pii

cells3030690

journal_volume

3

pub_type

杂志文章

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