Abstract：
:The turnip Brassica rapa has important economic value and represents a good model system to study gene function in crop plants. ERF/AP2 transcription factors are a major group of proteins that are often involved in regulating stress-responses and developmental programs. Some ERF/AP2 proteins are targets of CULLIN3-based E3 ligases that use BTB/POZ-MATH proteins as substrate receptors. These receptors bind the transcription factor and facilitate their ubiquitylation and subsequent degradation via the 26S proteasome. Here, we show tissue and stress-dependent expression patterns for three Brassica rapa ERF/AP2 proteins that are closely related to Arabidopsis thaliana AtRAP2.4. Cloning of the Brassica genes showed that the corresponding proteins can assemble with a BPM protein and CULLIN3, and that they are instable in a 26S proteasome dependent manner. This work demonstrates the conserved nature of the ERF/AP2-CULLIN3-based E3 ligase interplay, and represents a first step to analyze their function in a commercially relevant crop plant.
journal_name
Cellsjournal_title
Cellsauthors
Mooney S,Al-Saharin R,Choi CM,Tucker K,Beathard C,Hellmann HAdoi
10.3390/cells8040336subject
Has Abstractpub_date
2019-04-10 00:00:00issue
4issn
2073-4409pii
cells8040336journal_volume
8pub_type
杂志文章相关文献
Cells文献大全abstract：:In order to provide better therapy we strive to increase our knowledge of how the immune system behaves and communicates in common pediatric immunological diseases, such as type 1 diabetes, allergic and celiac diseases. However, when dealing with pediatric diseases, where study subjects are almost exclusively children...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells1020141
更新日期：2012-05-29 00:00:00
abstract：:The present Special Issue on "Cells in Cardiovascular Disease" wants to offer a general overview of current cardiovascular research and illustrate how advances in the molecular characterization at the cellular level are providing unique insights into pathologies of the circulatory system [...]. ...
journal_title：Cells
pub_type： 社论
doi：10.3390/cells9102192
更新日期：2020-09-29 00:00:00
abstract：BACKGROUND:The search for an effective therapy for local radiation injuries (LRI) is urgent; one option is mesenchymal stem cells (MSC) derived from the placenta and their conditioned medium for the regenerative processes of the skin. METHODS:We used 80 animals, randomly assigned to four groups: control (C) animals th...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9122558
更新日期：2020-11-29 00:00:00
abstract：:Type 1 diabetes (T1D) is an autoimmune condition where the body's immune cells destroy their insulin-producing pancreatic beta cells leading to dysregulated glycaemia. Individuals with T1D control their blood glucose through exogenous insulin replacement therapy, often using multiple daily injections or pumps. However...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9112403
更新日期：2020-11-03 00:00:00
abstract：:Xeroderma Pigmentosum (XP) is a DNA repair disease characterized by nucleotide excision repair (NER) malfunction, leading to photosensitivity and increased incidence of skin malignancies. The role of XP-A in NER pathways has been well studied while discrepancies associated with ROS levels and the role of radical speci...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8111377
更新日期：2019-11-01 00:00:00
abstract：:Alterations in glucose and glutamine utilizing pathways and in fatty acid metabolism are currently considered the most significant and prevalent metabolic changes observed in almost all types of tumors. Glucose, glutamine and fatty acids are the substrates for the hexosamine biosynthetic pathway (HBP). This metabolic ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7060053
更新日期：2018-06-02 00:00:00
abstract：:The genomes of all organisms abound with various cis-regulatory elements, which control gene activity. Transcriptional enhancers are a key group of such elements in eukaryotes and are DNA regions that form physical contacts with gene promoters and precisely orchestrate gene expression programs. Here, we follow gradual...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9071675
更新日期：2020-07-12 00:00:00
abstract：:Many cells rearrange proteins and other components into spatially distinct domains in a process called polarization. This asymmetric patterning is required for a number of biological processes including asymmetric division, cell migration, and embryonic development. Proteins involved in polarization are highly conserv...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9092036
更新日期：2020-09-05 00:00:00
abstract：:Lysosomal function has a central role in maintaining neuronal homeostasis, and, accordingly, lysosomal dysfunction has been linked to neurodegeneration and particularly to Parkinson's disease (PD). Lysosomes are the converging step where the substrates delivered by autophagy and endocytosis are degraded in order to re...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9112399
更新日期：2020-11-02 00:00:00
abstract：:Cardiovascular diseases remain the leading cause of death in the developed world, accounting for more than 30% of all deaths. In a large proportion of these patients, acute myocardial infarction is usually the first manifestation, which might further progress to heart failure. In addition, the human heart displays a l...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8121530
更新日期：2019-11-27 00:00:00
abstract：:Osteoarthritis (OA) is a degenerative disease of the hyaline articular cartilage. This disease is progressive and may lead to disability. Researchers proposed many regenerative approaches to treat osteoarthritis, including stem cells. Trans-differentiation of a fully differentiated cell state directly into another dif...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9010191
更新日期：2020-01-11 00:00:00
abstract：:Dysregulation of receptor tyrosine kinase-induced pathways is a critical step driving the oncogenic potential of brain cancer. In this study, we investigated the role of two members of the Sprouty (Spry) family in brain cancer-derived cell lines. Using immunoblot analyses we found essential differences in the pattern ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8080808
更新日期：2019-08-01 00:00:00
abstract：:Attention Deficit Hyperactivity Disorder (ADHD) is a highly heritable and prevalent neurodevelopmental disorder that frequently persists into adulthood. Strong evidence from genetic studies indicates that single nucleotide polymorphisms (SNPs) harboured in the ADGRL3 (LPHN3), SNAP25, FGF1, DRD4, and SLC6A2 genes are a...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8080907
更新日期：2019-08-16 00:00:00
abstract：:In the neonate forebrain, network formation is driven by the spontaneous synchronized activity of pyramidal cells and interneurons, consisting of bursts of electrical activity and intracellular Ca2+ oscillations. By employing ratiometric Na+ imaging in tissue slices obtained from animals at postnatal day 2-4 (P2-4), w...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9010102
更新日期：2019-12-31 00:00:00
abstract：:Peer review is the driving force of journal development, and reviewers are gatekeepers who ensure that Cells maintains its standards for the high quality of its published papers [...]. ...
journal_title：Cells
pub_type： 社论
doi：10.3390/cells10020244
更新日期：2021-01-27 00:00:00
abstract：:Mammalian Pumilio (PUM) proteins are sequence-specific, RNA-binding proteins (RBPs) with wide-ranging roles. They are involved in germ cell development, which has functional implications in development and fertility. Although human PUM1 and PUM2 are closely related to each other and recognize the same RNA binding moti...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9040984
更新日期：2020-04-16 00:00:00
abstract：:Integrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration. Integrins are bidirectional signalling molecules that mediate their effects by 'inside-out' and 'outside-in' ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7030020
更新日期：2018-03-10 00:00:00
abstract：:High-throughput transcriptomic profiling approaches have revealed that circular RNAs (circRNAs) are important transcriptional gene products, identified across a broad range of organisms throughout the eukaryotic tree of life. In the nervous system, they are particularly abundant, developmentally regulated, region-spec...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9081815
更新日期：2020-07-31 00:00:00
abstract：:Hepatitis C virus (HCV) infection is commonly attributed as a major cause of chronic hepatotropic diseases, such as, steatosis, cirrhosis and hepatocellular carcinoma. As HCV infects only humans and primates, its narrow host tropism hampers in vivo studies of HCV-mammalian host interactions and the development of effe...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8060604
更新日期：2019-06-17 00:00:00
abstract：:Apoptosis, a form of programmed cell death, is a highly regulated process critical for tissue development, homeostasis, and pathogenesis of various diseases [...]. ...
journal_title：Cells
pub_type： 社论
doi：10.3390/cells9092121
更新日期：2020-09-18 00:00:00
abstract：:Preeclampsia (PE) is a pregnancy-specific disorder associated with hypertension and proteinuria. Since there is no proven method to treat PE, early prediction and accurate diagnosis are essential for appropriate management of the disease. Thus, reliable biomarkers for diagnosing PE need to be identified and evaluated....
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9092003
更新日期：2020-08-31 00:00:00
abstract：:The nucleolus is a distinct sub-cellular compartment structure in the nucleus. First observed more than 200 years ago, the nucleolus is detectable by microscopy in eukaryotic cells and visible during the interphase as a sub-nuclear structure immersed in the nucleoplasm, from which it is not separated from any membrane...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8091090
更新日期：2019-09-16 00:00:00
abstract：:Aggressive and mesenchymal-transformed breast cancer cells show high expression levels of Rho GTPase activating protein 29 (ARHGAP29), a negative regulator of RhoA. ARHGAP29 was the only one of 32 GTPase-activating enzymes whose expression significantly increased after the induction of mesenchymal transformation in br...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9122616
更新日期：2020-12-05 00:00:00
abstract：:Glaucoma is one of the leading causes of irreversible blindness in the world and remains a major public health problem. To date, incomplete knowledge of this disease's pathophysiology has resulted in current therapies (pharmaceutical or surgical) unfortunately having only a slowing effect on disease progression. Recen...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9030535
更新日期：2020-02-25 00:00:00
abstract：:Angiopoietins 1-4 (Ang1-4) represent an important family of growth factors, whose activities are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized are angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2). Ang1 is a potent angiogenic growth factor signaling through Tie2, whereas Ang2 was ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8050471
更新日期：2019-05-17 00:00:00
abstract：:Patient-derived xenograft (PDX) models have been recognized as being more suitable for predicting therapeutic efficacy than cell-culture models. However, there are several limitations in applying PDX models in preclinical studies, including their availability-especially for cancers such as gastric cancer-that are not ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8060585
更新日期：2019-06-14 00:00:00
abstract：:TROP1 (EpCAM) and TROP2 are homologous cell surface proteins that are widely expressed, and often co-expressed, in developing and adult epithelia. Various functions have been ascribed to EpCAM and TROP2, but responsible mechanisms are incompletely characterized and functional equivalence has not been examined. Adult i...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9081847
更新日期：2020-08-06 00:00:00
abstract：:The hypoxia-inducible transcription factors (HIF)-1/2α are the main oxygen sensors which regulate the adaptation to intratumoral hypoxia. The aim of this study was to assess the role of the HIF proteins in regulating the radiation response of a non-small cell lung cancer (NSCLC) in vitro model. To directly assess the ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8010045
更新日期：2019-01-12 00:00:00
abstract：:Metastatic spread is mainly sustained by cancer stem cells (CSC), a subpopulation of cancer cells that displays stemness features. CSC are thought to be derived from cancer cells that undergo epithelial to mesenchymal transition (EMT), thus acquiring resistance to anoikis and anti-cancer drugs. After detachment from t...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8111434
更新日期：2019-11-13 00:00:00
abstract：:Sarcomas are deadly malignant tumors of mesenchymal origin occurring at all ages. The expression and function of the membrane-type matrix metalloproteinase MMP14 is closely related to the mesenchymal cell phenotype, and it is highly expressed in most sarcomas. MMP14 regulates the activity of multiple extracellular and...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8090991
更新日期：2019-08-28 00:00:00
