Abstract：
:Hepatitis C virus (HCV) infection is commonly attributed as a major cause of chronic hepatotropic diseases, such as, steatosis, cirrhosis and hepatocellular carcinoma. As HCV infects only humans and primates, its narrow host tropism hampers in vivo studies of HCV-mammalian host interactions and the development of effective therapeutics and vaccines. In this context, we will focus our discussion on humanized mice in HCV research. Here, these humanized mice are defined as animal models that encompass either only human hepatocytes or both human liver and immune cells. Aspects related to immunopathogenesis, anti-viral interventions, drug testing and perspectives of these models for future HCV research will be discussed.
journal_name
Cellsjournal_title
Cellsauthors
Yong KSM,Her Z,Chen Qdoi
10.3390/cells8060604subject
Has Abstractpub_date
2019-06-17 00:00:00issue
6issn
2073-4409pii
cells8060604journal_volume
8pub_type
杂志文章,评审相关文献
Cells文献大全abstract：:Drug resistance is the main obstacle to achieving cures with both conventional and targeted anticancer drugs. The emergence of acquired drug resistance is initially mediated by non-genetic transcriptional changes, which occur at a much higher frequency than mutations and may involve population-scale transcriptomic ada...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells10010144
更新日期：2021-01-12 00:00:00
abstract：:Glycogen synthase kinase 3β (GSK3β), originally described as a negative regulator of glycogen synthesis, is a molecular hub linking numerous signaling pathways in a cell. Specific GSK3β inhibitors have anti-depressant effects and reduce depressive-like behavior in animal models of depression. Therefore, GSK3β is sugge...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9030727
更新日期：2020-03-16 00:00:00
abstract：:Genetic disorders associated with metal metabolism form a large group of disorders and mostly result from defects in the proteins/enzymes involved in nutrient metabolism and energy production. These defects can affect different metabolic pathways and cause mild to severe disorders related to metal metabolism. Some dis...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8121598
更新日期：2019-12-09 00:00:00
abstract：:Recent studies have proven that Dimethylfumarate (DMF) has a marked anti-proliferative impact on diverse cancer entities e.g., on malignant melanoma. To explore its anti-tumorigenic potential, we examined the effects of DMF on human colon carcinoma cell lines and the underlying mechanisms of action. Human colon cancer...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8111329
更新日期：2019-10-28 00:00:00
abstract：:Identification of patients with activation of the immune system which indicates the presence of infection is essential, especially in the times of the global coronavirus 2019 (COVID-19) pandemic. The aim of the present study was to evaluate the reactive lymphocytes (RE-LYMP) parameter in COVID-19 and to correlate it w...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells10010082
更新日期：2021-01-06 00:00:00
abstract：:Cancer cells rely on aberrant transcription for growth and survival. Cyclin-dependent kinases (CDKs) play critical roles in regulating gene transcription by modulating the activity of RNA polymerase II (RNAPII). THZ1, a selective covalent inhibitor of CDK7, has antitumor effects in several human cancers. In this study...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8111469
更新日期：2019-11-19 00:00:00
abstract：:In 2011, I was invited to serve as the Editor-In-Chief for Cells, which back then was a "new kid on the block" among open access (OA) journals.[...]. ...
journal_title：Cells
pub_type： 社论
doi：10.3390/cells6040041
更新日期：2017-11-01 00:00:00
abstract：:Innate immune cells monitor invading pathogens and pose the first-line inflammatory response to coordinate with adaptive immunity for infection removal. Innate immunity also plays pivotal roles in injury-induced tissue remodeling and the maintenance of tissue homeostasis in physiological and pathological conditions. L...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8121633
更新日期：2019-12-13 00:00:00
abstract：:Histones are constitutive components of nucleosomes and key regulators of chromatin structure. We previously observed that an extrachromosomal histone H2B (ecH2B) localizes at the intercellular bridge (ICB) connecting the two daughter cells during cytokinesis independently of DNA and RNA. Here, we show that ecH2B bind...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8111391
更新日期：2019-11-05 00:00:00
abstract：:Epidermal growth factor receptor (EGFR) is the first discovered member of the receptor tyrosine kinase superfamily and plays a fundamental role during embryogenesis and in adult tissues, being involved in growth, differentiation, maintenance and repair of various tissues and organs. The role of EGFR in the regulation ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9081887
更新日期：2020-08-12 00:00:00
abstract：:The authors wish to make the following corrections to this paper [...]. ...
journal_title：Cells
pub_type： 已发布勘误
doi：10.3390/cells9102165
更新日期：2020-09-24 00:00:00
abstract：:(1) Aim: In the present paper we analyzed the transcriptome of CSCs (Cancer Stem Cells), in order to find defining molecular processes of breast cancer. (2) Methods: We performed RNA-Seq from CSCs isolated from the basal cell line MDA-MB-468. Enriched processes and networks were studied using the IPA (Ingenuity Pathwa...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9030709
更新日期：2020-03-13 00:00:00
abstract：:ELISpot is one of the most commonly used immune monitoring assays, which allows the functional assessment of the immune system at the single cell level. With its outstanding sensitivity and ease of performance, the assay has recently advanced from the mere single function cell analysis to multifunctional analysis by i...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells3041102
更新日期：2014-11-27 00:00:00
abstract：:Triple-negative breast cancer (TNBC) lacks estrogen receptor (ER) α, but the expression of estrogen receptors ERβ and G protein-coupled estrogen receptor 1 (GPER-1) is able to trigger estrogen-responsivity in TNBC. Estrogen signaling in TNBC can also be activated and modulated by the constitutively active estrogen-rel...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9112358
更新日期：2020-10-26 00:00:00
abstract：:Mast cells have been associated with arteriogenesis and collateral formation. In advanced human atherosclerotic plaques, mast cells have been shown to colocalize with plaque neovessels, and mast cells have also been associated with tumor vascularization. Based on these associations, we hypothesize that mast cells prom...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9030701
更新日期：2020-03-12 00:00:00
abstract：:Hspb8 is a member of the small heat shock protein (sHSP) family. Its expression is known to be upregulated under heat shock. This protein interacts with different partners and can, therefore, be involved in various processes relevant to tissue integrity and functioning. In humans, mutations in the gene encoding Hspb8 ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9061562
更新日期：2020-06-26 00:00:00
abstract：:CK2 is a Ser/Thr protein kinase overexpressed in many cancers. It is usually present in cells as a tetrameric enzyme, composed of two catalytic (α or α') and two regulatory (β) subunits, but it is active also in its monomeric form, and the specific role of the different isoforms is largely unknown. CK2 phosphorylates ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells10010181
更新日期：2021-01-18 00:00:00
abstract：:Sars-Cov-2 infection causes fever and cough that may rapidly lead to acute respiratory distress syndrome (ARDS). Few biomarkers have been identified but, unfortunately, these are individually poorly specific, and novel biomarkers are needed to better predict patient outcome. The aim of this study was to evaluate the d...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells10010085
更新日期：2021-01-07 00:00:00
abstract：:Insect adipokinetic hormones (AKHs) are short peptides produced in the corpora cardiaca and are responsible for mobilizing energy stores from the fat body to the hemolymph. Three related peptides, AKH1, AKH2, and AKH/corazonin-related peptide (ACP) as well as three AKH receptors have been reported in Bombyx mori. AKH1...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9122667
更新日期：2020-12-11 00:00:00
abstract：:With increasing multidrug resistance and contraindication for corticosteroid use, the goal of this study was to develop thymosin beta-4 (Tβ4) as an adjunctive therapy to antibiotics for the treatment of bacterial keratitis that effectively promotes enhanced wound healing, host defense, and inflammation resolution. Dis...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells7100145
更新日期：2018-09-20 00:00:00
abstract：:Ovulation denotes the discharge of fertilizable oocytes from ovarian follicles. Follicle rupture during ovulation requires extracellular matrix (ECM) degradation at the apex of the follicle. In the teleost medaka, an excellent model for vertebrate ovulation studies, LH-inducible matrix metalloproteinase 15 (Mmp15) pla...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8030215
更新日期：2019-03-04 00:00:00
abstract：:Neurodegenerative diseases (NDs) are a broad class of pathologies characterized by the progressive loss of neurons in the central nervous system. The main problem in the study of NDs is the lack of an adequate realistic experimental model to study the pathogenic mechanisms. Induced pluripotent stem cells (iPSCs) parti...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8080830
更新日期：2019-08-05 00:00:00
abstract：:Large tumor-derived Extracellular Vesicles (tdEVs) detected in blood of metastatic prostate, breast, colorectal, and non-small cell lung cancer patients after enrichment for Epithelial Cell Adhesion Molecule (EpCAM) expression and labeling with 4',6-diamidino-2-phenylindole (DAPI), phycoerythrin-conjugated antibodies ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8080937
更新日期：2019-08-20 00:00:00
abstract：:The human gut relies on several cellular and molecular mechanisms to allow for an intact and dynamical intestinal barrier. Normally, only small amounts of luminal content pass the mucosa, however, if the control is broken it can lead to enhanced passage, which might damage the mucosa, leading to pathological condition...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8020193
更新日期：2019-02-22 00:00:00
abstract：:We present a hiPSC-based 3D in vitro system suitable to test neurotoxicity (NT). Human iPSCs-derived 3D neurospheres grown in 96-well plate format were characterized timewise for 6-weeks. Changes in complexity and homogeneity were followed by immunocytochemistry and transmission electron microscopy. Transcriptional ac...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9051122
更新日期：2020-05-01 00:00:00
abstract：:Trichinella spiralis maintains chronic infections within its host, involving a variety of immunomodulatory properties, the mechanisms of which have not been completely elucidated. In this study, we found that T. spiralis infection induced strong regulatory T cell responses through parasite excretory-secretory (ES) pro...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8111404
更新日期：2019-11-07 00:00:00
abstract：:Canonical transient receptor potential (TRPC) channels are a family of polymodal cation channels with some degree of Ca2+ permeability. Although initially thought to be channels mediating store-operated Ca2+ influx, TRPC channels can be activated by stimulation of Gq-coupled G-protein coupled receptors, or by an incre...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells3020288
更新日期：2014-04-09 00:00:00
abstract：:The pathological hallmark of Parkinson's disease (PD) is the loss of neuromelanin-containing dopaminergic neurons within the substantia nigra pars compacta (SNpc). Additionally, numerous studies indicate an altered synaptic function during disease progression. To gain new insights into the molecular processes underlyi...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9122580
更新日期：2020-12-02 00:00:00
abstract：:Cancer cells perform a metabolic rewiring to sustain an increased growth rate and compensate for the redox stress caused by augmented energy metabolism. The metabolic changes are not the same in all cancers. Some features, however, are considered hallmarks of this disease. As an example, all cancer cells rewire the am...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9092028
更新日期：2020-09-03 00:00:00
abstract：:Lysosomal function has a central role in maintaining neuronal homeostasis, and, accordingly, lysosomal dysfunction has been linked to neurodegeneration and particularly to Parkinson's disease (PD). Lysosomes are the converging step where the substrates delivered by autophagy and endocytosis are degraded in order to re...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9112399
更新日期：2020-11-02 00:00:00
