Actomyosin Contractility in the Generation and Plasticity of Axons and Dendritic Spines.

Abstract:

:Actin and non-muscle myosins have long been known to play important roles in growth cone steering and neurite outgrowth. More recently, novel functions for non-muscle myosin have been described in axons and dendritic spines. Consequently, possible roles of actomyosin contraction in organizing and maintaining structural properties of dendritic spines, the size and location of axon initial segment and axonal diameter are emerging research topics. In this review, we aim to summarize recent findings involving myosin localization and function in these compartments and to discuss possible roles for actomyosin in their function and the signaling pathways that control them.

journal_name

Cells

journal_title

Cells

authors

Mikhaylova M,Rentsch J,Ewers H

doi

10.3390/cells9092006

subject

Has Abstract

pub_date

2020-09-01 00:00:00

issue

9

issn

2073-4409

pii

cells9092006

journal_volume

9

pub_type

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