Detecting Resistance to Therapeutic ALK Inhibitors in Tumor Tissue and Liquid Biopsy Markers: An Update to a Clinical Routine Practice.

abstract：:Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important roles in many physiological and pathological processes via carbohydrate-protein interactions, including cell-cell communication, bac...

journal_title：Cells

authors： Zhou X,Yang G,Guan F

更新日期：2020-01-22 00:00:00

abstract：:ELISpot is one of the most commonly used immune monitoring assays, which allows the functional assessment of the immune system at the single cell level. With its outstanding sensitivity and ease of performance, the assay has recently advanced from the mere single function cell analysis to multifunctional analysis by i...

journal_title：Cells

authors： Janetzki S,Rueger M,Dillenbeck T

更新日期：2014-11-27 00:00:00

abstract：:RhoBTB proteins constitute a subfamily of atypical Rho GTPases represented in mammals by RhoBTB1, RhoBTB2, and RhoBTB3. Their characteristic feature is a carboxyl terminal extension that harbors two BTB domains capable of assembling cullin 3-dependent ubiquitin ligase complexes. The expression of all three RHOBTB gene...

journal_title：Cells

authors： Ji W,Rivero F

更新日期：2016-06-14 00:00:00

abstract：:While high levels of saturated fatty acids are associated with impairment of cardiovascular functions, n-3 polyunsaturated fatty acids (PUFAs) have been shown to exert protective effects. However the molecular mechanisms underlying this evidence are not completely understood. In the present study we have used rat H9c2...

journal_title：Cells

authors： Cetrullo S,D'Adamo S,Panichi V,Borzì RM,Pignatti C,Flamigni F

更新日期：2020-02-26 00:00:00

abstract：:Tubulin is a heterodimer of α and β subunits, both existing as isotypes differing in amino acid sequence encoded by different genes. Specific isotypes of tubulin have associations with cancer that are not well understood. Previous studies found that βII-tubulin is expressed in a number of transformed cells and that th...

journal_title：Cells

authors： Ruksha K,Mezheyeuski A,Nerovnya A,Bich T,Tur G,Gorgun J,Luduena R,Portyanko A

更新日期：2019-01-07 00:00:00

abstract：:During strong parallel fiber stimulation, glutamate released at parallel fiber-Purkinje cell synapses activates type-1 metabotropic glutamate receptor (mGluR1) to trigger a slow excitatory postsynaptic current (sEPSC) in cerebellar Purkinje neurons. The sEPSC is mediated by transient receptor potential canonical 3 (TR...

journal_title：Cells

authors： Tian J,Zhu MX

更新日期：2018-07-29 00:00:00

abstract：:Stefin B (cystatin B) is an intracellular inhibitor of cysteine cathepsins and mutations in the stefin B gene, resulting in the development of Unverricht-Lundborg disease, which is a form of myoclonic epilepsy. It was suggested that a key mechanism behind stefin B-mediated disease progression was impaired redox homeos...

journal_title：Cells

authors： Trstenjak Prebanda M,Završnik J,Turk B,Kopitar Jerala N

更新日期：2019-11-21 00:00:00

abstract：:Motile cilia, also called flagella, are found across a broad range of species; some cilia propel prokaryotes and eukaryotic cells like sperm, while cilia on epithelial surfaces create complex fluid patterns e.g., in the brain or lung. For sperm, the picture has emerged that the flagellum is not only a motor but also a...

journal_title：Cells

authors： Hansen JN,Rassmann S,Jikeli JF,Wachten D

更新日期：2018-12-26 00:00:00

abstract：:Rab proteins compose the largest family of small GTPases and control the different steps of intracellular membrane traffic. More recently, they have been shown to also regulate cell signaling, division, survival, and migration. The regulation of these processes generally occurs through recruitment of effectors and reg...

journal_title：Cells

authors： Guadagno NA,Progida C

更新日期：2019-08-16 00:00:00

abstract：:Cancer is a complex expression of an altered state of cellular differentiation associated with severe clinical repercussions. The effort to characterize this pathological entity to understand its underlying mechanisms and visualize potential therapeutic strategies has been constant. In this context, some cellular (enh...

journal_title：Cells

authors： Campos-Contreras ADR,Díaz-Muñoz M,Vázquez-Cuevas FG

更新日期：2020-07-03 00:00:00

abstract：:The Hippo pathway is a cellular signalling network, which plays major roles in organ homeostasis and development[...]. ...

journal_title：Cells

authors： Hansen CG

更新日期：2019-09-30 00:00:00

abstract：BACKGROUND:The current approaches to distinguish follicular adenomas (FA) and follicular thyroid cancer (FTC) at the pre-operative stage have low predictive value. Liquid biopsy-based analysis of circulating extracellular vesicles (EVs) presents a promising diagnostic method. However, the extreme heterogeneity of plasm...

journal_title：Cells

authors： Zabegina L,Nazarova I,Knyazeva M,Nikiforova N,Slyusarenko M,Titov S,Vasilyev D,Sleptsov I,Malek A

更新日期：2020-08-18 00:00:00

abstract：:Most protein-encoding genes in eukaryotes contain introns, which are interwoven with exons. Introns need to be removed from initial transcripts in order to generate the final messenger RNA (mRNA), which can be translated into an amino acid sequence. Precise excision of introns by the spliceosome requires conserved din...

journal_title：Cells

authors： Frey K,Pucker B

更新日期：2020-02-18 00:00:00

abstract：:Many life activities and key functions in organisms are maintained by different types of protein⁻protein interactions (PPIs). In order to accelerate the discovery of PPIs for different species, many computational methods have been developed. Unfortunately, even though computational methods are constantly evolving, eff...

journal_title：Cells

authors： Wang Y,You ZH,Yang S,Li X,Jiang TH,Zhou X

更新日期：2019-02-03 00:00:00

abstract：:Endocytosis and autophagy are evolutionarily conserved degradative processes in all eukaryotes. Both pathways converge to the lysosome where cargo is degraded. Improper lysosomal degradation is observed in many human pathologies, so its regulatory mechanisms are important to understand. Sec20/BNIP1 (BCL2/adenovirus E1...

journal_title：Cells

authors： Lakatos Z,Lőrincz P,Szabó Z,Benkő P,Kenéz LA,Csizmadia T,Juhász G

更新日期：2019-07-24 00:00:00

abstract：:We have previously postulated that unconventional myosin VI (MVI) could be involved in myoblast differentiation. Here, we addressed the mechanism(s) of its involvement using primary myoblast culture derived from the hindlimb muscles of Snell's waltzer mice, the natural MVI knockouts (MVI-KO). We observed that MVI-KO m...

journal_title：Cells

authors： Lehka L,Topolewska M,Wojton D,Karatsai O,Alvarez-Suarez P,Pomorski P,Rędowicz MJ

更新日期：2020-07-11 00:00:00

abstract：:Podoplanin and CD44 are transmembrane glycoproteins involved in inflammation and cancer. In this paper, we report that podoplanin is coordinately expressed with the CD44 standard (CD44s) and variant (CD44v) isoforms in vivo-in hyperplastic skin after a pro-inflammatory stimulus with 12-O-tetradecanoylphorbol-13-acetat...

journal_title：Cells

authors： Montero-Montero L,Renart J,Ramírez A,Ramos C,Shamhood M,Jarcovsky R,Quintanilla M,Martín-Villar E

更新日期：2020-09-29 00:00:00

abstract：:The incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinoma continues to increase. Accurate diagnosis of the HPV status of a tumor is vital, as HPV+ versus HPV- tumors represent two unique biological and clinical entities with different treatment strategies. High-risk HPV subtypes encode ...

journal_title：Cells

authors： Wai KC,Strohl MP,van Zante A,Ha PK

更新日期：2020-02-22 00:00:00

abstract：:Parkinson's disease (PD) is currently the world's fastest-growing neurological disorder. It is characterized by motor and non-motor symptoms which progressively lead to significant clinical impairment, causing a high burden of disease. In addition to pharmacological therapies, various non-pharmacological treatment opt...

journal_title：Cells

authors： Richter D,Bartig D,Muhlack S,Hartelt E,Scherbaum R,Katsanos AH,Müller T,Jost W,Ebersbach G,Gold R,Krogias C,Tönges L

更新日期：2019-02-11 00:00:00

abstract：:The Drosophila ovary offers a suitable model system to study the mechanisms that orchestrate diverse cellular processes. Oogenesis starts from asymmetric stem cell division, proper differentiation and the production of fully patterned oocytes equipped with all the maternal information required for embryogenesis. Spati...

journal_title：Cells

authors： Antel M,Inaba M

更新日期：2020-01-22 00:00:00

abstract：:Human mesenchymal stromal/stem cells (hMSCs) show great promise in cell therapy due to their immunomodulatory properties. The overall immunomodulatory response of hMSCs resembles the resolution of inflammation, in which lipid mediators and regulatory macrophages (Mregs) play key roles. We investigated the effect of hM...

journal_title：Cells

authors： Holopainen M,Impola U,Lehenkari P,Laitinen S,Kerkelä E

更新日期：2020-09-22 00:00:00

abstract：:HDGF-related protein 2 (HRP-2) is a member of the Hepatoma-Derived Growth Factor-related protein family that harbors the structured PWWP and Integrase Binding Domain, known to associate with methylated histone tails or cellular and viral proteins, respectively. Interestingly, HRP-2 is a paralog of Lens Epithelium Deri...

journal_title：Cells

authors： Van Belle S,El Ashkar S,Čermáková K,Matthijssens F,Goossens S,Canella A,Hodges CH,Christ F,De Rijck J,Van Vlierberghe P,Veverka V,Debyser Z

更新日期：2021-01-19 00:00:00

abstract：:The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been identified in many types of cancer. Downstream of key oncogenic pathways, such as RAS, BCR-ABL, and Her2, NF-κB regulates transcription of target genes that promote cell s...

journal_title：Cells

authors： Rinkenbaugh AL,Baldwin AS

更新日期：2016-04-06 00:00:00

abstract：:Metabolic remodelling of the tumour microenvironment is a major mechanism by which cancer cells survive and resist treatment. The pro-oncogenic inflammatory cascade released by adipose tissue promotes oncogenic transformation, proliferation, angiogenesis, metastasis and evasion of apoptosis. STAT3 has emerged as an im...

journal_title：Cells

authors： Kadye R,Stoffels M,Fanucci S,Mbanxa S,Prinsloo E

更新日期：2020-04-22 00:00:00

abstract：:Tissue-resident macrophages play critical roles in controlling homeostasis, tissue repair, and immunity. Inflammatory macrophages can sustain tissue damage and promote the development of fibrosis during infections and sterile tissue injury. The NLRP3 inflammasome and its effector cytokine IL-1β have been identified as...

journal_title：Cells

authors： Köse-Vogel N,Stengel S,Gardey E,Kirchberger-Tolstik T,Reuken PA,Stallmach A,Bruns T

更新日期：2019-12-28 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is an aggressive breast tumor subtype that currently lacks targeted treatment options. The role played by the insulin-like growth factor-1 (IGF-1) and its cognate receptor IGF-1R in TNBC has been reported. Nevertheless, the molecular mechanisms by which the IGF-1/IGF-1R system may ...

journal_title：Cells

authors： Rigiracciolo DC,Nohata N,Lappano R,Cirillo F,Talia M,Scordamaglia D,Gutkind JS,Maggiolini M

更新日期：2020-04-18 00:00:00

abstract：:Human-induced pluripotent stem cells (hiPSCs) are reprogrammed cells that have hallmarks similar to embryonic stem cells including the capacity of self-renewal and differentiation into cardiac myocytes. The improvements in reprogramming and differentiating methods achieved in the past 10 years widened the use of hiPSC...

journal_title：Cells

authors： Di Baldassarre A,Cimetta E,Bollini S,Gaggi G,Ghinassi B

更新日期：2018-05-25 00:00:00

abstract：:The disease course of myelodysplastic syndromes (MDS) features chromosome instability and clonal evolution, leading to the sequential acquisition of novel cytogenetic aberrations and the accumulation of these abnormalities in the bone marrow. Although clonal cytogenetic abnormalities can be detected by conventional cy...

journal_title：Cells

authors： Rangel-Pozzo A,Corrêa de Souza D,Schmid-Braz AT,de Azambuja AP,Ferraz-Aguiar T,Borgonovo T,Mai S

更新日期：2019-04-02 00:00:00

abstract：:The 70 kDa heat shock protein (HSP70) is a stress-inducible protein that has been shown to protect the brain from various nervous system injuries. It allows cells to withstand potentially lethal insults through its chaperone functions. Its chaperone properties can assist in protein folding and prevent protein aggregat...

journal_title：Cells

authors： Kim JY,Barua S,Huang MY,Park J,Yenari MA,Lee JE

更新日期：2020-09-02 00:00:00

abstract：:The transcription factor Snail triggers epithelial-to-mesenchymal transition (EMT), endowing cancer cells with invasive properties during tumor progression. Extracellular vesicles (EVs) released from cancer cells at various stages of cancer progression are known to influence the tumor pre-metastatic niche and metastat...

journal_title：Cells

authors： Papiewska-Pająk I,Krzyżanowski D,Katela M,Rivet R,Michlewska S,Przygodzka P,Kowalska MA,Brézillon S

更新日期：2020-06-30 00:00:00