Abstract：
:Tissue-resident macrophages play critical roles in controlling homeostasis, tissue repair, and immunity. Inflammatory macrophages can sustain tissue damage and promote the development of fibrosis during infections and sterile tissue injury. The NLRP3 inflammasome and its effector cytokine IL-1β have been identified as important mediators of fibrosis. Epirubicin, an anthracycline topoisomerase II inhibitor, has been reported to inhibit myeloid inflammatory cytokine production and to promote tissue tolerance following bacterial infection. We investigated the anti-inflammatory properties of epirubicin on the NLRP3 inflammasome and TLR4-mediated inflammation in PMA-primed THP-1 and in primary human peritoneal macrophages (PM). Low-dose epirubicin at non-cytotoxic doses downregulated NLRP3 inflammasome components and reduced the release of cleaved caspase-1, bioactive IL-1β, and TNF-α following NLRP3 activation in a dose-dependent fashion. In addition, epirubicin attenuated inflammatory macrophage responses after TLR4 and TLR2 ligation. These anti-inflammatory effects were not mediated by the induction of autophagy or altered MAPK signaling, but as the result of a global transcriptional suppression of LPS-dependent genes. Epirubicin-treated macrophages displayed reduced acetylation of histone 3 lysine 9 (H3K9ac), suggesting anti-inflammatory epigenetic imprinting as one underlying mechanism.
journal_name
Cellsjournal_title
Cellsauthors
Köse-Vogel N,Stengel S,Gardey E,Kirchberger-Tolstik T,Reuken PA,Stallmach A,Bruns Tdoi
10.3390/cells9010079subject
Has Abstractpub_date
2019-12-28 00:00:00issue
1issn
2073-4409pii
cells9010079journal_volume
9pub_type
杂志文章相关文献
Cells文献大全abstract：:Patient-derived tumor organoids (PDOs) represent a promising preclinical cancer model that better replicates disease, compared with traditional cell culture models. We have established PDOs from various human tumors to accurately and efficiently recapitulate the tissue architecture and function. Molecular targeted the...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8050481
更新日期：2019-05-20 00:00:00
abstract：:All eukaryotes rely on the ubiquitin-proteasome system (UPS) and autophagy to control the abundance of key regulatory proteins and maintain a healthy intracellular environment. In the UPS, damaged or superfluous proteins are ubiquitinated and degraded in the proteasome, mediated by three types of ubiquitin enzymes: E1...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9102219
更新日期：2020-10-01 00:00:00
abstract：:Fear is a fundamental evolutionary process for survival. However, excess or irrational fear hampers normal activity and leads to phobia. The amygdala is the primary brain region associated with fear learning and conditioning. There, Rho GTPases are molecular switches that act as signaling molecules for further downstr...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9091972
更新日期：2020-08-26 00:00:00
abstract：:Background: Insulin resistance (IR), considered a hallmark of diabetes at the cellular level, is implicated in pre-diabetes, results in type 2 diabetes, and negatively affects mitochondrial function. Diabetes is increasingly associated with enhanced risk of developing Parkinson's disease (PD); however, the underlying ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9030740
更新日期：2020-03-17 00:00:00
abstract：:Human-induced pluripotent stem cells (hiPSCs) are reprogrammed cells that have hallmarks similar to embryonic stem cells including the capacity of self-renewal and differentiation into cardiac myocytes. The improvements in reprogramming and differentiating methods achieved in the past 10 years widened the use of hiPSC...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7060048
更新日期：2018-05-25 00:00:00
abstract：:Endocytosis and autophagy are evolutionarily conserved degradative processes in all eukaryotes. Both pathways converge to the lysosome where cargo is degraded. Improper lysosomal degradation is observed in many human pathologies, so its regulatory mechanisms are important to understand. Sec20/BNIP1 (BCL2/adenovirus E1...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8080768
更新日期：2019-07-24 00:00:00
abstract：:To investigate the role of PR isoforms on the homeostasis of stem cells in the normal and neoplastic mammary gland, we used PRA and PRB transgenic mice and the T47D human breast cancer cell line and its derivatives, T47D YA and YB (manipulated to express only PRA or PRB, respectively). Flow cytometry and mammosphere a...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9092074
更新日期：2020-09-11 00:00:00
abstract：:Cholesterol is an essential structural component of cellular membranes. In addition to the structural role, it also serves as a precursor to a variety of steroid hormones and has diverse functions in intracellular signal transduction. As one of its functions in cell signaling, recent evidence suggests that cholesterol...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8050389
更新日期：2019-04-28 00:00:00
abstract：:Aquaporins are membrane channels in the broad family of major intrinsic proteins (MIPs), with 13 classes showing tissue-specific distributions in humans. As key physiological modulators of water and solute homeostasis, mutations, and dysfunctions involving aquaporins have been associated with pathologies in all major ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells10020215
更新日期：2021-01-22 00:00:00
abstract：:Extracellular vesicles (EVs) contribute to a variety of signaling processes and the overall physiological and pathological states of stem cells and tissues. Human induced pluripotent stem cells (hiPSCs) have unique characteristics that can mimic embryonic tissue development. There is growing interest in the use of EVs...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8090993
更新日期：2019-08-28 00:00:00
abstract：:Macroautophagy (hereafter referred to as autophagy, a word derived from Greek meaning "auto-digestion") is a lysosome-dependent quality control process to degrade and turnover damaged or senescent organelles and proteins for cellular renewal [...]. ...
journal_title：Cells
pub_type： 社论
doi：10.3390/cells8070743
更新日期：2019-07-19 00:00:00
abstract：:HSPA8/HSC70 is a molecular chaperone involved in a wide variety of cellular processes. It plays a crucial role in protein quality control, ensuring the correct folding and re-folding of selected proteins, and controlling the elimination of abnormally-folded conformers and of proteins daily produced in excess in our ce...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8080849
更新日期：2019-08-07 00:00:00
abstract：:TROP1 (EpCAM) and TROP2 are homologous cell surface proteins that are widely expressed, and often co-expressed, in developing and adult epithelia. Various functions have been ascribed to EpCAM and TROP2, but responsible mechanisms are incompletely characterized and functional equivalence has not been examined. Adult i...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9081847
更新日期：2020-08-06 00:00:00
abstract：:Costimulatory molecules facilitate cross-talks among leukocytes via mutual stimulatory and inhibitory signalling, contributing to diverse immunological outcomes in normal physiological responses and pathological conditions. Systemic lupus erythematosus (SLE) is a complex multi-systemic autoimmune condition in which ce...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8091044
更新日期：2019-09-06 00:00:00
abstract：:Innate lymphoid cells (ILCs) are tissue-resident sentinels of the immune system that function to protect local tissue microenvironments against pathogens and maintain homeostasis. However, because ILCs are sensitively tuned to perturbations within tissues, they can also contribute to host pathology when critical activ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020334
更新日期：2020-02-01 00:00:00
abstract：:Successful RNAi applications depend on strategies allowing stable and persistent expression of minimal gene silencing triggers without perturbing endogenous gene expression. In this study, we proposed an endogenous microRNA (miRNA) cluster as a novel integration site for small hairpin RNAs (shRNAs). We successfully in...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8020113
更新日期：2019-02-01 00:00:00
abstract：:The authors wish to make the following corrections to this paper [...]. ...
journal_title：Cells
pub_type： 已发布勘误
doi：10.3390/cells9102165
更新日期：2020-09-24 00:00:00
abstract：:The transcription factor Snail triggers epithelial-to-mesenchymal transition (EMT), endowing cancer cells with invasive properties during tumor progression. Extracellular vesicles (EVs) released from cancer cells at various stages of cancer progression are known to influence the tumor pre-metastatic niche and metastat...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9071585
更新日期：2020-06-30 00:00:00
abstract：:Actin remodeling is frequently regulated by antagonistic activities driving protrusion and contraction downstream of Rac and Rho small GTPases, respectively. WAVE regulatory complex (WRC), which primarily operates downstream of Rac, plays pivotal roles in neuronal morphogenesis. Recently, two independent studies descr...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9061355
更新日期：2020-05-29 00:00:00
abstract：:Respiratory syncytial virus (RSV) is a key cause of severe respiratory infection in infants, immunosuppressed adults, and the elderly worldwide, but there is no licensed vaccine or effective, widely-available antiviral therapeutic. We recently reported staged redistribution of host cell mitochondria in RSV infected ce...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8111417
更新日期：2019-11-11 00:00:00
abstract：:Head and neck cancer (HNC), the seventh most common form of cancer worldwide, is a group of epithelial malignancies affecting sites in the upper aerodigestive tract. The 5-year overall survival for patients with HNC has stayed around 40-50% for decades, with mortality being attributable mainly to late diagnosis and re...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells10010048
更新日期：2020-12-31 00:00:00
abstract：:Mast cells have been associated with arteriogenesis and collateral formation. In advanced human atherosclerotic plaques, mast cells have been shown to colocalize with plaque neovessels, and mast cells have also been associated with tumor vascularization. Based on these associations, we hypothesize that mast cells prom...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9030701
更新日期：2020-03-12 00:00:00
abstract：:Fibrosis is a significant global health problem associated with many inflammatory and degenerative diseases affecting multiple organs, individually or simultaneously. Fibrosis develops when extracellular matrix (ECM) remodeling becomes excessive or uncontrolled and is associated with nearly all forms of heart disease....
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9030592
更新日期：2020-03-02 00:00:00
abstract：:The incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinoma continues to increase. Accurate diagnosis of the HPV status of a tumor is vital, as HPV+ versus HPV- tumors represent two unique biological and clinical entities with different treatment strategies. High-risk HPV subtypes encode ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9020500
更新日期：2020-02-22 00:00:00
abstract：:Hepatitis E virus (HEV) infection is one of the most common causes of acute hepatitis in the world. HEV is an enterically transmitted positive-strand RNA virus found as a non-enveloped particle in bile as well as stool and as a quasi-enveloped particle in blood. Current understanding of the molecular mechanisms and ho...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9051294
更新日期：2020-05-22 00:00:00
abstract：:Gene expression is often altered by epigenetic modifications that can significantly influence the growth ability and progression of cancers. SAHA (Suberoylanilide hydroxamic acid, also known as Vorinostat), a well-known Histone deacetylase (HDAC) inhibitor, can stop cancer growth and metastatic processes through epige...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8010008
更新日期：2018-12-22 00:00:00
abstract：:Anti-inflammatory treatment of chronic inflammatory diseases often increases susceptibility to infectious diseases such as tuberculosis (TB). Since numerous chronic inflammatory and autoimmune diseases are mediated by interleukin (IL)-6-induced T helper (TH) 17 cells, a TH17-directed anti-inflammatory therapy may be p...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells10010009
更新日期：2020-12-22 00:00:00
abstract：:The nucleolus is a distinct sub-cellular compartment structure in the nucleus. First observed more than 200 years ago, the nucleolus is detectable by microscopy in eukaryotic cells and visible during the interphase as a sub-nuclear structure immersed in the nucleoplasm, from which it is not separated from any membrane...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8091090
更新日期：2019-09-16 00:00:00
abstract：:Invariant chain (Ii/CD74) has been identified as a surface receptor for migration inhibitory factor (MIF). Most cells that express Ii also synthesize major histocompatibility complex class II (MHC II) molecules, which depend on Ii as a chaperone and a targeting factor. The assembly of nonameric complexes consisting of...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells6010006
更新日期：2017-02-10 00:00:00
abstract：:A combinatorial approach integrating stem cells and capable of exploiting available cues is likely needed to regenerate lost neural tissues and ultimately restore neurologic functions. This study investigates the effects of the subcutaneous maturation of adult-derived neural stem cell (aNSCs) seeded into biomaterial c...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells7100173
更新日期：2018-10-17 00:00:00
