Abstract：
:Breast cancer-related mortality remains high worldwide, despite tremendous advances in diagnostics and therapeutics; hence, the quest for better strategies for disease management, as well as the identification of modifiable risk factors, continues. With recent leaps in genomic technologies, microbiota have emerged as major players in most cancers, including breast cancer. Interestingly, microbial alterations have been observed with some of the established risk factors of breast cancer, such as obesity, aging and periodontal disease. Higher levels of estrogen, a risk factor for breast cancer that cross-talks with other risk factors such as alcohol intake, obesity, parity, breastfeeding, early menarche and late menopause, are also modulated by microbial dysbiosis. In this review, we discuss the association between known breast cancer risk factors and altered microbiota. An important question related to microbial dysbiosis and cancer is the underlying mechanisms by which alterations in microbiota can support cancer progression. To this end, we review the involvement of microbial metabolites as effector molecules, the modulation of the metabolism of xenobiotics, the induction of systemic immune modulation, and altered responses to therapy owing to microbial dysbiosis. Given the association of breast cancer risk factors with microbial dysbiosis and the multitude of mechanisms altered by dysbiotic microbiota, an impaired microbiome is, in itself, an important risk factor.
journal_name
Cellsjournal_title
Cellsauthors
Parida S,Sharma Ddoi
10.3390/cells9051091subject
Has Abstractpub_date
2020-04-28 00:00:00issue
5issn
2073-4409pii
cells9051091journal_volume
9pub_type
杂志文章,评审相关文献
Cells文献大全abstract：:We have previously shown that the combination of radiotherapy with human umbilical-cord-derived mesenchymal stromal/stem cells (MSCs) cell therapy significantly reduces the size of the xenotumors in mice, both in the directly irradiated tumor and in the distant nonirradiated tumor or its metastasis. We have also shown...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9092015
更新日期：2020-09-02 00:00:00
abstract：:Rab proteins compose the largest family of small GTPases and control the different steps of intracellular membrane traffic. More recently, they have been shown to also regulate cell signaling, division, survival, and migration. The regulation of these processes generally occurs through recruitment of effectors and reg...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8080909
更新日期：2019-08-16 00:00:00
abstract：:Circulating tumor cells (CTCs) as real-time liquid biopsy [...]. ...
journal_title：Cells
pub_type： 社论
doi：10.3390/cells9030661
更新日期：2020-03-09 00:00:00
abstract：:Actin remodeling is frequently regulated by antagonistic activities driving protrusion and contraction downstream of Rac and Rho small GTPases, respectively. WAVE regulatory complex (WRC), which primarily operates downstream of Rac, plays pivotal roles in neuronal morphogenesis. Recently, two independent studies descr...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9061355
更新日期：2020-05-29 00:00:00
abstract：:Neuroinflammation and cell death are among the common symptoms of many central nervous system diseases and injuries. Neuroinflammation and programmed cell death of the various cell types in the brain appear to be part of these disorders, and characteristic for each cell type, including neurons and glia cells. Concerni...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9040870
更新日期：2020-04-02 00:00:00
abstract：:BAG3, a multifunctional HSP70 co-chaperone and anti-apoptotic protein that interacts with the ATPase domain of HSP70 through its C-terminal BAG domain plays a key physiological role in cellular proteostasis. The HSP70/BAG3 complex determines the levels of a large number of selective client proteins by regulating their...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9030574
更新日期：2020-02-28 00:00:00
abstract：:Patient-derived xenograft (PDX) models have been recognized as being more suitable for predicting therapeutic efficacy than cell-culture models. However, there are several limitations in applying PDX models in preclinical studies, including their availability-especially for cancers such as gastric cancer-that are not ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8060585
更新日期：2019-06-14 00:00:00
abstract：:Angiopoietin-1 (Ang-1) is a ligand of Tie-2 receptors that promotes angiogenesis. It has been established that regulatory loops exist between angiogenic growth factors and distinct pro or anti-angiogenic miRNAs, but the nature and the roles of Ang-1-regulated miRNAs remain unclear. In this study, we assessed the role ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9071602
更新日期：2020-07-02 00:00:00
abstract：:The crosstalk between human gut microbiota and intestinal wall is essential for the organ's homeostasis and immune tolerance. The gut microbiota plays a role in healthy and pathological conditions mediated by inflammatory processes or by the gut-brain axes, both involving a possible role for S100B protein as a diffusi...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9071697
更新日期：2020-07-15 00:00:00
abstract：:Therapies intended to mitigate cardiovascular complications cannot be applied in practice without detailed knowledge of molecular mechanisms. Mitochondria, as the end-effector of cardioprotection, represent one of the possible therapeutic approaches. The present review provides an overview of factors affecting the reg...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8111449
更新日期：2019-11-17 00:00:00
abstract：:Endoscopic submucosal dissection (ESD) is an effective treatment of early esophageal adenocarcinomas (EACs). The decision of ESD over esophagectomy is based on clinical evaluation of tumor depth and invasion. On a molecular level, tumor invasion is strongly associated with epithelial-to-mesenchymal transition (EMT). H...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9020486
更新日期：2020-02-20 00:00:00
abstract：:The pathological hallmark of Parkinson's disease (PD) is the loss of neuromelanin-containing dopaminergic neurons within the substantia nigra pars compacta (SNpc). Additionally, numerous studies indicate an altered synaptic function during disease progression. To gain new insights into the molecular processes underlyi...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9122580
更新日期：2020-12-02 00:00:00
abstract：:Aberrant expressions of long non-coding RNAs (lncRNAs) are often associated with diseases and identification of disease-related lncRNAs is helpful for elucidating complex pathogenesis. Recent methods for predicting associations between lncRNAs and diseases integrate their pertinent heterogeneous data. However, they fa...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8091012
更新日期：2019-08-30 00:00:00
abstract：:CCN1 and CCN2 are members of the CCN family and play essential roles in the regulation of multiple female reproductive functions, including ovulation. Cyclooxygenase-2 (COX2) is a critical mediator of ovulation and can be induced by sphingosine-1-phosphate (S1P) through the S1P1/3-mediated Yes-associated protein (YAP)...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8111445
更新日期：2019-11-15 00:00:00
abstract：:The Hippo signaling pathway is involved in tissue size regulation and tumorigenesis. Genetic deletion or aberrant expression of some Hippo pathway genes lead to enhanced cell proliferation, tumorigenesis, and cancer metastasis. Recently, multiple studies have identified a wide range of upstream regulators of the Hippo...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells8050426
更新日期：2019-05-08 00:00:00
abstract：:Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder characterized by multiple basal cell carcinomas (BCC), mainly caused by PTCH1 gene mutations. Our current study aimed to establish (1) PTCH1 germinal and somatic mutational status, (2) component and Hedgehog (HH) pathway targets gene expres...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8020144
更新日期：2019-02-11 00:00:00
abstract：:Cystic Fibrosis (CF) is caused by >2000 mutations in the CF transmembrane conductance regulator (CFTR) gene, but one mutation-F508del-occurs in ~80% of patients worldwide. Besides its main function as an anion channel, the CFTR protein has been implicated in epithelial differentiation, tissue regeneration, and, when d...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9071607
更新日期：2020-07-02 00:00:00
abstract：:Glioblastomas are the most frequent and aggressive form of primary brain tumors with no efficient cure. However, they often exhibit specific metabolic shifts that include deficiency in the biosynthesis of and dependence on certain exogenous amino acids. Here, we evaluated, in vitro, a novel combinatory antiglioblastom...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9102217
更新日期：2020-09-30 00:00:00
abstract：:Metabolic remodelling of the tumour microenvironment is a major mechanism by which cancer cells survive and resist treatment. The pro-oncogenic inflammatory cascade released by adipose tissue promotes oncogenic transformation, proliferation, angiogenesis, metastasis and evasion of apoptosis. STAT3 has emerged as an im...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9041043
更新日期：2020-04-22 00:00:00
abstract：:Reactive oxygen species (ROS) are produced continuously throughout the cell as products of various redox reactions. Yet these products function as important signal messengers, acting through oxidation of specific target factors. Whilst excess ROS production has the potential to induce oxidative stress, physiological r...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells10020233
更新日期：2021-01-25 00:00:00
abstract：:Substantive evidence demonstrates the contribution of mitochondrial dysfunction in the etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive characterization of Mitochondrial‑Derived Peptides (MDPs) has revealed their cytoprotective role in several diseases, including AMD. Here we su...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9051102
更新日期：2020-04-29 00:00:00
abstract：:Induced pluripotent stem cells (iPSCs) and induced neuronal (iN) cells are very much touted in terms of their potential promises in therapeutics. However, from a more fundamental perspective, iPSCs and iNs are invaluable tools for the postnatal generation of specific diseased cell types from patients, which may offer ...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells7050038
更新日期：2018-05-08 00:00:00
abstract：:Recent studies have revealed synaptic dysfunction to be a hallmark of various psychiatric diseases, and that glial cells participate in synapse formation, development, and plasticity. Glial cells contribute to neuroinflammation and synaptic homeostasis, the latter being essential for maintaining the physiological func...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells9102176
更新日期：2020-09-27 00:00:00
abstract：:The nucleolus is a prominent, membraneless compartment found within the nucleus of eukaryotic cells. It forms around ribosomal RNA (rRNA) genes, where it coordinates the transcription, processing, and packaging of rRNA to produce ribosomal subunits. Recent efforts to characterize the biophysical properties of the nucl...
journal_title：Cells
pub_type： 社论
doi：10.3390/cells9030526
更新日期：2020-02-25 00:00:00
abstract：:One third of all human proteins are either transmembrane or soluble secretory proteins that first target the endoplasmic reticulum (ER). These proteins subsequently leave the ER and enter the Golgi apparatus via ER-Golgi intermediate vesicular structures. Live-cell imaging of cargos fused to fluorescent proteins (FPs)...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9102311
更新日期：2020-10-17 00:00:00
abstract：:Feline coronavirus is a highly contagious virus potentially resulting in feline infectious peritonitis (FIP), while the pathogenesis of FIP remains not well understood, particularly in the events leading to the disease. A predominant theory is that the pathogenic FIPV arises from a mutation, so that it could replicate...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9061431
更新日期：2020-06-09 00:00:00
abstract：:Alterations in glucose and glutamine utilizing pathways and in fatty acid metabolism are currently considered the most significant and prevalent metabolic changes observed in almost all types of tumors. Glucose, glutamine and fatty acids are the substrates for the hexosamine biosynthetic pathway (HBP). This metabolic ...
journal_title：Cells
pub_type： 杂志文章,评审
doi：10.3390/cells7060053
更新日期：2018-06-02 00:00:00
abstract：:Identification of patients with activation of the immune system which indicates the presence of infection is essential, especially in the times of the global coronavirus 2019 (COVID-19) pandemic. The aim of the present study was to evaluate the reactive lymphocytes (RE-LYMP) parameter in COVID-19 and to correlate it w...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells10010082
更新日期：2021-01-06 00:00:00
abstract：:In liver transplantation (LT), organ shortage has led to the use of steatotic and non-steatotic grafts from donors after cardiocirculatory death (DCD). However, these grafts, especially those with steatosis, exhibit poor post-operative outcomes. To address this problem, we investigated the roles of gut-derived glucago...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells8121599
更新日期：2019-12-09 00:00:00
abstract：:Anti-Müllerian hormone (AMH) is responsible for the Müllerian ducts' regression in male fetuses. In cells of cancers with AMH receptors (AMHRII), AMH induces cell cycle arrest or apoptosis. As AMH occurs naturally and does not exhibit significant side effects while reducing neoplastic cell colonies, it can be consider...
journal_title：Cells
pub_type： 杂志文章
doi：10.3390/cells9102312
更新日期：2020-10-17 00:00:00
