Abstract：
:Substantive evidence demonstrates the contribution of mitochondrial dysfunction in the etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive characterization of Mitochondrial‑Derived Peptides (MDPs) has revealed their cytoprotective role in several diseases, including AMD. Here we summarize the varied effects of MDPs on cellular and mitochondrial health, which establish the merit of MDPs as therapeutic targets for AMD. We argue that further research to delve into the mechanisms of action and delivery of MDPs may advance the field of AMD therapy.
journal_name
Cellsjournal_title
Cellsauthors
Nashine S,Kenney MCdoi
10.3390/cells9051102subject
Has Abstractpub_date
2020-04-29 00:00:00issue
5issn
2073-4409pii
cells9051102journal_volume
9pub_type
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