Abstract:
:β-adrenergic receptors (β-ARs) play a major role in the physiological regulation of cardiac function through signaling routes tightly controlled by G protein-coupled receptor kinases (GRKs). Although the acute stimulation of β-ARs and the subsequent production of cyclic AMP (cAMP) have beneficial effects on cardiac function, chronic stimulation of β-ARs as observed under sympathetic overdrive promotes the development of pathological cardiac remodeling and heart failure (HF), a leading cause of mortality worldwide. This is accompanied by an alteration in cAMP compartmentalization and the activation of the exchange protein directly activated by cAMP 1 (Epac1) signaling. Among downstream signals of β-ARs, compelling evidence indicates that GRK2, GRK5, and Epac1 represent attractive therapeutic targets for cardiac disease. Here, we summarize the pathophysiological roles of GRK2, GRK5, and Epac1 in the heart. We focus on their signalosome and describe how under pathological settings, these proteins can cross-talk and are part of scaffolded nodal signaling systems that contribute to a decreased cardiac function and HF development.
journal_name
Cellsjournal_title
Cellsauthors
Laudette M,Formoso K,Lezoualc'h Fdoi
10.3390/cells10010154subject
Has Abstractpub_date
2021-01-14 00:00:00issue
1issn
2073-4409pii
cells10010154journal_volume
10pub_type
杂志文章,评审相关文献
Cells文献大全abstract::During tumor progression, hypoxia, nutrient deprivation or changes in the extracellular environment (i.e., induced by anti-cancer drugs) elicit adaptive responses in cancer cells. Cellular plasticity increases the chance that tumor cells may survive in a challenging microenvironment, acquire new mechanisms of resistan...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9010034
更新日期:2019-12-21 00:00:00
abstract::Promyelocytic leukemia (PML) bodies are dynamic intracellular structures that recruit and release a variety of different proteins in response to stress, virus infection, DNA damage and cell cycle progression. While PML bodies primarily are regarded as nuclear compartments, they are forced to travel to the cytoplasm ea...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8080893
更新日期:2019-08-14 00:00:00
abstract::Telomere dysfunction has been strongly implicated in the initiation of genomic instability and is suspected to be an early event in the carcinogenesis of human solid tumors. Recent findings have established the presence of telomere fusions in human breast and prostate malignancies; however, the onset of this genomic i...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8050414
更新日期:2019-05-04 00:00:00
abstract::Ulcerative colitis is a chronic inflammatory disease confined to the colon. Although the etiopathogenesis remains unknown, small bowel dysfunctions like histological and permeability alterations have been described in ulcerative colitis. We evaluated the molecular gene signature in the non-inflamed terminal ileum of 3...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9081793
更新日期:2020-07-28 00:00:00
abstract::Multiple Sclerosis (MS) is a chronic demyelinating autoimmune disease primarily affecting young adults. Despite an unclear causal factor, symptoms and pathology arise from the infiltration of peripheral immune cells across the blood brain barrier. Accounting for the largest fraction of this infiltrate, macrophages are...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8060543
更新日期:2019-06-05 00:00:00
abstract::Successful RNAi applications depend on strategies allowing stable and persistent expression of minimal gene silencing triggers without perturbing endogenous gene expression. In this study, we proposed an endogenous microRNA (miRNA) cluster as a novel integration site for small hairpin RNAs (shRNAs). We successfully in...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8020113
更新日期:2019-02-01 00:00:00
abstract::Circulating levels of soluble interleukin 1 receptor-like 1 (sST2) are increased in heart failure and associated with poor outcome, likely because of the activation of inflammation and fibrosis. We investigated the pathogenic role of sST2 as an inductor of cardiac fibroblasts activation and collagen synthesis. The eff...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9071667
更新日期:2020-07-10 00:00:00
abstract::Apoptosis, a form of programmed cell death, is a highly regulated process critical for tissue development, homeostasis, and pathogenesis of various diseases [...]. ...
journal_title:Cells
pub_type: 社论
doi:10.3390/cells9092121
更新日期:2020-09-18 00:00:00
abstract::Endothelial cellular stiffening has been observed not only in inflamed cultured endothelial cells but also in the endothelium of atherosclerotic regions, which is an underlying cause of monocyte adhesion and accumulation. Although recombinant soluble thrombomodulin (rsTM) has been reported to suppress the inflammatory...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9081811
更新日期:2020-07-30 00:00:00
abstract::The generation of new ribosomes is a coordinated process essential to sustain cell growth. As such, it is tightly regulated according to cell needs. As cancer cells require intense protein translation to ensure their enhanced growth rate, they exploit various mechanisms to boost ribosome biogenesis. In this review, we...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8091098
更新日期:2019-09-17 00:00:00
abstract::The aim of this study was to compare the acute effects of thrombin and brain-derived neurotrophic factor (BDNF) on spontaneous miniature endplate potentials (MEPPs) and multiquantal evoked endplate potentials (EPPs) in mouse neuromuscular junctions (NMJs) of m. diaphragma and m. EDL. Intracellular microelectrode recor...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8070762
更新日期:2019-07-22 00:00:00
abstract::Rac1 is a small GTPase that belongs to the Rho family. The Rho family of small GTPases is a subfamily of the Ras superfamily. The Rho family of GTPases mediate a plethora of cellular effects, including regulation of cytoarchitecture, cell size, cell adhesion, cell polarity, cell motility, proliferation, apoptosis/surv...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells7120263
更新日期:2018-12-11 00:00:00
abstract::As sessile organisms, plants must adjust their growth to withstand several environmental conditions. The root is a crucial organ for plant survival as it is responsible for water and nutrient acquisition from the soil and has high phenotypic plasticity in response to a lack or excess of them. How plants sense and tran...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9122576
更新日期:2020-12-01 00:00:00
abstract::Mast cells have been associated with arteriogenesis and collateral formation. In advanced human atherosclerotic plaques, mast cells have been shown to colocalize with plaque neovessels, and mast cells have also been associated with tumor vascularization. Based on these associations, we hypothesize that mast cells prom...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9030701
更新日期:2020-03-12 00:00:00
abstract::Induced pluripotent stem cells (iPSCs) have revolutionized the study of human diseases as they can renew indefinitely, undergo multi-lineage differentiation, and generate disease-specific models. However, the difficulty of working with iPSCs is that they are prone to genetic instability. Furthermore, genetically unsta...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8091068
更新日期:2019-09-11 00:00:00
abstract::Mammarenaviruses are a diverse genus of emerging viruses that include several causative agents of severe viral hemorrhagic fevers with high mortality in humans. Although these viruses share many similarities, important differences with regard to pathogenicity, type of immune response, and molecular mechanisms during v...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9112525
更新日期:2020-11-23 00:00:00
abstract::With increasing multidrug resistance and contraindication for corticosteroid use, the goal of this study was to develop thymosin beta-4 (Tβ4) as an adjunctive therapy to antibiotics for the treatment of bacterial keratitis that effectively promotes enhanced wound healing, host defense, and inflammation resolution. Dis...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells7100145
更新日期:2018-09-20 00:00:00
abstract::There is a need to disentangle the etiological puzzle of age-related neurodegenerative diseases, whose clinical phenotypes arise from known, and as yet unknown, pathways that can act distinctly or in concert. Enhanced sub-phenotyping and the identification of in vivo biomarker-driven signature profiles could improve t...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9122581
更新日期:2020-12-02 00:00:00
abstract::Most protein-encoding genes in eukaryotes contain introns, which are interwoven with exons. Introns need to be removed from initial transcripts in order to generate the final messenger RNA (mRNA), which can be translated into an amino acid sequence. Precise excision of introns by the spliceosome requires conserved din...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9020458
更新日期:2020-02-18 00:00:00
abstract::During a time span of just a few years, the CD38 antibody, daratumumab, has been established as one of the most important new drugs for the treatment of multiple myeloma, both in the relapsed/refractory setting and, more recently, as a first-line treatment. Although much is known about the pleiotropic modes of action ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9020378
更新日期:2020-02-06 00:00:00
abstract::Stage I epithelial ovarian cancer (EOC) represents about 10% of all EOCs. It is characterized by a complex histopathological and molecular heterogeneity, and it is composed of five main histological subtypes (mucinous, endometrioid, clear cell and high, and low grade serous), which have peculiar genetic, molecular, an...
journal_title:Cells
pub_type: 杂志文章,多中心研究
doi:10.3390/cells8121554
更新日期:2019-12-01 00:00:00
abstract::S100B is an astrocytic protein acting either as an intracellular regulator or an extracellular signaling molecule. A direct correlation between increased amount of S100B and demyelination and inflammatory processes has been demonstrated. The aim of this study is to investigate the possible role of a small molecule abl...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9030748
更新日期:2020-03-18 00:00:00
abstract::Glioblastoma (GBM) remains the most devastating primary central nervous system malignancy with a median survival of around 15 months. The past decades of research have not yielded significant advancements in the treatment of GBM. In that same time, a novel class of molecules, long non-coding RNAs (lncRNAs), has been f...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9112369
更新日期:2020-10-28 00:00:00
abstract::Estrogen receptors (ER) include ER alpha, ER beta and new membrane receptor G protein-coupled receptor 30 (GPR30). Estrogen receptors are key receptors to maintain ovarian granulosa cell differentiation, follicle and oocyte growth and development, and ovulation function. The abnormal functions of estrogen, its recepto...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8101123
更新日期:2019-09-21 00:00:00
abstract::Commonly, circulating tumor cells (CTCs) are described as source of metastasis in cancer patients. However, in this process cancer cells of the primary tumor site need to survive the physical and biological challenges in the blood stream before leaving the circulation to become the seed of a new metastatic site in dis...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8070714
更新日期:2019-07-13 00:00:00
abstract::Peer review is the driving force of journal development, and reviewers are gatekeepers who ensure that Cells maintains its standards for the high quality of its published papers [...]. ...
journal_title:Cells
pub_type: 社论
doi:10.3390/cells10020244
更新日期:2021-01-27 00:00:00
abstract::Cancer frequency and prevalence have been increasing in the past decades, with devastating impacts on patients and their families. Despite the great advances in targeted approaches, there is still a lack of methods to predict individual patient responses, and therefore treatments are tailored according to average resp...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9020293
更新日期:2020-01-25 00:00:00
abstract::Costimulatory molecules facilitate cross-talks among leukocytes via mutual stimulatory and inhibitory signalling, contributing to diverse immunological outcomes in normal physiological responses and pathological conditions. Systemic lupus erythematosus (SLE) is a complex multi-systemic autoimmune condition in which ce...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8091044
更新日期:2019-09-06 00:00:00
abstract::Telomeres with G-rich repetitive DNA and particular proteins as special heterochromatin structures at the termini of eukaryotic chromosomes are tightly maintained to safeguard genetic integrity and functionality. Telomerase as a specialized reverse transcriptase uses its intrinsic RNA template to lengthen telomeric G-...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8010054
更新日期:2019-01-15 00:00:00
abstract::The disease course of myelodysplastic syndromes (MDS) features chromosome instability and clonal evolution, leading to the sequential acquisition of novel cytogenetic aberrations and the accumulation of these abnormalities in the bone marrow. Although clonal cytogenetic abnormalities can be detected by conventional cy...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8040304
更新日期:2019-04-02 00:00:00