Exploring MicroRNA Biomarkers for Parkinson's Disease from mRNA Expression Profiles.

abstract：:Anchoring of heterochromatin to the nuclear envelope appears to be an important process ensuring the spatial organization of the chromatin structure and genome function in eukaryotic nuclei. Proteins of the inner nuclear membrane (INM) mediating these interactions are able to recognize lamina-associated heterochromati...

journal_title：Cells

authors： Lukášová E,Kovařík A,Kozubek S

更新日期：2018-02-06 00:00:00

abstract：:(1) Aim: In the present paper we analyzed the transcriptome of CSCs (Cancer Stem Cells), in order to find defining molecular processes of breast cancer. (2) Methods: We performed RNA-Seq from CSCs isolated from the basal cell line MDA-MB-468. Enriched processes and networks were studied using the IPA (Ingenuity Pathwa...

journal_title：Cells

authors： Schwarz-Cruz Y Celis A,Ceballos-Cancino G,Vazquez-Santillan K,Espinosa M,Zampedri C,Bahena I,Ruiz V,Maldonado V,Melendez-Zajgla J

更新日期：2020-03-13 00:00:00

abstract：:Breast cancer is a heterogeneous disease that can be subdivided into unique molecular subtypes based on protein expression of the Estrogen Receptor, Progesterone Receptor, and/or the Human Epidermal Growth Factor Receptor 2. Therapeutic approaches are designed to inhibit these overexpressed receptors either by endocri...

journal_title：Cells

authors： BeLow M,Osipo C

更新日期：2020-09-29 00:00:00

abstract：:A new epoch is emerging with intense research on nutraceuticals, i.e., "food or food product that provides medical or health benefits including the prevention and treatment of diseases", such as Alzheimer's disease. Nutraceuticals act at different biochemical and metabolic levels and much evidence shows their neuropro...

journal_title：Cells

authors： Atlante A,Amadoro G,Bobba A,Latina V

更新日期：2020-10-23 00:00:00

abstract：:Some species of clover are reported to have beneficial effects in human diseases. However, little is known about the activity of the forage plant Trifolium repens, or white clover, which has been recently found to exert a hepatoprotective action. Scientific interest is increasingly focused on identifying new drugs, es...

journal_title：Cells

authors： Sarno F,Pepe G,Termolino P,Carafa V,Massaro C,Merciai F,Campiglia P,Nebbioso A,Altucci L

更新日期：2020-02-06 00:00:00

abstract：:NFATc1, which is ubiquitous in many cell types, is the master regulator of osteoclastogenesis. However, the molecular mechanisms by which NFATc1 drives its transcriptional program to produce osteoclasts from macrophages (M) remains poorly understood. We performed quantitative PCR (QPCR) arrays and bioinformatic analys...

journal_title：Cells

authors： Russo R,Mallia S,Zito F,Lampiasi N

更新日期：2019-02-07 00:00:00

abstract：:Large tumor-derived Extracellular Vesicles (tdEVs) detected in blood of metastatic prostate, breast, colorectal, and non-small cell lung cancer patients after enrichment for Epithelial Cell Adhesion Molecule (EpCAM) expression and labeling with 4',6-diamidino-2-phenylindole (DAPI), phycoerythrin-conjugated antibodies ...

journal_title：Cells

authors： Nanou A,Zeune LL,Terstappen LWMM

更新日期：2019-08-20 00:00:00

abstract：:Background: Mucopolysaccharidosis type I-Hurler (MPS1-H) is a severe genetic lysosomal storage disorder due to loss-of-function mutations in the IDUA gene. The subsequent complete deficiency of alpha l-iduronidase enzyme is directly responsible of a progressive accumulation of glycosaminoglycans (GAG) in lysosomes whi...

journal_title：Cells

authors： Lito S,Sidibe A,Ilmjarv S,Burda P,Baumgartner M,Wehrle-Haller B,Krause KH,Marteyn A

更新日期：2020-12-03 00:00:00

abstract：:ELISpot is one of the most commonly used immune monitoring assays, which allows the functional assessment of the immune system at the single cell level. With its outstanding sensitivity and ease of performance, the assay has recently advanced from the mere single function cell analysis to multifunctional analysis by i...

journal_title：Cells

authors： Janetzki S,Rueger M,Dillenbeck T

更新日期：2014-11-27 00:00:00

abstract：:To investigate the role of PR isoforms on the homeostasis of stem cells in the normal and neoplastic mammary gland, we used PRA and PRB transgenic mice and the T47D human breast cancer cell line and its derivatives, T47D YA and YB (manipulated to express only PRA or PRB, respectively). Flow cytometry and mammosphere a...

journal_title：Cells

authors： Recouvreux MS,Diaz Bessone MI,Taruselli A,Todaro L,Lago Huvelle MA,Sampayo RG,Bissell MJ,Simian M

更新日期：2020-09-11 00:00:00

abstract：:Vinyl chloride (VC) is a noninfective occupational risk factor. It is found in industrial chemicals, volatile organic compounds, cigarette smoke ingredients, etc. It is a kind of toxic gas that causes many diseases. VC exposure causes an increased risk of liver fibrosis and can result in angiosarcoma of the liver. Pre...

journal_title：Cells

authors： Hsu YH,Chuang HC,Lee YH,Lin YF,Chiu YJ,Wang YL,Wu MS,Chiu HW

更新日期：2019-06-17 00:00:00

abstract：:Patient-derived tumor organoids (PDOs) represent a promising preclinical cancer model that better replicates disease, compared with traditional cell culture models. We have established PDOs from various human tumors to accurately and efficiently recapitulate the tissue architecture and function. Molecular targeted the...

journal_title：Cells

authors： Takahashi N,Hoshi H,Higa A,Hiyama G,Tamura H,Ogawa M,Takagi K,Goda K,Okabe N,Muto S,Suzuki H,Shimomura K,Watanabe S,Takagi M

更新日期：2019-05-20 00:00:00

abstract：:In eukaryotic cells, a spindle assembly checkpoint (SAC) ensures accurate chromosome segregation, by monitoring proper attachment of chromosomes to spindle microtubules and delaying mitotic progression if connections are erroneous or absent. The SAC is thought to be relaxed during early embryonic development. Here, we...

journal_title：Cells

authors： Chenevert J,Roca M,Besnardeau L,Ruggiero A,Nabi D,McDougall A,Copley RR,Christians E,Castagnetti S

更新日期：2020-04-28 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disease. PD patients exhibit motor symptoms such as akinesia/bradykinesia, tremor, rigidity, and postural instability due to a loss of nigrostriatal dopaminergic neurons. Although the pathogenesis in sporadic PD remains unknown, there is a consensus ...

journal_title：Cells

authors： Miyazaki I,Asanuma M

更新日期：2020-12-07 00:00:00

abstract：:CircRNA is a type of closed circular non-coding RNA formed by reverse splicing and plays an important role in regulating the growth and development of plants and animals. To investigate the function of circ-FoxO3 in mouse myoblast cells' (C2C12) differentiation and proliferation, we used RT-qPCR to detect the expressi...

journal_title：Cells

authors： Li X,Li C,Liu Z,Ni W,Yao R,Xu Y,Quan R,Zhang M,Li H,Liu L,Hu S

更新日期：2019-06-19 00:00:00

abstract：:Characterisation of animal models of diabetic cardiomyopathy may help unravel new molecular targets for therapy. Long-living individuals are protected from the adverse influence of diabetes on the heart, and the transfer of a longevity-associated variant (LAV) of the human BPIFB4 gene protects cardiac function in the ...

journal_title：Cells

authors： Faulkner A,Dang Z,Avolio E,Thomas AC,Batstone T,Lloyd GR,Weber RJ,Najdekr L,Jankevics A,Dunn WB,Spinetti G,Vecchione C,Puca AA,Madeddu P

更新日期：2020-05-21 00:00:00

abstract：:Most protein-encoding genes in eukaryotes contain introns, which are interwoven with exons. Introns need to be removed from initial transcripts in order to generate the final messenger RNA (mRNA), which can be translated into an amino acid sequence. Precise excision of introns by the spliceosome requires conserved din...

journal_title：Cells

authors： Frey K,Pucker B

更新日期：2020-02-18 00:00:00

abstract：:Nile tilapia is the third most cultivated fish worldwide and a novel model species for evolutionary studies. Aiming to improve productivity and contribute to the selection of traits of economic impact, biotechnological approaches have been intensively applied to species enhancement. In this sense, recent studies have ...

journal_title：Cells

authors： Bovolenta LA,Pinhal D,Acencio ML,Oliveira AC,Moxon S,Martins C,Lemke N

更新日期：2020-07-22 00:00:00

abstract：BACKGROUND:The search for an effective therapy for local radiation injuries (LRI) is urgent; one option is mesenchymal stem cells (MSC) derived from the placenta and their conditioned medium for the regenerative processes of the skin. METHODS:We used 80 animals, randomly assigned to four groups: control (C) animals th...

journal_title：Cells

authors： Brunchukov V,Astrelina T,Usupzhanova D,Rastorgueva A,Kobzeva I,Nikitina V,Lishchuk S,Dubova E,Pavlov K,Brumberg V,Benderitter M,Samoylov A

更新日期：2020-11-29 00:00:00

abstract：:Fear is a fundamental evolutionary process for survival. However, excess or irrational fear hampers normal activity and leads to phobia. The amygdala is the primary brain region associated with fear learning and conditioning. There, Rho GTPases are molecular switches that act as signaling molecules for further downstr...

journal_title：Cells

authors： Sarowar T,Grabrucker AM

更新日期：2020-08-26 00:00:00

abstract：:Growth factors are important regulators during organ development. For many vertebrates (but not humans) it is known how they contribute to the formation and expansion of PDX1-positive cells during pancreas organogenesis. Here, the effects of the fibroblast growth factors FGF2, FGF7, FGF10, and epidermal growth factor ...

journal_title：Cells

authors： Dettmer R,Cirksena K,Münchhoff J,Kresse J,Diekmann U,Niwolik I,Buettner FFR,Naujok O

更新日期：2020-08-20 00:00:00

abstract：:Podoplanin and CD44 are transmembrane glycoproteins involved in inflammation and cancer. In this paper, we report that podoplanin is coordinately expressed with the CD44 standard (CD44s) and variant (CD44v) isoforms in vivo-in hyperplastic skin after a pro-inflammatory stimulus with 12-O-tetradecanoylphorbol-13-acetat...

journal_title：Cells

authors： Montero-Montero L,Renart J,Ramírez A,Ramos C,Shamhood M,Jarcovsky R,Quintanilla M,Martín-Villar E

更新日期：2020-09-29 00:00:00

abstract：:The family of MOBs (monopolar spindle-one-binder proteins) is highly conserved in the eukaryotic kingdom. MOBs represent globular scaffold proteins without any known enzymatic activities. They can act as signal transducers in essential intracellular pathways. MOBs have diverse cancer-associated cellular functions thro...

journal_title：Cells

authors： Gundogdu R,Hergovich A

更新日期：2019-06-10 00:00:00

abstract：:Alterations in glucose and glutamine utilizing pathways and in fatty acid metabolism are currently considered the most significant and prevalent metabolic changes observed in almost all types of tumors. Glucose, glutamine and fatty acids are the substrates for the hexosamine biosynthetic pathway (HBP). This metabolic ...

journal_title：Cells

authors： Chiaradonna F,Ricciardiello F,Palorini R

更新日期：2018-06-02 00:00:00

abstract：:In this study, the mechanism by which GSK-3β regulates protein synthesis and lipid deposition was investigated in zebrafish (Danio rerio). The vector of pEGFP-N1-GSK-3β was constructed and injected into the muscle of zebrafish. It was found that the mRNA and protein expression of tuberous sclerosis complex 2 (TSC2) wa...

journal_title：Cells

authors： Gu Y,Gao L,Han Q,Li A,Yu H,Liu D,Pang Q

更新日期：2019-02-28 00:00:00

abstract：:Cancer cells perform a metabolic rewiring to sustain an increased growth rate and compensate for the redox stress caused by augmented energy metabolism. The metabolic changes are not the same in all cancers. Some features, however, are considered hallmarks of this disease. As an example, all cancer cells rewire the am...

journal_title：Cells

authors： Scalise M,Console L,Rovella F,Galluccio M,Pochini L,Indiveri C

更新日期：2020-09-03 00:00:00

abstract：:In cancer pharmacology, a drug candidate's therapeutic potential is typically expressed as its ability to suppress cell growth. Different methods in assessing the cell phenotype and calculating the drug effect have been established. However, inconsistencies in drug response outcomes have been reported, and it is still...

journal_title：Cells

authors： Fischer I,Nickel AC,Qin N,Taban K,Pauck D,Steiger HJ,Kamp M,Muhammad S,Hänggi D,Fritsche E,Remke M,Kahlert UD

更新日期：2020-12-15 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a highly invasive and metastatic form of carcinoma with bleak prognosis due to limited therapies, frequent relapse, and chemotherapy resistance. There is an urgent need to identify the molecular regulators of CCA in order to develop novel therapeutics and advance diseases diagnosis. Many ce...

journal_title：Cells

authors： Pant K,Peixoto E,Richard S,Gradilone SA

更新日期：2020-03-23 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is strongly correlated with tumor metastasis and contains several protein markers, such as E-cadherin. Carbonic anhydrase III (CA III) exhibits low carbon dioxide hydratase activity in cancer. However, the detailed mechanisms of CA III and their roles in oral cancer are still un...

journal_title：Cells

authors： Chu YH,Su CW,Hsieh YS,Chen PN,Lin CW,Yang SF

更新日期：2020-03-13 00:00:00

abstract：:Invariant chain (Ii/CD74) has been identified as a surface receptor for migration inhibitory factor (MIF). Most cells that express Ii also synthesize major histocompatibility complex class II (MHC II) molecules, which depend on Ii as a chaperone and a targeting factor. The assembly of nonameric complexes consisting of...

journal_title：Cells

authors： Lindner R

更新日期：2017-02-10 00:00:00