Abstract：
:Mitochondria are bilayer sub-cellular organelles that are an integral part of normal cellular physiology. They are responsible for producing the majority of a cell's ATP, thus supplying energy for a variety of key cellular processes, especially in the brain. Although energy production is a key aspect of mitochondrial metabolism, its role extends far beyond energy production to cell signaling and epigenetic regulation⁻functions that contribute to cellular proliferation, differentiation, apoptosis, migration, and autophagy. Recent research on neurological disorders suggest a major metabolic component in disease pathophysiology, and mitochondria have been shown to be in the center of metabolic dysregulation and possibly disease manifestation. This review will discuss the basic functions of mitochondria and how alterations in mitochondrial activity lead to neurological disease progression.
journal_name
Cellsjournal_title
Cellsauthors
Zhou Z,Austin GL,Young LEA,Johnson LA,Sun Rdoi
10.3390/cells7120229subject
Has Abstractpub_date
2018-11-23 00:00:00issue
12issn
2073-4409pii
cells7120229journal_volume
7pub_type
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