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Monitoring Autophagy in the Model Green Microalga Chlamydomonas reinhardtii.

Abstract：

:Autophagy is an intracellular catabolic system that delivers cytoplasmic constituents and organelles in the vacuole. This degradative process is mediated by a group of proteins coded by autophagy-related (ATG) genes that are widely conserved from yeasts to plants and mammals. Homologs of ATG genes have been also identified in algal genomes including the unicellular model green alga Chlamydomonas reinhardtii. The development of specific tools to monitor autophagy in Chlamydomonas has expanded our current knowledge about the regulation and function of this process in algae. Recent findings indicated that autophagy is regulated by redox signals and the TOR network in Chlamydomonas and revealed that this process may play in important role in the control of lipid metabolism and ribosomal protein turnover in this alga. Here, we will describe the different techniques and approaches that have been reported to study autophagy and autophagic flux in Chlamydomonas.

journal_name

Cells

journal_title

Cells

authors

Pérez-Pérez ME,Couso I,Heredia-Martínez LG,Crespo JL

doi

10.3390/cells6040036

subject

Has Abstract

pub_date

2017-10-22 00:00:00

issue

4

issn

2073-4409

pii

cells6040036

journal_volume

6

pub_type

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