Abstract:
:Lipid exchange among biological membranes, lipoprotein particles, micelles, and liposomes is an important yet underrated phenomenon with repercussions throughout the life sciences. The premature loss of lipid molecules from liposomal formulations severely impacts therapeutic applications of the latter and thus limits the type of lipids and lipid conjugates available for fine-tuning liposomal properties. While cholesterol derivatives, with their irregular lipophilic surface shape, are known to readily undergo lipid exchange and interconvert, e.g., with serum, the situation is unclear for lipids with regular, linear-shaped alkyl chains. This study compares the propensity of fluorescence-labeled lipid conjugates of systematically varied lengths to migrate from liposomal particles consisting mainly of egg phosphatidyl choline 3 (EPC3) and cholesterol into biomembranes. We show that dialkyl glyceryl lipids with chains of 18-20 methylene units are inherently stable in liposomal membranes. In contrast, C16 lipids show some lipid exchange, albeit significantly less than comparable cholesterol conjugates. Remarkably, the C18 chain length, which confers noticeable anchor stability, corresponds to the typical chain length in biological membranes.
journal_name
Cellsjournal_title
Cellsauthors
Gleue L,Schupp J,Zimmer N,Becker E,Frey H,Tuettenberg A,Helm Mdoi
10.3390/cells9102213subject
Has Abstractpub_date
2020-09-29 00:00:00issue
10issn
2073-4409pii
cells9102213journal_volume
9pub_type
杂志文章相关文献
Cells文献大全abstract::The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating necrosis, bypassing cellular senescence program, interfering with tumor immunity, promoting angiogenesis and supporting metastasis. This direct ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9030587
更新日期:2020-03-02 00:00:00
abstract::Here we show that the serine/arginine rich splicing factor 2 (SRSF2) promotes cryptic 3' splice-site (3'AG') usage during cassette exon exclusion in survival of motor neuron (SMN2) minigenes. Deletion of the 3'AG' (3'AG'1), its associated branch point (BP') and polypyrimidine tract (PPT') sequences directs SRSF2 to pr...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8070696
更新日期:2019-07-10 00:00:00
abstract::Lysosomal function has a central role in maintaining neuronal homeostasis, and, accordingly, lysosomal dysfunction has been linked to neurodegeneration and particularly to Parkinson's disease (PD). Lysosomes are the converging step where the substrates delivered by autophagy and endocytosis are degraded in order to re...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9112399
更新日期:2020-11-02 00:00:00
abstract::Evaluation of myelin by magnetic resonance imaging (MRI) is a difficult challenge, but holds promise in demyelinating diseases, such as multiple sclerosis (MS). Although multiple techniques have been developed, no gold standard has been established. This study aims to evaluate the correlation between synthetic MRI mye...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9020393
更新日期:2020-02-08 00:00:00
abstract::Macrophages are central to inflammation resolution, an active process aimed at restoring tissue homeostasis following an inflammatory response. Here, the effects of db-cAMP on macrophage phenotype and function were investigated. Injection of db-cAMP into the pleural cavity of mice induced monocytes recruitment in a ma...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9010128
更新日期:2020-01-06 00:00:00
abstract::Xanthohumol (XN), a prenylated chalcone from hops, has been reported to exhibit a variety of health-beneficial effects. However, poor bioavailability may limit its application in the prevention and therapy of diseases. The objective of this study was to determine whether a micellar solubilization of xanthohumol could ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8040359
更新日期:2019-04-17 00:00:00
abstract::There is a need to disentangle the etiological puzzle of age-related neurodegenerative diseases, whose clinical phenotypes arise from known, and as yet unknown, pathways that can act distinctly or in concert. Enhanced sub-phenotyping and the identification of in vivo biomarker-driven signature profiles could improve t...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9122581
更新日期:2020-12-02 00:00:00
abstract::Poly(A)-specific ribonuclease (PARN), a multifunctional multi-domain deadenylase, is crucial to the regulation of mRNA turnover and the maturation of various non-coding RNAs. Despite extensive studies of the well-folding domains responsible for PARN catalysis, the structure and function of the C-terminal domain (CTD) ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8080836
更新日期:2019-08-05 00:00:00
abstract::Innate immune cells monitor invading pathogens and pose the first-line inflammatory response to coordinate with adaptive immunity for infection removal. Innate immunity also plays pivotal roles in injury-induced tissue remodeling and the maintenance of tissue homeostasis in physiological and pathological conditions. L...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8121633
更新日期:2019-12-13 00:00:00
abstract:BACKGROUND:The current approaches to distinguish follicular adenomas (FA) and follicular thyroid cancer (FTC) at the pre-operative stage have low predictive value. Liquid biopsy-based analysis of circulating extracellular vesicles (EVs) presents a promising diagnostic method. However, the extreme heterogeneity of plasm...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9081917
更新日期:2020-08-18 00:00:00
abstract::Induced pluripotent stem cells (iPSCs) and induced neuronal (iN) cells are very much touted in terms of their potential promises in therapeutics. However, from a more fundamental perspective, iPSCs and iNs are invaluable tools for the postnatal generation of specific diseased cell types from patients, which may offer ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells7050038
更新日期:2018-05-08 00:00:00
abstract::Mammalian Pumilio (PUM) proteins are sequence-specific, RNA-binding proteins (RBPs) with wide-ranging roles. They are involved in germ cell development, which has functional implications in development and fertility. Although human PUM1 and PUM2 are closely related to each other and recognize the same RNA binding moti...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9040984
更新日期:2020-04-16 00:00:00
abstract::Synchronous communication between the developing embryo and the receptive endometrium is crucial for embryo implantation. Thus, uterine receptivity evaluation is vital in managing recurrent implantation failure (RIF). The potential roles of small extracellular vesicle (sEV) miRNAs in pregnancy have been widely studied...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9030645
更新日期:2020-03-06 00:00:00
abstract::Fungal keratitis is a potentially blinding infection of the cornea that afflicts diverse patient populations worldwide. The development of better treatment options requires a more thorough understanding of both microbial and host determinants of pathology, and a spectrum of experimental models have been developed towa...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9071713
更新日期:2020-07-16 00:00:00
abstract::Multiple tissues and systems in the organism undergo modifications during aging due to an accumulation of damaged proteins, lipids, and genetic material. To counteract this process, the cells are equipped with specific mechanisms, such as autophagy and senescence. Particularly, the immune system undergoes a process ca...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells7100162
更新日期:2018-10-10 00:00:00
abstract::During strong parallel fiber stimulation, glutamate released at parallel fiber-Purkinje cell synapses activates type-1 metabotropic glutamate receptor (mGluR1) to trigger a slow excitatory postsynaptic current (sEPSC) in cerebellar Purkinje neurons. The sEPSC is mediated by transient receptor potential canonical 3 (TR...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells7080090
更新日期:2018-07-29 00:00:00
abstract::The crosstalk between human gut microbiota and intestinal wall is essential for the organ's homeostasis and immune tolerance. The gut microbiota plays a role in healthy and pathological conditions mediated by inflammatory processes or by the gut-brain axes, both involving a possible role for S100B protein as a diffusi...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9071697
更新日期:2020-07-15 00:00:00
abstract::The role of reactive oxygen species (ROS) in the metabolic reprogramming of cells adapted to hypoxia and the interplay between ROS and hypoxia in malignancy is under debate. Here, we examined how ROS levels are modulated by hypoxia in human cancer compared to untransformed cells. Short time exposure (20 min) of either...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells7070064
更新日期:2018-06-21 00:00:00
abstract::The Rho GTPases comprise a subfamily of the Ras superfamily of small GTPases. Their importance in regulation of cell morphology and cell migration is well characterized. According to the prevailing paradigm, Cdc42 regulates the formation of filopodia, Rac1 regulates the formation of lamellipodia, and RhoA triggers the...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8070759
更新日期:2019-07-21 00:00:00
abstract::The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been identified in many types of cancer. Downstream of key oncogenic pathways, such as RAS, BCR-ABL, and Her2, NF-κB regulates transcription of target genes that promote cell s...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells5020016
更新日期:2016-04-06 00:00:00
abstract::Lupus flares when genetically predisposed people encounter exogenous agents such as infections and sun exposure and drugs such as procainamide and hydralazine, but the mechanisms by which these agents trigger the flares has been unclear. Current evidence indicates that procainamide and hydralazine, as well as inflamma...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8020127
更新日期:2019-02-05 00:00:00
abstract::Cystic Fibrosis (CF) is caused by >2000 mutations in the CF transmembrane conductance regulator (CFTR) gene, but one mutation-F508del-occurs in ~80% of patients worldwide. Besides its main function as an anion channel, the CFTR protein has been implicated in epithelial differentiation, tissue regeneration, and, when d...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9071607
更新日期:2020-07-02 00:00:00
abstract::The heart exhibits incredible plasticity in response to both environmental and genetic alterations that affect workload. Over the course of development, or in response to physiological or pathological stimuli, the heart responds to fluctuations in workload by hypertrophic growth primarily by individual cardiac myocyte...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9030602
更新日期:2020-03-03 00:00:00
abstract::Mutations in tubulin genes are responsible for a large spectrum of brain malformations secondary to abnormal neuronal migration, organization, differentiation and axon guidance and maintenance. Motor impairment, intellectual disability and epilepsy are the main clinical symptoms. In the present study 15 patients from ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8070669
更新日期:2019-07-02 00:00:00
abstract::Fibrosis is a significant global health problem associated with many inflammatory and degenerative diseases affecting multiple organs, individually or simultaneously. Fibrosis develops when extracellular matrix (ECM) remodeling becomes excessive or uncontrolled and is associated with nearly all forms of heart disease....
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9030592
更新日期:2020-03-02 00:00:00
abstract::Cell division cycle 42 (CDC42), a small Rho GTPase, plays a critical role in many cellular processes, including cell proliferation and survival. CDC42 interacts with the CRIB (Cdc42- and Rac-interactive binding) domain of CDC42SE1, a small effector protein of 9 kDa. We found that the expression of CDC42SE1 was reduced...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8020117
更新日期:2019-02-02 00:00:00
abstract::This study was aimed to investigate the role of SHP2 (Src-homology-2-containing phosphotyrosine phosphatase) in intricate signaling networks invoked by bovine oocyte to achieve maturation and blastocyst development. PTPN11 (Protein Tyrosine Phosphatase, non-receptor type 11) encoding protein SHP2, a positive transduce...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8101272
更新日期:2019-10-18 00:00:00
abstract::The endoplasmic reticulum (ER) stress response and autophagy are important cellular responses that determine cell fate and whose dysregulation is implicated in the perturbation of homeostasis and diseases. Tonicity-responsive enhancer-binding protein (TonEBP, also called NFAT5) is a pleiotropic stress protein that med...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9091928
更新日期:2020-08-20 00:00:00
abstract::Genetic disorders associated with metal metabolism form a large group of disorders and mostly result from defects in the proteins/enzymes involved in nutrient metabolism and energy production. These defects can affect different metabolic pathways and cause mild to severe disorders related to metal metabolism. Some dis...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8121598
更新日期:2019-12-09 00:00:00
abstract::Drug resistance is the main obstacle to achieving cures with both conventional and targeted anticancer drugs. The emergence of acquired drug resistance is initially mediated by non-genetic transcriptional changes, which occur at a much higher frequency than mutations and may involve population-scale transcriptomic ada...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells10010144
更新日期:2021-01-12 00:00:00