Regulating the BCL2 Family to Improve Sensitivity to Microtubule Targeting Agents.

abstract：:Human embryonic stem cells (hESCs) have important roles in regenerative medicine, but only a few studies have investigated the cytokines secreted by hESCs. We screened and identified chemokine (C-X-C motif) ligand 14 (CXCL14), which plays crucial roles in hESC renewal. CXCL14, a C-X-C motif chemokine, is also named as...

journal_title：Cells

authors： Cheng CL,Yang SC,Lai CY,Wang CK,Chang CF,Lin CY,Chen WJ,Lin PY,Wu HC,Ma N,Lu FL,Lu J

更新日期：2020-07-16 00:00:00

abstract：:Extracellular matrix (ECM) remodeling is required for many physiological and pathological processes. Metalloproteinases (MMPs) are endopeptidases which are able to degrade different components of the ECM and nucleus matrix and to cleave numerous non-ECM proteins. Among pathological processes, MMPs are involved in adip...

journal_title：Cells

authors： Berg G,Barchuk M,Miksztowicz V

更新日期：2019-02-14 00:00:00

abstract：:Myelodysplastic syndromes (MDS) are a heterogeneous group of hematological malignancies characterized by peripheral blood cytopenia and abnormal myeloproliferation, as well as a variable risk of evolution into acute myeloid leukemia (AML). The nucleus is a highly organized organelle with several distinct domains where...

journal_title：Cells

authors： Xian J,Owusu Obeng E,Ratti S,Rusciano I,Marvi MV,Fazio A,De Stefano A,Mongiorgi S,Cappellini A,Ramazzotti G,Manzoli L,Cocco L,Follo MY

更新日期：2020-03-12 00:00:00

abstract：:Endocytosis and autophagy are evolutionarily conserved degradative processes in all eukaryotes. Both pathways converge to the lysosome where cargo is degraded. Improper lysosomal degradation is observed in many human pathologies, so its regulatory mechanisms are important to understand. Sec20/BNIP1 (BCL2/adenovirus E1...

journal_title：Cells

authors： Lakatos Z,Lőrincz P,Szabó Z,Benkő P,Kenéz LA,Csizmadia T,Juhász G

更新日期：2019-07-24 00:00:00

abstract：:(1) Aim: In the present paper we analyzed the transcriptome of CSCs (Cancer Stem Cells), in order to find defining molecular processes of breast cancer. (2) Methods: We performed RNA-Seq from CSCs isolated from the basal cell line MDA-MB-468. Enriched processes and networks were studied using the IPA (Ingenuity Pathwa...

journal_title：Cells

authors： Schwarz-Cruz Y Celis A,Ceballos-Cancino G,Vazquez-Santillan K,Espinosa M,Zampedri C,Bahena I,Ruiz V,Maldonado V,Melendez-Zajgla J

更新日期：2020-03-13 00:00:00

abstract：:Cyclic AMP promotes EPAC1 and EPAC2 activation through direct binding to a specific cyclic nucleotide-binding domain (CNBD) within each protein, leading to activation of Rap GTPases, which control multiple cell responses, including cell proliferation, adhesion, morphology, exocytosis, and gene expression. As a result,...

journal_title：Cells

authors： Beck EM,Parnell E,Cowley A,Porter A,Gillespie J,Robinson J,Robinson L,Pannifer AD,Hamon V,Jones P,Morrison A,McElroy S,Timmerman M,Rutjes H,Mahajan P,Wiejak J,Luchowska-Stańska U,Morgan D,Barker G,Rehmann H,Yarwoo

更新日期：2019-11-12 00:00:00

abstract：:Neural precursor cells differentiate into several cell types that display distinct functions. However, little is known about how cell surface mechanics vary during the differentiation process. Here, by precisely measuring membrane tension and bending modulus, we map their variations and correlate them with changes in ...

journal_title：Cells

authors： Soares J,Araujo GRS,Santana C,Matias D,Moura-Neto V,Farina M,Frases S,Viana NB,Romão L,Nussenzveig HM,Pontes B

更新日期：2020-05-26 00:00:00

abstract：:Large tumor-derived Extracellular Vesicles (tdEVs) detected in blood of metastatic prostate, breast, colorectal, and non-small cell lung cancer patients after enrichment for Epithelial Cell Adhesion Molecule (EpCAM) expression and labeling with 4',6-diamidino-2-phenylindole (DAPI), phycoerythrin-conjugated antibodies ...

journal_title：Cells

authors： Nanou A,Zeune LL,Terstappen LWMM

更新日期：2019-08-20 00:00:00

abstract：:We have previously postulated that unconventional myosin VI (MVI) could be involved in myoblast differentiation. Here, we addressed the mechanism(s) of its involvement using primary myoblast culture derived from the hindlimb muscles of Snell's waltzer mice, the natural MVI knockouts (MVI-KO). We observed that MVI-KO m...

journal_title：Cells

authors： Lehka L,Topolewska M,Wojton D,Karatsai O,Alvarez-Suarez P,Pomorski P,Rędowicz MJ

更新日期：2020-07-11 00:00:00

abstract：:The role of kinases in the regulation of cell cycle transitions is very well established, however, over the past decade, studies have identified the ever-growing importance of phosphatases in these processes. It is well-known that an intact or otherwise non-deformed nuclear envelope (NE) is essential for maintaining h...

journal_title：Cells

authors： Huguet F,Flynn S,Vagnarelli P

更新日期：2019-07-07 00:00:00

abstract：:TROP1 (EpCAM) and TROP2 are homologous cell surface proteins that are widely expressed, and often co-expressed, in developing and adult epithelia. Various functions have been ascribed to EpCAM and TROP2, but responsible mechanisms are incompletely characterized and functional equivalence has not been examined. Adult i...

journal_title：Cells

authors： Nakato G,Morimura S,Lu M,Feng X,Wu C,Udey MC

更新日期：2020-08-06 00:00:00

abstract：:Nile tilapia is the third most cultivated fish worldwide and a novel model species for evolutionary studies. Aiming to improve productivity and contribute to the selection of traits of economic impact, biotechnological approaches have been intensively applied to species enhancement. In this sense, recent studies have ...

journal_title：Cells

authors： Bovolenta LA,Pinhal D,Acencio ML,Oliveira AC,Moxon S,Martins C,Lemke N

更新日期：2020-07-22 00:00:00

abstract：:In the last decade, positron emission tomography (PET) and single-photon emission computed tomography (SPECT) in in vivo imaging has attempted to demonstrate the presence of neuroinflammatory reactions by measuring the 18 kDa translocator protein (TSPO) expression in many diseases of the central nervous system. We foc...

journal_title：Cells

authors： Tournier BB,Tsartsalis S,Ceyzériat K,Garibotto V,Millet P

更新日期：2020-08-21 00:00:00

abstract：:Muscle cell plasma membrane is frequently damaged by mechanical activity, and its repair requires the membrane protein dysferlin. We previously identified that, similar to dysferlin deficit, lack of annexin A2 (AnxA2) also impairs repair of skeletal myofibers. Here, we have studied the mechanism of AnxA2-mediated musc...

journal_title：Cells

authors： Bittel DC,Chandra G,Tirunagri LMS,Deora AB,Medikayala S,Scheffer L,Defour A,Jaiswal JK

更新日期：2020-08-19 00:00:00

abstract：:Some species of clover are reported to have beneficial effects in human diseases. However, little is known about the activity of the forage plant Trifolium repens, or white clover, which has been recently found to exert a hepatoprotective action. Scientific interest is increasingly focused on identifying new drugs, es...

journal_title：Cells

authors： Sarno F,Pepe G,Termolino P,Carafa V,Massaro C,Merciai F,Campiglia P,Nebbioso A,Altucci L

更新日期：2020-02-06 00:00:00

abstract：:Mutations in the LMNA gene, encoding the nuclear envelope A-type lamins, are responsible for muscular dystrophies, the most severe form being the LMNA-related congenital muscular dystrophy (L-CMD), with severe defects in myonucleus integrity. We previously reported that L-CMD mutations compromise the ability of muscle...

journal_title：Cells

authors： Owens DJ,Fischer M,Jabre S,Moog S,Mamchaoui K,Butler-Browne G,Coirault C

更新日期：2020-03-27 00:00:00

abstract：:TonEBP (tonicity-responsive enhancer binding protein) is a transcriptional regulator whose expression is elevated in response to various forms of stress including hyperglycemia, inflammation, and hypoxia. Here we investigated the role of TonEBP in acute kidney injury (AKI) using a line of TonEBP haplo-deficient mice s...

journal_title：Cells

authors： Yoo EJ,Lim SW,Kang HJ,Park H,Yoon S,Nam D,Sanada S,Kwon MJ,Lee-Kwon W,Choi SY,Kwon HM

更新日期：2019-10-20 00:00:00

abstract：:The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenan...

journal_title：Cells

authors： Laronha H,Caldeira J

更新日期：2020-04-26 00:00:00

abstract：:Triple-negative breast cancer (TNBC) lacks estrogen receptor (ER) α, but the expression of estrogen receptors ERβ and G protein-coupled estrogen receptor 1 (GPER-1) is able to trigger estrogen-responsivity in TNBC. Estrogen signaling in TNBC can also be activated and modulated by the constitutively active estrogen-rel...

journal_title：Cells

authors： Treeck O,Schüler-Toprak S,Ortmann O

更新日期：2020-10-26 00:00:00

abstract：:The proliferation of molds in domestic environments can lead to uncontrolled continuous exposure to mycotoxins. Even if not immediately symptomatic, this may result in chronic effects, such as, for instance, immunosuppression or allergenic promotion. Alternariol (AOH) is one of the most abundant mycotoxins produced by...

journal_title：Cells

authors： Del Favero G,Mayer RM,Dellafiora L,Janker L,Niederstaetter L,Dall'Asta C,Gerner C,Marko D

更新日期：2020-03-31 00:00:00

abstract：:Telomeres with G-rich repetitive DNA and particular proteins as special heterochromatin structures at the termini of eukaryotic chromosomes are tightly maintained to safeguard genetic integrity and functionality. Telomerase as a specialized reverse transcriptase uses its intrinsic RNA template to lengthen telomeric G-...

journal_title：Cells

authors： Liu J,Wang L,Wang Z,Liu JP

更新日期：2019-01-15 00:00:00

abstract：:Vector transmission of plant viruses is basically of two types that depend on the virus helper component proteins or the capsid proteins. A number of plant viruses belonging to disparate groups have developed unusual capsid proteins providing for interactions with the vector. Thus, cauliflower mosaic virus, a plant pa...

journal_title：Cells

authors： Agranovsky A

更新日期：2021-01-07 00:00:00

abstract：:Stefin B (cystatin B) is an intracellular inhibitor of cysteine cathepsins and mutations in the stefin B gene, resulting in the development of Unverricht-Lundborg disease, which is a form of myoclonic epilepsy. It was suggested that a key mechanism behind stefin B-mediated disease progression was impaired redox homeos...

journal_title：Cells

authors： Trstenjak Prebanda M,Završnik J,Turk B,Kopitar Jerala N

更新日期：2019-11-21 00:00:00

abstract：:: Cholangiocarcinoma (CCA) comprises a group of heterogeneous biliary cancers with dismal prognosis. The etiologies of most CCAs are unknown, but primary sclerosing cholangitis (PSC) is a risk factor. Non-invasive diagnosis of CCA is challenging and accurate biomarkers are lacking. We aimed to characterize the transcr...

journal_title：Cells

authors： Lapitz A,Arbelaiz A,O'Rourke CJ,Lavin JL,Casta A,Ibarra C,Jimeno JP,Santos-Laso A,Izquierdo-Sanchez L,Krawczyk M,Perugorria MJ,Jimenez-Aguero R,Sanchez-Campos A,Riaño I,Gónzalez E,Lammert F,Marzioni M,Macias RIR,Marin

更新日期：2020-03-14 00:00:00

abstract：:Canonical transient receptor potential (TRPC) channels are a family of polymodal cation channels with some degree of Ca2+ permeability. Although initially thought to be channels mediating store-operated Ca2+ influx, TRPC channels can be activated by stimulation of Gq-coupled G-protein coupled receptors, or by an incre...

journal_title：Cells

authors： Zheng F,Phelan KD

更新日期：2014-04-09 00:00:00

abstract：:YRNAs are a class of non-coding RNAs that are components of the Ro60 ribonucleoprotein particle and are essential for initiation of DNA replication. Ro60 ribonucleoprotein particle is a target of autoimmune antibodies in patients suffering from systemic lupus erythematosus and Sjögren's syndrome. Deregulation of YRNAs...

journal_title：Cells

authors： Guglas K,Kolenda T,Stasiak M,Kopczyńska M,Teresiak A,Ibbs M,Bliźniak R,Lamperska K

更新日期：2020-05-21 00:00:00

abstract：:Mitochondrial DNA (mtDNA) replication is thought to be an integral part of exercise-training-induced mitochondrial adaptations. Thus, mtDNA level is often used as an index of mitochondrial adaptations in training studies. We investigated the hypothesis that endurance exercise training-induced mitochondrial enzymatic c...

journal_title：Cells

authors： Fritzen AM,Thøgersen FB,Thybo K,Vissing CR,Krag TO,Ruiz-Ruiz C,Risom L,Wibrand F,Høeg LD,Kiens B,Duno M,Vissing J,Jeppesen TD

更新日期：2019-03-12 00:00:00

abstract：:Heat shock proteins (HSPs) constitute a large family of molecular chaperones classified by their molecular weights, and they include HSP27, HSP40, HSP60, HSP70, and HSP90. HSPs function in diverse physiological and protective processes to assist in maintaining cellular homeostasis. In particular, HSPs participate in p...

journal_title：Cells

authors： Yun CW,Kim HJ,Lim JH,Lee SH

更新日期：2019-12-24 00:00:00

abstract：:Innate immune cells monitor invading pathogens and pose the first-line inflammatory response to coordinate with adaptive immunity for infection removal. Innate immunity also plays pivotal roles in injury-induced tissue remodeling and the maintenance of tissue homeostasis in physiological and pathological conditions. L...

journal_title：Cells

authors： Tzeng HT,Chyuan IT,Chen WY

更新日期：2019-12-13 00:00:00

abstract：:The endoplasmic reticulum (ER) stress response and autophagy are important cellular responses that determine cell fate and whose dysregulation is implicated in the perturbation of homeostasis and diseases. Tonicity-responsive enhancer-binding protein (TonEBP, also called NFAT5) is a pleiotropic stress protein that med...

journal_title：Cells

authors： Kang HJ,Yoo EJ,Lee HH,An SM,Park H,Lee-Kwon W,Choi SY,Kwon HM

更新日期：2020-08-20 00:00:00