Abstract:
:Liver fibrosis is a common feature of sustained liver injury and represents a major public health problem worldwide. Fibrosis is an active research field and discoveries in the last years have contributed to the development of new antifibrotic drugs, although none of them have been approved yet. Liver sinusoidal endothelial cells (LSEC) are highly specialized endothelial cells localized at the interface between the blood and other liver cell types. They lack a basement membrane and display open channels (fenestrae), making them exceptionally permeable. LSEC are the first cells affected by any kind of liver injury orchestrating the liver response to damage. LSEC govern the regenerative process initiation, but aberrant LSEC activation in chronic liver injury induces fibrosis. LSEC are also main players in fibrosis resolution. They maintain liver homeostasis and keep hepatic stellate cell and Kupffer cell quiescence. After sustained hepatic injury, they lose their phenotype and protective properties, promoting angiogenesis and vasoconstriction and contributing to inflammation and fibrosis. Therefore, improving LSEC phenotype is a promising strategy to prevent liver injury progression and complications. This review focuses on changes occurring in LSEC after liver injury and their consequences on fibrosis progression, liver regeneration, and resolution. Finally, a synopsis of the available strategies for LSEC-specific targeting is provided.
journal_name
Cellsjournal_title
Cellsauthors
Lafoz E,Ruart M,Anton A,Oncins A,Hernández-Gea Vdoi
10.3390/cells9040929subject
Has Abstractpub_date
2020-04-10 00:00:00issue
4issn
2073-4409pii
cells9040929journal_volume
9pub_type
杂志文章,评审相关文献
Cells文献大全abstract::Dietary restriction (DR) is one of the most efficient approaches ameliorating the severity of different pathological conditions including aging. We investigated the protective potential of short-term DR in the model of acute kidney injury (AKI) in young and old rats. In kidney tissue, the levels of autophagy and mitop...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells7100178
更新日期:2018-10-22 00:00:00
abstract::High-throughput transcriptomic profiling approaches have revealed that circular RNAs (circRNAs) are important transcriptional gene products, identified across a broad range of organisms throughout the eukaryotic tree of life. In the nervous system, they are particularly abundant, developmentally regulated, region-spec...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9081815
更新日期:2020-07-31 00:00:00
abstract::Type 1 diabetes (T1D) is an autoimmune condition where the body's immune cells destroy their insulin-producing pancreatic beta cells leading to dysregulated glycaemia. Individuals with T1D control their blood glucose through exogenous insulin replacement therapy, often using multiple daily injections or pumps. However...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9112403
更新日期:2020-11-03 00:00:00
abstract::TROP1 (EpCAM) and TROP2 are homologous cell surface proteins that are widely expressed, and often co-expressed, in developing and adult epithelia. Various functions have been ascribed to EpCAM and TROP2, but responsible mechanisms are incompletely characterized and functional equivalence has not been examined. Adult i...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9081847
更新日期:2020-08-06 00:00:00
abstract::Hepatic fibrosis is the consequence of an unresolved wound healing process in response to chronic liver injury and involves multiple cell types and molecular mechanisms. The hepatic endocannabinoid and apelin systems are two signalling pathways with a substantial role in the liver fibrosis pathophysiology-both are upr...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8111311
更新日期:2019-10-24 00:00:00
abstract::Microautophagy is a type of autophagy. It is characterized by direct enclosing with the vacuolar/lysosomal membrane, which completes the isolation and uptake of cell components in the vacuole. Several publications present evidence that plants exhibit microautophagy. Plant microautophagy is involved in anthocyanin accu...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9040887
更新日期:2020-04-04 00:00:00
abstract::Circular RNAs (circRNAs) are genome transcripts that are produced from back-splicing of specific regions of pre-mRNA. These single-stranded RNA molecules are widely expressed across diverse phyla and many of them are stable and evolutionary conserved between species. Growing evidence suggests that many circRNAs functi...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9061473
更新日期:2020-06-16 00:00:00
abstract::Here we show that the serine/arginine rich splicing factor 2 (SRSF2) promotes cryptic 3' splice-site (3'AG') usage during cassette exon exclusion in survival of motor neuron (SMN2) minigenes. Deletion of the 3'AG' (3'AG'1), its associated branch point (BP') and polypyrimidine tract (PPT') sequences directs SRSF2 to pr...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8070696
更新日期:2019-07-10 00:00:00
abstract::Mutations in tubulin genes are responsible for a large spectrum of brain malformations secondary to abnormal neuronal migration, organization, differentiation and axon guidance and maintenance. Motor impairment, intellectual disability and epilepsy are the main clinical symptoms. In the present study 15 patients from ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8070669
更新日期:2019-07-02 00:00:00
abstract::Chronic hyperglycemia has been associated with an increased prevalence of pathological conditions including cardiovascular disease, cancer, or various disorders of the immune system. In some cases, these associations may be traced back to a common underlying cause, but more often, hyperglycemia and the disturbance in ...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8090999
更新日期:2019-08-28 00:00:00
abstract::As sessile organisms, plants must adjust their growth to withstand several environmental conditions. The root is a crucial organ for plant survival as it is responsible for water and nutrient acquisition from the soil and has high phenotypic plasticity in response to a lack or excess of them. How plants sense and tran...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9122576
更新日期:2020-12-01 00:00:00
abstract::Chemotherapeutic targeting of microtubules has been the standard of care in treating a variety of malignancies for decades. During mitosis, increased microtubule dynamics are necessary for mitotic spindle formation and successful chromosomal segregation. Microtubule targeting agents (MTAs) disrupt the dynamics necessa...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8040346
更新日期:2019-04-12 00:00:00
abstract::Telomeres with G-rich repetitive DNA and particular proteins as special heterochromatin structures at the termini of eukaryotic chromosomes are tightly maintained to safeguard genetic integrity and functionality. Telomerase as a specialized reverse transcriptase uses its intrinsic RNA template to lengthen telomeric G-...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8010054
更新日期:2019-01-15 00:00:00
abstract::Genetic disorders associated with metal metabolism form a large group of disorders and mostly result from defects in the proteins/enzymes involved in nutrient metabolism and energy production. These defects can affect different metabolic pathways and cause mild to severe disorders related to metal metabolism. Some dis...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8121598
更新日期:2019-12-09 00:00:00
abstract::Drug screening-i.e., testing the effects of a number of drugs in multiple cell lines-is used for drug discovery and development, and can also be performed to evaluate the heterogeneity of a disease entity. Notably, intertumoral heterogeneity is a large hurdle to overcome for establishing standard cancer treatment, nec...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8050470
更新日期:2019-05-17 00:00:00
abstract::Background: In retinitis pigmentosa (RP), inherited rod death is followed by cone loss and blindness. Why cones die is still a matter of consideration. Here, we investigate the pathogenic role of the sympathetic transmission in the rd10 mouse model of RP. Methods: Retinal levels of beta adrenergic receptor (BAR) 2 and...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9092060
更新日期:2020-09-09 00:00:00
abstract::A number of oxylipins have been described as endogenous PPAR ligands. The very short biological half-lives of oxylipins suggest roles as autocrine or paracrine signaling molecules. While coronary arterial atherosclerosis is the root of myocardial infarction, aortic atherosclerotic plaque formation is a common readout ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9051096
更新日期:2020-04-29 00:00:00
abstract::Human-induced pluripotent stem cells (hiPSCs) are reprogrammed cells that have hallmarks similar to embryonic stem cells including the capacity of self-renewal and differentiation into cardiac myocytes. The improvements in reprogramming and differentiating methods achieved in the past 10 years widened the use of hiPSC...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells7060048
更新日期:2018-05-25 00:00:00
abstract::Lamins are important filaments forming the inner nuclear membrane. Lamin A is processed by zinc metalloproteinase (ZMPSTE24). Failure to cleave a truncated form of prelamin A-also called progerin-causes Hutchinson-Gilford progeria syndrome a well-known premature aging disease. Minor levels of progerin are readily expr...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9091981
更新日期:2020-08-28 00:00:00
abstract::Respiratory syncytial virus (RSV) infection affects the lives of neonates throughout the globe, causing a high rate of mortality upon hospital admission. Yet, therapeutic options to deal with this pulmonary pathogen are currently limited. Helminth therapy has been well received for its immunomodulatory role in hosts, ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9051314
更新日期:2020-05-25 00:00:00
abstract::Autophagy is a ubiquitous eukaryotic process that also occurs in trypanosomatid parasites, protist organisms belonging to the supergroup Excavata, distinct from the supergroup Opistokontha that includes mammals and fungi. Half of the known yeast and mammalian AuTophaGy (ATG) proteins were detected in trypanosomatids, ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells1030346
更新日期:2012-07-27 00:00:00
abstract::Epithelial organs are the first barrier against microorganisms and genotoxic stress, in which the p53 family members p63 and p73 have both overlapping and distinct functions. Intriguingly, p73 displays a very specific localization to basal epithelial cells in human tissues, while p63 is expressed in both basal and dif...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells10010025
更新日期:2020-12-25 00:00:00
abstract::The heart exhibits incredible plasticity in response to both environmental and genetic alterations that affect workload. Over the course of development, or in response to physiological or pathological stimuli, the heart responds to fluctuations in workload by hypertrophic growth primarily by individual cardiac myocyte...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells9030602
更新日期:2020-03-03 00:00:00
abstract::(1) Background: Hyperglycemia leads to several biochemical and physiological consequences, such as the generation of advanced glycation end products (AGEs) and reactive oxygen species (ROS), which are involved in the development of several human diseases. Intestinal cells are continuously exposed to pro-oxidants and l...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells8121616
更新日期:2019-12-11 00:00:00
abstract::The human gut relies on several cellular and molecular mechanisms to allow for an intact and dynamical intestinal barrier. Normally, only small amounts of luminal content pass the mucosa, however, if the control is broken it can lead to enhanced passage, which might damage the mucosa, leading to pathological condition...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8020193
更新日期:2019-02-22 00:00:00
abstract::The role of kinases in the regulation of cell cycle transitions is very well established, however, over the past decade, studies have identified the ever-growing importance of phosphatases in these processes. It is well-known that an intact or otherwise non-deformed nuclear envelope (NE) is essential for maintaining h...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells8070687
更新日期:2019-07-07 00:00:00
abstract::Hsp60 is a molecular chaperone classically described as a mitochondrial protein with multiple roles in health and disease, participating to the maintenance of protein homeostasis. It is well known that skeletal muscle is a complex tissue, rich in proteins, that is, subjected to continuous rearrangements, and this home...
journal_title:Cells
pub_type: 杂志文章,评审
doi:10.3390/cells7120224
更新日期:2018-11-22 00:00:00
abstract::Through the combined action of ubiquitinating and deubiquitinating enzymes, conjugation of ubiquitin to a target protein acts as a reversible post-translational modification functionally similar to phosphorylation. Indeed, ubiquitination is more and more recognized as a central process for the fine regulation of many ...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells3020386
更新日期:2014-05-06 00:00:00
abstract::The traditional enzyme-linked immunospot (ELISpot) assay is the gold standard for the enumeration of antigen-specific B cells. Since B cell availability from biological samples is often limited, either because of sample size/volume or the need of performing multiple analyses on the same sample, the implementation of E...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells1010015
更新日期:2012-03-21 00:00:00
abstract::Stroke is a leading cause of death and disability globally and is associated with a number of co-morbidities including sepsis and sickle cell disease (SCD). Despite thrombo-inflammation underlying these co-morbidities, its pathogenesis remains complicated and drug discovery programs aimed at reducing and resolving the...
journal_title:Cells
pub_type: 杂志文章
doi:10.3390/cells9112473
更新日期:2020-11-13 00:00:00