Reappraisal of Human HOG and MO3.13 Cell Lines as a Model to Study Oligodendrocyte Functioning.

abstract：:Compartmentalization of diverse types of signaling molecules contributes to the precise coordination of signal propagation. The primary cilium fulfills this function by acting as a spatiotemporally confined sensory signaling platform. For the integrity of ciliary signaling, it is mandatory that the ciliary signaling p...

journal_title：Cells

authors： Tschaikner P,Enzler F,Torres-Quesada O,Aanstad P,Stefan E

更新日期：2020-01-03 00:00:00

abstract：:Drug screening-i.e., testing the effects of a number of drugs in multiple cell lines-is used for drug discovery and development, and can also be performed to evaluate the heterogeneity of a disease entity. Notably, intertumoral heterogeneity is a large hurdle to overcome for establishing standard cancer treatment, nec...

journal_title：Cells

authors： Kondo J,Inoue M

更新日期：2019-05-17 00:00:00

abstract：:Identification of patients with activation of the immune system which indicates the presence of infection is essential, especially in the times of the global coronavirus 2019 (COVID-19) pandemic. The aim of the present study was to evaluate the reactive lymphocytes (RE-LYMP) parameter in COVID-19 and to correlate it w...

journal_title：Cells

authors： Rutkowska E,Kwiecień I,Kulik K,Chełstowska B,Kłos K,Rzepecki P,Chciałowski A

更新日期：2021-01-06 00:00:00

abstract：:Hypoxia-inducible transcription factors 1 and 2 (HIFs) are major mediators of cancer development and progression and validated targets for cancer therapy. Although calcitriol, the biologically active metabolite of vitamin D, was attributed with anticancer properties, there is little information on the effect of calcit...

journal_title：Cells

authors： Gkotinakou IM,Kechagia E,Pazaitou-Panayiotou K,Mylonis I,Liakos P,Tsakalof A

更新日期：2020-11-09 00:00:00

abstract：:Transient receptor potential canonical 6 (TRPC6) is a cation selective, DAG-regulated, Ca2+-permeable channel activated by the agonists of Gq-protein-coupled heptahelical receptors. Dysfunctions of TRPC6 are implicated in the pathogenesis of various cardiovascular and kidney conditions such as vasospasm and glomerulos...

journal_title：Cells

authors： Chen X,Egly C,Riley AM,Li W,Tewson P,Hughes TE,Quinn AM,Obukhov AG

更新日期：2014-04-04 00:00:00

abstract：:Angiopoietin-1 (Ang-1) is a ligand of Tie-2 receptors that promotes angiogenesis. It has been established that regulatory loops exist between angiogenic growth factors and distinct pro or anti-angiogenic miRNAs, but the nature and the roles of Ang-1-regulated miRNAs remain unclear. In this study, we assessed the role ...

journal_title：Cells

authors： Harel S,Sanchez-Gonzalez V,Echavarria R,Mayaki D,Hussain SN

更新日期：2020-07-02 00:00:00

abstract：:Synchronous communication between the developing embryo and the receptive endometrium is crucial for embryo implantation. Thus, uterine receptivity evaluation is vital in managing recurrent implantation failure (RIF). The potential roles of small extracellular vesicle (sEV) miRNAs in pregnancy have been widely studied...

journal_title：Cells

authors： Tan Q,Shi S,Liang J,Zhang X,Cao D,Wang Z

更新日期：2020-03-06 00:00:00

abstract：:Stem cell therapy represents a promising approach in the treatment of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). The beneficial effect of stem cells is exerted by paracrine mediators, as exosomes, suggesting a possible potential use of these extracellular vesicles as non-cell b...

journal_title：Cells

authors： Bonafede R,Brandi J,Manfredi M,Scambi I,Schiaffino L,Merigo F,Turano E,Bonetti B,Marengo E,Cecconi D,Mariotti R

更新日期：2019-09-14 00:00:00

abstract：:ELISpot is one of the most commonly used immune monitoring assays, which allows the functional assessment of the immune system at the single cell level. With its outstanding sensitivity and ease of performance, the assay has recently advanced from the mere single function cell analysis to multifunctional analysis by i...

journal_title：Cells

authors： Janetzki S,Rueger M,Dillenbeck T

更新日期：2014-11-27 00:00:00

abstract：:Vector transmission of plant viruses is basically of two types that depend on the virus helper component proteins or the capsid proteins. A number of plant viruses belonging to disparate groups have developed unusual capsid proteins providing for interactions with the vector. Thus, cauliflower mosaic virus, a plant pa...

journal_title：Cells

authors： Agranovsky A

更新日期：2021-01-07 00:00:00

abstract：:Muscle cell plasma membrane is frequently damaged by mechanical activity, and its repair requires the membrane protein dysferlin. We previously identified that, similar to dysferlin deficit, lack of annexin A2 (AnxA2) also impairs repair of skeletal myofibers. Here, we have studied the mechanism of AnxA2-mediated musc...

journal_title：Cells

authors： Bittel DC,Chandra G,Tirunagri LMS,Deora AB,Medikayala S,Scheffer L,Defour A,Jaiswal JK

更新日期：2020-08-19 00:00:00

abstract：:Some species of clover are reported to have beneficial effects in human diseases. However, little is known about the activity of the forage plant Trifolium repens, or white clover, which has been recently found to exert a hepatoprotective action. Scientific interest is increasingly focused on identifying new drugs, es...

journal_title：Cells

authors： Sarno F,Pepe G,Termolino P,Carafa V,Massaro C,Merciai F,Campiglia P,Nebbioso A,Altucci L

更新日期：2020-02-06 00:00:00

abstract：:In mammal myocytes, endothelial cells and inner ear cells, ferlins are proteins involved in membrane processes such as fusion, recycling, endo- and exocytosis. They harbour several C2 domains allowing their interaction with phospholipids. The expression of several Ferlin genes was described as altered in several tumou...

journal_title：Cells

authors： Peulen O,Rademaker G,Anania S,Turtoi A,Bellahcène A,Castronovo V

更新日期：2019-08-22 00:00:00

abstract：:Siglecs (Sialic acid-binding immunoglobulin-type lectins) are a I-type lectin that typically binds sialic acid. Siglecs are predominantly expressed in immune cells and generate activating or inhibitory signals. They are also shown to be expressed on the surface of cells in the nervous system and have been shown to pla...

journal_title：Cells

authors： Siddiqui SS,Matar R,Merheb M,Hodeify R,Vazhappilly CG,Marton J,Shamsuddin SA,Al Zouabi H

更新日期：2019-09-22 00:00:00

abstract：:Mitochondrial dysfunction and iron (Fe) dyshomeostasis are invoked among the mechanisms contributing to muscle aging, possibly via a detrimental mitochondrial-iron feed-forward loop. We quantified the labile Fe pool, Fe isotopes, and the expression of mitochondrial Fe handling proteins in muscle biopsies obtained from...

journal_title：Cells

authors： Picca A,Saini SK,Mankowski RT,Kamenov G,Anton SD,Manini TM,Buford TW,Wohlgemuth SE,Xiao R,Calvani R,Coelho-Júnior HJ,Landi F,Bernabei R,Hood DA,Marzetti E,Leeuwenburgh C

更新日期：2020-12-02 00:00:00

abstract：:We have previously postulated that unconventional myosin VI (MVI) could be involved in myoblast differentiation. Here, we addressed the mechanism(s) of its involvement using primary myoblast culture derived from the hindlimb muscles of Snell's waltzer mice, the natural MVI knockouts (MVI-KO). We observed that MVI-KO m...

journal_title：Cells

authors： Lehka L,Topolewska M,Wojton D,Karatsai O,Alvarez-Suarez P,Pomorski P,Rędowicz MJ

更新日期：2020-07-11 00:00:00

abstract：:Growth factors are important regulators during organ development. For many vertebrates (but not humans) it is known how they contribute to the formation and expansion of PDX1-positive cells during pancreas organogenesis. Here, the effects of the fibroblast growth factors FGF2, FGF7, FGF10, and epidermal growth factor ...

journal_title：Cells

authors： Dettmer R,Cirksena K,Münchhoff J,Kresse J,Diekmann U,Niwolik I,Buettner FFR,Naujok O

更新日期：2020-08-20 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) and induced neuronal (iN) cells are very much touted in terms of their potential promises in therapeutics. However, from a more fundamental perspective, iPSCs and iNs are invaluable tools for the postnatal generation of specific diseased cell types from patients, which may offer ...

journal_title：Cells

authors： Tang BL

更新日期：2018-05-08 00:00:00

abstract：:Diabetes-associated advanced glycation end-products (AGEs) can increase extracellular matrix (ECM) expression and induce renal fibrosis. Calbindin-D28k, which plays a role in calcium reabsorption in renal distal convoluted tubules, is increased in a diabetic kidney. The role of calbindin-D28k in diabetic nephropathy s...

journal_title：Cells

authors： Huang KH,Guan SS,Lin WH,Wu CT,Sheu ML,Chiang CK,Liu SH

更新日期：2019-06-30 00:00:00

abstract：:Head and neck cancer (HNC), the seventh most common form of cancer worldwide, is a group of epithelial malignancies affecting sites in the upper aerodigestive tract. The 5-year overall survival for patients with HNC has stayed around 40-50% for decades, with mortality being attributable mainly to late diagnosis and re...

journal_title：Cells

authors： Diez-Fraile A,Ceulaer J,Derpoorter C,Spaas C,Backer T,Lamoral P,Abeloos J,Lammens T

更新日期：2020-12-31 00:00:00

abstract：:Angiopoietins 1-4 (Ang1-4) represent an important family of growth factors, whose activities are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized are angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2). Ang1 is a potent angiogenic growth factor signaling through Tie2, whereas Ang2 was ...

journal_title：Cells

authors： Akwii RG,Sajib MS,Zahra FT,Mikelis CM

更新日期：2019-05-17 00:00:00

abstract：:Human embryonic stem cells (hESCs) have important roles in regenerative medicine, but only a few studies have investigated the cytokines secreted by hESCs. We screened and identified chemokine (C-X-C motif) ligand 14 (CXCL14), which plays crucial roles in hESC renewal. CXCL14, a C-X-C motif chemokine, is also named as...

journal_title：Cells

authors： Cheng CL,Yang SC,Lai CY,Wang CK,Chang CF,Lin CY,Chen WJ,Lin PY,Wu HC,Ma N,Lu FL,Lu J

更新日期：2020-07-16 00:00:00

abstract：:Aquaporins (AQPs) facilitate transmembrane water and solute transport, and in addition to contributing to transepithelial water transport, they safeguard cell volume homeostasis. This study examined the expression and localization of AQP1 and AQP3 in the gills of Japanese medaka (Oryzias latipes) in response to osmoti...

journal_title：Cells

authors： Ellis LV,Bollinger RJ,Weber HM,Madsen SS,Tipsmark CK

更新日期：2019-05-08 00:00:00

abstract：:Ion channels (IChs) are transmembrane proteins that selectively drive ions across membranes. The function of IChs partially relies on their abundance and proper location in the cell, fine-tuned by the delicate balance between secretory, endocytic, and degradative pathways. The disruption of this balance is associated ...

journal_title：Cells

authors： Estadella I,Pedrós-Gámez O,Colomer-Molera M,Bosch M,Sorkin A,Felipe A

更新日期：2020-08-04 00:00:00

abstract：:The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating necrosis, bypassing cellular senescence program, interfering with tumor immunity, promoting angiogenesis and supporting metastasis. This direct ...

journal_title：Cells

authors： Albakova Z,Armeev GA,Kanevskiy LM,Kovalenko EI,Sapozhnikov AM

更新日期：2020-03-02 00:00:00

abstract：:In 2011, I was invited to serve as the Editor-In-Chief for Cells, which back then was a "new kid on the block" among open access (OA) journals.[...]. ...

journal_title：Cells

authors： Kalyuzhny AE

更新日期：2017-11-01 00:00:00

abstract：:Alcohol use disorder is associated with a wide array of hepatic pathologies ranging from steatosis to alcoholic-related cirrhosis (AC), alcoholic hepatitis (AH), or hepatocellular carcinoma (HCC). Biomarkers are categorized into two main categories: biomarkers associated with alcohol consumption and biomarkers of alco...

journal_title：Cells

authors： Gala KS,Vatsalya V

更新日期：2020-02-25 00:00:00

abstract：:Autophagy is a conserved bulk degradation and recycling process that plays important roles in multiple biological functions, including inflammatory responses. As an important component of the innate immune system, macrophages are involved in defending cells from invading pathogens, clearing cellular debris, and regula...

journal_title：Cells

authors： Wu MY,Lu JH

更新日期：2019-12-27 00:00:00

abstract：:The generation of new ribosomes is a coordinated process essential to sustain cell growth. As such, it is tightly regulated according to cell needs. As cancer cells require intense protein translation to ensure their enhanced growth rate, they exploit various mechanisms to boost ribosome biogenesis. In this review, we...

journal_title：Cells

authors： Gaviraghi M,Vivori C,Tonon G

更新日期：2019-09-17 00:00:00

abstract：:Glycogen synthase kinase 3β (GSK3β), originally described as a negative regulator of glycogen synthesis, is a molecular hub linking numerous signaling pathways in a cell. Specific GSK3β inhibitors have anti-depressant effects and reduce depressive-like behavior in animal models of depression. Therefore, GSK3β is sugge...

journal_title：Cells

authors： Duda P,Hajka D,Wójcicka O,Rakus D,Gizak A

更新日期：2020-03-16 00:00:00