Siglecs in Brain Function and Neurological Disorders.

abstract：:Hspb8 is a member of the small heat shock protein (sHSP) family. Its expression is known to be upregulated under heat shock. This protein interacts with different partners and can, therefore, be involved in various processes relevant to tissue integrity and functioning. In humans, mutations in the gene encoding Hspb8 ...

journal_title：Cells

authors： Dubińska-Magiera M,Niedbalska-Tarnowska J,Migocka-Patrzałek M,Posyniak E,Daczewska M

更新日期：2020-06-26 00:00:00

abstract：:Around 2 × 103-2.5 × 103 million years ago, a unicellular organism with radically novel features, ancestor of all eukaryotes, dwelt the earth. This organism, commonly referred as the last eukaryotic common ancestor, contained in its proteome the same functionally capable ubiquitin molecule that all eukaryotic species ...

journal_title：Cells

authors： Zuin A,Isasa M,Crosas B

更新日期：2014-07-10 00:00:00

abstract：:Inhibitors of Apoptosis (IAPs) are a family of proteins with various biological functions including regulation of innate immunity and inflammation, cell proliferation, cell migration and apoptosis. They are characterized by the presence of at least one N-terminal baculoviral IAP repeat (BIR) domain involved in protein...

journal_title：Cells

authors： Berthelet J,Dubrez L

更新日期：2013-03-14 00:00:00

abstract：:Astrocytes are essential players in brain circuit development and homeostasis, controlling many aspects of synapse formation, function, plasticity and elimination both during development and adulthood. Accordingly, alterations in astrocyte morphogenesis and physiology may severely affect proper brain development, caus...

journal_title：Cells

authors： Fossati G,Matteoli M,Menna E

更新日期：2020-09-26 00:00:00

abstract：:Many receptors for neurotransmitters, such as dopamine, norepinephrine, acetylcholine, and neuropeptides, belong to the superfamily of G protein-coupled receptors (GPCRs). A general model posits that GPCRs undergo two-step homologous desensitization: the active receptor is phosphorylated by kinases of the G protein-co...

journal_title：Cells

authors： Gurevich EV,Gurevich VV

更新日期：2020-12-31 00:00:00

abstract：:Liver fibrosis is a common feature of sustained liver injury and represents a major public health problem worldwide. Fibrosis is an active research field and discoveries in the last years have contributed to the development of new antifibrotic drugs, although none of them have been approved yet. Liver sinusoidal endot...

journal_title：Cells

authors： Lafoz E,Ruart M,Anton A,Oncins A,Hernández-Gea V

更新日期：2020-04-10 00:00:00

abstract：:A major challenge in neuroscience is how to study structural alterations in the brain. Even small changes in synaptic composition could have severe outcomes for body functions. Many neuropathological diseases are attributable to disorganization of particular synaptic proteins. Yet, to detect and comprehensively descri...

journal_title：Cells

authors： Tröger J,Hoischen C,Perner B,Monajembashi S,Barbotin A,Löschberger A,Eggeling C,Kessels MM,Qualmann B,Hemmerich P

更新日期：2020-06-01 00:00:00

abstract：:Meiosis is required to reduce to haploid the diploid genome content of a cell, generating gametes-oocytes and sperm-with the correct number of chromosomes. To achieve this goal, two specialized cell divisions without intermediate S-phase are executed in a time-controlled manner. In mammalian female meiosis, these divi...

journal_title：Cells

authors： Keating L,Touati SA,Wassmann K

更新日期：2020-02-07 00:00:00

abstract：:Extracellular matrix (ECM) remodeling is required for many physiological and pathological processes. Metalloproteinases (MMPs) are endopeptidases which are able to degrade different components of the ECM and nucleus matrix and to cleave numerous non-ECM proteins. Among pathological processes, MMPs are involved in adip...

journal_title：Cells

authors： Berg G,Barchuk M,Miksztowicz V

更新日期：2019-02-14 00:00:00

abstract：:As sessile organisms, plants must adjust their growth to withstand several environmental conditions. The root is a crucial organ for plant survival as it is responsible for water and nutrient acquisition from the soil and has high phenotypic plasticity in response to a lack or excess of them. How plants sense and tran...

journal_title：Cells

authors： López-Ruiz BA,Zluhan-Martínez E,Sánchez MP,Álvarez-Buylla ER,Garay-Arroyo A

更新日期：2020-12-01 00:00:00

abstract：:Tendons are vital to joint movement by connecting muscles to bones. Along with an increasing incidence of tendon injuries, tendon disorders can burden the quality of life of patients or the career of athletes. Current treatments involve surgical reconstruction and conservative therapy. Especially in the elderly popula...

journal_title：Cells

authors： Chu J,Lu M,Pfeifer CG,Alt V,Docheva D

更新日期：2020-09-08 00:00:00

abstract：:Hepatitis C virus (HCV) infection is commonly attributed as a major cause of chronic hepatotropic diseases, such as, steatosis, cirrhosis and hepatocellular carcinoma. As HCV infects only humans and primates, its narrow host tropism hampers in vivo studies of HCV-mammalian host interactions and the development of effe...

journal_title：Cells

authors： Yong KSM,Her Z,Chen Q

更新日期：2019-06-17 00:00:00

abstract：:Ferritin, the principal intracellular iron-storage protein localized in the cytoplasm, nucleus, and mitochondria, plays a major role in iron metabolism. The encoding ferritin genes are members of a multigene family that includes some pseudogenes. Even though pseudogenes have been initially considered as relics of anci...

journal_title：Cells

authors： Di Sanzo M,Quaresima B,Biamonte F,Palmieri C,Faniello MC

更新日期：2020-11-28 00:00:00

abstract：:Patient-derived xenograft (PDX) models have been recognized as being more suitable for predicting therapeutic efficacy than cell-culture models. However, there are several limitations in applying PDX models in preclinical studies, including their availability-especially for cancers such as gastric cancer-that are not ...

journal_title：Cells

authors： Kuwata T,Yanagihara K,Iino Y,Komatsu T,Ochiai A,Sekine S,Taniguchi H,Katai H,Kinoshita T,Ohtsu A

更新日期：2019-06-14 00:00:00

abstract：:Tumors lack a well-regulated vascular supply of O2 and often fail to balance O2 supply and demand. Net O2 tension within many tumors may not only depend on O2 delivery but also depend strongly on O2 demand. Thus, tumor O2 consumption rates may influence tumor hypoxia up to true anoxia. Recent reports have shown that m...

journal_title：Cells

authors： Gammon ST,Pisaneschi F,Bandi ML,Smith MG,Sun Y,Rao Y,Muller F,Wong F,De Groot J,Ackroyd J,Mawlawi O,Davies MA,Gopal YNV,Di Francesco ME,Marszalek JR,Dewhirst M,Piwnica-Worms D

更新日期：2019-11-21 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with no recognized clinical prognostic factor. Creatinine kinase (CK) increase in these patients is already described with conflicting results on prognosis and survival. In 126 ALS patients who were fast or slow disease progressors, CK levels were assa...

journal_title：Cells

authors： Ceccanti M,Pozzilli V,Cambieri C,Libonati L,Onesti E,Frasca V,Fiorini I,Petrucci A,Garibaldi M,Palma E,Bendotti C,Fabbrizio P,Trolese MC,Nardo G,Inghilleri M

更新日期：2020-05-08 00:00:00

abstract：:One third of all human proteins are either transmembrane or soluble secretory proteins that first target the endoplasmic reticulum (ER). These proteins subsequently leave the ER and enter the Golgi apparatus via ER-Golgi intermediate vesicular structures. Live-cell imaging of cargos fused to fluorescent proteins (FPs)...

journal_title：Cells

authors： Rauter T,Burgstaller S,Gottschalk B,Ramadani-Muja J,Bischof H,Hay JC,Graier WF,Malli R

更新日期：2020-10-17 00:00:00

abstract：:Metastatic spread is mainly sustained by cancer stem cells (CSC), a subpopulation of cancer cells that displays stemness features. CSC are thought to be derived from cancer cells that undergo epithelial to mesenchymal transition (EMT), thus acquiring resistance to anoikis and anti-cancer drugs. After detachment from t...

journal_title：Cells

authors： Paolillo M,Colombo R,Serra M,Belvisi L,Papetti A,Ciusani E,Comincini S,Schinelli S

更新日期：2019-11-13 00:00:00

abstract：:The knowledge about the molecular alterations which are found in head and neck squamous cell carcinomas (HNSCC) has much increased in recent years. However, we are still awaiting the translation of this knowledge to new diagnostic and therapeutic options. Among the many molecular changes that are detected in head and ...

journal_title：Cells

authors： Paluszczak J

更新日期：2020-03-15 00:00:00

abstract：:This review briefly summarizes the single cell application of classical chemical dyes used to visualize cardiomyocyte physiology and their undesirable toxicities which have the potential to confound experimental observations. We will discuss, in detail, the more recent iterative development of fluorescent and biolumin...

journal_title：Cells

authors： Broyles CN,Robinson P,Daniels MJ

更新日期：2018-05-31 00:00:00

abstract：:Aquaporins (AQPs) facilitate transmembrane water and solute transport, and in addition to contributing to transepithelial water transport, they safeguard cell volume homeostasis. This study examined the expression and localization of AQP1 and AQP3 in the gills of Japanese medaka (Oryzias latipes) in response to osmoti...

journal_title：Cells

authors： Ellis LV,Bollinger RJ,Weber HM,Madsen SS,Tipsmark CK

更新日期：2019-05-08 00:00:00

abstract：:Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear receptor family whose expression and activities are restricted to a limited number of organs including the liver and gastrointestinal tract. In this review, we present robust evidence pointing to HNF4 as a master regulator of ce...

journal_title：Cells

authors： Dubois V,Staels B,Lefebvre P,Verzi MP,Eeckhoute J

更新日期：2020-09-28 00:00:00

abstract：:The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been identified in many types of cancer. Downstream of key oncogenic pathways, such as RAS, BCR-ABL, and Her2, NF-κB regulates transcription of target genes that promote cell s...

journal_title：Cells

authors： Rinkenbaugh AL,Baldwin AS

更新日期：2016-04-06 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is an aggressive breast tumor subtype that currently lacks targeted treatment options. The role played by the insulin-like growth factor-1 (IGF-1) and its cognate receptor IGF-1R in TNBC has been reported. Nevertheless, the molecular mechanisms by which the IGF-1/IGF-1R system may ...

journal_title：Cells

authors： Rigiracciolo DC,Nohata N,Lappano R,Cirillo F,Talia M,Scordamaglia D,Gutkind JS,Maggiolini M

更新日期：2020-04-18 00:00:00

abstract：:Mast cells are long-lived, granular, myeloid-derived leukocytes that have significant protective and repair functions in tissues. Mast cells sense disruptions in the local microenvironment and are first responders to physical, chemical and biological insults. When activated, mast cells release growth factors, protease...

journal_title：Cells

authors： Willows S,Kulka M

更新日期：2020-12-18 00:00:00

abstract：:Recent observations related to the structure of the cytoskeleton in neurons and novel cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases are changing our view on the function of the cytoskeletal proteins in the nervous system. These efforts allow a better understanding of the mole...

journal_title：Cells

authors： Muñoz-Lasso DC,Romá-Mateo C,Pallardó FV,Gonzalez-Cabo P

更新日期：2020-02-04 00:00:00

abstract：:Wnt/β-catenin signaling plays vital role in the regulation of cellular proliferation, migration, stem cells cell renewal and genetic stability. This pathway is crucial during the early developmental process; however, the distinct role of Wnt/β-catenin signaling during pre-implantation period of bovine embryonic develo...

journal_title：Cells

authors： Sidrat T,Khan AA,Idrees M,Joo MD,Xu L,Lee KL,Kong IK

更新日期：2020-04-09 00:00:00

abstract：:Autophagy is a highly regulated bulk degradation process that plays a key role in the maintenance of cellular homeostasis. During autophagy, a double membrane-bound compartment termed the autophagosome is formed through de novo nucleation and assembly of membrane sources to engulf unwanted cytoplasmic components and t...

journal_title：Cells

authors： Lai LTF,Ye H,Zhang W,Jiang L,Lau WCY

更新日期：2019-12-12 00:00:00

abstract：:Neural precursor cells differentiate into several cell types that display distinct functions. However, little is known about how cell surface mechanics vary during the differentiation process. Here, by precisely measuring membrane tension and bending modulus, we map their variations and correlate them with changes in ...

journal_title：Cells

authors： Soares J,Araujo GRS,Santana C,Matias D,Moura-Neto V,Farina M,Frases S,Viana NB,Romão L,Nussenzveig HM,Pontes B

更新日期：2020-05-26 00:00:00

abstract：:Although thousands of long noncoding RNAs (lncRNAs) have been identified in porcine growth and development, the regulation mechanisms of functional lncRNAs have not been well explored. In this study, using 5'- and 3'-rapid amplification of cDNA ends (RACE) assays, we obtained two different variants of lncRNA maternall...

journal_title：Cells

authors： Cheng X,Li L,Shi G,Chen L,Fang C,Li M,Li C

更新日期：2020-02-15 00:00:00