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Cardiac Autophagy in Sepsis.

Abstract：

:Sepsis is a leading cause of death in intensive care units, and cardiac dysfunction is an identified serious component of the multi-organ failure associated with this critical condition. This review summarized the current discoveries and hypothesizes of how autophagy changes in the heart during sepsis and the underlying mechanisms. Recent investigations suggest that specific activation of autophagy initiation factor Beclin-1 has a potential to protect cardiac mitochondria, attenuate inflammation, and improve cardiac function in sepsis. Accordingly, pharmacological interventions targeting this pathway have a potential to become an effective approach to control sepsis outcomes. The role of autophagy during sepsis pathogenesis has been under intensive investigation in recent years. It is expected that developing therapeutic approaches with specificities targeting at autophagy regulatory factors may provide new opportunities to alleviate organ dysfunction caused by maladaptive autophagy during sepsis.

journal_name

Cells

journal_title

Cells

authors

Sun Y,Cai Y,Zang QS

doi

10.3390/cells8020141

subject

Has Abstract

pub_date

2019-02-10 00:00:00

issue

2

issn

2073-4409

pii

cells8020141

journal_volume

8

pub_type

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