A Novel Approach for Detecting Unique Variations among Infectious Bacterial Species in Endocarditic Cardiac Valve Vegetation.

abstract：BACKGROUND:The search for an effective therapy for local radiation injuries (LRI) is urgent; one option is mesenchymal stem cells (MSC) derived from the placenta and their conditioned medium for the regenerative processes of the skin. METHODS:We used 80 animals, randomly assigned to four groups: control (C) animals th...

journal_title：Cells

authors： Brunchukov V,Astrelina T,Usupzhanova D,Rastorgueva A,Kobzeva I,Nikitina V,Lishchuk S,Dubova E,Pavlov K,Brumberg V,Benderitter M,Samoylov A

更新日期：2020-11-29 00:00:00

abstract：:The function and regulation of amyloid-beta (Aβ) in healthy and diseased liver remains unexplored. Because Aβ reduces the integrity of the blood-brain barrier we have examined its potential role in regulating the sinusoidal permeability of normal and cirrhotic liver. Aβ and key proteins that generate (beta-secretase 1...

journal_title：Cells

authors： Buniatian GH,Weiskirchen R,Weiss TS,Schwinghammer U,Fritz M,Seferyan T,Proksch B,Glaser M,Lourhmati A,Buadze M,Borkham-Kamphorst E,Gaunitz F,Gleiter CH,Lang T,Schaeffeler E,Tremmel R,Cynis H,Frey WH 2nd,Gebhardt R,F

更新日期：2020-02-17 00:00:00

abstract：:Alterations in glucose and glutamine utilizing pathways and in fatty acid metabolism are currently considered the most significant and prevalent metabolic changes observed in almost all types of tumors. Glucose, glutamine and fatty acids are the substrates for the hexosamine biosynthetic pathway (HBP). This metabolic ...

journal_title：Cells

authors： Chiaradonna F,Ricciardiello F,Palorini R

更新日期：2018-06-02 00:00:00

abstract：:An inflammatory response is essential for combating invading pathogens. Several effector components, as well as immune cell populations, are involved in mounting an immune response, thereby destroying pathogenic organisms such as bacteria, fungi, viruses, and parasites. In the past decade, microRNAs (miRNAs), a group ...

journal_title：Cells

authors： Acuña SM,Floeter-Winter LM,Muxel SM

更新日期：2020-01-02 00:00:00

abstract：:Animal growth requires coordination of cell growth and cell cycle progression with developmental signaling. Loss of cell cycle control is extremely detrimental, with reduced cycles leading to impaired organ growth and excessive proliferation, potentially resulting in tissue overgrowth and driving tumour initiation. Du...

journal_title：Cells

authors： Lee JE,Cranna NJ,Chahal AS,Quinn LM

更新日期：2012-12-05 00:00:00

abstract：:During the development of hypertrophic cardiomyopathy, the heart returns to fetal energy metabolism where cells utilize more glucose instead of fatty acids as a source of energy. Metabolism of glucose can increase synthesis of the extracellular glycosaminoglycan hyaluronan, which has been shown to be involved in the d...

journal_title：Cells

authors： Lorén CE,Dahl CP,Do L,Almaas VM,Geiran OR,Mörner S,Hellman U

更新日期：2019-01-29 00:00:00

abstract：:Gene editing permits changing specific DNA sequences within the vast genomes of human cells. Stem cells are particularly attractive targets for gene editing interventions as their self-renewal and differentiation capabilities consent studying cellular differentiation processes, screening small-molecule drugs, modeling...

journal_title：Cells

authors： Tasca F,Wang Q,Gonçalves MAFV

更新日期：2020-04-13 00:00:00

abstract：:T-cell acute lymphoblastic leukemia (T-ALL) is a rare, aggressive disease arising from T-cell precursors. NOTCH1 plays an important role both in T-cell development and leukemia progression, and more than 60% of human T-ALLs harbor mutations in components of the NOTCH1 signaling pathway, leading to deregulated cell gro...

journal_title：Cells

authors： Saccomani V,Grassi A,Piovan E,Bongiovanni D,Di Martino L,Minuzzo S,Tosello V,Zanovello P

更新日期：2020-07-18 00:00:00

abstract：:The aim of this study was to compare the acute effects of thrombin and brain-derived neurotrophic factor (BDNF) on spontaneous miniature endplate potentials (MEPPs) and multiquantal evoked endplate potentials (EPPs) in mouse neuromuscular junctions (NMJs) of m. diaphragma and m. EDL. Intracellular microelectrode recor...

journal_title：Cells

authors： Gaydukov A,Bogacheva P,Tarasova E,Molchanova A,Miteva A,Pravdivceva E,Balezina O

更新日期：2019-07-22 00:00:00

abstract：:Differentiation therapy is an alternative strategy used to induce the differentiation of blast cells toward mature cells and to inhibit tumor cell proliferation for cancer treatment. Nobiletin (NOB), a polymethoxyflavone phytochemical, is present abundantly in citrus peels and has been reported to possess anti-cancer ...

journal_title：Cells

authors： Yen JH,Lin CY,Chuang CH,Chin HK,Wu MJ,Chen PY

更新日期：2020-04-03 00:00:00

abstract：:Transient receptor potential canonical (TRPC) channels are ubiquitously expressed in excitable and non-excitable cardiac cells where they sense and respond to a wide variety of physical and chemical stimuli. As other TRP channels, TRPC channels may form homo or heterotetrameric ion channels, and they can associate wit...

journal_title：Cells

authors： Falcón D,Galeano-Otero I,Martín-Bórnez M,Fernández-Velasco M,Gallardo-Castillo I,Rosado JA,Ordóñez A,Smani T

更新日期：2020-01-10 00:00:00

abstract：:Tumors lack a well-regulated vascular supply of O2 and often fail to balance O2 supply and demand. Net O2 tension within many tumors may not only depend on O2 delivery but also depend strongly on O2 demand. Thus, tumor O2 consumption rates may influence tumor hypoxia up to true anoxia. Recent reports have shown that m...

journal_title：Cells

authors： Gammon ST,Pisaneschi F,Bandi ML,Smith MG,Sun Y,Rao Y,Muller F,Wong F,De Groot J,Ackroyd J,Mawlawi O,Davies MA,Gopal YNV,Di Francesco ME,Marszalek JR,Dewhirst M,Piwnica-Worms D

更新日期：2019-11-21 00:00:00

abstract：:Background: In retinitis pigmentosa (RP), inherited rod death is followed by cone loss and blindness. Why cones die is still a matter of consideration. Here, we investigate the pathogenic role of the sympathetic transmission in the rd10 mouse model of RP. Methods: Retinal levels of beta adrenergic receptor (BAR) 2 and...

journal_title：Cells

authors： Cammalleri M,Dal Monte M,Amato R,Lapi D,Bagnoli P

更新日期：2020-09-09 00:00:00

abstract：:MicroRNAs (miRNAs), a class of small non-coding RNA molecules, are responsible for RNA silencing and post-transcriptional regulation of gene expression. They can mediate a fine-tuned crosstalk among coding and non-coding RNA molecules sharing miRNA response elements (MREs). In a suitable environment, both coding and n...

journal_title：Cells

authors： Ala U

更新日期：2020-06-28 00:00:00

abstract：:Radiotherapy is one of the major cancer treatment strategies. Exposure to penetrating radiation causes cellular stress, directly or indirectly, due to the generation of reactive oxygen species, DNA damage, and subcellular organelle damage and autophagy. These radiation-induced damage responses cooperatively contribute...

journal_title：Cells

authors： Kim W,Lee S,Seo D,Kim D,Kim K,Kim E,Kang J,Seong KM,Youn H,Youn B

更新日期：2019-09-18 00:00:00

abstract：:Intestinal dysbiosis has recently become known as an important driver of gastrointestinal and liver disease. It remains poorly understood, however, how gastrointestinal microbes bypass the intestinal mucosa and enter systemic circulation to enact an inflammatory immune response. In the context of chronic liver disease...

journal_title：Cells

authors： Chen D,Le TH,Shahidipour H,Read SA,Ahlenstiel G

更新日期：2019-10-27 00:00:00

abstract：:Telomeres with G-rich repetitive DNA and particular proteins as special heterochromatin structures at the termini of eukaryotic chromosomes are tightly maintained to safeguard genetic integrity and functionality. Telomerase as a specialized reverse transcriptase uses its intrinsic RNA template to lengthen telomeric G-...

journal_title：Cells

authors： Liu J,Wang L,Wang Z,Liu JP

更新日期：2019-01-15 00:00:00

abstract：:Sepsis is a leading cause of death in intensive care units, and cardiac dysfunction is an identified serious component of the multi-organ failure associated with this critical condition. This review summarized the current discoveries and hypothesizes of how autophagy changes in the heart during sepsis and the underlyi...

journal_title：Cells

authors： Sun Y,Cai Y,Zang QS

更新日期：2019-02-10 00:00:00

abstract：:Many cells rearrange proteins and other components into spatially distinct domains in a process called polarization. This asymmetric patterning is required for a number of biological processes including asymmetric division, cell migration, and embryonic development. Proteins involved in polarization are highly conserv...

journal_title：Cells

authors： Seirin-Lee S,Gaffney EA,Dawes AT

更新日期：2020-09-05 00:00:00

abstract：:Host immune responses play an important role in the outcome of infection with hepatitis C virus (HCV). They can lead to viral clearance and a positive outcome, or progression and severity of chronic disease. Extensive research in the past >25 years into understanding the immune responses against HCV have still resulte...

journal_title：Cells

authors： Agrawal B,Gupta N,Vedi S,Singh S,Li W,Garg S,Li J,Kumar R

更新日期：2019-05-26 00:00:00

abstract：:The calcium (Ca2+)-dependent membrane-binding Annexin A6 (AnxA6), is a multifunctional, predominantly intracellular scaffolding protein, now known to play relevant roles in different cancer types through diverse, often cell-type-specific mechanisms. AnxA6 is differentially expressed in various stages/subtypes of sever...

journal_title：Cells

authors： Korolkova OY,Widatalla SE,Williams SD,Whalen DS,Beasley HK,Ochieng J,Grewal T,Sakwe AM

更新日期：2020-08-07 00:00:00

abstract：:Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a component of the extracellular environment, where it mediates diverse processes including matrix regulation/turnover, inflammation and angiogenesis. Rare TIMP-3 risk alleles and mutations are directly linked with retinopathies such as age-related macular degenerati...

journal_title：Cells

authors： Dewing JM,Carare RO,Lotery AJ,Ratnayaka JA

更新日期：2019-12-21 00:00:00

abstract：:Extracellular matrix (ECM) remodeling is required for many physiological and pathological processes. Metalloproteinases (MMPs) are endopeptidases which are able to degrade different components of the ECM and nucleus matrix and to cleave numerous non-ECM proteins. Among pathological processes, MMPs are involved in adip...

journal_title：Cells

authors： Berg G,Barchuk M,Miksztowicz V

更新日期：2019-02-14 00:00:00

abstract：:Growth factors are important regulators during organ development. For many vertebrates (but not humans) it is known how they contribute to the formation and expansion of PDX1-positive cells during pancreas organogenesis. Here, the effects of the fibroblast growth factors FGF2, FGF7, FGF10, and epidermal growth factor ...

journal_title：Cells

authors： Dettmer R,Cirksena K,Münchhoff J,Kresse J,Diekmann U,Niwolik I,Buettner FFR,Naujok O

更新日期：2020-08-20 00:00:00

abstract：:All the therapeutic strategies for treating cancers aim at killing the cancer cells via apoptosis (programmed cell death type I). Defective apoptosis endow tumor cells with survival. The cell can respond to such defects with autophagy. Autophagy is a cellular process by which cytoplasmic material is either degraded to...

journal_title：Cells

authors： Kumar P,Zhang DM,Degenhardt K,Chen ZS

更新日期：2012-08-23 00:00:00

abstract：:Mutations in tubulin genes are responsible for a large spectrum of brain malformations secondary to abnormal neuronal migration, organization, differentiation and axon guidance and maintenance. Motor impairment, intellectual disability and epilepsy are the main clinical symptoms. In the present study 15 patients from ...

journal_title：Cells

authors： Romaniello R,Zucca C,Arrigoni F,Bonanni P,Panzeri E,Bassi MT,Borgatti R

更新日期：2019-07-02 00:00:00

abstract：:Integrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration. Integrins are bidirectional signalling molecules that mediate their effects by 'inside-out' and 'outside-in' ...

journal_title：Cells

authors： Cheah M,Andrews MR

更新日期：2018-03-10 00:00:00

abstract：:The third isotype of beta-adrenoreceptors (β3-AR) has recently come (back) into focus after the observation of its expression in white and beige human adipocytes and its implication in metabolic regulation. This coincides with the recent development and marketing of agonists at the human receptor with superior specifi...

journal_title：Cells

authors： Michel LYM,Farah C,Balligand JL

更新日期：2020-12-02 00:00:00

abstract：:Metastasis is the leading cause of cancer death worldwide. Circulating tumor cells (CTCs) are a critical step in the metastatic cascade and a good tool to study this process. We isolated CTCs from a syngeneic mouse model of hepatocellular carcinoma (HCC) and a human xenograft mouse model of castration-resistant prosta...

journal_title：Cells

authors： Huaman J,Naidoo M,Zang X,Ogunwobi OO

更新日期：2019-06-20 00:00:00

abstract：:Parkinson's Disease (PD) is typically classified as a neurodegenerative disease affecting the motor system. Recent evidence, however, has uncovered the presence of Lewy bodies in locations outside the CNS, in direct contact with the external environment, including the olfactory bulbs and the enteric nervous system. Th...

journal_title：Cells

authors： Miraglia F,Colla E

更新日期：2019-03-07 00:00:00