PPAR-Mediated Toxicology and Applied Pharmacology.

abstract：:Rac1 is a small GTPase that belongs to the Rho family. The Rho family of small GTPases is a subfamily of the Ras superfamily. The Rho family of GTPases mediate a plethora of cellular effects, including regulation of cytoarchitecture, cell size, cell adhesion, cell polarity, cell motility, proliferation, apoptosis/surv...

journal_title：Cells

authors： Abdrabou A,Wang Z

更新日期：2018-12-11 00:00:00

abstract：:Metastasis is the leading cause of cancer death worldwide. Circulating tumor cells (CTCs) are a critical step in the metastatic cascade and a good tool to study this process. We isolated CTCs from a syngeneic mouse model of hepatocellular carcinoma (HCC) and a human xenograft mouse model of castration-resistant prosta...

journal_title：Cells

authors： Huaman J,Naidoo M,Zang X,Ogunwobi OO

更新日期：2019-06-20 00:00:00

abstract：:Cell plasticity, defined as the ability to undergo phenotypical transformation in a reversible manner, is a physiological process that also exerts important roles in disease progression. Two forms of cellular plasticity are epithelial-mesenchymal transition (EMT) and its inverse process, mesenchymal-epithelial transit...

journal_title：Cells

authors： Kiełbus M,Czapiński J,Kałafut J,Woś J,Stepulak A,Rivero-Müller A

更新日期：2019-12-15 00:00:00

abstract：:Motile cilia, also called flagella, are found across a broad range of species; some cilia propel prokaryotes and eukaryotic cells like sperm, while cilia on epithelial surfaces create complex fluid patterns e.g., in the brain or lung. For sperm, the picture has emerged that the flagellum is not only a motor but also a...

journal_title：Cells

authors： Hansen JN,Rassmann S,Jikeli JF,Wachten D

更新日期：2018-12-26 00:00:00

abstract：:For decades, cardiovascular disease (CVD) has been the leading cause of death throughout most developed countries. Several studies relate RNA splicing, and more recently also circular RNAs (circRNAs), to CVD. CircRNAs originate from linear transcripts and have been shown to exhibit tissue-specific expression profiles....

journal_title：Cells

authors： Jakobi T,Siede D,Eschenbach J,Heumüller AW,Busch M,Nietsch R,Meder B,Most P,Dimmeler S,Backs J,Katus HA,Dieterich C

更新日期：2020-07-04 00:00:00

abstract：:In cancer pharmacology, a drug candidate's therapeutic potential is typically expressed as its ability to suppress cell growth. Different methods in assessing the cell phenotype and calculating the drug effect have been established. However, inconsistencies in drug response outcomes have been reported, and it is still...

journal_title：Cells

authors： Fischer I,Nickel AC,Qin N,Taban K,Pauck D,Steiger HJ,Kamp M,Muhammad S,Hänggi D,Fritsche E,Remke M,Kahlert UD

更新日期：2020-12-15 00:00:00

abstract：:The second messenger 3',5'-cyclic adenosine monophosphate (cAMP) is one of the most important signalling molecules in the heart as it regulates many physiological and pathophysiological processes. In addition to the classical protein kinase A (PKA) signalling route, the exchange proteins directly activated by cAMP (Ep...

journal_title：Cells

authors： Bouvet M,Blondeau JP,Lezoualc'h F

更新日期：2019-11-29 00:00:00

abstract：:Hspb8 is a member of the small heat shock protein (sHSP) family. Its expression is known to be upregulated under heat shock. This protein interacts with different partners and can, therefore, be involved in various processes relevant to tissue integrity and functioning. In humans, mutations in the gene encoding Hspb8 ...

journal_title：Cells

authors： Dubińska-Magiera M,Niedbalska-Tarnowska J,Migocka-Patrzałek M,Posyniak E,Daczewska M

更新日期：2020-06-26 00:00:00

abstract：:Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder characterized by multiple basal cell carcinomas (BCC), mainly caused by PTCH1 gene mutations. Our current study aimed to establish (1) PTCH1 germinal and somatic mutational status, (2) component and Hedgehog (HH) pathway targets gene expres...

journal_title：Cells

authors： Martinez MF,Romano MV,Martinez AP,González A,Muchnik C,Stengel FM,Mazzuoccolo LD,Azurmendi PJ

更新日期：2019-02-11 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disorder that progressively affects motor neurons in the brain and spinal cord. Due to the biological complexity of the disease, its etiology remains unknown. Several cellular mechanisms involved in the neurodegenerative process in ALS have been found, ...

journal_title：Cells

authors： Vicencio E,Beltrán S,Labrador L,Manque P,Nassif M,Woehlbier U

更新日期：2020-02-07 00:00:00

abstract：:Detachment and the formation of spheroids under microgravity conditions can be observed with various types of intrinsically adherent human cells. In particular, for cancer cells this process mimics metastasis and may provide insights into cancer biology and progression that can be used to identify new drug/target comb...

journal_title：Cells

authors： Melnik D,Sahana J,Corydon TJ,Kopp S,Nassef MZ,Wehland M,Infanger M,Grimm D,Krüger M

更新日期：2020-02-05 00:00:00

abstract：:The bioactive lipid sphingosine-1-phosphate (S1P), along with its receptors, modulates lymphocyte trafficking and immune responses to regulate skin inflammation. Macrophages are important in the pathogenesis of psoriasiform skin inflammation and express various S1P receptors. How they respond to S1P in skin inflammati...

journal_title：Cells

authors： Syed SN,Raue R,Weigert A,von Knethen A,Brüne B

更新日期：2019-07-28 00:00:00

abstract：:The third isotype of beta-adrenoreceptors (β3-AR) has recently come (back) into focus after the observation of its expression in white and beige human adipocytes and its implication in metabolic regulation. This coincides with the recent development and marketing of agonists at the human receptor with superior specifi...

journal_title：Cells

authors： Michel LYM,Farah C,Balligand JL

更新日期：2020-12-02 00:00:00

abstract：BACKGROUND:The current approaches to distinguish follicular adenomas (FA) and follicular thyroid cancer (FTC) at the pre-operative stage have low predictive value. Liquid biopsy-based analysis of circulating extracellular vesicles (EVs) presents a promising diagnostic method. However, the extreme heterogeneity of plasm...

journal_title：Cells

authors： Zabegina L,Nazarova I,Knyazeva M,Nikiforova N,Slyusarenko M,Titov S,Vasilyev D,Sleptsov I,Malek A

更新日期：2020-08-18 00:00:00

abstract：:The family of heterochromatin protein 1 (HP1) isoforms is essential for chromatin packaging, regulation of gene expression, and repair of damaged DNA. Here we document that γ-radiation reduced the number of HP1α-positive foci, but not HP1β and HP1γ foci, located in the vicinity of the fibrillarin-positive region of th...

journal_title：Cells

authors： Legartová S,Lochmanová G,Zdráhal Z,Kozubek S,Šponer J,Krepl M,Pokorná P,Bártová E

更新日期：2019-09-17 00:00:00

abstract：:HDGF-related protein 2 (HRP-2) is a member of the Hepatoma-Derived Growth Factor-related protein family that harbors the structured PWWP and Integrase Binding Domain, known to associate with methylated histone tails or cellular and viral proteins, respectively. Interestingly, HRP-2 is a paralog of Lens Epithelium Deri...

journal_title：Cells

authors： Van Belle S,El Ashkar S,Čermáková K,Matthijssens F,Goossens S,Canella A,Hodges CH,Christ F,De Rijck J,Van Vlierberghe P,Veverka V,Debyser Z

更新日期：2021-01-19 00:00:00

abstract：:Gene expression is often altered by epigenetic modifications that can significantly influence the growth ability and progression of cancers. SAHA (Suberoylanilide hydroxamic acid, also known as Vorinostat), a well-known Histone deacetylase (HDAC) inhibitor, can stop cancer growth and metastatic processes through epige...

journal_title：Cells

authors： Natarajan U,Venkatesan T,Radhakrishnan V,Samuel S,Rathinavelu A

更新日期：2018-12-22 00:00:00

abstract：:The pathological hallmark of Parkinson's disease (PD) is the loss of neuromelanin-containing dopaminergic neurons within the substantia nigra pars compacta (SNpc). Additionally, numerous studies indicate an altered synaptic function during disease progression. To gain new insights into the molecular processes underlyi...

journal_title：Cells

authors： Plum S,Eggers B,Helling S,Stepath M,Theiss C,Leite REP,Molina M,Grinberg LT,Riederer P,Gerlach M,May C,Marcus K

更新日期：2020-12-02 00:00:00

abstract：:Filamins are large dimeric F-actin cross-linking proteins, crucial for the mechanosensitive properties of a number of cell types. Due to their interaction with a variety of different proteins, they exert important regulatory functions. However, in the human testis the role of filamins has been insufficiently explored....

journal_title：Cells

authors： Welter H,Herrmann C,Fröhlich T,Flenkenthaler F,Eubler K,Schorle H,Nettersheim D,Mayerhofer A,Müller-Taubenberger A

更新日期：2020-11-30 00:00:00

abstract：:Small GTPases regulate cytoskeletal dynamics, cell motility, and division under precise spatiotemporal control. Different small GTPases exhibit cross talks to exert feedback response or to act in concert during signal transduction. However, whether and how specific cytoskeletal components' feedback to upstream signali...

journal_title：Cells

authors： Huang Y,Yi X,Kang C,Wu C

更新日期：2019-10-16 00:00:00

abstract：:Autophagy is an intracellular catabolic system that delivers cytoplasmic constituents and organelles in the vacuole. This degradative process is mediated by a group of proteins coded by autophagy-related (ATG) genes that are widely conserved from yeasts to plants and mammals. Homologs of ATG genes have been also ident...

journal_title：Cells

authors： Pérez-Pérez ME,Couso I,Heredia-Martínez LG,Crespo JL

更新日期：2017-10-22 00:00:00

abstract：:The role of small, non-coding microRNAs (miRNAs) has recently emerged as fundamental in the regulation of the physiology of the cardiovascular system. Several specific miRNAs were found to be expressed in embryonic, postnatal, and adult cardiac tissues. In the present review, we will provide an overview about their ro...

journal_title：Cells

authors： Piubelli C,Meraviglia V,Pompilio G,D'Alessandra Y,Colombo GI,Rossini A

更新日期：2014-08-05 00:00:00

abstract：:The pathogenesis of inflammatory bowel disease (IBD) is not well-understood; however, increased and persistent intestinal inflammation, due to inappropriate immune responses that are caused by interactions between genetic factors, gut microbiota, and environmental factors, are thought to lead to IBD. Various studies h...

journal_title：Cells

authors： Park SC,Jeen YT

更新日期：2019-05-01 00:00:00

abstract：:We prepared cellulose nanofibrils-based (CNF), alginate-based and single-walled carbon nanotubes (SWCNT)-based inks for freeform reversible embedding hydrogel (FRESH) 3D bioprinting of conductive scaffolds. The 3D printability of conductive inks was evaluated in terms of their rheological properties. The differentiati...

journal_title：Cells

authors： Bordoni M,Karabulut E,Kuzmenko V,Fantini V,Pansarasa O,Cereda C,Gatenholm P

更新日期：2020-03-11 00:00:00

abstract：:We have previously discovered that HDAC6 regulates the DNA damage response (DDR) via modulating the homeostasis of a DNA mismatch repair protein, MSH2, through HDAC6's ubiquitin E3 ligase activity. Here, we have reported HDAC6's second potential E3 ligase substrate, a critical cell cycle checkpoint protein, Chk1. We h...

journal_title：Cells

authors： Moses N,Zhang M,Wu JY,Hu C,Xiang S,Geng X,Chen Y,Bai W,Zhang YW,Bepler G,Zhang XM

更新日期：2020-10-04 00:00:00

abstract：:Dysregulation of receptor tyrosine kinase-induced pathways is a critical step driving the oncogenic potential of brain cancer. In this study, we investigated the role of two members of the Sprouty (Spry) family in brain cancer-derived cell lines. Using immunoblot analyses we found essential differences in the pattern ...

journal_title：Cells

authors： Celik-Selvi BE,Stütz A,Mayer CE,Salhi J,Siegwart G,Sutterlüty H

更新日期：2019-08-01 00:00:00

abstract：:High-throughput transcriptomic profiling approaches have revealed that circular RNAs (circRNAs) are important transcriptional gene products, identified across a broad range of organisms throughout the eukaryotic tree of life. In the nervous system, they are particularly abundant, developmentally regulated, region-spec...

journal_title：Cells

authors： Gasparini S,Licursi V,Presutti C,Mannironi C

更新日期：2020-07-31 00:00:00

abstract：:Mast cells have been associated with arteriogenesis and collateral formation. In advanced human atherosclerotic plaques, mast cells have been shown to colocalize with plaque neovessels, and mast cells have also been associated with tumor vascularization. Based on these associations, we hypothesize that mast cells prom...

journal_title：Cells

authors： Bot I,Velden DV,Bouwman M,Kröner MJ,Kuiper J,Quax PHA,de Vries MR

更新日期：2020-03-12 00:00:00

abstract：:In this study, the mechanism by which GSK-3β regulates protein synthesis and lipid deposition was investigated in zebrafish (Danio rerio). The vector of pEGFP-N1-GSK-3β was constructed and injected into the muscle of zebrafish. It was found that the mRNA and protein expression of tuberous sclerosis complex 2 (TSC2) wa...

journal_title：Cells

authors： Gu Y,Gao L,Han Q,Li A,Yu H,Liu D,Pang Q

更新日期：2019-02-28 00:00:00

abstract：:Glaucoma is one of the leading causes of irreversible blindness in the world and remains a major public health problem. To date, incomplete knowledge of this disease's pathophysiology has resulted in current therapies (pharmaceutical or surgical) unfortunately having only a slowing effect on disease progression. Recen...

journal_title：Cells

authors： Mélik Parsadaniantz S,Réaux-le Goazigo A,Sapienza A,Habas C,Baudouin C

更新日期：2020-02-25 00:00:00