Transient Receptor Potential (TRP) Channels in Health and Disease.

abstract：:Background: The evidence on high-dose ifosfamide (HD-IFO) use in patients with relapsed osteosarcoma is limited. We performed a retrospective study to analyze HD-IFO activity. Methods: Patients with osteosarcoma relapsed after standard treatment [methotrexate, doxorubicin, cisplatin +/- ifosfamide (MAP+/-I)] with meas...

journal_title：Cells

authors： Palmerini E,Setola E,Grignani G,D'Ambrosio L,Comandone A,Righi A,Longhi A,Cesari M,Paioli A,Hakim R,Pierini M,Marchesi E,Vanel D,Pignochino Y,Donati DM,Picci P,Ferrari S

更新日期：2020-10-31 00:00:00

abstract：:Mammalian Pumilio (PUM) proteins are sequence-specific, RNA-binding proteins (RBPs) with wide-ranging roles. They are involved in germ cell development, which has functional implications in development and fertility. Although human PUM1 and PUM2 are closely related to each other and recognize the same RNA binding moti...

journal_title：Cells

authors： Smialek MJ,Ilaslan E,Sajek MP,Swiercz A,Janecki DM,Kusz-Zamelczyk K,Wozniak T,Kotecki M,Handschuh L,Figlerowicz M,Jaruzelska J

更新日期：2020-04-16 00:00:00

abstract：:Antiphospholipid syndrome (APS) is a systemic autoimmune disease, characterized by thrombosis, obstetric complications and the presence of antiphospholipid antibodies (aPL), which drive endothelial injury and thrombophilia. Extracellular vesicles (EVs) have been implicated in endothelial and thrombotic pathologies. He...

journal_title：Cells

authors： Štok U,Blokar E,Lenassi M,Holcar M,Frank-Bertoncelj M,Erman A,Resnik N,Sodin-Šemrl S,Čučnik S,Pirkmajer KP,Ambrožič A,Žigon P

更新日期：2020-05-13 00:00:00

abstract：:Purine nucleotides are involved in a multitude of cellular processes, and the dysfunction of purine metabolism has drastic physiological and pathological consequences. Accordingly, several genetic disorders associated with defective purine metabolism have been reported. The etiology of these diseases is poorly underst...

journal_title：Cells

authors： Daignan-Fornier B,Pinson B

更新日期：2019-01-17 00:00:00

abstract：:Tissue-resident macrophages play critical roles in controlling homeostasis, tissue repair, and immunity. Inflammatory macrophages can sustain tissue damage and promote the development of fibrosis during infections and sterile tissue injury. The NLRP3 inflammasome and its effector cytokine IL-1β have been identified as...

journal_title：Cells

authors： Köse-Vogel N,Stengel S,Gardey E,Kirchberger-Tolstik T,Reuken PA,Stallmach A,Bruns T

更新日期：2019-12-28 00:00:00

abstract：:The bioactive lipid sphingosine-1-phosphate (S1P), along with its receptors, modulates lymphocyte trafficking and immune responses to regulate skin inflammation. Macrophages are important in the pathogenesis of psoriasiform skin inflammation and express various S1P receptors. How they respond to S1P in skin inflammati...

journal_title：Cells

authors： Syed SN,Raue R,Weigert A,von Knethen A,Brüne B

更新日期：2019-07-28 00:00:00

abstract：:Animal growth requires coordination of cell growth and cell cycle progression with developmental signaling. Loss of cell cycle control is extremely detrimental, with reduced cycles leading to impaired organ growth and excessive proliferation, potentially resulting in tissue overgrowth and driving tumour initiation. Du...

journal_title：Cells

authors： Lee JE,Cranna NJ,Chahal AS,Quinn LM

更新日期：2012-12-05 00:00:00

abstract：:We have previously discovered that HDAC6 regulates the DNA damage response (DDR) via modulating the homeostasis of a DNA mismatch repair protein, MSH2, through HDAC6's ubiquitin E3 ligase activity. Here, we have reported HDAC6's second potential E3 ligase substrate, a critical cell cycle checkpoint protein, Chk1. We h...

journal_title：Cells

authors： Moses N,Zhang M,Wu JY,Hu C,Xiang S,Geng X,Chen Y,Bai W,Zhang YW,Bepler G,Zhang XM

更新日期：2020-10-04 00:00:00

abstract：:Histones are constitutive components of nucleosomes and key regulators of chromatin structure. We previously observed that an extrachromosomal histone H2B (ecH2B) localizes at the intercellular bridge (ICB) connecting the two daughter cells during cytokinesis independently of DNA and RNA. Here, we show that ecH2B bind...

journal_title：Cells

authors： Monteonofrio L,Valente D,Rinaldo C,Soddu S

更新日期：2019-11-05 00:00:00

abstract：:Spermatogonial stem cells (SSCs) are the only adult stem cells capable of passing genes onto the next generation. SSCs also have the potential to provide important knowledge about stem cells in general and to offer critical in vitro and in vivo applications in assisted reproductive technologies. After century-long res...

journal_title：Cells

authors： Ibtisham F,Honaramooz A

更新日期：2020-03-18 00:00:00

abstract：:The roles and interactions of platelets and liver sinusoidal endothelial cells in liver regeneration are unclear, and the trigger that initiates hepatocyte proliferation is unknown. We aimed to identify the key factors released by activated platelets that induce liver sinusoidal endothelial cells to produce interleuki...

journal_title：Cells

authors： Balaphas A,Meyer J,Perozzo R,Zeisser-Labouebe M,Berndt S,Turzi A,Fontana P,Scapozza L,Gonelle-Gispert C,Bühler LH

更新日期：2020-05-25 00:00:00

abstract：:The second messenger 3',5'-cyclic adenosine monophosphate (cAMP) is one of the most important signalling molecules in the heart as it regulates many physiological and pathophysiological processes. In addition to the classical protein kinase A (PKA) signalling route, the exchange proteins directly activated by cAMP (Ep...

journal_title：Cells

authors： Bouvet M,Blondeau JP,Lezoualc'h F

更新日期：2019-11-29 00:00:00

abstract：:Nicotinamide (NAM), the amide form of vitamin B3, plays pivotal roles in regulating various cellular processes including energy production and maintenance of genomic stability. The current study aimed at deciphering the effect of NAM, when administered during in vitro maturation (IVM), on the developmental competence ...

journal_title：Cells

authors： El Sheikh M,Mesalam AA,Idrees M,Sidrat T,Mesalam A,Lee KL,Kong IK

更新日期：2020-06-25 00:00:00

abstract：:Vinyl chloride (VC) is a noninfective occupational risk factor. It is found in industrial chemicals, volatile organic compounds, cigarette smoke ingredients, etc. It is a kind of toxic gas that causes many diseases. VC exposure causes an increased risk of liver fibrosis and can result in angiosarcoma of the liver. Pre...

journal_title：Cells

authors： Hsu YH,Chuang HC,Lee YH,Lin YF,Chiu YJ,Wang YL,Wu MS,Chiu HW

更新日期：2019-06-17 00:00:00

abstract：:Integrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration. Integrins are bidirectional signalling molecules that mediate their effects by 'inside-out' and 'outside-in' ...

journal_title：Cells

authors： Cheah M,Andrews MR

更新日期：2018-03-10 00:00:00

abstract：:ELISpot is one of the most commonly used immune monitoring assays, which allows the functional assessment of the immune system at the single cell level. With its outstanding sensitivity and ease of performance, the assay has recently advanced from the mere single function cell analysis to multifunctional analysis by i...

journal_title：Cells

authors： Janetzki S,Rueger M,Dillenbeck T

更新日期：2014-11-27 00:00:00

abstract：:Sepsis is a leading cause of death in intensive care units, and cardiac dysfunction is an identified serious component of the multi-organ failure associated with this critical condition. This review summarized the current discoveries and hypothesizes of how autophagy changes in the heart during sepsis and the underlyi...

journal_title：Cells

authors： Sun Y,Cai Y,Zang QS

更新日期：2019-02-10 00:00:00

abstract：:Apoptosis, a form of programmed cell death, is a highly regulated process critical for tissue development, homeostasis, and pathogenesis of various diseases [...]. ...

journal_title：Cells

authors： Ladokhin AS

更新日期：2020-09-18 00:00:00

abstract：:This review briefly summarizes the single cell application of classical chemical dyes used to visualize cardiomyocyte physiology and their undesirable toxicities which have the potential to confound experimental observations. We will discuss, in detail, the more recent iterative development of fluorescent and biolumin...

journal_title：Cells

authors： Broyles CN,Robinson P,Daniels MJ

更新日期：2018-05-31 00:00:00

abstract：:Hypoxia-inducible transcription factors 1 and 2 (HIFs) are major mediators of cancer development and progression and validated targets for cancer therapy. Although calcitriol, the biologically active metabolite of vitamin D, was attributed with anticancer properties, there is little information on the effect of calcit...

journal_title：Cells

authors： Gkotinakou IM,Kechagia E,Pazaitou-Panayiotou K,Mylonis I,Liakos P,Tsakalof A

更新日期：2020-11-09 00:00:00

abstract：:The proliferation of molds in domestic environments can lead to uncontrolled continuous exposure to mycotoxins. Even if not immediately symptomatic, this may result in chronic effects, such as, for instance, immunosuppression or allergenic promotion. Alternariol (AOH) is one of the most abundant mycotoxins produced by...

journal_title：Cells

authors： Del Favero G,Mayer RM,Dellafiora L,Janker L,Niederstaetter L,Dall'Asta C,Gerner C,Marko D

更新日期：2020-03-31 00:00:00

abstract：:Mammarenaviruses are a diverse genus of emerging viruses that include several causative agents of severe viral hemorrhagic fevers with high mortality in humans. Although these viruses share many similarities, important differences with regard to pathogenicity, type of immune response, and molecular mechanisms during v...

journal_title：Cells

authors： Fernandes J,Miranda RL,de Lemos ERS,Guterres A

更新日期：2020-11-23 00:00:00

abstract：:The generation of new ribosomes is a coordinated process essential to sustain cell growth. As such, it is tightly regulated according to cell needs. As cancer cells require intense protein translation to ensure their enhanced growth rate, they exploit various mechanisms to boost ribosome biogenesis. In this review, we...

journal_title：Cells

authors： Gaviraghi M,Vivori C,Tonon G

更新日期：2019-09-17 00:00:00

abstract：:Nitric oxide (NO) is an important mediator of inflammation response and the production of NO has been linked to a variety of diseases, including tumors, inflammation and central nervous system diseases. In macrophages, a high level of NO is generated by iNOS during inflammatory responses triggered by cytokines or path...

journal_title：Cells

authors： Wang J,Wu MY,Su H,Lu J,Chen X,Tan J,Lu JH

更新日期：2019-10-15 00:00:00

abstract：:Recent studies have revealed synaptic dysfunction to be a hallmark of various psychiatric diseases, and that glial cells participate in synapse formation, development, and plasticity. Glial cells contribute to neuroinflammation and synaptic homeostasis, the latter being essential for maintaining the physiological func...

journal_title：Cells

authors： Kim YS,Choi J,Yoon BE

更新日期：2020-09-27 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) have revolutionized the study of human diseases as they can renew indefinitely, undergo multi-lineage differentiation, and generate disease-specific models. However, the difficulty of working with iPSCs is that they are prone to genetic instability. Furthermore, genetically unsta...

journal_title：Cells

authors： Erkilic N,Gatinois V,Torriano S,Bouret P,Sanjurjo-Soriano C,Luca V,Damodar K,Cereso N,Puechberty J,Sanchez-Alcudia R,Hamel CP,Ayuso C,Meunier I,Pellestor F,Kalatzis V

更新日期：2019-09-11 00:00:00

abstract：:Telomeres with G-rich repetitive DNA and particular proteins as special heterochromatin structures at the termini of eukaryotic chromosomes are tightly maintained to safeguard genetic integrity and functionality. Telomerase as a specialized reverse transcriptase uses its intrinsic RNA template to lengthen telomeric G-...

journal_title：Cells

authors： Liu J,Wang L,Wang Z,Liu JP

更新日期：2019-01-15 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) in or near the IL2RA gene, that encodes the interleukin-2 (IL-2) receptor α (CD25), are associated with increased risk of immune-mediated diseases including multiple sclerosis (MS). We investigated how the MS-associated IL2RA SNPs rs2104286 and rs11256593 are associated with CD25...

journal_title：Cells

authors： Buhelt S,Søndergaard HB,Oturai A,Ullum H,von Essen MR,Sellebjerg F

更新日期：2019-06-25 00:00:00

abstract：:Gene expression is often altered by epigenetic modifications that can significantly influence the growth ability and progression of cancers. SAHA (Suberoylanilide hydroxamic acid, also known as Vorinostat), a well-known Histone deacetylase (HDAC) inhibitor, can stop cancer growth and metastatic processes through epige...

journal_title：Cells

authors： Natarajan U,Venkatesan T,Radhakrishnan V,Samuel S,Rathinavelu A

更新日期：2018-12-22 00:00:00

abstract：:High-content and high-throughput digital microscopes have generated large image sets in biological experiments and clinical practice. Automatic image analysis techniques, such as cell counting, are in high demand. Here, cell counting was treated as a regression problem using image features (phenotypes) extracted by de...

journal_title：Cells

authors： Liu Q,Junker A,Murakami K,Hu P

更新日期：2019-09-02 00:00:00