Abstract：
:CXCR5 is a key marker of follicular helper T (TFH) cells. Using primary lymph nodes (LNs) from HIV-infected patients, we identified a population of CXCR5- CD4+ T cells with TFH-cell-like features. This CXCR5- subset becomes expanded in severe HIV infection and is characterized by the upregulation of activation markers and high PD-1 and ICOS surface expression. Integrated analyses on the phenotypic heterogeneity, functional capacity, T cell receptor (TCR) repertoire, transcriptional profile, and epigenetic state of CXCR5-PD-1+ICOS+ T cells revealed a shared clonal relationship with TFH cells. CXCR5-PD-1+ICOS+ T cells retained a poised state for CXCR5 expression and exhibited a migratory transcriptional program. TCR sequence overlap revealed a contribution of LN-derived CXCR5-PD-1+ICOS+ T cells to circulating CXCR5- CD4+ T cells with B cell help function. These data link LN pathology to circulating T cells and expand the current understanding on the diversity of T cells that regulate B cell responses during chronic inflammation.
journal_name
Cell Repjournal_title
Cell reportsauthors
Del Alcazar D,Wang Y,He C,Wendel BS,Del Río-Estrada PM,Lin J,Ablanedo-Terrazas Y,Malone MJ,Hernandez SM,Frank I,Naji A,Reyes-Terán G,Jiang N,Su LFdoi
10.1016/j.celrep.2019.08.037subject
Has Abstractpub_date
2019-09-17 00:00:00pages
3047-3060.e7issue
12issn
2211-1247pii
S2211-1247(19)31077-0journal_volume
28pub_type
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