Abstract：
:Signal transducer and activator of transcription 3 (STAT3) is a transcription factor central to axon regrowth with an enigmatic ability to act in different subcellular regions independently of its transcriptional roles. However, its roles in mature CNS neurons remain unclear. Here, we show that along with nuclear translocation, STAT3 translocates to mitochondria in mature CNS neurons upon cytokine stimulation. Loss- and gain-of-function studies using knockout mice and viral expression of various STAT3 mutants demonstrate that STAT3's transcriptional function is indispensable for CNS axon regrowth, whereas mitochondrial STAT3 enhances bioenergetics and further potentiates regrowth. STAT3's localization, functions, and growth-promoting effects are regulated by mitogen-activated protein kinase kinase (MEK), an effect further enhanced by Pten deletion, leading to extensive axon regrowth in the mouse optic pathway and spinal cord. These results highlight CNS neuronal dependence on STAT3 transcriptional activity, with mitochondrial STAT3 providing ancillary roles, and illustrate a critical contribution for MEK in enhancing diverse STAT3 functions and axon regrowth.
journal_name
Cell Repjournal_title
Cell reportsauthors
Luo X,Ribeiro M,Bray ER,Lee DH,Yungher BJ,Mehta ST,Thakor KA,Diaz F,Lee JK,Moraes CT,Bixby JL,Lemmon VP,Park KKdoi
10.1016/j.celrep.2016.03.029subject
Has Abstractpub_date
2016-04-12 00:00:00pages
398-410issue
2issn
2211-1247pii
S2211-1247(16)30285-6journal_volume
15pub_type
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