Abstract：
:Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid uptake by BAT that synchronized with the light/dark cycle. Highest uptake was found at the onset of the active period, which coincided with high lipoprotein lipase expression and low angiopoietin-like 4 expression by BAT. Diurnal rhythmicity in BAT activity determined the rate at which lipids were cleared from the circulation, thereby imposing the daily rhythm in plasma lipid concentrations. In mice as well as humans, postprandial lipid excursions were nearly absent at waking. We anticipate that diurnal BAT activity is an important factor to consider when studying the therapeutic potential of promoting BAT activity.
journal_name
Cell Repjournal_title
Cell reportsauthors
van den Berg R,Kooijman S,Noordam R,Ramkisoensing A,Abreu-Vieira G,Tambyrajah LL,Dijk W,Ruppert P,Mol IM,Kramar B,Caputo R,Puig LS,de Ruiter EM,Kroon J,Hoekstra M,van der Sluis RJ,Meijer OC,Willems van Dijk K,van Kerkdoi
10.1016/j.celrep.2018.03.004subject
Has Abstractpub_date
2018-03-27 00:00:00pages
3521-3533issue
13issn
2211-1247pii
S2211-1247(18)30318-8journal_volume
22pub_type
杂志文章相关文献
Cell Reports文献大全abstract：:Nucleoplasmin (Npm) is an abundant histone chaperone in vertebrate oocytes and embryos. During embryogenesis, regulation of Npm histone binding is critical for its function in storing and releasing maternal histones to establish and maintain the zygotic epigenome. Here, we demonstrate that Xenopus laevis Npm post-tran...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.02.038
更新日期：2015-03-17 00:00:00
abstract：:The MLL gene is a common target of chromosomal translocations found in human leukemia. MLL-fusion leukemia has a consistently poor outcome. One of the most common translocation partners is AF9 (MLLT3). MLL-AF9 recruits DOT1L, a histone 3 lysine 79 methyltransferase (H3K79me1/me2/me3), leading to aberrant gene transcri...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.04.004
更新日期：2015-05-05 00:00:00
abstract：:Governance of protein phosphorylation by kinases and phosphatases constitutes an essential regulatory network in eukaryotic cells. Network dysregulation leads to severe consequences and is often a key factor in disease pathogenesis. Previous studies revealed multiple roles for protein phosphorylation and pathway struc...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.10.034
更新日期：2019-11-12 00:00:00
abstract：:Engrailed homeoproteins are expressed in adult dopaminergic neurons of the substantia nigra. In Engrailed1 heterozygous mice, these neurons start dying at 6 weeks, are more sensitive to oxidative stress, and progressively develop traits similar to those observed following an acute and strong oxidative stress inflected...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.08.076
更新日期：2015-10-13 00:00:00
abstract：:Dentate gyrus (DG) development requires specification of granule cell (GC) progenitors in the hippocampal neuroepithelium, as well as their proliferation and migration into the primordial DG. We identify the Plexin family members Plxna2 and Plxna4 as important regulators of DG development. Distribution of immature GCs...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.12.044
更新日期：2018-01-09 00:00:00
abstract：:A systematic cataloging of genes affected by genomic rearrangement, using multiple patient cohorts and cancer types, can provide insight into cancer-relevant alterations outside of exomes. By integrative analysis of whole-genome sequencing (predominantly low pass) and gene expression data from 1,448 cancers involving ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.06.025
更新日期：2018-07-10 00:00:00
abstract：:Medulloblastoma (MB) is a neoplasm linked to dysregulated cerebellar development. Previously, we demonstrated that the Sonic Hedgehog (SHH) subgroup grows hierarchically, with Sox2+ cells at the apex of tumor progression and relapse. To test whether this mechanism is rooted in a normal developmental process, we studie...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.03.075
更新日期：2020-04-14 00:00:00
abstract：:Dorsal root ganglia (DRG) relay sensory information to the brain, giving rise to the perception of pain, disorders of which are prevalent and burdensome. Here, we mapped expression quantitative trait loci (eQTLs) in a collection of human DRGs. DRG eQTLs were enriched within untranslated regions of coding genes of low ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.05.018
更新日期：2017-05-30 00:00:00
abstract：:Transcriptional analysis of brain tissue from people with molecularly defined causes of obesity may highlight disease mechanisms and therapeutic targets. We performed RNA sequencing of hypothalamus from individuals with Prader-Willi syndrome (PWS), a genetic obesity syndrome characterized by severe hyperphagia. We fou...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.03.018
更新日期：2018-03-27 00:00:00
abstract：:LIN28 is an RNA binding protein that plays crucial roles in pluripotency, glucose metabolism, tissue regeneration, and tumorigenesis. LIN28 binds to the let-7 primary and precursor microRNAs through bipartite recognition and induces degradation of let-7 precursors (pre-let-7) by promoting oligouridylation by terminal ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.02.044
更新日期：2017-03-14 00:00:00
abstract：:The role of CD4+ T cells in the ischemic tissues of T2D patients remains unclear. Here, we report that T2D patients' vascular density was negatively correlated with the number of infiltrating CD4+ T cells after ischemic injury. Th1 was the predominant subset, and Th1-derived IFN-γ and TNF-α directly impaired human ang...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.07.019
更新日期：2018-08-07 00:00:00
abstract：:Mammalian neocortex size primarily reflects the number and mode of divisions of neural stem and progenitor cells. Cortical stem cells (apical progenitors) switching from symmetric divisions, which expand their population, to asymmetric divisions, which generate downstream neuronal progenitors (basal progenitors), star...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.03.033
更新日期：2014-04-24 00:00:00
abstract：:The basement membrane (BM), a sheet of extracellular matrix lining the basal side of epithelia, is essential for epithelial cell function and integrity, yet the mechanisms that control the basal restriction of BM proteins are poorly understood. In epithelial cells, a specialized pathway is dedicated to restrict the de...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.02.002
更新日期：2017-02-21 00:00:00
abstract：:The phosphatidylinositol 3-kinase (PI3K) signaling cascade downstream of the B cell receptor (BCR) signalosome is essential for B cell maturation. Proper signaling strength is maintained through the PI3K negative regulator phosphatase and tensin homolog (PTEN). Although a role for microRNA (miRNA)-dependent control of...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108436
更新日期：2020-12-01 00:00:00
abstract：:Mutations in citron (CIT), leading to loss or inactivation of the citron kinase protein (CITK), cause primary microcephaly in humans and rodents, associated with cytokinesis failure and apoptosis in neural progenitors. We show that CITK loss induces DNA damage accumulation and chromosomal instability in both mammals a...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.01.054
更新日期：2017-02-14 00:00:00
abstract：:Mutations in WNK kinases cause the human hypertensive disease pseudohypoaldosteronism type II (PHAII), but the regulatory mechanisms of the WNK kinases are not well understood. Mutations in kelch-like 3 (KLHL3) and Cullin3 were also recently identified as causing PHAII. Therefore, new insights into the mechanisms of h...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.02.024
更新日期：2013-03-28 00:00:00
abstract：:The Argonaute subfamily of proteins (AGO) loads microRNAs (miRNAs) to form the effector complex that mediates target gene silencing. Empty AGO, but not miRNA-loaded AGO, is selectively degraded across species. We have reported that the degradation of empty AGO is part of a quality control pathway that eliminates dysfu...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.07.003
更新日期：2019-07-30 00:00:00
abstract：:The joint contribution of pre-existing and de novo genetic variation to clonal adaptation is poorly understood but essential to designing successful antimicrobial or cancer therapies. To address this, we evolve genetically diverse populations of budding yeast, S. cerevisiae, consisting of diploid cells with unique hap...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.09.046
更新日期：2017-10-17 00:00:00
abstract：:Cells, from microbes to mammals, adapt their membrane lipid composition in response to environmental changes to maintain optimal properties. Global patterns of lipidome remodeling are poorly understood, particularly in organisms with simple lipid compositions that can provide insight into fundamental principles of mem...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108165
更新日期：2020-09-22 00:00:00
abstract：:Glucagon, the principal hyperglycemic hormone, is secreted from pancreatic islet α cells as part of the counter-regulatory response to hypoglycemia. Hence, secretory output from α cells is under high demand in conditions of low glucose supply. Many tissues oxidize fat as an alternate energy substrate. Here, we show th...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.05.035
更新日期：2018-06-12 00:00:00
abstract：:The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to govern mechanosensing, growth, and motility of cells, while its deregulation is associated with disease development. Here, we describe the generation of a RhoA-fluorescence resonance e...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.09.022
更新日期：2017-10-03 00:00:00
abstract：:The bacterial pathogen Listeria monocytogenes (Lm) capitalizes on natural killer (NK) cell production of regulatory interleukin (IL)-10 to establish severe systemic infections. Here, we identify regulators of this IL-10 secretion. We show that IL-18 signals to NK cells license their ability to produce IL-10. IL-18 act...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.04.106
更新日期：2018-05-29 00:00:00
abstract：:HIV-1 uses the microtubule network to traffic the viral capsid core toward the nucleus. Viral nuclear trafficking and infectivity require the kinesin-1 adaptor protein FEZ1. Here, we demonstrate that FEZ1 directly interacts with the HIV-1 capsid and specifically binds capsid protein (CA) hexamers. FEZ1 contains multip...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.07.079
更新日期：2019-08-27 00:00:00
abstract：:The 26S proteasome is the central ATP-dependent protease in eukaryotes and is essential for organismal health. Proteasome assembly is mediated by several dedicated, evolutionarily conserved chaperone proteins. These chaperones associate transiently with assembly intermediates but are absent from mature proteasomes. Ch...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.12.042
更新日期：2019-01-08 00:00:00
abstract：:Mechanistic (or mammalian) target of rapamycin complex 1 (mTORC1) integrates signals from growth factors and nutrients to control biosynthetic processes, including protein, lipid, and nucleic acid synthesis. We find that the mTORC1 pathway is responsive to changes in purine nucleotides in a manner analogous to its sen...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.10.029
更新日期：2017-10-31 00:00:00
abstract：:Transcriptome analyses have revealed that convergent gene transcription can produce many 3'-overlapping mRNAs in diverse organisms. Few studies have examined the fate of 3'-complementary mRNAs in double-stranded RNA-dependent nuclear phenomena, and nothing is known about the cytoplasmic destiny of 3'-overlapping messe...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.08.016
更新日期：2015-09-22 00:00:00
abstract：:Although poly(ADP-ribose) polymerase (PARP) inhibitors are active in homologous recombination (HR)-deficient cancers, their utility is limited by acquired resistance after restoration of HR. Here, we report that dinaciclib, an inhibitor of cyclin-dependent kinases (CDKs) 1, 2, 5, and 9, additionally has potent activit...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.10.077
更新日期：2016-11-22 00:00:00
abstract：:The JAK/STAT1 pathway is generally activated by cytokines, providing essential antiviral defense. Here, we identify that STAT1 activation is independent of cytokines and JAKs at the early infection stage of some viruses, including influenza A virus (IAV). Instead, STAT1 is activated mainly through spleen tyrosine kina...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108627
更新日期：2021-01-19 00:00:00
abstract：:The rate at which genomes diverge during speciation is unknown, as are the physical dynamics of the process. Here, we compare full genome sequences of 32 butterflies, representing five species from a hybridizing Heliconius butterfly community, to examine genome-wide patterns of introgression and infer how divergence e...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.09.042
更新日期：2013-11-14 00:00:00
abstract：:Oncogenic mutations of FLT3 and KIT receptors are associated with poor survival in patients with acute myeloid leukemia (AML) and myeloproliferative neoplasms (MPNs), and currently available drugs are largely ineffective. Although Stat5 has been implicated in regulating several myeloid and lymphoid malignancies, how p...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.10.039
更新日期：2014-11-20 00:00:00
