abstract：:Although vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are under development, the antigen epitopes on the virus and their immunogenicity are poorly understood. Here, we simulate the 3D structures and predict the B cell epitopes on the spike (S), envelope (E), membrane (M), and nucleocap...

journal_title：Cell reports

authors： Lu S,Xie XX,Zhao L,Wang B,Zhu J,Yang TR,Yang GW,Ji M,Lv CP,Xue J,Dai EH,Fu XM,Liu DQ,Zhang L,Hou SJ,Yu XL,Wang YL,Gao HX,Shi XH,Ke CW,Ke BX,Jiang CG,Liu RT

更新日期：2021-01-26 00:00:00

abstract：:In contrast to our extensive knowledge on covalent small ubiquitin-like modifier (SUMO) target proteins, we are limited in our understanding of non-covalent SUMO-binding proteins. We identify interactors of different SUMO isoforms-monomeric SUMO1, monomeric SUMO2, or linear trimeric SUMO2 chains-using a mass spectrome...

journal_title：Cell reports

authors： González-Prieto R,Eifler-Olivi K,Claessens LA,Willemstein E,Xiao Z,Talavera Ormeno CMP,Ovaa H,Ulrich HD,Vertegaal ACO

更新日期：2021-01-26 00:00:00

abstract：:Self-renewal is a key characteristic of leukemia stem cells (LSCs) responsible for the development and maintenance of leukemia. In this study, we identify CD93 as an important regulator of self-renewal and proliferation of murine and human LSCs, but not hematopoietic stem cells (HSCs). The intracellular domain of CD93...

journal_title：Cell reports

authors： Riether C,Radpour R,Kallen NM,Bürgin DT,Bachmann C,Schürch CM,Lüthi U,Arambasic M,Hoppe S,Albers CE,Baerlocher GM,Ochsenbein AF

更新日期：2021-01-26 00:00:00

abstract：:Tissue-resident memory T (TRM) cells provide key adaptive immune responses in infection, cancer, and autoimmunity. However, transcriptional heterogeneity of human intestinal TRM cells remains undefined. Here, we investigate transcriptional and functional heterogeneity of human TRM cells through study of donor-derived ...

journal_title：Cell reports

authors： FitzPatrick MEB,Provine NM,Garner LC,Powell K,Amini A,Irwin SL,Ferry H,Ambrose T,Friend P,Vrakas G,Reddy S,Soilleux E,Klenerman P,Allan PJ

更新日期：2021-01-19 00:00:00

abstract：:Maintaining organelle function in the face of stress is known to involve organelle-specific retrograde signaling. Using Caenorhabditis elegans, we present evidence of the existence of such retrograde signaling for peroxisomes, which we define as the peroxisomal retrograde signaling (PRS). Specifically, we show that pe...

journal_title：Cell reports

authors： Rackles E,Witting M,Forné I,Zhang X,Zacherl J,Schrott S,Fischer C,Ewbank JJ,Osman C,Imhof A,Rolland SG

更新日期：2021-01-19 00:00:00

abstract：:The JAK/STAT1 pathway is generally activated by cytokines, providing essential antiviral defense. Here, we identify that STAT1 activation is independent of cytokines and JAKs at the early infection stage of some viruses, including influenza A virus (IAV). Instead, STAT1 is activated mainly through spleen tyrosine kina...

journal_title：Cell reports

authors： Liu S,Liao Y,Chen B,Chen Y,Yu Z,Wei H,Zhang L,Huang S,Rothman PB,Gao GF,Chen JL

更新日期：2021-01-19 00:00:00

abstract：:Eosinophils mediate protection against filarial nematodes. Our results demonstrate that eosinophil extracellular traps (EETosis) are induced by microfilariae and infective L3 larvae of Litomosoides sigmodontis. These extracellular DNA traps inhibit microfilariae motility in a DNA- and contact-dependent manner in vitro...

journal_title：Cell reports

authors： Ehrens A,Lenz B,Neumann AL,Giarrizzo S,Reichwald JJ,Frohberger SJ,Stamminger W,Buerfent BC,Fercoq F,Martin C,Kulke D,Hoerauf A,Hübner MP

更新日期：2021-01-12 00:00:00

abstract：:Animal nervous systems remodel following stress. Although global stress-dependent changes are well documented, contributions of individual neuron remodeling events to animal behavior modification are challenging to study. In response to environmental insults, C. elegans become stress-resistant dauers. Dauer entry indu...

journal_title：Cell reports

authors： Lee IH,Procko C,Lu Y,Shaham S

更新日期：2021-01-12 00:00:00

abstract：:Heterobifunctional proteolysis-targeting chimeric compounds leverage the activity of E3 ligases to induce degradation of target oncoproteins and exhibit potent preclinical antitumor activity. To dissect the mechanisms regulating tumor cell sensitivity to different classes of pharmacological "degraders" of oncoproteins...

journal_title：Cell reports

authors： Shirasaki R,Matthews GM,Gandolfi S,de Matos Simoes R,Buckley DL,Raja Vora J,Sievers QL,Brüggenthies JB,Dashevsky O,Poarch H,Tang H,Bariteau MA,Sheffer M,Hu Y,Downey-Kopyscinski SL,Hengeveld PJ,Glassner BJ,Dhimolea E,O

更新日期：2021-01-05 00:00:00

abstract：:Early lineage-specific master regulators are essential for the specification of cell types. However, once cells are committed to a specific fate, it is critical to restrict the activity of such factors to enable differentiation. To date, it remains unclear how these factors are silenced. Using the Drosophila mesoderm ...

journal_title：Cell reports

authors： Domsch K,Schröder J,Janeschik M,Schaub C,Lohmann I

更新日期：2021-01-05 00:00:00

abstract：:Immune cells can metabolize glucose, amino acids, and fatty acids (FAs) to generate energy. The roles of different FA species and their impacts on humoral immunity remain poorly understood. Here, we report that proliferating B cells require monounsaturated FAs (MUFAs) to maintain mitochondrial metabolism and mTOR acti...

journal_title：Cell reports

authors： Zhou X,Zhu X,Li C,Li Y,Ye Z,Shapiro VS,Copland JA 3rd,Hitosugi T,Bernlohr DA,Sun J,Zeng H

更新日期：2021-01-05 00:00:00

abstract：:The MRE11-RAD50-NBS1 complex plays a central role in response to DNA double-strand breaks. Here, we identify a patient with bone marrow failure and developmental defects caused by biallelic RAD50 mutations. One of the mutations creates a null allele, whereas the other (RAD50E1035Δ) leads to the loss of a single residu...

journal_title：Cell reports

authors： Chansel-Da Cruz M,Hohl M,Ceppi I,Kermasson L,Maggiorella L,Modesti M,de Villartay JP,Ileri T,Cejka P,Petrini JHJ,Revy P

更新日期：2020-12-29 00:00:00

abstract：:Generating mammalian cells with desired mitochondrial DNA (mtDNA) sequences is enabling for studies of mitochondria, disease modeling, and potential regenerative therapies. MitoPunch, a high-throughput mitochondrial transfer device, produces cells with specific mtDNA-nuclear DNA (nDNA) combinations by transferring iso...

journal_title：Cell reports

authors： Patananan AN,Sercel AJ,Wu TH,Ahsan FM,Torres A Jr,Kennedy SAL,Vandiver A,Collier AJ,Mehrabi A,Van Lew J,Zakin L,Rodriguez N,Sixto M,Tadros W,Lazar A,Sieling PA,Nguyen TL,Dawson ER,Braas D,Golovato J,Cisneros L,V

更新日期：2020-12-29 00:00:00

abstract：:During chronic infection, the inflammatory cytokine interferon gamma (IFNγ) damages hematopoietic stem cells (HSCs) by disrupting quiescence and promoting excessive terminal differentiation. However, the mechanism by which IFNγ hinders HSC quiescence remains undefined. Using intravital 3-dimensional microscopy, we fin...

journal_title：Cell reports

authors： Florez MA,Matatall KA,Jeong Y,Ortinau L,Shafer PW,Lynch AM,Jaksik R,Kimmel M,Park D,King KY

更新日期：2020-12-22 00:00:00

abstract：:CELF6 is a CELF-RNA-binding protein, and thus part of a protein family with roles in human disease; however, its mRNA targets in the brain are largely unknown. Using cross-linking immunoprecipitation and sequencing (CLIP-seq), we define its CNS targets, which are enriched for 3' UTRs in synaptic protein-coding genes. ...

journal_title：Cell reports

authors： Rieger MA,King DM,Crosby H,Liu Y,Cohen BA,Dougherty JD

更新日期：2020-12-22 00:00:00

abstract：:A central paradigm in the field of lymphocyte biology asserts that replicatively senescent memory T cells express the carbohydrate epitope CD57. These cells nonetheless accumulate with age and expand numerically in response to persistent antigenic stimulation. Here, we use in vivo deuterium labeling and ex vivo analys...

journal_title：Cell reports

authors： Ahmed R,Miners KL,Lahoz-Beneytez J,Jones RE,Roger L,Baboonian C,Zhang Y,Wang ECY,Hellerstein MK,McCune JM,Baird DM,Price DA,Macallan DC,Asquith B,Ladell K

更新日期：2020-12-15 00:00:00

abstract：:The innate immune system plays key roles in tissue regeneration. For example, microglia promote neurogenesis in Müller glia in birds and fish after injury. Although mammalian retina does not normally regenerate, neurogenesis can be induced in mouse Müller glia by Ascl1, a proneural transcription factor. We show that i...

journal_title：Cell reports

authors： Todd L,Finkbeiner C,Wong CK,Hooper MJ,Reh TA

更新日期：2020-12-15 00:00:00

abstract：:We have identified and validated a spaceflight-associated microRNA (miRNA) signature that is shared by rodents and humans in response to simulated, short-duration and long-duration spaceflight. Previous studies have identified miRNAs that regulate rodent responses to spaceflight in low-Earth orbit, and we have confirm...

journal_title：Cell reports

authors： Malkani S,Chin CR,Cekanaviciute E,Mortreux M,Okinula H,Tarbier M,Schreurs AS,Shirazi-Fard Y,Tahimic CGT,Rodriguez DN,Sexton BS,Butler D,Verma A,Bezdan D,Durmaz C,MacKay M,Melnick A,Meydan C,Li S,Garrett-Bakelman F,

更新日期：2020-12-08 00:00:00

abstract：:A role for cancer cell epithelial-to-mesenchymal transition (EMT) in cancer is well established. Here, we show that, in addition to cancer cell EMT, ovarian cancer cell metastasis relies on an epigenomic mesenchymal-to-epithelial transition (MET) in host mesenchymal stem cells (MSCs). These reprogrammed MSCs, termed c...

journal_title：Cell reports

authors： Fan H,Atiya HI,Wang Y,Pisanic TR,Wang TH,Shih IM,Foy KK,Frisbie L,Buckanovich RJ,Chomiak AA,Tiedemann RL,Rothbart SB,Chandler C,Shen H,Coffman LG

更新日期：2020-12-08 00:00:00

abstract：:Dicistrovirus intergenic region internal ribosomal entry sites (IGR IRESs) do not require initiator tRNA, an AUG codon, or initiation factors and jumpstart translation from the middle of the elongation cycle via formation of IRES/80S complexes resembling the pre-translocation state. eEF2 then translocates the [codon-a...

journal_title：Cell reports

authors： Abaeva IS,Vicens Q,Bochler A,Soufari H,Simonetti A,Pestova TV,Hashem Y,Hellen CUT

更新日期：2020-12-08 00:00:00

abstract：:The phosphatidylinositol 3-kinase (PI3K) signaling cascade downstream of the B cell receptor (BCR) signalosome is essential for B cell maturation. Proper signaling strength is maintained through the PI3K negative regulator phosphatase and tensin homolog (PTEN). Although a role for microRNA (miRNA)-dependent control of...

journal_title：Cell reports

authors： Hines MJ,Coffre M,Mudianto T,Panduro M,Wigton EJ,Tegla C,Osorio-Vasquez V,Kageyama R,Benhamou D,Perez O,Bajwa S,McManus MT,Ansel KM,Melamed D,Koralov SB

更新日期：2020-12-01 00:00:00

abstract：:People tend to fall asleep when gently rocked or vibrated. Experimental studies have shown that rocking promotes sleep in humans and mice. However, the mechanisms underlying the phenomenon are not well understood. A habituation model proposes that habituation, a form of non-associative learning, mediates sleep inducti...

journal_title：Cell reports

authors： Öztürk-Çolak A,Inami S,Buchler JR,McClanahan PD,Cruz A,Fang-Yen C,Koh K

更新日期：2020-12-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease. CAV1 and CAV2 organize membrane lipid rafts (MLRs) important for cell signaling and neuronal survival, and overexpression of CAV1 ameliorates ALS phenotypes in vivo. Genome-wide association studies localize a large proportion of ALS risk va...

journal_title：Cell reports

authors： Cooper-Knock J,Zhang S,Kenna KP,Moll T,Franklin JP,Allen S,Nezhad HG,Iacoangeli A,Yacovzada NY,Eitan C,Hornstein E,Elhaik E,Celadova P,Bose D,Farhan S,Fishilevich S,Lancet D,Morrison KE,Shaw CE,Al-Chalabi A,Projec

更新日期：2020-12-01 00:00:00

abstract：:The activation of G-protein-coupled receptors (GPCRs) leads to the activation of mTORC2 in cell migration and metabolism. However, the mechanism that links GPCRs to mTORC2 remains unknown. Here, using Dictyostelium cells, we show that GPCR-mediated chemotactic stimulation induces hetero-oligomerization of phosphorylat...

journal_title：Cell reports

authors： Senoo H,Wai M,Matsubayashi HT,Sesaki H,Iijima M

更新日期：2020-11-24 00:00:00

abstract：:Soluble envelope (Env) trimers, stabilized in a prefusion-closed conformation, can elicit neutralizing responses against HIV-1 strains closely related to the immunizing trimer. However, to date such stabilization has succeeded with only a limited number of HIV-1 strains. To address this issue, here we develop ADROITri...

journal_title：Cell reports

authors： Rawi R,Rutten L,Lai YT,Olia AS,Blokland S,Juraszek J,Shen CH,Tsybovsky Y,Verardi R,Yang Y,Zhang B,Zhou T,Chuang GY,Kwong PD,Langedijk JPM

更新日期：2020-11-24 00:00:00

abstract：:Salivary proteins are essential for maintaining health in the oral cavity and proximal digestive tract, and they serve as potential diagnostic markers for monitoring human health and disease. However, their precise organ origins remain unclear. Through transcriptomic analysis of major adult and fetal salivary glands a...

journal_title：Cell reports

authors： Saitou M,Gaylord EA,Xu E,May AJ,Neznanova L,Nathan S,Grawe A,Chang J,Ryan W,Ruhl S,Knox SM,Gokcumen O

更新日期：2020-11-17 00:00:00

abstract：:The NLRP3 inflammasome, a critical component of the innate immune system, induces caspase-1 activation and interleukin (IL)-1β maturation in response to microbial infection and cellular damage. However, aberrant activation of the NLRP3 inflammasome contributes to the pathogenesis of several inflammatory disorders, inc...

journal_title：Cell reports

authors： Duan Y,Zhang L,Angosto-Bazarra D,Pelegrín P,Núñez G,He Y

更新日期：2020-11-17 00:00:00

abstract：:Stringent targeting of membrane proteins to corresponding organelles is essential for organelle identity and functions. In addition to molecular pathways that target proteins to appropriate organelles, surveillance mechanisms clear mistargeted proteins from undesired destinations. Although Msp1 functions on the mitoch...

journal_title：Cell reports

authors： Qin Q,Zhao T,Zou W,Shen K,Wang X

更新日期：2020-11-10 00:00:00

abstract：:Protein isoforms generated by alternative splicing contribute to proteome diversity. Because of the lack of effective techniques, the isoform-specific function, expression, localization, and signaling of endogenous proteins are unknown for most genes. Here, we report a genetic method, isoTarget, for multi-purpose stud...

journal_title：Cell reports

authors： Liu H,Pizzano S,Li R,Zhao W,Veling MW,Hu Y,Yang L,Ye B

更新日期：2020-11-10 00:00:00

abstract：:Complex febrile seizures (FSs) lead to a high risk of intractable temporal lobe epilepsy during adulthood, yet the pathological process of complex FSs is largely unknown. Here, we demonstrate that activated microglia extensively associated with glutamatergic neuronal soma displace surrounding GABAergic presynapses in ...

journal_title：Cell reports

authors： Wan Y,Feng B,You Y,Yu J,Xu C,Dai H,Trapp BD,Shi P,Chen Z,Hu W

更新日期：2020-11-03 00:00:00

abstract：:Bat cells and tissue have elevated basal expression levels of antiviral genes commonly associated with interferon alpha (IFNα) signaling. Here, we show Interferon Regulatory Factor 1 (IRF1), 3, and 7 levels are elevated in most bat tissues and that, basally, IRFs contribute to the expression of type I IFN ligands and ...

journal_title：Cell reports

authors： Irving AT,Zhang Q,Kong PS,Luko K,Rozario P,Wen M,Zhu F,Zhou P,Ng JHJ,Sobota RM,Wang LF

更新日期：2020-11-03 00:00:00

abstract：:Granule cells (GCs) of the cerebellar input layer express high-affinity δ GABAA subunit-containing GABAA receptors (δGABAARs) that respond to ambient GABA levels and context-dependent neuromodulators like steroids. We find that GC-specific deletion of δGABAA (cerebellar [cb] δ knockout [KO]) decreases tonic inhibition...

journal_title：Cell reports

authors： Rudolph S,Guo C,Pashkovski SL,Osorno T,Gillis WF,Krauss JM,Nyitrai H,Flaquer I,El-Rifai M,Datta SR,Regehr WG

更新日期：2020-11-03 00:00:00

abstract：:Graft-versus-host disease (GVHD) limits the success of allogeneic hematopoietic cell transplantation (allo-HCT). Lysosomal acid lipase (LAL) mediates the intrinsic lipolysis of cells to generate free fatty acids (FFAs), which play an essential role in the development, proliferation, and function of T cells. Here, we f...

journal_title：Cell reports

authors： Nguyen HD,Ticer T,Bastian D,Kuril S,Li H,Du H,Yan C,Yu XZ

更新日期：2020-10-27 00:00:00

abstract：:The architecture of renal glomeruli is acquired through intricate and still poorly understood developmental steps. In our study we identify a crucial glomerular morphogenetic event in nephrogenesis that drives the remodeling/separation of the prospective vascular pole (the future entrance of the glomerular arterioles)...

journal_title：Cell reports

authors： Fiorentino A,Christophorou A,Massa F,Garbay S,Chiral M,Ramsing M,Rasmussen M,Gubler MC,Bessieres B,Heidet L,Fischer E,Pontoglio M

更新日期：2020-10-27 00:00:00

abstract：:G9a is a lysine methyltransferase that regulates epigenetic modifications, transcription, and genome organization. However, whether these properties are dependent on one another or represent distinct functions of G9a remains unclear. In this study, we observe widespread DNA methylation loss in G9a depleted and catalyt...

journal_title：Cell reports

authors： Jiang Q,Ang JYJ,Lee AY,Cao Q,Li KY,Yip KY,Leung DCY

更新日期：2020-10-27 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is a well-established risk factor for cardiovascular mortality worldwide. Although hypertrophy is traditionally regarded as an adaptive response to physiological or pathological stress, prolonged hypertrophy can lead to heart failure. Here we demonstrate that Prdm16 is dispensable for...

journal_title：Cell reports

authors： Cibi DM,Bi-Lin KW,Shekeran SG,Sandireddy R,Tee N,Singh A,Wu Y,Srinivasan DK,Kovalik JP,Ghosh S,Seale P,Singh MK

更新日期：2020-10-20 00:00:00

abstract：:The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration of cell proliferation and apoptosis. How this pathway triggers cell apoptosis remains largely unexplored. Here, we identify NR4A1 as a target of the Hippo pathway that mediates the pro-apoptotic and anti-tumor effects of the Hipp...

journal_title：Cell reports

authors： He L,Yuan L,Yu W,Sun Y,Jiang D,Wang X,Feng X,Wang Z,Xu J,Yang R,Zhang W,Feng H,Chen HZ,Zeng YA,Hui L,Wu Q,Zhang Y,Zhang L

更新日期：2020-10-20 00:00:00

abstract：:Fragile X mental retardation protein (FMRP) promotes cyclic AMP (cAMP) signaling. Using an in vivo protein kinase A activity sensor (PKA-SPARK), we find that Drosophila FMRP (dFMRP) and human FMRP (hFMRP) enhance PKA activity in a central brain learning and memory center. Increasing neuronal PKA activity suppresses FM...

journal_title：Cell reports

authors： Sears JC,Broadie K

更新日期：2020-10-13 00:00:00

abstract：:Major depressive disorder is associated with weight loss and decreased appetite; however, the signaling that connects these conditions is unclear. Here, we show that MC4R signaling in the dorsal raphe nucleus (DRN) affects feeding, anxiety, and depression. DRN infusion of α-MSH decreases DRN neuronal activation and fe...

journal_title：Cell reports

authors： Bruschetta G,Jin S,Liu ZW,Kim JD,Diano S

更新日期：2020-10-13 00:00:00

abstract：:Here, we ask how neural stem cells (NSCs) transition in the developing neocortex from a rapidly to a slowly proliferating state, a process required to maintain lifelong stem cell pools. We identify LRIG1, known to regulate receptor tyrosine kinase signaling in other cell types, as a negative regulator of cortical NSC ...

journal_title：Cell reports

authors： Jeong D,Lozano Casasbuenas D,Gengatharan A,Edwards K,Saghatelyan A,Kaplan DR,Miller FD,Yuzwa SA

更新日期：2020-10-13 00:00:00