A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.

abstract：:RIP1 is a central mediator of cell death in response to cell stress but can also mediate cell survival by activating NF-κB. Here, we show that RIP1 acts as a switch in EGFR signaling. EGFRvIII is an oncogenic mutant that does not bind ligand and is coexpressed with EGFRWT in glioblastoma multiforme (GBM). EGFRvIII rec...

journal_title：Cell reports

authors： Puliyappadamba VT,Chakraborty S,Chauncey SS,Li L,Hatanpaa KJ,Mickey B,Noorani S,Shu HK,Burma S,Boothman DA,Habib AA

更新日期：2013-08-29 00:00:00

abstract：:Replication of a damaged DNA template can threaten the integrity of the genome, requiring the use of various mechanisms to tolerate DNA lesions. The Smc5/6 complex, together with the Nse2/Mms21 SUMO ligase, plays essential roles in genome stability through undefined tasks at damaged replication forks. Various subunits...

journal_title：Cell reports

authors： Zapatka M,Pociño-Merino I,Heluani-Gahete H,Bermúdez-López M,Tarrés M,Ibars E,Solé-Soler R,Gutiérrez-Escribano P,Apostolova S,Casas C,Aragon L,Wellinger R,Colomina N,Torres-Rosell J

更新日期：2019-12-03 00:00:00

abstract：:Although transcription factors are prevalent among yeast prion proteins, the role of prion-mediated transcriptional regulation remains elusive. Here, we show that the yeast prion [SWI(+)] abolishes flocculin (FLO) gene expression and results in a complete loss of multicellularity. Further investigation demonstrates th...

journal_title：Cell reports

authors： Du Z,Zhang Y,Li L

更新日期：2015-12-29 00:00:00

abstract：:The epithelial-specific splicing regulators Esrp1 and Esrp2 are required for mammalian development, including establishment of epidermal barrier functions. However, the mechanisms by which Esrp ablation causes defects in epithelial barriers remain undefined. We determined that the ablation of Esrp1 and Esrp2 impairs e...

journal_title：Cell reports

authors： Lee S,Cieply B,Yang Y,Peart N,Glaser C,Chan P,Carstens RP

更新日期：2018-11-27 00:00:00

abstract：:Building an integrated view of cellular responses to environmental cues remains a fundamental challenge due to the complexity of intracellular networks in mammalian cells. Here, we introduce an integrative biochemical and genetic framework to dissect signal transduction events using multiple data types and, in particu...

journal_title：Cell reports

authors： Mertins P,Przybylski D,Yosef N,Qiao J,Clauser K,Raychowdhury R,Eisenhaure TM,Maritzen T,Haucke V,Satoh T,Akira S,Carr SA,Regev A,Hacohen N,Chevrier N

更新日期：2017-06-27 00:00:00

abstract：:Riboswitches are mRNA elements regulating gene expression in response to direct binding of a metabolite. While these RNAs are increasingly well understood with respect to interactions between receptor domains and their cognate effector molecules, little is known about the specific mechanistic relationship between meta...

journal_title：Cell reports

authors： Polaski JT,Holmstrom ED,Nesbitt DJ,Batey RT

更新日期：2016-05-03 00:00:00

abstract：:Large-scale, cooperative rearrangements underlie the functions of RNA in RNA-protein machines and gene regulation. To understand how such rearrangements are orchestrated, we used high-throughput chemical footprinting to dissect a seemingly concerted rearrangement in P5abc RNA, a paradigm of RNA folding studies. With m...

journal_title：Cell reports

authors： Gracia B,Al-Hashimi HM,Bisaria N,Das R,Herschlag D,Russell R

更新日期：2018-03-20 00:00:00

abstract：:Recently developed brain stimulation techniques have significantly advanced our ability to manipulate the brain's function. However, stimulating specific neurons in a desired region without significant surgical invasion remains a challenge. Here, we demonstrate a neuron-specific and region-targeted neural excitation s...

journal_title：Cell reports

authors： Qiu Z,Kala S,Guo J,Xian Q,Zhu J,Zhu T,Hou X,Wong KF,Yang M,Wang H,Sun L

更新日期：2020-08-18 00:00:00

abstract：:This study evaluates HIV antibody responses and their evolution during the course of HIV infection. A phage display system is used to characterize antibody binding to >3,300 HIV peptides in 57 adults with early- to late-stage infection. We find that the number of unique epitopes targeted ("antibody breadth") increases...

journal_title：Cell reports

authors： Eshleman SH,Laeyendecker O,Kammers K,Chen A,Sivay MV,Kottapalli S,Sie BM,Yuan T,Monaco DR,Mohan D,Wansley D,Kula T,Morrison C,Elledge SJ,Brookmeyer R,Ruczinski I,Larman HB

更新日期：2019-04-30 00:00:00

abstract：:PIWI-interacting RNAs (piRNAs) protect the genome from transposons in animal gonads. Maelstrom (Mael) is an evolutionarily conserved protein, composed of a high-mobility group (HMG) domain and a MAEL domain, and is essential for piRNA-mediated transcriptional transposon silencing in various species, such as Drosophila...

journal_title：Cell reports

authors： Matsumoto N,Sato K,Nishimasu H,Namba Y,Miyakubi K,Dohmae N,Ishitani R,Siomi H,Siomi MC,Nureki O

更新日期：2015-04-21 00:00:00

abstract：:Spinal cord longitudinal axons comprise some of the longest axons in our body. However, mechanisms that drive this extra long-distance axonal growth are largely unclear. We found that ascending axons of rapidly adapting (RA) mechanoreceptors closely abut a previously undescribed population of roof plate-derived radial...

journal_title：Cell reports

authors： Kridsada K,Niu J,Haldipur P,Wang Z,Ding L,Li JJ,Lindgren AG,Herrera E,Thomas GM,Chizhikov VV,Millen KJ,Luo W

更新日期：2018-06-05 00:00:00

abstract：:The newest classes of anti-diabetic agents include sodium-glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide 1 receptor (GLP1R) agonists. The SGLT2 inhibitor dapagliflozin reduces glucotoxicity by glycosuria but elevates glucagon secretion. The GLP1R agonist liraglutide inhibits glucagon; therefore, ...

journal_title：Cell reports

authors： Saponaro C,Gmyr V,Thévenet J,Moerman E,Delalleau N,Pasquetti G,Coddeville A,Quenon A,Daoudi M,Hubert T,Vantyghem MC,Bousquet C,Martineau Y,Kerr-Conte J,Staels B,Pattou F,Bonner C

更新日期：2019-08-06 00:00:00

abstract：:The twin-ATPase ABCE1 has a vital function in mRNA translation by recycling terminated or stalled ribosomes. As for other functionally distinct ATP-binding cassette (ABC) proteins, the mechanochemical coupling of ATP hydrolysis to conformational changes remains elusive. Here, we use an integrated biophysical approach ...

journal_title：Cell reports

authors： Gouridis G,Hetzert B,Kiosze-Becker K,de Boer M,Heinemann H,Nürenberg-Goloub E,Cordes T,Tampé R

更新日期：2019-07-16 00:00:00

abstract：:FAM46C is a non-canonical poly(A) polymerase uniquely mutated in up to 20% of multiple myeloma (MM) patients, implying a tissue-specific tumor suppressor function. Here, we report that FAM46C selectively stabilizes mRNAs encoding endoplasmic reticulum (ER)-targeted proteins, thereby concertedly enhancing the expressio...

journal_title：Cell reports

authors： Fucci C,Resnati M,Riva E,Perini T,Ruggieri E,Orfanelli U,Paradiso F,Cremasco F,Raimondi A,Pasqualetto E,Nuvolone M,Rampoldi L,Cenci S,Milan E

更新日期：2020-09-22 00:00:00

abstract：:The rate at which genomes diverge during speciation is unknown, as are the physical dynamics of the process. Here, we compare full genome sequences of 32 butterflies, representing five species from a hybridizing Heliconius butterfly community, to examine genome-wide patterns of introgression and infer how divergence e...

journal_title：Cell reports

authors： Kronforst MR,Hansen ME,Crawford NG,Gallant JR,Zhang W,Kulathinal RJ,Kapan DD,Mullen SP

更新日期：2013-11-14 00:00:00

abstract：:Meiotic progression in S. pombe is regulated by stage-specific gene expression and translation, changes in RNA stability, expression of anti-sense transcripts, and targeted proteolysis of regulatory proteins. We have used SILAC labeling to examine the relative levels of proteins in diploid S. pombe cells during meiosi...

journal_title：Cell reports

authors： Krapp A,Hamelin R,Armand F,Chiappe D,Krapp L,Cano E,Moniatte M,Simanis V

更新日期：2019-01-22 00:00:00

abstract：:Antimitotic agents, including Taxol, disrupt microtubule dynamics and cause a protracted mitotic arrest and subsequent cell death. Despite the broad utility of these drugs in breast cancer and other tumor types, clinical response remains variable. Tumor-associated macrophages (TAMs) suppress the duration of Taxol-indu...

journal_title：Cell reports

authors： Olson OC,Kim H,Quail DF,Foley EA,Joyce JA

更新日期：2017-04-04 00:00:00

abstract：:We provide a catalog for the effects of the human kinome on cell survival in response to DNA-damaging agents, covering all major DNA repair pathways. By treating 313 kinase-deficient cell lines with ten diverse DNA-damaging agents, including seven commonly used chemotherapeutics, we identified examples of vulnerabilit...

journal_title：Cell reports

authors： Owusu M,Bannauer P,Ferreira da Silva J,Mourikis TP,Jones A,Májek P,Caldera M,Wiedner M,Lardeau CH,Mueller AC,Menche J,Kubicek S,Ciccarelli FD,Loizou JI

更新日期：2019-01-15 00:00:00

abstract：:The NLRP3 inflammasome, a critical component of the innate immune system, induces caspase-1 activation and interleukin (IL)-1β maturation in response to microbial infection and cellular damage. However, aberrant activation of the NLRP3 inflammasome contributes to the pathogenesis of several inflammatory disorders, inc...

journal_title：Cell reports

authors： Duan Y,Zhang L,Angosto-Bazarra D,Pelegrín P,Núñez G,He Y

更新日期：2020-11-17 00:00:00

abstract：:Despite the significance for fetal nourishment in mammals, mechanisms of umbilical cord vascular growth remain poorly understood. Here, the secreted metalloprotease ADAMTS9 is shown to be necessary for murine umbilical cord vascular development. Restricting it to the cell surface using a gene trap allele, Adamts9(Gt),...

journal_title：Cell reports

authors： Nandadasa S,Nelson CM,Apte SS

更新日期：2015-06-16 00:00:00

abstract：:Neurogenesis continues in the ventricular-subventricular zone (V-SVZ) of the adult forebrain from quiescent neural stem cells (NSCs). V-SVZ NSCs are a reservoir for new olfactory bulb (OB) neurons that migrate through the rostral migratory stream (RMS). To generate neurons, V-SVZ NSCs need to activate and enter the ce...

journal_title：Cell reports

authors： Engler A,Rolando C,Giachino C,Saotome I,Erni A,Brien C,Zhang R,Zimber-Strobl U,Radtke F,Artavanis-Tsakonas S,Louvi A,Taylor V

更新日期：2018-01-23 00:00:00

abstract：:Transient receptor potential (TRP) channels are regulated by diverse stimuli comprising thermal, chemical, and mechanical modalities. They are also commonly regulated by phosphatidylinositol-4,5-bisphosphate (PIP2), with underlying mechanisms largely unknown. We here revealed an intramolecular interaction of the TRPP3...

journal_title：Cell reports

authors： Zheng W,Cai R,Hofmann L,Nesin V,Hu Q,Long W,Fatehi M,Liu X,Hussein S,Kong T,Li J,Light PE,Tang J,Flockerzi V,Tsiokas L,Chen XZ

更新日期：2018-02-06 00:00:00

abstract：:Large cohorts of human induced pluripotent stem cells (iPSCs) from healthy donors are a potentially powerful tool for investigating the relationship between genetic variants and cellular behavior. Here, we integrate high content imaging of cell shape, proliferation, and other phenotypes with gene expression and DNA se...

journal_title：Cell reports

authors： Vigilante A,Laddach A,Moens N,Meleckyte R,Leha A,Ghahramani A,Culley OJ,Kathuria A,Hurling C,Vickers A,Wiseman E,Tewary M,Zandstra PW,HipSci Consortium.,Durbin R,Fraternali F,Stegle O,Birney E,Luscombe NM,Danovi D,

更新日期：2019-02-19 00:00:00

abstract：:Lysosomes play a critical role in maintenance of the integrity of neuronal function, and mutations in genes that contribute to lysosome formation, transport, and activity are associated with neurodegenerative disorders. Recently, the multisubunit complex, BLOC-one-related complex (BORC), has been shown to be involved ...

journal_title：Cell reports

authors： Snouwaert JN,Church RJ,Jania L,Nguyen M,Wheeler ML,Saintsing A,Mieczkowski P,Manuel de Villena FP,Armao D,Moy SS,Lorenzo DN,Koller BH

更新日期：2018-07-31 00:00:00

abstract：:Hypoxia-inducible factors (HIFs) are crucial for cellular and organismal adaptation to hypoxia. The mitochondrial respiratory chain is the largest consumer of oxygen in most mammalian cells; however, it is unknown whether the respiratory chain is necessary for in vivo activation of HIFs and organismal adaptation to hy...

journal_title：Cell reports

authors： Hamanaka RB,Weinberg SE,Reczek CR,Chandel NS

更新日期：2016-04-19 00:00:00

abstract：:The translation initiation repressor 4E-BP2 is deamidated in the brain on asparagines N99/N102 during early postnatal brain development. This post-translational modification enhances 4E-BP2 association with Raptor, a central component of mTORC1 and alters the kinetics of excitatory synaptic transmission. We show that ...

journal_title：Cell reports

authors： Kouloulia S,Hallin EI,Simbriger K,Amorim IS,Lach G,Amvrosiadis T,Chalkiadaki K,Kampaite A,Truong VT,Hooshmandi M,Jafarnejad SM,Skehel P,Kursula P,Khoutorsky A,Gkogkas CG

更新日期：2019-12-10 00:00:00

abstract：:Bacterial genes that change in expression upon environmental disturbance have commonly been seen as those that must also phenotypically matter. However, several studies suggest that differentially expressed genes are rarely phenotypically important. We demonstrate, for Gram-positive and Gram-negative bacteria, that th...

journal_title：Cell reports

authors： Jensen PA,Zhu Z,van Opijnen T

更新日期：2017-08-15 00:00:00

abstract：:Specific cellular fates and functions depend on differential gene expression, which occurs primarily at the transcriptional level and is controlled by complex regulatory networks of transcription factors (TFs). TFs act through combinatorial interactions with other TFs, cofactors, and chromatin-remodeling proteins. Her...

journal_title：Cell reports

authors： Rhee DY,Cho DY,Zhai B,Slattery M,Ma L,Mintseris J,Wong CY,White KP,Celniker SE,Przytycka TM,Gygi SP,Obar RA,Artavanis-Tsakonas S

更新日期：2014-09-25 00:00:00

abstract：:The innate immune system plays key roles in tissue regeneration. For example, microglia promote neurogenesis in Müller glia in birds and fish after injury. Although mammalian retina does not normally regenerate, neurogenesis can be induced in mouse Müller glia by Ascl1, a proneural transcription factor. We show that i...

journal_title：Cell reports

authors： Todd L,Finkbeiner C,Wong CK,Hooper MJ,Reh TA

更新日期：2020-12-15 00:00:00

abstract：:Mutations in WNK kinases cause the human hypertensive disease pseudohypoaldosteronism type II (PHAII), but the regulatory mechanisms of the WNK kinases are not well understood. Mutations in kelch-like 3 (KLHL3) and Cullin3 were also recently identified as causing PHAII. Therefore, new insights into the mechanisms of h...

journal_title：Cell reports

authors： Wakabayashi M,Mori T,Isobe K,Sohara E,Susa K,Araki Y,Chiga M,Kikuchi E,Nomura N,Mori Y,Matsuo H,Murata T,Nomura S,Asano T,Kawaguchi H,Nonoyama S,Rai T,Sasaki S,Uchida S

更新日期：2013-03-28 00:00:00