Abstract：
:Engrailed homeoproteins are expressed in adult dopaminergic neurons of the substantia nigra. In Engrailed1 heterozygous mice, these neurons start dying at 6 weeks, are more sensitive to oxidative stress, and progressively develop traits similar to those observed following an acute and strong oxidative stress inflected to wild-type neurons. These changes include DNA strand breaks and the modification (intensity and distribution) of several nuclear and nucleolar heterochromatin marks. Engrailed1 and Engrailed2 are biochemically equivalent transducing proteins previously used to antagonize dopaminergic neuron death in Engrailed1 heterozygous mice and in mouse models of Parkinson disease. Accordingly, we show that, following an acute oxidative stress, a single Engrailed2 injection restores all nuclear and nucleolar heterochromatin marks, decreases the number of DNA strand breaks, and protects dopaminergic neurons against apoptosis.
journal_name
Cell Repjournal_title
Cell reportsauthors
Rekaik H,Blaudin de Thé FX,Fuchs J,Massiani-Beaudoin O,Prochiantz A,Joshi RLdoi
10.1016/j.celrep.2015.08.076subject
Has Abstractpub_date
2015-10-13 00:00:00pages
242-50issue
2issn
2211-1247pii
S2211-1247(15)00989-4journal_volume
13pub_type
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