Abstract：
:The achievement of the final form of an individual requires not only the control of cell size and differentiation but also integrative directional cues to instruct cell movements, positions, and orientations. In Drosophila, the adult epidermis of the abdomen is created de novo by histoblasts. As these expand and fuse, they uniformly orient along the anteroposterior axis. We found that the Dachsous/Fat/Four-jointed (Ds/Ft/Fj) pathway is key for their alignment. The refinement of the tissue-wide expression of the atypical cadherins Ds and Ft result in their polarization and directional adhesiveness. Mechanistically, the axially oriented changes in histoblasts respond to the redesign of the epithelial field. We suggest that the role of Ds/Ft/Fj in long-range oriented cell alignment is a general function and that the regulation of the expression of its components will be crucial in other morphogenetic models or during tissue repair.
journal_name
Cell Repjournal_title
Cell reportsauthors
Mangione F,Martín-Blanco Edoi
10.1016/j.celrep.2018.11.036subject
Has Abstractpub_date
2018-12-04 00:00:00pages
2836-2850.e4issue
10issn
2211-1247pii
S2211-1247(18)31799-6journal_volume
25pub_type
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