From Retina to Stem Cell and Back Again: Memories of a Chromatin Journey.

abstract：:Zinc-finger E-box binding homeobox 1 (Zeb1) is a key regulator of epithelial-mesenchymal transition and cancer metastasis. Mutation of ZEB1 is associated with human diseases and defective brain development. Here we show that downregulation of Zeb1 expression in embryonic cortical neural progenitor cells (NPCs) is nece...

journal_title：Cell reports

authors： Wang H,Xiao Z,Zheng J,Wu J,Hu XL,Yang X,Shen Q

更新日期：2019-05-21 00:00:00

abstract：:In mammalian skin, Merkel cells are mechanoreceptor cells that are required for the perception of gentle touch. Recent evidence indicates that mature Merkel cells descend from the proliferative layer of skin epidermis; however, the stem cell niche for Merkel cell homeostasis has not been reported. Here, we provide gen...

journal_title：Cell reports

authors： Doucet YS,Woo SH,Ruiz ME,Owens DM

更新日期：2013-06-27 00:00:00

abstract：:Activation of phosphoinositide 3-kinase (PI3K) signaling plays a central role in regulating proliferation and survival of B cells. Here, we tested the hypothesis that B cell receptor (BCR)-mediated activation of PI3K induces the terminal differentiation factor Blimp-1 that interferes with proliferation and survival, t...

journal_title：Cell reports

authors： Setz CS,Hug E,Khadour A,Abdelrasoul H,Bilal M,Hobeika E,Jumaa H

更新日期：2018-07-10 00:00:00

abstract：:Isotope-based assessment of metabolic flux is achieved through a judicious balance of measurements and assumptions. Recent publications debate the validity of key assumptions used to model stable isotope labeling of liver metabolism in vivo. Here, we examine the controversy surrounding estimates of liver citric acid c...

journal_title：Cell reports

authors： Hasenour CM,Rahim M,Young JD

更新日期：2020-08-04 00:00:00

abstract：:Dietary nutrients interact with gene networks to orchestrate adaptive responses during metabolic stress. Here, we identify Baf60a as a diet-sensitive subunit of the SWI/SNF chromatin-remodeling complexes in the mouse liver that links the consumption of fat- and cholesterol-rich diet to elevated plasma cholesterol leve...

journal_title：Cell reports

authors： Meng ZX,Wang L,Chang L,Sun J,Bao J,Li Y,Chen YE,Lin JD

更新日期：2015-11-24 00:00:00

abstract：:Alzheimer's disease (AD) is associated with the intracellular aggregation of hyperphosphorylated tau and the accumulation of β-amyloid in the neocortex. We use transgenic mice harboring human tau (rTg4510) and amyloid precursor protein (J20) mutations to investigate transcriptional changes associated with the progress...

journal_title：Cell reports

authors： Castanho I,Murray TK,Hannon E,Jeffries A,Walker E,Laing E,Baulf H,Harvey J,Bradshaw L,Randall A,Moore K,O'Neill P,Lunnon K,Collier DA,Ahmed Z,O'Neill MJ,Mill J

更新日期：2020-02-11 00:00:00

abstract：:Kappa opioid receptors (KORs) are involved in a variety of aversive behavioral states, including anxiety. To date, a circuit-based mechanism for KOR-driven anxiety has not been described. Here, we show that activation of KORs inhibits glutamate release from basolateral amygdala (BLA) inputs to the bed nucleus of the s...

journal_title：Cell reports

authors： Crowley NA,Bloodgood DW,Hardaway JA,Kendra AM,McCall JG,Al-Hasani R,McCall NM,Yu W,Schools ZL,Krashes MJ,Lowell BB,Whistler JL,Bruchas MR,Kash TL

更新日期：2016-03-29 00:00:00

abstract：:The brain is a major site of relapse for several cancers, yet deciphering the mechanisms of brain metastasis remains a challenge because of the complexity of the brain tumor microenvironment (TME). To define the molecular landscape of brain metastasis from intact tissue in vivo, we employ an RNA-sequencing-based appro...

journal_title：Cell reports

authors： Wingrove E,Liu ZZ,Patel KD,Arnal-Estapé A,Cai WL,Melnick MA,Politi K,Monteiro C,Zhu L,Valiente M,Kluger HM,Chiang VL,Nguyen DX

更新日期：2019-04-23 00:00:00

abstract：:Transcription factors and chromatin-remodeling complexes are key determinants of embryonic stem cell (ESC) identity. Here, we demonstrate that BRD4, a member of the bromodomain and extraterminal domain (BET) family of epigenetic readers, regulates the self-renewal ability and pluripotency of ESCs. BRD4 inhibition resu...

journal_title：Cell reports

authors： Di Micco R,Fontanals-Cirera B,Low V,Ntziachristos P,Yuen SK,Lovell CD,Dolgalev I,Yonekubo Y,Zhang G,Rusinova E,Gerona-Navarro G,Cañamero M,Ohlmeyer M,Aifantis I,Zhou MM,Tsirigos A,Hernando E

更新日期：2014-10-09 00:00:00

abstract：:Glucagon, the principal hyperglycemic hormone, is secreted from pancreatic islet α cells as part of the counter-regulatory response to hypoglycemia. Hence, secretory output from α cells is under high demand in conditions of low glucose supply. Many tissues oxidize fat as an alternate energy substrate. Here, we show th...

journal_title：Cell reports

authors： Briant LJB,Dodd MS,Chibalina MV,Rorsman NJG,Johnson PRV,Carmeliet P,Rorsman P,Knudsen JG

更新日期：2018-06-12 00:00:00

abstract：:Precise patterns of connectivity are established by different types of afferents on a given target neuron, leading to well-defined and non-overlapping synaptic territories. What regulates the specific characteristics of each type of synapse, in terms of number, morphology, and subcellular localization, remains to be u...

journal_title：Cell reports

authors： Sigoillot SM,Iyer K,Binda F,González-Calvo I,Talleur M,Vodjdani G,Isope P,Selimi F

更新日期：2015-02-10 00:00:00

abstract：:Plant glutamate receptor homologs (GLRs) have long been proposed to function as ligand-gated Ca2+ channels, but no in planta evidence has been provided. Here, we present genetic evidence that Arabidopsis GLR3.1 and GLR3.5 form Ca2+ channels activated by L-methionine (L-Met) at physiological concentrations and regulate...

journal_title：Cell reports

authors： Kong D,Hu HC,Okuma E,Lee Y,Lee HS,Munemasa S,Cho D,Ju C,Pedoeim L,Rodriguez B,Wang J,Im W,Murata Y,Pei ZM,Kwak JM

更新日期：2016-12-06 00:00:00

abstract：:The transmission of malaria parasites to mosquitoes relies on the rapid induction of sexual reproduction upon their ingestion into a blood meal. Haploid female and male gametocytes become activated and emerge from their host cells, and the males enter the cell cycle to produce eight microgametes. The synchronized natu...

journal_title：Cell reports

authors： Invergo BM,Brochet M,Yu L,Choudhary J,Beltrao P,Billker O

更新日期：2017-11-14 00:00:00

abstract：:Biomineralization of the extracellular matrix is an essential, regulated process. Inappropriate mineralization of bone and the vasculature has devastating effects on patient health, yet an integrated understanding of the chemical and cell biological processes that lead to mineral nucleation remains elusive. Here, we r...

journal_title：Cell reports

authors： Müller KH,Hayward R,Rajan R,Whitehead M,Cobb AM,Ahmad S,Sun M,Goldberga I,Li R,Bashtanova U,Puszkarska AM,Reid DG,Brooks RA,Skepper JN,Bordoloi J,Chow WY,Oschkinat H,Groombridge A,Scherman OA,Harrison JA,Verhulst

更新日期：2019-06-11 00:00:00

abstract：:SUMOylation has been implicated in cellular stress adaptation, but its role in regulating liver kinase B1 (LKB1), a major upstream kinase of the energy sensor AMP-activated protein kinase (AMPK), is unknown. Here, we show that energy stress triggers an increase in SUMO1 modification of LKB1, despite a global reduction...

journal_title：Cell reports

authors： Ritho J,Arold ST,Yeh ET

更新日期：2015-08-04 00:00:00

abstract：:Primary afferents transduce environmental stimuli into electrical activity that is transmitted centrally to be decoded into corresponding sensations. However, it remains unknown how afferent populations encode different somatosensory inputs. To address this, we performed two-photon Ca2+ imaging from thousands of dorsa...

journal_title：Cell reports

authors： Wang F,Bélanger E,Côté SL,Desrosiers P,Prescott SA,Côté DC,De Koninck Y

更新日期：2018-05-15 00:00:00

abstract：:Immunoglobulin M (IgM) memory cells undergo differentiation in germinal centers following antigen challenge, but the full effector cell potential of these cells is unknown. We monitored the differentiation of enhanced yellow fluorescent protein (eYFP)-labeled CD11c+ and CD11cneg T-bet+ IgM memory cells after their tra...

journal_title：Cell reports

authors： Kenderes KJ,Levack RC,Papillion AM,Cabrera-Martinez B,Dishaw LM,Winslow GM

更新日期：2018-07-24 00:00:00

abstract：:Over 80% of pancreatic ductal adenocarcinoma (PDA) patients are diagnosed with non-resectable late-stage disease that lacks effective neoadjuvant therapies. Stereotactic body radiation therapy (SBRT) has shown promise as an emerging neoadjuvant approach for treating PDA, and here, we report that its combination with l...

journal_title：Cell reports

authors： Mills BN,Connolly KA,Ye J,Murphy JD,Uccello TP,Han BJ,Zhao T,Drage MG,Murthy A,Qiu H,Patel A,Figueroa NM,Johnston CJ,Prieto PA,Egilmez NK,Belt BA,Lord EM,Linehan DC,Gerber SA

更新日期：2019-10-08 00:00:00

abstract：:Inflammatory bowel disease (IBD) is prevalent, but the mechanisms underlying disease development remain elusive. We identify a role for the E3 ubiquitin ligase RNF5 in IBD. Intestinal epithelial cells (IECs) express a high level of RNF5, while the colon of Rnf5-/- mice exhibits activated dendritic cells and intrinsic ...

journal_title：Cell reports

authors： Fujita Y,Khateb A,Li Y,Tinoco R,Zhang T,Bar-Yoseph H,Tam MA,Chowers Y,Sabo E,Gerassy-Vainberg S,Starosvetsky E,James B,Brown K,Shen-Orr SS,Bradley LM,Tessier PA,Ronai ZA

更新日期：2018-09-18 00:00:00

abstract：:Physicians have observed that surgical wounds in the elderly heal with thinner scars than wounds in young patients. Understanding this phenomenon may reveal strategies for promoting scarless wound repair. We show that full-thickness skin wounds in aged but not young mice fully regenerate. Exposure of aged animals to b...

journal_title：Cell reports

authors： Nishiguchi MA,Spencer CA,Leung DH,Leung TH

更新日期：2018-09-25 00:00:00

abstract：:Exposure to low-dose irradiation causes transiently elevated expression of the long ncRNA PARTICLE (gene PARTICLE, promoter of MAT2A-antisense radiation-induced circulating lncRNA). PARTICLE affords both a cytosolic scaffold for the tumor suppressor methionine adenosyltransferase (MAT2A) and a nuclear genetic platform...

journal_title：Cell reports

authors： O'Leary VB,Ovsepian SV,Carrascosa LG,Buske FA,Radulovic V,Niyazi M,Moertl S,Trau M,Atkinson MJ,Anastasov N

更新日期：2015-04-21 00:00:00

abstract：:A two-step, automated, high-throughput RNAi silencing screen was used to identify host cell factors required during vaccinia virus infection. Validation and analysis of clustered hits revealed previously unknown processes during virus entry, including a mechanism for genome uncoating. Viral core proteins were found to...

journal_title：Cell reports

authors： Mercer J,Snijder B,Sacher R,Burkard C,Bleck CK,Stahlberg H,Pelkmans L,Helenius A

更新日期：2012-10-25 00:00:00

abstract：:Immune checkpoint blockade (ICB) has led to therapeutic responses in some cancer patients for whom no effective treatment previously existed. ICB acts on T lymphocytes and other immune cells that are inactivated due to checkpoint signals that inhibit their infiltration and function within tumors. But for more than 80%...

journal_title：Cell reports

authors： Samanta D,Huang TY,Shah R,Yang Y,Pan F,Semenza GL

更新日期：2020-08-25 00:00:00

abstract：:Recurrent copy-number alterations, mutations, and transcript fusions of the genes encoding CDKs/cyclins are characterized in >10,000 tumors. Genomic alterations of CDKs/cyclins are dominantly driven by copy number aberrations. In contrast to cell-cycle-related CDKs/cyclins, which are globally amplified, transcriptiona...

journal_title：Cell reports

authors： Shan W,Yuan J,Hu Z,Jiang J,Wang Y,Loo N,Fan L,Tang Z,Zhang T,Xu M,Pan Y,Lu J,Long M,Tanyi JL,Montone KT,Fan Y,Hu X,Zhang Y,Zhang L

更新日期：2020-07-14 00:00:00

abstract：:Transcriptional analysis of brain tissue from people with molecularly defined causes of obesity may highlight disease mechanisms and therapeutic targets. We performed RNA sequencing of hypothalamus from individuals with Prader-Willi syndrome (PWS), a genetic obesity syndrome characterized by severe hyperphagia. We fou...

journal_title：Cell reports

authors： Bochukova EG,Lawler K,Croizier S,Keogh JM,Patel N,Strohbehn G,Lo KK,Humphrey J,Hokken-Koelega A,Damen L,Donze S,Bouret SG,Plagnol V,Farooqi IS

更新日期：2018-03-27 00:00:00

abstract：:The recent availability of somatic haploid cell lines has provided a unique tool for genetic studies in mammals. However, the percentage of haploid cells rapidly decreases in these cell lines, which we recently showed is due to their overgrowth by diploid cells present in the cultures. Based on this property, we have ...

journal_title：Cell reports

authors： Olbrich T,Vega-Sendino M,Murga M,de Carcer G,Malumbres M,Ortega S,Ruiz S,Fernandez-Capetillo O

更新日期：2019-07-16 00:00:00

abstract：:In humans, Vγ9Vδ2 T cells respond to self and pathogen-associated, diphosphate-containing isoprenoids, also known as phosphoantigens (pAgs). However, activation and homeostasis of Vγ9Vδ2 T cells remain incompletely understood. Here, we show that pAgs induced expression of the ecto-ATPase CD39, which, however, not only...

journal_title：Cell reports

authors： Gruenbacher G,Gander H,Rahm A,Idzko M,Nussbaumer O,Thurnher M

更新日期：2016-07-12 00:00:00

abstract：:Mcm2-7 helicase is loaded onto double-stranded origin DNA as an inactive double hexamer (DH) in G1 phase. The mechanisms of Mcm2-7 remodeling that trigger helicase activation in S phase remain unknown. Here, we develop an approach to detect and purify the endogenous DHs directly. Through cellular fractionation, we pro...

journal_title：Cell reports

authors： Quan Y,Xia Y,Liu L,Cui J,Li Z,Cao Q,Chen XS,Campbell JL,Lou H

更新日期：2015-12-22 00:00:00

abstract：:Embryonic stem cells (ESCs) exhibit high levels of ribosomal RNA (rRNA) transcription and ribosome biogenesis. Here, we reveal an unexpected role for an essential DEAD-box helicase, DDX18, in antagonizing the polycomb repressive complex 2 (PRC2) to prevent deposition of the repressive H3K27me3 mark onto rDNA in plurip...

journal_title：Cell reports

authors： Zhang H,Wu Z,Lu JY,Huang B,Zhou H,Xie W,Wang J,Shen X

更新日期：2020-01-07 00:00:00

abstract：:The Hippo pathway effectors YAP and TAZ act as nuclear sensors of mechanical signals in response to extracellular matrix (ECM) cues. However, the identity and nature of regulators in the ECM and the precise pathways relaying mechanoresponsive signals into intracellular sensors remain unclear. Here, we uncover a functi...

journal_title：Cell reports

authors： Chakraborty S,Njah K,Pobbati AV,Lim YB,Raju A,Lakshmanan M,Tergaonkar V,Lim CT,Hong W

更新日期：2017-03-07 00:00:00