Abstract：
:Kappa opioid receptors (KORs) are involved in a variety of aversive behavioral states, including anxiety. To date, a circuit-based mechanism for KOR-driven anxiety has not been described. Here, we show that activation of KORs inhibits glutamate release from basolateral amygdala (BLA) inputs to the bed nucleus of the stria terminalis (BNST) and occludes the anxiolytic phenotype seen with optogenetic activation of BLA-BNST projections. In addition, deletion of KORs from amygdala neurons results in an anxiolytic phenotype. Furthermore, we identify a frequency-dependent, optically evoked local dynorphin-induced heterosynaptic plasticity of glutamate inputs in the BNST. We also find that there is cell type specificity to the KOR modulation of the BLA-BNST input with greater KOR-mediated inhibition of BLA dynorphin-expressing neurons. Collectively, these results provide support for a model in which local dynorphin release can inhibit an anxiolytic pathway, providing a discrete therapeutic target for the treatment of anxiety disorders.
journal_name
Cell Repjournal_title
Cell reportsauthors
Crowley NA,Bloodgood DW,Hardaway JA,Kendra AM,McCall JG,Al-Hasani R,McCall NM,Yu W,Schools ZL,Krashes MJ,Lowell BB,Whistler JL,Bruchas MR,Kash TLdoi
10.1016/j.celrep.2016.02.069subject
Has Abstractpub_date
2016-03-29 00:00:00pages
2774-83issue
12issn
2211-1247pii
S2211-1247(16)30204-2journal_volume
14pub_type
杂志文章相关文献
Cell Reports文献大全abstract：:In spinal muscular atrophy, a neurodegenerative disease caused by ubiquitous deficiency in the survival motor neuron (SMN) protein, sensory-motor synaptic dysfunction and increased excitability precede motor neuron (MN) loss. Whether central synaptic dysfunction and MN hyperexcitability are cell-autonomous events or t...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.06.087
更新日期：2016-08-02 00:00:00
abstract：:Most tumor cells exhibit obligatory demands for essential amino acids (EAAs), but the regulatory mechanisms whereby tumor cells take up EAAs and EAAs promote malignant transformation remain to be determined. Here, we show that oncogenic MYC, solute carrier family (SLC) 7 member 5 (SLC7A5), and SLC43A1 constitute a fee...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.12.002
更新日期：2017-12-26 00:00:00
abstract：:Although transcription factors are prevalent among yeast prion proteins, the role of prion-mediated transcriptional regulation remains elusive. Here, we show that the yeast prion [SWI(+)] abolishes flocculin (FLO) gene expression and results in a complete loss of multicellularity. Further investigation demonstrates th...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.11.060
更新日期：2015-12-29 00:00:00
abstract：:Coordinate control of T cell proliferation, survival, and differentiation are essential for host protection from pathogens and cancer. Long-lived memory cells, whose precursors are formed during the initial immunological insult, provide protection from future encounters, and their generation is the goal of many vaccin...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.07.064
更新日期：2019-08-20 00:00:00
abstract：:Silencing of FMR1 and loss of its gene product, FMRP, results in fragile X syndrome (FXS). FMRP binds brain mRNAs and inhibits polypeptide elongation. Using ribosome profiling of the hippocampus, we find that ribosome footprint levels in Fmr1-deficient tissue mostly reflect changes in RNA abundance. Profiling over a t...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.02.076
更新日期：2020-03-31 00:00:00
abstract：:Governance of protein phosphorylation by kinases and phosphatases constitutes an essential regulatory network in eukaryotic cells. Network dysregulation leads to severe consequences and is often a key factor in disease pathogenesis. Previous studies revealed multiple roles for protein phosphorylation and pathway struc...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.10.034
更新日期：2019-11-12 00:00:00
abstract：:The mammalian heart is incapable of regenerating a sufficient number of cardiomyocytes to ameliorate the loss of contractile muscle after acute myocardial injury. Several reports have demonstrated that mononucleated cardiomyocytes are more responsive than are binucleated cardiomyocytes to pro-proliferative stimuli. We...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.02.034
更新日期：2020-03-03 00:00:00
abstract：:The H3K4me3 demethylase Kdm5a regulates gene transcription and is implicated in carcinogenesis. However, the role of Kdm5a in innate immune response remains poorly understood. Here, we demonstrate that Kdm5a deficiency impairs activation of natural killer (NK) cells, with decreased IFN-γ production. Accordingly, Kdm5a...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.03.035
更新日期：2016-04-12 00:00:00
abstract：:Hox genes are required for the development of the intestinal cecum, a major organ of plant-eating species. We have analyzed the transcriptional regulation of Hoxd genes in cecal buds and show that they are controlled by a series of enhancers located in a gene desert flanking the HoxD cluster. The start site of two opp...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.09.002
更新日期：2013-10-17 00:00:00
abstract：:Trimethylated H3K27 (H3K27me3) is associated with transcriptional repression, and its abundance in chromatin is frequently altered in cancer. However, it has remained unclear how genomic regions modified by H3K27me3 are specified and formed. We previously showed that downregulation of transcription by oncogenic Ras si...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.06.034
更新日期：2016-07-19 00:00:00
abstract：:Isotope-based assessment of metabolic flux is achieved through a judicious balance of measurements and assumptions. Recent publications debate the validity of key assumptions used to model stable isotope labeling of liver metabolism in vivo. Here, we examine the controversy surrounding estimates of liver citric acid c...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107986
更新日期：2020-08-04 00:00:00
abstract：:Nutrient transporters can be rapidly removed from the cell surface via substrate-stimulated endocytosis as a way to control nutrient influx, but the molecular underpinnings are not well understood. In this work, we focus on zinc-dependent endocytosis of human ZIP4 (hZIP4), a zinc transporter that is essential for diet...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107582
更新日期：2020-04-28 00:00:00
abstract：:Increased calpain activity is linked to neuroinflammation including a heritable retinal disease caused by hyper-activating mutations in the calcium-activated calpain-5 (CAPN5) protease. Although structures for classical calpains are known, the structure of CAPN5, a non-classical calpain, remains undetermined. Here we ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.12.077
更新日期：2020-01-21 00:00:00
abstract：:In the eukaryotic cell, spliceosomes assemble onto pre-mRNA cotranscriptionally. Spliceosome assembly takes place in the context of the chromatin environment, suggesting that the state of the chromatin may affect splicing. The molecular details and mechanisms through which chromatin affects splicing, however, are stil...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.05.100
更新日期：2019-06-25 00:00:00
abstract：:Deubiquitylases (DUBs) regulate critical signaling pathways at the intersection of host immunity and viral pathogenesis. Although RIG-I activation is heavily dependent on ubiquitylation, systematic analyses of DUBs that regulate this pathway have not been performed. Using a ubiquitin C-terminal electrophile, we profil...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.01.015
更新日期：2020-02-04 00:00:00
abstract：:Phenylalanine-glycine-rich nucleoporins (FG-Nups) are intrinsically disordered proteins, constituting the selective barrier of the nuclear pore complex (NPC). Previous studies showed that nuclear transport receptors (NTRs) were found to interact with FG-Nups by forming an "archetypal-fuzzy" complex through the rapid f...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.03.022
更新日期：2018-03-27 00:00:00
abstract：:Oncogenic Ras plays a key role in cancer initiation but also contributes to malignant phenotypes by stimulating nutrient uptake and promoting invasive migration. Because these latter cellular responses require Rac-mediated remodeling of the actin cytoskeleton, we hypothesized that molecules involved in Rac activation ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.04.016
更新日期：2017-05-02 00:00:00
abstract：:The hallmarks of age-related immune senescence are chronic inflammation, aberrant expansion of effector memory, and loss of naive T lymphocytes due in part to systemic activation of innate immune sensor NLRP3 inflammasome in myeloid lineage cells. The endogenous mechanisms that regulate inflammasome activation during ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.01.044
更新日期：2016-02-23 00:00:00
abstract：:The endoplasmic reticulum (ER) unfolded protein response (UPR(er)) pathway plays an important role in helping pancreatic β cells to adapt their cellular responses to environmental cues and metabolic stress. Although altered UPR(er) gene expression appears in rodent and human type 2 diabetic (T2D) islets, the underlyin...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.03.079
更新日期：2016-05-03 00:00:00
abstract：:Bacterial genes that change in expression upon environmental disturbance have commonly been seen as those that must also phenotypically matter. However, several studies suggest that differentially expressed genes are rarely phenotypically important. We demonstrate, for Gram-positive and Gram-negative bacteria, that th...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.07.062
更新日期：2017-08-15 00:00:00
abstract：:Synapses are fundamental to the normal function of the nervous system. Glia play a pivotal role in regulating synaptic formation. However, how presynaptic neurons assemble synaptic structure in response to the glial signals remains largely unexplored. To address this question, we use cima-1 mutant C. elegans as an in ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.01.102
更新日期：2020-02-25 00:00:00
abstract：:5-methylcytosine (5mC) is converted to 5-hydroxymethylcytosine (5hmC) by the TET family of enzymes as part of a recently discovered active DNA de-methylation pathway. 5hmC plays important roles in regulation of gene expression and differentiation and has been implicated in T cell malignancies and autoimmunity. Here, w...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.05.091
更新日期：2016-07-12 00:00:00
abstract：:Shoot formation is accompanied by active cell proliferation and expansion, requiring that metabolic state adapts to developmental control. Despite the importance of such metabolic reprogramming, it remains unclear how development and metabolism are integrated. Here, we show that disruption of ANGUSTIFOLIA3 orthologs (...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108127
更新日期：2020-09-08 00:00:00
abstract：:The heavy chain IGHV1-69 germline gene exhibits a high level of polymorphism and shows biased use in protective antibody (Ab) responses to infections and vaccines. It is also highly expressed in several B cell malignancies and autoimmune diseases. G6 is an anti-idiotypic monoclonal Ab that selectively binds to IGHV1-6...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.11.056
更新日期：2017-12-12 00:00:00
abstract：:CISD2 is located within the chromosome 4q region frequently deleted in hepatocellular carcinoma (HCC). Mice with Cisd2 heterozygous deficiency develop a phenotype similar to the clinical manifestation of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Cisd2 haploinsufficiency causes a...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.10.099
更新日期：2017-11-21 00:00:00
abstract：:Hepatocyte nuclear factor 4α (HNF4α) is a dimeric transcription factor that controls as much as 60% of all liver genes. However, how it achieves such broad functional diversity is unknown. Here, we show that inflammation and immune pathway genes are differentially regulated in an isoform-dependent manner, confirming t...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.02.033
更新日期：2019-03-05 00:00:00
abstract：:Lung disease is a major cause of death in the United States, with current therapeutic approaches serving only to manage symptoms. The most common chronic and life-threatening genetic disease of the lung is cystic fibrosis (CF) caused by mutations in the cystic fibrosis transmembrane regulator (CFTR). We have generated...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.07.062
更新日期：2015-09-01 00:00:00
abstract：:Schwann cells (SCs) myelinate peripheral neurons to promote the rapid conduction of action potentials, and the process of myelination is known to be regulated by signals from axons to SCs. Given that SC mitochondria are one of the potential regulators of myelination, we investigated whether SC mitochondria are regulat...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.08.039
更新日期：2015-09-29 00:00:00
abstract：:Premature closure of the sutures that connect the cranial bones during development of the mammalian skull results in a phenotype called craniosynostosis. Recently, several craniosynostosis patients with missense mutations within the gene encoding the interleukin-11 receptor (IL-11R) have been described, but the underl...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.09.005
更新日期：2018-10-02 00:00:00
abstract：:The development of non-alcoholic fatty liver disease (NAFLD) is a multiple step process. Here, we show that activation of cdk4 triggers the development of NAFLD. We found that cdk4 protein levels are elevated in mouse models of NAFLD and in patients with fatty livers. This increase leads to C/EBPα phosphorylation on S...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.06.019
更新日期：2016-07-19 00:00:00
