Abstract：
:Bacterial genes that change in expression upon environmental disturbance have commonly been seen as those that must also phenotypically matter. However, several studies suggest that differentially expressed genes are rarely phenotypically important. We demonstrate, for Gram-positive and Gram-negative bacteria, that these seemingly uncoordinated gene sets are involved in responses that can be linked through topological network analysis. However, the level of coordination is stress dependent. While a well-coordinated response is triggered in response to nutrient stress, antibiotics trigger an uncoordinated response in which transcriptionally and phenotypically important genes are neither linked spatially nor in their magnitude. Moreover, a gene expression meta-analysis reveals that genes with large fitness changes during stress have low transcriptional variation across hundreds of other conditions, and vice versa. Our work suggests that cellular responses can be understood through network models that incorporate regulatory and genetic relationships, which could aid drug target predictions and genetic network engineering.
journal_name
Cell Repjournal_title
Cell reportsauthors
Jensen PA,Zhu Z,van Opijnen Tdoi
10.1016/j.celrep.2017.07.062subject
Has Abstractpub_date
2017-08-15 00:00:00pages
1705-1716issue
7issn
2211-1247pii
S2211-1247(17)31041-0journal_volume
20pub_type
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