Neuronal Regulation of Schwann Cell Mitochondrial Ca(2+) Signaling during Myelination.

abstract：:G9a is a lysine methyltransferase that regulates epigenetic modifications, transcription, and genome organization. However, whether these properties are dependent on one another or represent distinct functions of G9a remains unclear. In this study, we observe widespread DNA methylation loss in G9a depleted and catalyt...

journal_title：Cell reports

authors： Jiang Q,Ang JYJ,Lee AY,Cao Q,Li KY,Yip KY,Leung DCY

更新日期：2020-10-27 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) significantly influence the development and regulation of genome expression in cells. Here, we demonstrate the role of lncRNA ceruloplasmin (NRCP) in cancer metabolism and elucidate functional effects leading to increased tumor progression. NRCP was highly upregulated in ovarian tumors, a...

journal_title：Cell reports

authors： Rupaimoole R,Lee J,Haemmerle M,Ling H,Previs RA,Pradeep S,Wu SY,Ivan C,Ferracin M,Dennison JB,Millward NMZ,Nagaraja AS,Gharpure KM,McGuire M,Sam N,Armaiz-Pena GN,Sadaoui NC,Rodriguez-Aguayo C,Calin GA,Drapkin RI,K

更新日期：2015-12-22 00:00:00

abstract：:The p110β isoform of PI3K is preferentially activated in many tumors deficient in the phosphatase and tensin homolog (PTEN). However, the mechanism(s) linking PTEN loss to p110β activation remain(s) mysterious. Here, we identify CRKL as a member of the class of PI3Kβ-interacting proteins. Silencing CRKL expression in ...

journal_title：Cell reports

authors： Zhang J,Gao X,Schmit F,Adelmant G,Eck MJ,Marto JA,Zhao JJ,Roberts TM

更新日期：2017-07-18 00:00:00

abstract：:Eosinophils mediate protection against filarial nematodes. Our results demonstrate that eosinophil extracellular traps (EETosis) are induced by microfilariae and infective L3 larvae of Litomosoides sigmodontis. These extracellular DNA traps inhibit microfilariae motility in a DNA- and contact-dependent manner in vitro...

journal_title：Cell reports

authors： Ehrens A,Lenz B,Neumann AL,Giarrizzo S,Reichwald JJ,Frohberger SJ,Stamminger W,Buerfent BC,Fercoq F,Martin C,Kulke D,Hoerauf A,Hübner MP

更新日期：2021-01-12 00:00:00

abstract：:The development of non-alcoholic fatty liver disease (NAFLD) is a multiple step process. Here, we show that activation of cdk4 triggers the development of NAFLD. We found that cdk4 protein levels are elevated in mouse models of NAFLD and in patients with fatty livers. This increase leads to C/EBPα phosphorylation on S...

journal_title：Cell reports

authors： Jin J,Valanejad L,Nguyen TP,Lewis K,Wright M,Cast A,Stock L,Timchenko L,Timchenko NA

更新日期：2016-07-19 00:00:00

abstract：:Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid up...

journal_title：Cell reports

authors： van den Berg R,Kooijman S,Noordam R,Ramkisoensing A,Abreu-Vieira G,Tambyrajah LL,Dijk W,Ruppert P,Mol IM,Kramar B,Caputo R,Puig LS,de Ruiter EM,Kroon J,Hoekstra M,van der Sluis RJ,Meijer OC,Willems van Dijk K,van Kerk

更新日期：2018-03-27 00:00:00

abstract：:Cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) or directly reprogrammed from non-myocytes (induced cardiomyocytes [iCMs]) are promising sources for heart regeneration or disease modeling. However, the similarities and differences between iPSC-CMs and iCMs are still unknown. Here, we performed tr...

journal_title：Cell reports

authors： Zhou Y,Wang L,Liu Z,Alimohamadi S,Yin C,Liu J,Qian L

更新日期：2017-09-26 00:00:00

abstract：:Let-7 microRNAs (miRNAs) are critical regulators of animal development, stem cell differentiation, glucose metabolism, and tumorigenesis. Mammalian genomes contain 12 let-7 isoforms that suppress expression of a common set of target mRNAs. LIN28 proteins selectively block let-7 biogenesis in undifferentiated cells and...

journal_title：Cell reports

authors： Triboulet R,Pirouz M,Gregory RI

更新日期：2015-10-13 00:00:00

abstract：:Nuclear actin has been elusive due to the lack of knowledge about molecular mechanisms. From actin-containing chromatin remodeling complexes, we discovered an arginine mono-methylation mark on an evolutionarily conserved R256 residue of actin (R256me1). Actin R256 mutations in yeast affect nuclear functions and cause ...

journal_title：Cell reports

authors： Kumar A,Zhong Y,Albrecht A,Sang PB,Maples A,Liu Z,Vinayachandran V,Reja R,Lee CF,Kumar A,Chen J,Xiao J,Park B,Shen J,Liu B,Person MD,Trybus KM,Zhang KYJ,Pugh BF,Kamm KE,Milewicz DM,Shen X,Kapoor P

更新日期：2020-09-29 00:00:00

abstract：:Mural cells (pericytes and vascular smooth muscle cells) are essential for the regulation of vascular networks and maintenance of vascular integrity, but their origins are diverse in different tissues and not known in the organs that arise from the ectoderm, such as skin. Here, we show that tissue-localized myeloid pr...

journal_title：Cell reports

authors： Yamazaki T,Nalbandian A,Uchida Y,Li W,Arnold TD,Kubota Y,Yamamoto S,Ema M,Mukouyama YS

更新日期：2017-03-21 00:00:00

abstract：:Communication between organelles plays key roles in cell biology. In particular, physical and functional coupling of the endoplasmic reticulum (ER) and mitochondria is crucial for regulation of various physiological and pathophysiological processes. Here, we demonstrate that Presenilin 2 (PS2), mutations in which unde...

journal_title：Cell reports

authors： Filadi R,Greotti E,Turacchio G,Luini A,Pozzan T,Pizzo P

更新日期：2016-06-07 00:00:00

abstract：:Pancreatitis is an inflammatory disease of the exocrine pancreas and ranks among the most common gastrointestinal disorders. Inflamed tissues frequently experience conditions of insufficient oxygen availability, or hypoxia. Here, we demonstrate that hypoxia and consequent stabilization of the hypoxia-inducible factor ...

journal_title：Cell reports

authors： Lee KE,Spata M,Maduka R,Vonderheide RH,Simon MC

更新日期：2018-06-19 00:00:00

abstract：:Understanding how p53 activates certain gene programs and not others is critical. Here, we identify low-density lipoprotein receptor-related protein 1 (LRP1), a transmembrane endocytic receptor, as a p53 target gene. We show that, although LRP1 transcript expression is upregulated in response to both sub-lethal and le...

journal_title：Cell reports

authors： Leslie PL,Franklin DA,Liu Y,Zhang Y

更新日期：2018-08-07 00:00:00

abstract：:Ethanol is the most common drug of abuse. It exerts its behavioral effects by acting on widespread neural circuits; however, its impact on glial cells is less understood. We show that Drosophila perineurial glia are critical for ethanol tolerance, a simple form of behavioral plasticity. The perineurial glia form the c...

journal_title：Cell reports

authors： Parkhurst SJ,Adhikari P,Navarrete JS,Legendre A,Manansala M,Wolf FW

更新日期：2018-02-13 00:00:00

abstract：:Learning critically depends on the ability to rapidly form and store non-overlapping representations of the external world. In line with their postulated role in episodic memory, hippocampal place cells can undergo a rapid reorganization of their firing fields upon contextual manipulations. To explore the mechanisms u...

journal_title：Cell reports

authors： Diamantaki M,Coletta S,Nasr K,Zeraati R,Laturnus S,Berens P,Preston-Ferrer P,Burgalossi A

更新日期：2018-04-03 00:00:00

abstract：:Sustained canonical Wnt signaling requires the inhibition of glycogen synthase kinase 3 (GSK3) activity by sequestration of GSK3 inside multivesicular endosomes (MVEs). Here, we show that Wnt signaling is increased by the lysosomal inhibitor chloroquine, which causes accumulation of MVEs. A similar MVE expansion and i...

journal_title：Cell reports

authors： Dobrowolski R,Vick P,Ploper D,Gumper I,Snitkin H,Sabatini DD,De Robertis EM

更新日期：2012-11-29 00:00:00

abstract：:The accumulation of damage caused by oxidative stress has been linked to aging and to the etiology of numerous age-related diseases. The longevity gene, sirtuin 6 (SIRT6), promotes genome stability by facilitating DNA repair, especially under oxidative stress conditions. Here we uncover the mechanism by which SIRT6 is...

journal_title：Cell reports

authors： Van Meter M,Simon M,Tombline G,May A,Morello TD,Hubbard BP,Bredbenner K,Park R,Sinclair DA,Bohr VA,Gorbunova V,Seluanov A

更新日期：2016-09-06 00:00:00

abstract：:Viral persistence specifically inhibits CD4 Th1 responses and promotes Tfh immunity, but the mechanisms that suppress Th1 cells and the disease consequences of their loss are unclear. Here, we demonstrate that the loss of CD4 Th1 cells specifically leads to progressive CD8 T cell decline and dysfunction during viral p...

journal_title：Cell reports

authors： Snell LM,Osokine I,Yamada DH,De la Fuente JR,Elsaesser HJ,Brooks DG

更新日期：2016-09-20 00:00:00

abstract：:The chemokine receptor CCR7 plays a crucial role in the homing of central memory and naive T cells to peripheral lymphoid organs. Here, we show that the HIV-1 accessory protein Vpu downregulates CCR7 on the surface of CD4(+) T cells. Vpu and CCR7 were found to specifically interact and colocalize within the trans-Golg...

journal_title：Cell reports

authors： Ramirez PW,Famiglietti M,Sowrirajan B,DePaula-Silva AB,Rodesch C,Barker E,Bosque A,Planelles V

更新日期：2014-06-26 00:00:00

abstract：:Exercise improves whole-body metabolic health through adaptations to various tissues, including adipose tissue, but the effects of exercise training on the lipidome of white adipose tissue (WAT) and brown adipose tissue (BAT) are unknown. Here, we utilize MS/MSALL shotgun lipidomics to determine the molecular signatur...

journal_title：Cell reports

authors： May FJ,Baer LA,Lehnig AC,So K,Chen EY,Gao F,Narain NR,Gushchina L,Rose A,Doseff AI,Kiebish MA,Goodyear LJ,Stanford KI

更新日期：2017-02-07 00:00:00

abstract：:Plasmodium parasites are highly selective when infecting hepatocytes and induce many changes within the host cell upon infection. While several host cell factors have been identified that are important for liver infection, our understanding of what facilitates the maintenance of infection remains incomplete. Here, we ...

journal_title：Cell reports

authors： Glennon EKK,Austin LS,Arang N,Kain HS,Mast FD,Vijayan K,Aitchison JD,Kappe SHI,Kaushansky A

更新日期：2019-03-19 00:00:00

abstract：:The regulation and functional roles of secreted coding and long noncoding RNAs (lncRNAs; >200 nt) are largely unknown. We previously showed that mutant KRAS colorectal cancer (CRC) cells release extracellular vesicles (EVs) containing distinct proteomes, microRNAs (miRNAs), and circular RNAs. Here, we comprehensively ...

journal_title：Cell reports

authors： Hinger SA,Cha DJ,Franklin JL,Higginbotham JN,Dou Y,Ping J,Shu L,Prasad N,Levy S,Zhang B,Liu Q,Weaver AM,Coffey RJ,Patton JG

更新日期：2018-10-16 00:00:00

abstract：:Hox genes are required for the development of the intestinal cecum, a major organ of plant-eating species. We have analyzed the transcriptional regulation of Hoxd genes in cecal buds and show that they are controlled by a series of enhancers located in a gene desert flanking the HoxD cluster. The start site of two opp...

journal_title：Cell reports

authors： Delpretti S,Montavon T,Leleu M,Joye E,Tzika A,Milinkovitch M,Duboule D

更新日期：2013-10-17 00:00:00

abstract：:During postnatal development, cerebellar climbing fibers alter their innervation strengths onto supernumerary Purkinje cell targets, generating a one-to-few connectivity pattern in adulthood. To get insight about the processes responsible for this remapping, we reconstructed serial electron microscopy datasets from mi...

journal_title：Cell reports

authors： Wilson AM,Schalek R,Suissa-Peleg A,Jones TR,Knowles-Barley S,Pfister H,Lichtman JW

更新日期：2019-11-26 00:00:00

abstract：:Oxytocin and its receptor (Oxtr) play a crucial role in the postnatal transition of neuronal GABA neurotransmission from excitatory to inhibitory, a developmental process known as the GABA switch. Using hippocampal neurons from Oxtr-null mice, we show that (1) Oxtr is necessary for the correct timing of the GABA switc...

journal_title：Cell reports

authors： Leonzino M,Busnelli M,Antonucci F,Verderio C,Mazzanti M,Chini B

更新日期：2016-04-05 00:00:00

abstract：:Mosquito-transmitted malaria parasites infect hepatocytes and asymptomatically replicate as liver stages. Using RNA sequencing, we show that a rodent malaria liver-stage infection stimulates a robust innate immune response including type I interferon (IFN) and IFNγ pathways. Liver-stage infection is suppressed by thes...

journal_title：Cell reports

authors： Miller JL,Sack BK,Baldwin M,Vaughan AM,Kappe SHI

更新日期：2014-04-24 00:00:00

abstract：:The Hedgehog (Hh) and Wnt/β-Catenin (Wnt) cascades are morphogen pathways whose pronounced influence on adult liver metabolism has been identified in recent years. How both pathways communicate and control liver metabolic functions are largely unknown. Detecting core components of Wnt and Hh signaling and mathematical...

journal_title：Cell reports

authors： Kolbe E,Aleithe S,Rennert C,Spormann L,Ott F,Meierhofer D,Gajowski R,Stöpel C,Hoehme S,Kücken M,Brusch L,Seifert M,von Schoenfels W,Schafmayer C,Brosch M,Hofmann U,Damm G,Seehofer D,Hampe J,Gebhardt R,Matz-Soja M

更新日期：2019-12-24 00:00:00

abstract：:RNA viruses have specific mutation rates that balance the conflicting needs of an evolutionary response to host antiviral defenses and avoidance of the error catastrophe. While most mutations are known to originate in replication errors, difficulties of capturing the underlying dynamics have left the mechanochemical b...

journal_title：Cell reports

authors： Dulin D,Vilfan ID,Berghuis BA,Hage S,Bamford DH,Poranen MM,Depken M,Dekker NH

更新日期：2015-02-17 00:00:00

abstract：:Specific cellular fates and functions depend on differential gene expression, which occurs primarily at the transcriptional level and is controlled by complex regulatory networks of transcription factors (TFs). TFs act through combinatorial interactions with other TFs, cofactors, and chromatin-remodeling proteins. Her...

journal_title：Cell reports

authors： Rhee DY,Cho DY,Zhai B,Slattery M,Ma L,Mintseris J,Wong CY,White KP,Celniker SE,Przytycka TM,Gygi SP,Obar RA,Artavanis-Tsakonas S

更新日期：2014-09-25 00:00:00

abstract：:Heterobifunctional proteolysis-targeting chimeric compounds leverage the activity of E3 ligases to induce degradation of target oncoproteins and exhibit potent preclinical antitumor activity. To dissect the mechanisms regulating tumor cell sensitivity to different classes of pharmacological "degraders" of oncoproteins...

journal_title：Cell reports

authors： Shirasaki R,Matthews GM,Gandolfi S,de Matos Simoes R,Buckley DL,Raja Vora J,Sievers QL,Brüggenthies JB,Dashevsky O,Poarch H,Tang H,Bariteau MA,Sheffer M,Hu Y,Downey-Kopyscinski SL,Hengeveld PJ,Glassner BJ,Dhimolea E,O

更新日期：2021-01-05 00:00:00