Abstract：
:The mammalian heart is incapable of regenerating a sufficient number of cardiomyocytes to ameliorate the loss of contractile muscle after acute myocardial injury. Several reports have demonstrated that mononucleated cardiomyocytes are more responsive than are binucleated cardiomyocytes to pro-proliferative stimuli. We have developed a strategy to isolate and characterize highly enriched populations of mononucleated and binucleated cardiomyocytes at various times of development. Our results suggest that an E2f/Rb transcriptional network is central to the divergence of these two populations and that remnants of the differences acquired during the neonatal period remain in adult cardiomyocytes. Moreover, inducing binucleation by genetically blocking the ability of cardiomyocytes to complete cytokinesis leads to a reduction in E2f target gene expression, directly linking the E2f pathway with nucleation. These data identify key molecular differences between mononucleated and binucleated mammalian cardiomyocytes that can be used to leverage cardiomyocyte proliferation for promoting injury repair in the heart.
journal_name
Cell Repjournal_title
Cell reportsauthors
Windmueller R,Leach JP,Babu A,Zhou S,Morley MP,Wakabayashi A,Petrenko NB,Viatour P,Morrisey EEdoi
10.1016/j.celrep.2020.02.034subject
Has Abstractpub_date
2020-03-03 00:00:00pages
3105-3116.e4issue
9issn
2211-1247pii
S2211-1247(20)30195-9journal_volume
30pub_type
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