Interplay of Histone Marks with Serine ADP-Ribosylation.


:Serine ADP-ribosylation (Ser-ADPr) is a recently discovered protein modification that is catalyzed by PARP1 and PARP2 when in complex with the eponymous histone PARylation factor 1 (HPF1). In addition to numerous other targets, core histone tails are primary acceptors of Ser-ADPr in the DNA damage response. Here, we show that specific canonical histone marks interfere with Ser-ADPr of neighboring residues and vice versa. Most notably, acetylation, but not methylation of H3K9, is mutually exclusive with ADPr of H3S10 in vitro and in vivo. We also broaden the O-linked ADPr spectrum by providing evidence for tyrosine ADPr on HPF1 and other proteins. Finally, we facilitate wider investigations into the interplay of histone marks with Ser-ADPr by introducing a simple approach for profiling posttranslationally modified peptides. Our findings implicate Ser-ADPr as a dynamic addition to the complex interplay of modifications that shape the histone code.


Cell Rep


Cell reports


Bartlett E,Bonfiglio JJ,Prokhorova E,Colby T,Zobel F,Ahel I,Matic I




Has Abstract


2018-09-25 00:00:00












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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Guo Y,Wang Y,Wang Q,Wang Z

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  • The touch dome defines an epidermal niche specialized for mechanosensory signaling.

    abstract::In mammalian skin, Merkel cells are mechanoreceptor cells that are required for the perception of gentle touch. Recent evidence indicates that mature Merkel cells descend from the proliferative layer of skin epidermis; however, the stem cell niche for Merkel cell homeostasis has not been reported. Here, we provide gen...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Doucet YS,Woo SH,Ruiz ME,Owens DM

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  • Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment.

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    authors: Lu H,Chen I,Shimoda LA,Park Y,Zhang C,Tran L,Zhang H,Semenza GL

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  • CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse.

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    authors: Dong W,Radulovic T,Goral RO,Thomas C,Suarez Montesinos M,Guerrero-Given D,Hagiwara A,Putzke T,Hida Y,Abe M,Sakimura K,Kamasawa N,Ohtsuka T,Young SM Jr

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    authors: Seth M,Shirayama M,Tang W,Shen EZ,Tu S,Lee HC,Weng Z,Mello CC

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    authors: Vink CS,Calero-Nieto FJ,Wang X,Maglitto A,Mariani SA,Jawaid W,Göttgens B,Dzierzak E

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Sun T,Qiao H,Pan PY,Chen Y,Sheng ZH

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  • Developmental Rewiring between Cerebellar Climbing Fibers and Purkinje Cells Begins with Positive Feedback Synapse Addition.

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Wilson AM,Schalek R,Suissa-Peleg A,Jones TR,Knowles-Barley S,Pfister H,Lichtman JW

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    authors: Fong AP,Yao Z,Zhong JW,Johnson NM,Farr GH 3rd,Maves L,Tapscott SJ

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    pub_type: 杂志文章


    authors: Chaturvedi R,Luan Z,Guo P,Li HS

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    authors: Setz CS,Hug E,Khadour A,Abdelrasoul H,Bilal M,Hobeika E,Jumaa H

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    pub_type: 杂志文章


    authors: Perez-Perri JI,Dengler VL,Audetat KA,Pandey A,Bonner EA,Urh M,Mendez J,Daniels DL,Wappner P,Galbraith MD,Espinosa JM

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    journal_title:Cell reports

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    authors: Didiot MC,Ferguson CM,Ly S,Coles AH,Smith AO,Bicknell AA,Hall LM,Sapp E,Echeverria D,Pai AA,DiFiglia M,Moore MJ,Hayward LJ,Aronin N,Khvorova A

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Parkhurst SJ,Adhikari P,Navarrete JS,Legendre A,Manansala M,Wolf FW

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Huang H,Lindgren A,Wu X,Liu NA,Lin S

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  • Crosstalk between the Rb pathway and AKT signaling forms a quiescence-senescence switch.

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Imai Y,Takahashi A,Hanyu A,Hori S,Sato S,Naka K,Hirao A,Ohtani N,Hara E

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  • Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage.

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Belenky P,Ye JD,Porter CB,Cohen NR,Lobritz MA,Ferrante T,Jain S,Korry BJ,Schwarz EG,Walker GC,Collins JJ

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    pub_type: 杂志文章


    authors: Kang HM,Huang S,Reidy K,Han SH,Chinga F,Susztak K

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Sigoillot SM,Iyer K,Binda F,González-Calvo I,Talleur M,Vodjdani G,Isope P,Selimi F

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Flor-Parra I,Iglesias-Romero AB,Salas-Pino S,Lucena R,Jimenez J,Daga RR

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    abstract::Human rhinovirus (HRV) causes upper respiratory infections and asthma exacerbations. We screened multiple orthologous RNAi reagents and identified host proteins that modulate HRV replication. Here, we show that RNASEK, a transmembrane protein, was needed for the replication of HRV, influenza A virus, and dengue virus....

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Perreira JM,Aker AM,Savidis G,Chin CR,McDougall WM,Portmann JM,Meraner P,Smith MC,Rahman M,Baker RE,Gauthier A,Franti M,Brass AL

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  • p53 Integrates Temporal WDR5 Inputs during Neuroectoderm and Mesoderm Differentiation of Mouse Embryonic Stem Cells.

    abstract::How ubiquitous transcription factors (TFs) coordinate temporal inputs from broadly expressed epigenetic factors to control cell fate remains poorly understood. Here, we uncover a molecular relationship between p53, an abundant embryonic TF, and WDR5, an essential member of the MLL chromatin modifying complex, that reg...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Li Q,Mao F,Zhou B,Huang Y,Zou Z,denDekker AD,Xu J,Hou S,Liu J,Dou Y,Rao RC

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Nobis M,Herrmann D,Warren SC,Kadir S,Leung W,Killen M,Magenau A,Stevenson D,Lucas MC,Reischmann N,Vennin C,Conway JRW,Boulghourjian A,Zaratzian A,Law AM,Gallego-Ortega D,Ormandy CJ,Walters SN,Grey ST,Bailey J,Chta

    更新日期:2017-10-03 00:00:00

  • Post-translational Modifications of OLIG2 Regulate Glioma Invasion through the TGF-β Pathway.

    abstract::In glioblastoma, invasion and proliferation are presumed to be mutually exclusive events; however, the molecular mechanisms that mediate this switch at the cellular level remain elusive. Previously, we have shown that phospho-OLIG2, a central-nervous-system-specific transcription factor, is essential for tumor growth ...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Singh SK,Fiorelli R,Kupp R,Rajan S,Szeto E,Lo Cascio C,Maire CL,Sun Y,Alberta JA,Eschbacher JM,Ligon KL,Berens ME,Sanai N,Mehta S

    更新日期:2016-07-26 00:00:00

  • Antibiotics Disrupt Coordination between Transcriptional and Phenotypic Stress Responses in Pathogenic Bacteria.

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Jensen PA,Zhu Z,van Opijnen T

    更新日期:2017-08-15 00:00:00

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Wei T,Najmi SM,Liu H,Peltonen K,Kucerova A,Schneider DA,Laiho M

    更新日期:2018-04-10 00:00:00

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: King CM,Bohmbach K,Minge D,Delekate A,Zheng K,Reynolds J,Rakers C,Zeug A,Petzold GC,Rusakov DA,Henneberger C

    更新日期:2020-03-10 00:00:00

  • A Positive Twist to the Centromeric Nucleosome.

    abstract::Centromeric nucleosomes are critical for chromosome attachment to the mitotic spindle. In this issue of Cell Reports, Diaz-Ingelmo et al. (2015) propose that the yeast centromeric nucleosome is stabilized by a positively supercoiled loop formed by the sequence-specific CBF3 complex. ...

    journal_title:Cell reports

    pub_type: 评论,杂志文章


    authors: Ocampo J,Clark DJ

    更新日期:2015-10-27 00:00:00