Interplay of Histone Marks with Serine ADP-Ribosylation.


:Serine ADP-ribosylation (Ser-ADPr) is a recently discovered protein modification that is catalyzed by PARP1 and PARP2 when in complex with the eponymous histone PARylation factor 1 (HPF1). In addition to numerous other targets, core histone tails are primary acceptors of Ser-ADPr in the DNA damage response. Here, we show that specific canonical histone marks interfere with Ser-ADPr of neighboring residues and vice versa. Most notably, acetylation, but not methylation of H3K9, is mutually exclusive with ADPr of H3S10 in vitro and in vivo. We also broaden the O-linked ADPr spectrum by providing evidence for tyrosine ADPr on HPF1 and other proteins. Finally, we facilitate wider investigations into the interplay of histone marks with Ser-ADPr by introducing a simple approach for profiling posttranslationally modified peptides. Our findings implicate Ser-ADPr as a dynamic addition to the complex interplay of modifications that shape the histone code.


Cell Rep


Cell reports


Bartlett E,Bonfiglio JJ,Prokhorova E,Colby T,Zobel F,Ahel I,Matic I




Has Abstract


2018-09-25 00:00:00












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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Wang J,Xu L,Shaheen S,Liu S,Zheng W,Sun X,Li Z,Liu W

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Murillo MM,Rana S,Spencer-Dene B,Nye E,Stamp G,Downward J

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Izawa T,Rohatgi N,Fukunaga T,Wang QT,Silva MJ,Gardner MJ,McDaniel ML,Abumrad NA,Semenkovich CF,Teitelbaum SL,Zou W

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    authors: Chen K,Jiao X,Di Rocco A,Shen D,Xu S,Ertel A,Yu Z,Di Sante G,Wang M,Li Z,Pestell TG,Casimiro MC,Skordalakes E,Achilefu S,Pestell RG

    更新日期:2020-09-15 00:00:00

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    authors: Carugo A,Genovese G,Seth S,Nezi L,Rose JL,Bossi D,Cicalese A,Shah PK,Viale A,Pettazzoni PF,Akdemir KC,Bristow CA,Robinson FS,Tepper J,Sanchez N,Gupta S,Estecio MR,Giuliani V,Dellino GI,Riva L,Yao W,Di Francesco

    更新日期:2016-06-28 00:00:00

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    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Süß P,Hoffmann A,Rothe T,Ouyang Z,Baum W,Staszewski O,Schett G,Prinz M,Krönke G,Glass CK,Winkler J,Schlachetzki JCM

    更新日期:2020-03-24 00:00:00