Abstract：
:Polymorphisms that alter serotonin transporter SERT expression and functionality increase the risks for autism and psychiatric traits. Here, we investigate how SERT controls serotonin signaling in developing CNS in mice. SERT is transiently expressed in specific sets of glutamatergic neurons and uptakes extrasynaptic serotonin during perinatal CNS development. We show that SERT expression in glutamatergic thalamocortical axons (TCAs) dictates sensory map architecture. Knockout of SERT in TCAs causes lasting alterations in TCA patterning, spatial organizations of cortical neurons, and dendritic arborization in sensory cortex. Pharmacological reduction of serotonin synthesis during the first postnatal week rescues sensory maps in SERTGluΔ mice. Furthermore, knockdown of SERT expression in serotonin-producing neurons does not impair barrel maps. We propose that spatiotemporal SERT expression in non-serotonin-producing neurons represents a determinant in early life genetic programming of cortical circuits. Perturbing this SERT function could be involved in the origin of sensory and cognitive deficits associated with neurodevelopmental disorders.
journal_name
Cell Repjournal_title
Cell reportsauthors
Chen X,Ye R,Gargus JJ,Blakely RD,Dobrenis K,Sze JYdoi
10.1016/j.celrep.2014.12.033subject
Has Abstractpub_date
2015-01-20 00:00:00pages
346-358issue
3issn
2211-1247pii
S2211-1247(14)01062-6journal_volume
10pub_type
杂志文章相关文献
Cell Reports文献大全abstract：:Metazoan genomes are partitioned into modular chromosomal domains containing active or repressive chromatin. In flies, Polycomb group (PcG) response elements (PREs) recruit PHO and other DNA-binding factors and act as nucleation sites for the formation of Polycomb repressive domains. The sequence specificity of PREs i...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.08.072
更新日期：2014-10-09 00:00:00
abstract：:The central mechanism by which neurotensin (Nts) potentiates weight loss has remained elusive. We leveraged chemogenetics to reveal that Nts-expressing neurons of the lateral hypothalamic area (LHA) promote weight loss in mice by increasing volitional activity and restraining food intake. Intriguingly, these dual weig...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.11.068
更新日期：2017-12-12 00:00:00
abstract：:Major depressive disorder is associated with weight loss and decreased appetite; however, the signaling that connects these conditions is unclear. Here, we show that MC4R signaling in the dorsal raphe nucleus (DRN) affects feeding, anxiety, and depression. DRN infusion of α-MSH decreases DRN neuronal activation and fe...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108267
更新日期：2020-10-13 00:00:00
abstract：:Centromeric nucleosomes are critical for chromosome attachment to the mitotic spindle. In this issue of Cell Reports, Diaz-Ingelmo et al. (2015) propose that the yeast centromeric nucleosome is stabilized by a positively supercoiled loop formed by the sequence-specific CBF3 complex. ...
journal_title：Cell reports
pub_type： 评论,杂志文章
doi：10.1016/j.celrep.2015.10.007
更新日期：2015-10-27 00:00:00
abstract：:Cellular translation surveillance rescues ribosomes that stall on problematic mRNAs. During translation surveillance, endonucleolytic cleavage of the problematic mRNA is a critical step in rescuing stalled ribosomes. Here we identify NONU-1 as a factor required for translation surveillance pathways including no-go and...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.03.023
更新日期：2020-03-31 00:00:00
abstract：:Intratumoral (IT) STING activation results in tumor regression in preclinical models, yet factors dictating the balance between innate and adaptive anti-tumor immunity are unclear. Here, clinical candidate STING agonist ADU-S100 (S100) is used in an IT dosing regimen optimized for adaptive immunity to uncover requirem...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.11.047
更新日期：2018-12-11 00:00:00
abstract：:Over 80% of pancreatic ductal adenocarcinoma (PDA) patients are diagnosed with non-resectable late-stage disease that lacks effective neoadjuvant therapies. Stereotactic body radiation therapy (SBRT) has shown promise as an emerging neoadjuvant approach for treating PDA, and here, we report that its combination with l...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.08.095
更新日期：2019-10-08 00:00:00
abstract：:Synapsin III (SynIII) is a phosphoprotein that is highly expressed at early stages of neuronal development. Whereas in vitro evidence suggests a role for SynIII in neuronal differentiation, in vivo evidence is lacking. Here, we demonstrate that in vivo downregulation of SynIII expression affects neuronal migration and...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.03.022
更新日期：2015-04-14 00:00:00
abstract：:CD4 and CD8 T cells play a pivotal role in controlling tumor growth. However, the interplay of both cell types and their role in tumor suppression still remain elusive. In this study, we investigated the regulation of CD4 and CD8 T cell responses to different classes of tumor-specific antigens in liver cancer mouse mo...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.10.086
更新日期：2016-11-22 00:00:00
abstract：:Humoral immune responses are tailored to the invading pathogen through regulation of key transcription factors and their networks. This is critical to establishing effective antibody-mediated responses, yet it is unknown how B cells integrate pathogen-induced signals to drive or suppress transcriptional programs speci...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.03.060
更新日期：2017-04-18 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating disease that progresses from detachment of motor nerve terminals to complete muscle paralysis and lethal respiratory failure within 5 years of diagnosis. Genetic studies have linked mutations in several genes to ALS, and mice bearing mutations in SOD1 recapitulate h...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2012.08.004
更新日期：2012-09-27 00:00:00
abstract：:As three-dimensional cell culture formats gain in popularity, there emerges a need for tools that produce vast amounts of data on individual cells within the spheroids or organoids. Here, we present a microfluidic platform that provides access to such data by parallelizing the manipulation of individual spheroids with...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107670
更新日期：2020-05-26 00:00:00
abstract：:Spondweni virus (SPOV) is the flavivirus that is most closely related to Zika virus (ZIKV). Although SPOV causes sporadic human infections in Africa, recently it was found in Culex mosquitoes in Haiti. To investigate the pathogenic spectrum of SPOV, we developed infection models in mice. Although two SPOV strains fail...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.01.052
更新日期：2019-02-05 00:00:00
abstract：:The recent success of derivation of mammalian haploid embryonic stem cells (haESCs) has provided a powerful tool for large-scale functional analysis of the mammalian genome. However, haESCs rapidly become diploidized after differentiation, posing challenges for genetic analysis. Here, we show that the spontaneous dipl...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.07.081
更新日期：2017-08-29 00:00:00
abstract：:Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehensive molecular characterization of 19 Hippo core genes in 9,125 tumor samples across 33 cancer types using multidimensional "omic" data from The Cancer Genome Atlas. We identify somatic drivers among Hippo genes and the ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.10.001
更新日期：2018-10-30 00:00:00
abstract：:The NLRP3 inflammasome, a critical component of the innate immune system, induces caspase-1 activation and interleukin (IL)-1β maturation in response to microbial infection and cellular damage. However, aberrant activation of the NLRP3 inflammasome contributes to the pathogenesis of several inflammatory disorders, inc...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108405
更新日期：2020-11-17 00:00:00
abstract：:The development of non-alcoholic fatty liver disease (NAFLD) is a multiple step process. Here, we show that activation of cdk4 triggers the development of NAFLD. We found that cdk4 protein levels are elevated in mouse models of NAFLD and in patients with fatty livers. This increase leads to C/EBPα phosphorylation on S...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.06.019
更新日期：2016-07-19 00:00:00
abstract：:Gambogic acid (GA) is a natural compound derived from Chinese herbs that has been approved by the Chinese Food and Drug Administration for clinical trials in cancer patients; however, its molecular targets have not been thoroughly studied. Here, we report that GA inhibits tumor proteasome activity, with potency compar...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2012.11.023
更新日期：2013-01-31 00:00:00
abstract：:A two-step, automated, high-throughput RNAi silencing screen was used to identify host cell factors required during vaccinia virus infection. Validation and analysis of clustered hits revealed previously unknown processes during virus entry, including a mechanism for genome uncoating. Viral core proteins were found to...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2012.09.003
更新日期：2012-10-25 00:00:00
abstract：:Changes in epigenetic states affect organismal homeostasis, including stress resistance. However, the mechanisms coordinating epigenetic states and systemic stress resistance remain largely unknown. Here, we identify the intestine-to-germline communication of epigenetic states, which intergenerationally enhances stres...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.02.050
更新日期：2020-03-10 00:00:00
abstract：:Evidence suggests that Polycomb (Pc) is present at chromatin loop anchors in Drosophila. Pc is recruited to DNA through interactions with the GAGA binding factors GAF and Pipsqueak (Psq). Using HiChIP in Drosophila cells, we find that the psq gene, which has diverse roles in development and tumorigenesis, encodes dist...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.07.096
更新日期：2019-09-03 00:00:00
abstract：:Traditionally, hippocampal long-term potentiation (LTP) of synaptic strength requires Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) and other kinases, whereas long-term depression (LTD) requires phosphatases. Here, we found that LTD also requires CaMKII and its phospho-T286-induced "autonomous" (Ca(2+)-...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.01.005
更新日期：2014-02-13 00:00:00
abstract：:Emerging evidence suggests that crosstalk between glioma cells and the brain microenvironment may influence brain tumor growth. To date, known reciprocal interactions among these cells have been limited to the release of paracrine factors. Combining a genetic strategy with longitudinal live imaging, we find that indiv...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.01.089
更新日期：2020-02-25 00:00:00
abstract：:One of the most notable characteristics of synaptic transmission is the wide variation in synaptic strength in response to identical stimulation. In hippocampal neurons, approximately one-third of axonal mitochondria are highly motile, and some dynamically pass through presynaptic boutons. This raises a fundamental qu...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.06.040
更新日期：2013-08-15 00:00:00
abstract：:Systemic immune dysregulation contributes to the development of neuropsychiatric and neurodegenerative diseases. The precise effect of chronic peripheral immune stimulation on myeloid cells across anatomical brain regions is unclear. Here, we demonstrate brain-region-specific differences in myeloid responses induced b...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.02.109
更新日期：2020-03-24 00:00:00
abstract：:Within the field of computational neuroscience there are great expectations of finding new ways to rebalance the complex dynamic system of the human brain through controlled pharmacological or electromagnetic perturbation. Yet many obstacles remain between the ability to accurately predict how and where best to pertur...
journal_title：Cell reports
pub_type： 杂志文章,评审
doi：10.1016/j.celrep.2020.108128
更新日期：2020-09-08 00:00:00
abstract：:Dissecting the in vivo host-pathogen interplay is crucial to understanding the molecular mechanisms governing control or progression of intracellular infections. In this work, we explore the in vivo molecular dynamics of Mtb infection by performing dual RNA-seq on Mycobacterium tuberculosis-infected, ontogenetically d...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.12.033
更新日期：2020-01-14 00:00:00
abstract：:The function of regulatory T (Treg) cells depends on lipid oxidation. However, the molecular mechanism by which Treg cells maintain lipid metabolism after activation remains elusive. Liver kinase B1 (LKB1) acts as a coordinator by linking cellular metabolism to substrate AMP-activated protein kinase (AMPK). We show th...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.05.020
更新日期：2019-06-04 00:00:00
abstract：:Loss of NF-κB signaling causes immunodeficiency, whereas inhibition of NF-κB can be efficacious in treating chronic inflammatory disease. Inflammatory NF-κB signaling must therefore be tightly regulated, and although many mechanisms to downregulate NF-κB have been elucidated, there have only been limited studies demon...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.06.050
更新日期：2015-07-28 00:00:00
abstract：:Normal mammalian brain aging is characterized by the selective loss of discrete populations of dendritic spines and synapses, particularly affecting neuroanatomical regions such as the hippocampus. Although previous investigations have quantified this morphologically, the molecular pathways orchestrating preferential ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.03.096
更新日期：2019-04-23 00:00:00
