A Positive Twist to the Centromeric Nucleosome.


:Centromeric nucleosomes are critical for chromosome attachment to the mitotic spindle. In this issue of Cell Reports, Diaz-Ingelmo et al. (2015) propose that the yeast centromeric nucleosome is stabilized by a positively supercoiled loop formed by the sequence-specific CBF3 complex.


Cell Rep


Cell reports


Ocampo J,Clark DJ




Has Abstract


2015-10-27 00:00:00












  • Cortical Polarity of the RING Protein PAR-2 Is Maintained by Exchange Rate Kinetics at the Cortical-Cytoplasmic Boundary.

    abstract::Cell polarity arises through the spatial segregation of polarity regulators. PAR proteins are polarity regulators that localize asymmetrically to two opposing cortical domains. However, it is unclear how the spatially segregated PAR proteins interact to maintain their mutually exclusive partitioning. Here, single-mole...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Arata Y,Hiroshima M,Pack CG,Ramanujam R,Motegi F,Nakazato K,Shindo Y,Wiseman PW,Sawa H,Kobayashi TJ,Brandão HB,Shibata T,Sako Y

    更新日期:2016-08-23 00:00:00

  • Structural Insights into the Unique Activation Mechanisms of a Non-classical Calpain and Its Disease-Causing Variants.

    abstract::Increased calpain activity is linked to neuroinflammation including a heritable retinal disease caused by hyper-activating mutations in the calcium-activated calpain-5 (CAPN5) protease. Although structures for classical calpains are known, the structure of CAPN5, a non-classical calpain, remains undetermined. Here we ...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Velez G,Sun YJ,Khan S,Yang J,Herrmann J,Chemudupati T,MacLaren RE,Gakhar L,Wakatsuki S,Bassuk AG,Mahajan VB

    更新日期:2020-01-21 00:00:00

  • Lineage-Specific and Non-specific Cytokine-Sensing Genes Respond Differentially to the Master Regulator STAT5.

    abstract::STAT5, a member of the family of signal transducers and activators of transcription, senses cytokines and controls the biology of cell lineages, including mammary, liver, and T cells. Here, we show that STAT5 activates lineage-specific and widely expressed genes through different mechanisms. STAT5 preferentially binds...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Zeng X,Willi M,Shin HY,Hennighausen L,Wang C

    更新日期:2016-12-20 00:00:00

  • Identifying Extrinsic versus Intrinsic Drivers of Variation in Cell Behavior in Human iPSC Lines from Healthy Donors.

    abstract::Large cohorts of human induced pluripotent stem cells (iPSCs) from healthy donors are a potentially powerful tool for investigating the relationship between genetic variants and cellular behavior. Here, we integrate high content imaging of cell shape, proliferation, and other phenotypes with gene expression and DNA se...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Vigilante A,Laddach A,Moens N,Meleckyte R,Leha A,Ghahramani A,Culley OJ,Kathuria A,Hurling C,Vickers A,Wiseman E,Tewary M,Zandstra PW,HipSci Consortium.,Durbin R,Fraternali F,Stegle O,Birney E,Luscombe NM,Danovi D,

    更新日期:2019-02-19 00:00:00

  • The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs.

    abstract::The t(8;21) acute myeloid leukemia (AML)-associated oncoprotein AML1-ETO disrupts normal hematopoietic differentiation. Here, we have investigated its effects on the transcriptome and epigenome in t(8,21) patient cells. AML1-ETO binding was found at promoter regions of active genes with high levels of histone acetylat...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Mandoli A,Singh AA,Prange KHM,Tijchon E,Oerlemans M,Dirks R,Ter Huurne M,Wierenga ATJ,Janssen-Megens EM,Berentsen K,Sharifi N,Kim B,Matarese F,Nguyen LN,Hubner NC,Rao NA,van den Akker E,Altucci L,Vellenga E,Stunnenb

    更新日期:2016-11-15 00:00:00

  • Roof Plate-Derived Radial Glial-like Cells Support Developmental Growth of Rapidly Adapting Mechanoreceptor Ascending Axons.

    abstract::Spinal cord longitudinal axons comprise some of the longest axons in our body. However, mechanisms that drive this extra long-distance axonal growth are largely unclear. We found that ascending axons of rapidly adapting (RA) mechanoreceptors closely abut a previously undescribed population of roof plate-derived radial...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Kridsada K,Niu J,Haldipur P,Wang Z,Ding L,Li JJ,Lindgren AG,Herrera E,Thomas GM,Chizhikov VV,Millen KJ,Luo W

    更新日期:2018-06-05 00:00:00

  • Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis.

    abstract::The brain is a major site of relapse for several cancers, yet deciphering the mechanisms of brain metastasis remains a challenge because of the complexity of the brain tumor microenvironment (TME). To define the molecular landscape of brain metastasis from intact tissue in vivo, we employ an RNA-sequencing-based appro...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Wingrove E,Liu ZZ,Patel KD,Arnal-Estapé A,Cai WL,Melnick MA,Politi K,Monteiro C,Zhu L,Valiente M,Kluger HM,Chiang VL,Nguyen DX

    更新日期:2019-04-23 00:00:00

  • Sensory Neuroblast Quiescence Depends on Vascular Cytoneme Contacts and Sensory Neuronal Differentiation Requires Initiation of Blood Flow.

    abstract::In many organs, stem cell function depends on communication with their niche partners. Cranial sensory neurons develop in close proximity to blood vessels; however, whether vasculature is an integral component of their niches is yet unknown. Here, two separate roles for vasculature in cranial sensory neurogenesis in z...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Taberner L,Bañón A,Alsina B

    更新日期:2020-07-14 00:00:00

  • The Coding Regions of Germline mRNAs Confer Sensitivity to Argonaute Regulation in C. elegans.

    abstract::Protein-coding genes undergo a wide array of regulatory interactions with factors that engage non-coding regions. Open reading frames (ORFs), in contrast, are thought to be constrained by coding function, precluding a major role in gene regulation. Here, we explore Piwi-interacting (pi)RNA-mediated transgene silencing...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Seth M,Shirayama M,Tang W,Shen EZ,Tu S,Lee HC,Weng Z,Mello CC

    更新日期:2018-02-27 00:00:00

  • The KRAB Zinc Finger Protein Roma/Zfp157 Is a Critical Regulator of Cell-Cycle Progression and Genomic Stability.

    abstract::Regulation of DNA replication and cell division is essential for tissue growth and maintenance of genomic integrity and is particularly important in tissues that undergo continuous regeneration such as mammary glands. We have previously shown that disruption of the KRAB-domain zinc finger protein Roma/Zfp157 results i...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Ho TLF,Guilbaud G,Blow JJ,Sale JE,Watson CJ

    更新日期:2016-04-26 00:00:00

  • Infection Reveals a Modification of SIRT2 Critical for Chromatin Association.

    abstract::Sirtuin 2 is a nicotinamide-adenine-dinucleotide-dependent deacetylase that regulates cell processes such as carcinogenesis, cell cycle, DNA damage, and infection. Subcellular localization of SIRT2 is crucial for its function but is poorly understood. Infection with the bacterial pathogen Listeria monocytogenes, which...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Pereira JM,Chevalier C,Chaze T,Gianetto Q,Impens F,Matondo M,Cossart P,Hamon MA

    更新日期:2018-04-24 00:00:00

  • Suppression of host p53 is critical for Plasmodium liver-stage infection.

    abstract::Plasmodium parasites infect the liver and replicate inside hepatocytes before they invade erythrocytes and trigger clinical malaria. Analysis of host signaling pathways affected by liver-stage infection could provide critical insights into host-pathogen interactions and reveal targets for intervention. Using protein l...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Kaushansky A,Ye AS,Austin LS,Mikolajczak SA,Vaughan AM,Camargo N,Metzger PG,Douglass AN,MacBeath G,Kappe SH

    更新日期:2013-03-28 00:00:00

  • Individual Control and Quantification of 3D Spheroids in a High-Density Microfluidic Droplet Array.

    abstract::As three-dimensional cell culture formats gain in popularity, there emerges a need for tools that produce vast amounts of data on individual cells within the spheroids or organoids. Here, we present a microfluidic platform that provides access to such data by parallelizing the manipulation of individual spheroids with...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Tomasi RF,Sart S,Champetier T,Baroud CN

    更新日期:2020-05-26 00:00:00

  • Sox9-Positive Progenitor Cells Play a Key Role in Renal Tubule Epithelial Regeneration in Mice.

    abstract::The kidney has a tremendous capacity to regenerate following injury, but factors that govern this response are still largely unknown. We isolated cells from mouse kidneys with high proliferative and multi-lineage differentiation capacity. These cells expressed a high level of Sox9. In regenerating kidneys, Sox9 expres...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Kang HM,Huang S,Reidy K,Han SH,Chinga F,Susztak K

    更新日期:2016-02-02 00:00:00

  • Effect of Human Genetic Variability on Gene Expression in Dorsal Root Ganglia and Association with Pain Phenotypes.

    abstract::Dorsal root ganglia (DRG) relay sensory information to the brain, giving rise to the perception of pain, disorders of which are prevalent and burdensome. Here, we mapped expression quantitative trait loci (eQTLs) in a collection of human DRGs. DRG eQTLs were enriched within untranslated regions of coding genes of low ...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Parisien M,Khoury S,Chabot-Doré AJ,Sotocinal SG,Slade GD,Smith SB,Fillingim RB,Ohrbach R,Greenspan JD,Maixner W,Mogil JS,Belfer I,Diatchenko L

    更新日期:2017-05-30 00:00:00

  • Manipulation of Mitochondria Dynamics Reveals Separate Roles for Form and Function in Mitochondria Distribution.

    abstract::Mitochondria shape is controlled by membrane fusion and fission mediated by mitofusins, Opa1, and Drp1, whereas mitochondrial motility relies on microtubule motors. These processes govern mitochondria subcellular distribution, whose defects are emphasized in neurons because of their polarized structure. We have studie...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Trevisan T,Pendin D,Montagna A,Bova S,Ghelli AM,Daga A

    更新日期:2018-05-08 00:00:00

  • Exosome secretion is enhanced by invadopodia and drives invasive behavior.

    abstract::Unconventional secretion of exosome vesicles from multivesicular endosomes (MVEs) occurs across a broad set of systems and is reported to be upregulated in cancer, where it promotes aggressive behavior. However, regulatory control of exosome secretion is poorly understood. Using cancer cells, we identified specialized...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Hoshino D,Kirkbride KC,Costello K,Clark ES,Sinha S,Grega-Larson N,Tyska MJ,Weaver AM

    更新日期:2013-12-12 00:00:00

  • Immune cell Toll-like receptor 4 mediates the development of obesity- and endotoxemia-associated adipose tissue fibrosis.

    abstract::Adipose tissue fibrosis development blocks adipocyte hypertrophy and favors ectopic lipid accumulation. Here, we show that adipose tissue fibrosis is associated with obesity and insulin resistance in humans and mice. Kinetic studies in C3H mice fed a high-fat diet show activation of macrophages and progression of fibr...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Vila IK,Badin PM,Marques MA,Monbrun L,Lefort C,Mir L,Louche K,Bourlier V,Roussel B,Gui P,Grober J,Štich V,Rossmeislová L,Zakaroff-Girard A,Bouloumié A,Viguerie N,Moro C,Tavernier G,Langin D

    更新日期:2014-05-22 00:00:00

  • Conversion of MyoD to a neurogenic factor: binding site specificity determines lineage.

    abstract::MyoD and NeuroD2, master regulators of myogenesis and neurogenesis, bind to a "shared" E-box sequence (CAGCTG) and a "private" sequence (CAGGTG or CAGATG, respectively). To determine whether private-site recognition is sufficient to confer lineage specification, we generated a MyoD mutant with the DNA-binding specific...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Fong AP,Yao Z,Zhong JW,Johnson NM,Farr GH 3rd,Maves L,Tapscott SJ

    更新日期:2015-03-31 00:00:00

  • Absence of Specific Chlamydia trachomatis Inclusion Membrane Proteins Triggers Premature Inclusion Membrane Lysis and Host Cell Death.

    abstract::Chlamydia trachomatis is a human pathogen associated with significant morbidity worldwide. As obligate intracellular parasites, chlamydiae must survive within eukaryotic cells for sufficient time to complete their developmental cycle. To promote host cell survival, chlamydiae express poorly understood anti-apoptotic f...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Weber MM,Lam JL,Dooley CA,Noriea NF,Hansen BT,Hoyt FH,Carmody AB,Sturdevant GL,Hackstadt T

    更新日期:2017-05-16 00:00:00

  • KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response.

    abstract::The endoplasmic reticulum (ER) unfolded protein response (UPR(er)) pathway plays an important role in helping pancreatic β cells to adapt their cellular responses to environmental cues and metabolic stress. Although altered UPR(er) gene expression appears in rodent and human type 2 diabetic (T2D) islets, the underlyin...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Rabhi N,Denechaud PD,Gromada X,Hannou SA,Zhang H,Rashid T,Salas E,Durand E,Sand O,Bonnefond A,Yengo L,Chavey C,Bonner C,Kerr-Conte J,Abderrahmani A,Auwerx J,Fajas L,Froguel P,Annicotte JS

    更新日期:2016-05-03 00:00:00

  • Nontargeted Metabolomics Reveals the Multilevel Response to Antibiotic Perturbations.

    abstract::Microbes have shown a remarkable ability in evading the killing actions of antimicrobial agents, such that treatment of bacterial infections represents once more an urgent global challenge. Understanding the initial bacterial response to antimicrobials may reveal intrinsic tolerance mechanisms to antibiotics and sugge...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Zampieri M,Zimmermann M,Claassen M,Sauer U

    更新日期:2017-05-09 00:00:00

  • Developmental Apoptosis Promotes a Disease-Related Gene Signature and Independence from CSF1R Signaling in Retinal Microglia.

    abstract::Microglia have important remodeling functions in neurodevelopment, aging, and disease, with evidence for molecular diversity. However, the signaling pathways and environmental cues that drive diverse states of microglia are incompletely understood. We profiled microglia of a discrete developing CNS region, the murine ...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Anderson SR,Roberts JM,Zhang J,Steele MR,Romero CO,Bosco A,Vetter ML

    更新日期:2019-05-14 00:00:00

  • Regulatory T Cells Promote Apelin-Mediated Sprouting Angiogenesis in Type 2 Diabetes.

    abstract::The role of CD4+ T cells in the ischemic tissues of T2D patients remains unclear. Here, we report that T2D patients' vascular density was negatively correlated with the number of infiltrating CD4+ T cells after ischemic injury. Th1 was the predominant subset, and Th1-derived IFN-γ and TNF-α directly impaired human ang...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Leung OM,Li J,Li X,Chan VW,Yang KY,Ku M,Ji L,Sun H,Waldmann H,Tian XY,Huang Y,Lau J,Zhou B,Lui KO

    更新日期:2018-08-07 00:00:00

  • Presenilin deficiency or lysosomal inhibition enhances Wnt signaling through relocalization of GSK3 to the late-endosomal compartment.

    abstract::Sustained canonical Wnt signaling requires the inhibition of glycogen synthase kinase 3 (GSK3) activity by sequestration of GSK3 inside multivesicular endosomes (MVEs). Here, we show that Wnt signaling is increased by the lysosomal inhibitor chloroquine, which causes accumulation of MVEs. A similar MVE expansion and i...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Dobrowolski R,Vick P,Ploper D,Gumper I,Snitkin H,Sabatini DD,De Robertis EM

    更新日期:2012-11-29 00:00:00

  • Post-translational Modifications of OLIG2 Regulate Glioma Invasion through the TGF-β Pathway.

    abstract::In glioblastoma, invasion and proliferation are presumed to be mutually exclusive events; however, the molecular mechanisms that mediate this switch at the cellular level remain elusive. Previously, we have shown that phospho-OLIG2, a central-nervous-system-specific transcription factor, is essential for tumor growth ...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Singh SK,Fiorelli R,Kupp R,Rajan S,Szeto E,Lo Cascio C,Maire CL,Sun Y,Alberta JA,Eschbacher JM,Ligon KL,Berens ME,Sanai N,Mehta S

    更新日期:2016-07-26 00:00:00

  • FEZ1 Is Recruited to a Conserved Cofactor Site on Capsid to Promote HIV-1 Trafficking.

    abstract::HIV-1 uses the microtubule network to traffic the viral capsid core toward the nucleus. Viral nuclear trafficking and infectivity require the kinesin-1 adaptor protein FEZ1. Here, we demonstrate that FEZ1 directly interacts with the HIV-1 capsid and specifically binds capsid protein (CA) hexamers. FEZ1 contains multip...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Huang PT,Summers BJ,Xu C,Perilla JR,Malikov V,Naghavi MH,Xiong Y

    更新日期:2019-08-27 00:00:00

  • Chronic optogenetic activation augments aβ pathology in a mouse model of Alzheimer disease.

    abstract::In vivo experimental evidence indicates that acute neuronal activation increases Aβ release from presynaptic terminals, whereas long-term effects of chronic synaptic activation on Aβ pathology remain unclear. To address this issue, we adopted optogenetics and transduced stabilized step-function opsin, a channelrhodops...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Yamamoto K,Tanei ZI,Hashimoto T,Wakabayashi T,Okuno H,Naka Y,Yizhar O,Fenno LE,Fukayama M,Bito H,Cirrito JR,Holtzman DM,Deisseroth K,Iwatsubo T

    更新日期:2015-05-12 00:00:00

  • ZEB1 Represses Neural Differentiation and Cooperates with CTBP2 to Dynamically Regulate Cell Migration during Neocortex Development.

    abstract::Zinc-finger E-box binding homeobox 1 (Zeb1) is a key regulator of epithelial-mesenchymal transition and cancer metastasis. Mutation of ZEB1 is associated with human diseases and defective brain development. Here we show that downregulation of Zeb1 expression in embryonic cortical neural progenitor cells (NPCs) is nece...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Wang H,Xiao Z,Zheng J,Wu J,Hu XL,Yang X,Shen Q

    更新日期:2019-05-21 00:00:00

  • Non-acylated Wnts Can Promote Signaling.

    abstract::Wnts are a family of 19 extracellular ligands that regulate cell fate, proliferation, and migration during metazoan embryogenesis and throughout adulthood. Wnts are acylated post-translationally at a conserved serine and bind the extracellular cysteine-rich domain (CRD) of Frizzled (FZD) seven-pass transmembrane recep...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Speer KF,Sommer A,Tajer B,Mullins MC,Klein PS,Lemmon MA

    更新日期:2019-01-22 00:00:00