A Positive Twist to the Centromeric Nucleosome.


:Centromeric nucleosomes are critical for chromosome attachment to the mitotic spindle. In this issue of Cell Reports, Diaz-Ingelmo et al. (2015) propose that the yeast centromeric nucleosome is stabilized by a positively supercoiled loop formed by the sequence-specific CBF3 complex.


Cell Rep


Cell reports


Ocampo J,Clark DJ




Has Abstract


2015-10-27 00:00:00












  • Sleep Induction by Mechanosensory Stimulation in Drosophila.

    abstract::People tend to fall asleep when gently rocked or vibrated. Experimental studies have shown that rocking promotes sleep in humans and mice. However, the mechanisms underlying the phenomenon are not well understood. A habituation model proposes that habituation, a form of non-associative learning, mediates sleep inducti...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Öztürk-Çolak A,Inami S,Buchler JR,McClanahan PD,Cruz A,Fang-Yen C,Koh K

    更新日期:2020-12-01 00:00:00

  • Piwi Is a Key Regulator of Both Somatic and Germline Stem Cells in the Drosophila Testis.

    abstract::The Piwi-piRNA pathway is well known for its germline function, yet its somatic role remains elusive. We show here that Piwi is required autonomously not only for germline stem cell (GSC) but also for somatic cyst stem cell (CySC) maintenance in the Drosophila testis. Reducing Piwi activity in the testis caused defect...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Gonzalez J,Qi H,Liu N,Lin H

    更新日期:2015-07-07 00:00:00

  • PHB3 Maintains Root Stem Cell Niche Identity through ROS-Responsive AP2/ERF Transcription Factors in Arabidopsis.

    abstract::The root stem cell niche, which is composed of four mitotically inactive quiescent center (QC) cells and the surrounding actively divided stem cells in Arabidopsis, is critical for growth and root development. Here, we demonstrate that the Arabidopsis prohibitin protein PHB3 is required for the maintenance of root ste...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Kong X,Tian H,Yu Q,Zhang F,Wang R,Gao S,Xu W,Liu J,Shani E,Fu C,Zhou G,Zhang L,Zhang X,Ding Z

    更新日期:2018-01-30 00:00:00

  • Colonic Lysine Homocysteinylation Induced by High-Fat Diet Suppresses DNA Damage Repair.

    abstract::Colorectal cancer (CRC) onset is profoundly affected by Western diet. Here, we report that high-fat (HF) diet-induced, organ-specific colonic lysine homocysteinylation (K-Hcy) increase might promote CRC onset by impeding DNA damage repair. HF chow induced elevated methionyl-tRNA synthetase (MARS) expression and K-Hcy ...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Wang D,Zhao R,Qu YY,Mei XY,Zhang X,Zhou Q,Li Y,Yang SB,Zuo ZG,Chen YM,Lin Y,Xu W,Chen C,Zhao SM,Zhao JY

    更新日期:2018-10-09 00:00:00

  • Dissecting Cell Lineage Specification and Sex Fate Determination in Gonadal Somatic Cells Using Single-Cell Transcriptomics.

    abstract::Sex determination is a unique process that allows the study of multipotent progenitors and their acquisition of sex-specific fates during differentiation of the gonad into a testis or an ovary. Using time series single-cell RNA sequencing (scRNA-seq) on ovarian Nr5a1-GFP+ somatic cells during sex determination, we ide...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Stévant I,Kühne F,Greenfield A,Chaboissier MC,Dermitzakis ET,Nef S

    更新日期:2019-03-19 00:00:00

  • NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression.

    abstract::Cancer stem cells (CSCs) are associated with the refractory nature of cancer, and elucidating the targetable pathways for CSCs is crucial for devising innovative antitumor therapies. We find that the proliferation of CSC-enriched colon spheroids from clinical specimen is dependent on mTORC1 kinase, which is activated ...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Ohata H,Shiokawa D,Obata Y,Sato A,Sakai H,Fukami M,Hara W,Taniguchi H,Ono M,Nakagama H,Okamoto K

    更新日期:2019-07-30 00:00:00

  • A Minimum Epitope Overlap between Infections Strongly Narrows the Emerging T Cell Repertoire.

    abstract::Many infections are caused by pathogens that are similar, but not identical, to previously encountered viruses, bacteria, or vaccines. In such re-infections, pathogens introduce known antigens, which are recognized by memory T cells and new antigens that activate naive T cells. How preexisting memory T cells impact th...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Oberle SG,Hanna-El-Daher L,Chennupati V,Enouz S,Scherer S,Prlic M,Zehn D

    更新日期:2016-10-11 00:00:00

  • Comprehensive Profiling of HIV Antibody Evolution.

    abstract::This study evaluates HIV antibody responses and their evolution during the course of HIV infection. A phage display system is used to characterize antibody binding to >3,300 HIV peptides in 57 adults with early- to late-stage infection. We find that the number of unique epitopes targeted ("antibody breadth") increases...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Eshleman SH,Laeyendecker O,Kammers K,Chen A,Sivay MV,Kottapalli S,Sie BM,Yuan T,Monaco DR,Mohan D,Wansley D,Kula T,Morrison C,Elledge SJ,Brookmeyer R,Ruczinski I,Larman HB

    更新日期:2019-04-30 00:00:00

  • Global Reprogramming of Host SUMOylation during Influenza Virus Infection.

    abstract::Dynamic nuclear SUMO modifications play essential roles in orchestrating cellular responses to proteotoxic stress, DNA damage, and DNA virus infection. Here, we describe a non-canonical host SUMOylation response to the nuclear-replicating RNA pathogen, influenza virus, and identify viral RNA polymerase activity as a m...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Domingues P,Golebiowski F,Tatham MH,Lopes AM,Taggart A,Hay RT,Hale BG

    更新日期:2015-11-17 00:00:00

  • Transcriptome analysis of individual stromal cell populations identifies stroma-tumor crosstalk in mouse lung cancer model.

    abstract::Emerging studies have begun to demonstrate that reprogrammed stromal cells play pivotal roles in tumor growth, metastasis, and resistance to therapy. However, the contribution of stromal cells to non-small-cell lung cancer (NSCLC) has remained underexplored. We used an orthotopic model of Kras-driven NSCLC to systemat...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Choi H,Sheng J,Gao D,Li F,Durrans A,Ryu S,Lee SB,Narula N,Rafii S,Elemento O,Altorki NK,Wong ST,Mittal V

    更新日期:2015-02-24 00:00:00

  • Lack of Transcription Triggers H3K27me3 Accumulation in the Gene Body.

    abstract::Trimethylated H3K27 (H3K27me3) is associated with transcriptional repression, and its abundance in chromatin is frequently altered in cancer. However, it has remained unclear how genomic regions modified by H3K27me3 are specified and formed. We previously showed that downregulation of transcription by oncogenic Ras si...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Hosogane M,Funayama R,Shirota M,Nakayama K

    更新日期:2016-07-19 00:00:00

  • Bioinformatics Screening of Genes Specific for Well-Regenerating Vertebrates Reveals c-answer, a Regulator of Brain Development and Regeneration.

    abstract::The molecular basis of higher regenerative capacity of cold-blooded animals comparing to warm-blooded ones is poorly understood. Although this difference in regenerative capacities is commonly thought to be a result of restructuring of the same regulatory gene network, we hypothesized that it may be due to loss of som...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Korotkova DD,Lyubetsky VA,Ivanova AS,Rubanov LI,Seliverstov AV,Zverkov OA,Martynova NY,Nesterenko AM,Tereshina MB,Peshkin L,Zaraisky AG

    更新日期:2019-10-22 00:00:00

  • Facilitates chromatin transcription complex is an "accelerator" of tumor transformation and potential marker and target of aggressive cancers.

    abstract::The facilitates chromatin transcription (FACT) complex is involved in chromatin remodeling during transcription, replication, and DNA repair. FACT was previously considered to be ubiquitously expressed and not associated with any disease. However, we discovered that FACT is the target of a class of anticancer compound...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Garcia H,Miecznikowski JC,Safina A,Commane M,Ruusulehto A,Kilpinen S,Leach RW,Attwood K,Li Y,Degan S,Omilian AR,Guryanova O,Papantonopoulou O,Wang J,Buck M,Liu S,Morrison C,Gurova KV

    更新日期:2013-07-11 00:00:00

  • SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease.

    abstract::Nonalcoholic fatty liver disease is the most common chronic liver disorder in developed countries. Its pathogenesis is poorly understood, and therapeutic options are limited. Here, we show that SIRT7, an NAD(+)-dependent H3K18Ac deacetylase, functions at chromatin to suppress ER stress and prevent the development of f...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Shin J,He M,Liu Y,Paredes S,Villanova L,Brown K,Qiu X,Nabavi N,Mohrin M,Wojnoonski K,Li P,Cheng HL,Murphy AJ,Valenzuela DM,Luo H,Kapahi P,Krauss R,Mostoslavsky R,Yancopoulos GD,Alt FW,Chua KF,Chen D

    更新日期:2013-11-14 00:00:00

  • Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing ω3 Polyunsaturated Fatty Acids in WAT.

    abstract::Polyunsaturated fatty acids (PUFAs) confer health benefits by preventing inflammation and obesity and by increasing thermogenesis in brown and beige adipocytes. As well as being supplied exogenously as nutrients, PUFAs are largely stored in membrane glycerophospholipids and released by phospholipase A2s (PLA2s). Howev...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Sato H,Taketomi Y,Miki Y,Murase R,Yamamoto K,Murakami M

    更新日期:2020-05-05 00:00:00

  • Alterations in Phosphorylation of Hepatocyte Ribosomal Protein S6 Control Plasmodium Liver Stage Infection.

    abstract::Plasmodium parasites are highly selective when infecting hepatocytes and induce many changes within the host cell upon infection. While several host cell factors have been identified that are important for liver infection, our understanding of what facilitates the maintenance of infection remains incomplete. Here, we ...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Glennon EKK,Austin LS,Arang N,Kain HS,Mast FD,Vijayan K,Aitchison JD,Kappe SHI,Kaushansky A

    更新日期:2019-03-19 00:00:00

  • Stress-Induced Neural Plasticity Mediated by Glial GPCR REMO-1 Promotes C. elegans Adaptive Behavior.

    abstract::Animal nervous systems remodel following stress. Although global stress-dependent changes are well documented, contributions of individual neuron remodeling events to animal behavior modification are challenging to study. In response to environmental insults, C. elegans become stress-resistant dauers. Dauer entry indu...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Lee IH,Procko C,Lu Y,Shaham S

    更新日期:2021-01-12 00:00:00

  • Mechanistic Insights into Cofactor-Dependent Coupling of RNA Folding and mRNA Transcription/Translation by a Cobalamin Riboswitch.

    abstract::Riboswitches are mRNA elements regulating gene expression in response to direct binding of a metabolite. While these RNAs are increasingly well understood with respect to interactions between receptor domains and their cognate effector molecules, little is known about the specific mechanistic relationship between meta...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Polaski JT,Holmstrom ED,Nesbitt DJ,Batey RT

    更新日期:2016-05-03 00:00:00

  • Unique preservation of neural cells in Hutchinson- Gilford progeria syndrome is due to the expression of the neural-specific miR-9 microRNA.

    abstract::One puzzling observation in patients affected with Hutchinson-Gilford progeria syndrome (HGPS), who overall exhibit systemic and dramatic premature aging, is the absence of any conspicuous cognitive impairment. Recent studies based on induced pluripotent stem cells derived from HGPS patient cells have revealed a lack ...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Nissan X,Blondel S,Navarro C,Maury Y,Denis C,Girard M,Martinat C,De Sandre-Giovannoli A,Levy N,Peschanski M

    更新日期:2012-07-26 00:00:00

  • Selective Vulnerability of Cancer Cells by Inhibition of Ca(2+) Transfer from Endoplasmic Reticulum to Mitochondria.

    abstract::In the absence of low-level ER-to-mitochondrial Ca(2+) transfer, ATP levels fall, and AMPK-dependent, mTOR-independent autophagy is induced as an essential survival mechanism in many cell types. Here, we demonstrate that tumorigenic cancer cell lines, transformed primary human fibroblasts, and tumors in vivo respond s...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Cárdenas C,Müller M,McNeal A,Lovy A,Jaňa F,Bustos G,Urra F,Smith N,Molgó J,Diehl JA,Ridky TW,Foskett JK

    更新日期:2016-03-15 00:00:00

  • T-Bet+ IgM Memory Cells Generate Multi-lineage Effector B Cells.

    abstract::Immunoglobulin M (IgM) memory cells undergo differentiation in germinal centers following antigen challenge, but the full effector cell potential of these cells is unknown. We monitored the differentiation of enhanced yellow fluorescent protein (eYFP)-labeled CD11c+ and CD11cneg T-bet+ IgM memory cells after their tra...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Kenderes KJ,Levack RC,Papillion AM,Cabrera-Martinez B,Dishaw LM,Winslow GM

    更新日期:2018-07-24 00:00:00

  • Anterior Cingulate Cortex Modulation of the Ventral Tegmental Area in an Effort Task.

    abstract::Information gained during goal pursuit motivates adaptive behavior. The anterior cingulate cortex (ACC) supports adaptive behavior, but how ACC signals are translated into motivational signals remains unclear. Rats with implants in the ACC and ventral tegmental area (VTA), a dopaminergic brain area implicated in motiv...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Elston TW,Bilkey DK

    更新日期:2017-06-13 00:00:00

  • Poly(A)-specific ribonuclease mediates 3'-end trimming of Argonaute2-cleaved precursor microRNAs.

    abstract::MicroRNAs (miRNAs) are typically generated as ~22-nucleotide double-stranded RNAs via the processing of precursor hairpins by the ribonuclease III enzyme Dicer, after which they are loaded into Argonaute (Ago) proteins to form an RNA-induced silencing complex (RISC). However, the biogenesis of miR-451, an erythropoiet...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Yoda M,Cifuentes D,Izumi N,Sakaguchi Y,Suzuki T,Giraldez AJ,Tomari Y

    更新日期:2013-11-14 00:00:00

  • Multimodal Enhancement of Remyelination by Exercise with a Pivotal Role for Oligodendroglial PGC1α.

    abstract::Remyelination is a multistep regenerative process that results in the reformation of myelin sheaths around demyelinated axons and is a critical therapeutic target. Here we show that immediate access to a running wheel following toxin-induced demyelination in mice enhances oligodendrogenesis, the rate of remyelination,...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Jensen SK,Michaels NJ,Ilyntskyy S,Keough MB,Kovalchuk O,Yong VW

    更新日期:2018-09-18 00:00:00

  • BDNF Reduces Toxic Extrasynaptic NMDA Receptor Signaling via Synaptic NMDA Receptors and Nuclear-Calcium-Induced Transcription of inhba/Activin A.

    abstract::The health of neurons is critically dependent on the relative signaling intensities of survival-promoting synaptic and death-inducing extrasynaptic NMDA receptors. Here, we show that BDNF is a regulator of this balance and promotes neuroprotection by reducing toxic NMDA receptor signaling. BDNF acts by initiating syna...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Lau D,Bengtson CP,Buchthal B,Bading H

    更新日期:2015-08-25 00:00:00

  • Shank Proteins Couple the Endocytic Zone to the Postsynaptic Density to Control Trafficking and Signaling of Metabotropic Glutamate Receptor 5.

    abstract::Activation of postsynaptic metabotropic glutamate receptors (mGluRs) modulates neuronal excitability and synaptic plasticity, while deregulation of mGluR signaling has been implicated in neurodevelopmental disorders. Overstimulation of mGluRs is restricted by the rapid endocytosis of receptors after activation. Howeve...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Scheefhals N,Catsburg LAE,Westerveld ML,Blanpied TA,Hoogenraad CC,MacGillavry HD

    更新日期:2019-10-08 00:00:00

  • Tailored Tumor Immunogenicity Reveals Regulation of CD4 and CD8 T Cell Responses against Cancer.

    abstract::CD4 and CD8 T cells play a pivotal role in controlling tumor growth. However, the interplay of both cell types and their role in tumor suppression still remain elusive. In this study, we investigated the regulation of CD4 and CD8 T cell responses to different classes of tumor-specific antigens in liver cancer mouse mo...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Knocke S,Fleischmann-Mundt B,Saborowski M,Manns MP,Kühnel F,Wirth TC,Woller N

    更新日期:2016-11-22 00:00:00

  • Discovery and Characterization of piRNAs in the Human Fetal Ovary.

    abstract::Piwi-interacting RNAs (piRNAs), a class of 26- to 32-nt non-coding RNAs (ncRNAs), function in germline development, transposon silencing, and epigenetic regulation. We performed deep sequencing and annotation of untreated and periodate-treated small RNA cDNA libraries from human fetal and adult germline and reference ...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Williams Z,Morozov P,Mihailovic A,Lin C,Puvvula PK,Juranek S,Rosenwaks Z,Tuschl T

    更新日期:2015-10-27 00:00:00

  • Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity.

    abstract::Recent studies have elucidated the molecular mechanism of RORγT transcriptional regulation of Th17 differentiation and function. RORγT was initially identified as a transcription factor required for thymopoiesis by maintaining survival of CD4+CD8+ (DP) thymocytes. While RORγ antagonists are currently being developed t...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Guo Y,MacIsaac KD,Chen Y,Miller RJ,Jain R,Joyce-Shaikh B,Ferguson H,Wang IM,Cristescu R,Mudgett J,Engstrom L,Piers KJ,Baltus GA,Barr K,Zhang H,Mehmet H,Hegde LG,Hu X,Carter LL,Aicher TD,Glick G,Zaller D,Hawwar

    更新日期:2016-12-20 00:00:00

  • Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin.

    abstract::Chronic exposure to stress is a major risk factor for neuropsychiatric disease, and elevated plasma corticosterone (CORT) correlates with reduced levels of both brain-derived neurotrophic factor (BDNF) and hippocampal neurogenesis. Precisely how these phenomena are linked, however, remains unclear. Using a cortico-hip...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Agasse F,Mendez-David I,Christaller W,Carpentier R,Braz BY,David DJ,Saudou F,Humbert S

    更新日期:2020-07-07 00:00:00