A Positive Twist to the Centromeric Nucleosome.


:Centromeric nucleosomes are critical for chromosome attachment to the mitotic spindle. In this issue of Cell Reports, Diaz-Ingelmo et al. (2015) propose that the yeast centromeric nucleosome is stabilized by a positively supercoiled loop formed by the sequence-specific CBF3 complex.


Cell Rep


Cell reports


Ocampo J,Clark DJ




Has Abstract


2015-10-27 00:00:00












  • Experience-Dependent Equilibration of AMPAR-Mediated Synaptic Transmission during the Critical Period.

    abstract::Experience-dependent synapse refinement is essential for functional optimization of neural circuits. However, how sensory experience sculpts excitatory synaptic transmission is poorly understood. Here, we show that despite substantial remodeling of synaptic connectivity, AMPAR-mediated synaptic transmission remains at...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Han KS,Cooke SF,Xu W

    更新日期:2017-01-24 00:00:00

  • Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis.

    abstract::The resolution phase of acute inflammation is essential for tissue homeostasis, yet the underlying mechanisms remain unclear. We demonstrate that resolution of inflammation involves interactions between CD38 and tristetraprolin (TTP). During the onset of acute inflammation, CD38 levels are increased, leading to the pr...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Joe Y,Chen Y,Park J,Kim HJ,Rah SY,Ryu J,Cho GJ,Choi HS,Ryter SW,Park JW,Kim UH,Chung HT

    更新日期:2020-01-28 00:00:00

  • GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss.

    abstract::The anorectic and weight-suppressive effects of growth differentiation factor-15 (GDF15) are attracting considerable attention for treating obesity. Current experiments in rats investigate whether GDF15 induces an aversive visceral malaise-based state that mediates its acute anorectic effect and, through aversion cond...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Borner T,Wald HS,Ghidewon MY,Zhang B,Wu Z,De Jonghe BC,Breen D,Grill HJ

    更新日期:2020-04-21 00:00:00

  • Origin of a Non-Clarke's Column Division of the Dorsal Spinocerebellar Tract and the Role of Caudal Proprioceptive Neurons in Motor Function.

    abstract::Proprioception, the sense of limb and body position, is essential for generating proper movement. Unconscious proprioceptive information travels through cerebellar-projecting neurons in the spinal cord and medulla. The progenitor domain defined by the basic-helix-loop-helix (bHLH) transcription factor, ATOH1, has been...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Yuengert R,Hori K,Kibodeaux EE,McClellan JX,Morales JE,Huang TP,Neul JL,Lai HC

    更新日期:2015-11-10 00:00:00

  • Parabrachial Interleukin-6 Reduces Body Weight and Food Intake and Increases Thermogenesis to Regulate Energy Metabolism.

    abstract::Chronic low-grade inflammation and increased serum levels of the cytokine IL-6 accompany obesity. For brain-produced IL-6, the mechanisms by which it controls energy balance and its role in obesity remain unclear. Here, we show that brain-produced IL-6 is decreased in obese mice and rats in a neuroanatomically and sex...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Mishra D,Richard JE,Maric I,Porteiro B,Häring M,Kooijman S,Musovic S,Eerola K,López-Ferreras L,Peris E,Grycel K,Shevchouk OT,Micallef P,Olofsson CS,Wernstedt Asterholm I,Grill HJ,Nogueiras R,Skibicka KP

    更新日期:2019-03-12 00:00:00

  • MicroRNA Regulation of nAChR Expression and Nicotine-Dependent Behavior in C. elegans.

    abstract::Chronic exposure to nicotine upregulates nicotinic acetylcholine receptors (nAChRs), and such upregulation is critical for the development of nicotine dependence in humans and animal models. However, how nicotine upregulates nAChRs is not well understood. Here, we identify a key role for microRNA in regulating nicotin...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Rauthan M,Gong J,Liu J,Li Z,Wescott SA,Liu J,Xu XZS

    更新日期:2017-11-07 00:00:00

  • Two Differential Binding Mechanisms of FG-Nucleoporins and Nuclear Transport Receptors.

    abstract::Phenylalanine-glycine-rich nucleoporins (FG-Nups) are intrinsically disordered proteins, constituting the selective barrier of the nuclear pore complex (NPC). Previous studies showed that nuclear transport receptors (NTRs) were found to interact with FG-Nups by forming an "archetypal-fuzzy" complex through the rapid f...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Tan PS,Aramburu IV,Mercadante D,Tyagi S,Chowdhury A,Spitz D,Shammas SL,Gräter F,Lemke EA

    更新日期:2018-03-27 00:00:00

  • Comprehensive Immunoprofiling of Pediatric Zika Reveals Key Role for Monocytes in the Acute Phase and No Effect of Prior Dengue Virus Infection.

    abstract::Zika virus (ZIKV) is an emerging, mosquito-borne flavivirus responsible for recent epidemics across the Americas, and it is closely related to dengue virus (DENV). Here, we study samples from 46 DENV-naive and 43 DENV-immune patients with RT-PCR-confirmed ZIKV infection at early-acute, late-acute, and convalescent tim...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Michlmayr D,Kim EY,Rahman AH,Raghunathan R,Kim-Schulze S,Che Y,Kalayci S,Gümüş ZH,Kuan G,Balmaseda A,Kasarskis A,Wolinsky SM,Suaréz-Fariñas M,Harris E

    更新日期:2020-04-28 00:00:00

  • A Batf3/Nlrp3/IL-18 Axis Promotes Natural Killer Cell IL-10 Production during Listeria monocytogenes Infection.

    abstract::The bacterial pathogen Listeria monocytogenes (Lm) capitalizes on natural killer (NK) cell production of regulatory interleukin (IL)-10 to establish severe systemic infections. Here, we identify regulators of this IL-10 secretion. We show that IL-18 signals to NK cells license their ability to produce IL-10. IL-18 act...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Clark SE,Schmidt RL,McDermott DS,Lenz LL

    更新日期:2018-05-29 00:00:00

  • FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function.

    abstract::53BP1 plays a central role in dictating DNA repair choice between non-homologous end joining (NHEJ) and homologous recombination (HR), which is important for the sensitivity to poly(ADP-ribose) polymerase inhibitors (PARPis) of BRCA1-deficient cancers. In this study, we show that FOXK1 associates with 53BP1 and regula...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Tang M,Feng X,Pei G,Srivastava M,Wang C,Chen Z,Li S,Zhang H,Zhao Z,Li X,Chen J

    更新日期:2020-08-11 00:00:00

  • The GTPase Rab43 Controls the Anterograde ER-Golgi Trafficking and Sorting of GPCRs.

    abstract::G-protein-coupled receptors (GPCRs) constitute the largest superfamily of cell-surface signaling proteins. However, mechanisms underlying their surface targeting and sorting are poorly understood. Here, we screen the Rab family of small GTPases in the surface transport of multiple GPCRs. We find that manipulation of R...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Li C,Wei Z,Fan Y,Huang W,Su Y,Li H,Dong Z,Fukuda M,Khater M,Wu G

    更新日期:2017-10-24 00:00:00

  • Lateral Hypothalamic Neurotensin Neurons Orchestrate Dual Weight Loss Behaviors via Distinct Mechanisms.

    abstract::The central mechanism by which neurotensin (Nts) potentiates weight loss has remained elusive. We leveraged chemogenetics to reveal that Nts-expressing neurons of the lateral hypothalamic area (LHA) promote weight loss in mice by increasing volitional activity and restraining food intake. Intriguingly, these dual weig...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Woodworth HL,Beekly BG,Batchelor HM,Bugescu R,Perez-Bonilla P,Schroeder LE,Leinninger GM

    更新日期:2017-12-12 00:00:00

  • The TIP60 Complex Is a Conserved Coactivator of HIF1A.

    abstract::Hypoxia-inducible factors (HIFs) are critical regulators of the cellular response to hypoxia. Despite their established roles in normal physiology and numerous pathologies, the molecular mechanisms by which they control gene expression remain poorly understood. We report here a conserved role for the TIP60 complex as ...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Perez-Perri JI,Dengler VL,Audetat KA,Pandey A,Bonner EA,Urh M,Mendez J,Daniels DL,Wappner P,Galbraith MD,Espinosa JM

    更新日期:2016-06-28 00:00:00

  • XBP1-KLF9 Axis Acts as a Molecular Rheostat to Control the Transition from Adaptive to Cytotoxic Unfolded Protein Response.

    abstract::Transcription factor XBP1s, activated by endoplasmic reticulum (ER) stress in a dose-dependent manner, plays a central role in adaptive unfolded protein response (UPR) via direct activation of multiple genes controlling protein refolding. Here, we report that elevation of ER stress above a critical threshold causes ac...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Fink EE,Moparthy S,Bagati A,Bianchi-Smiraglia A,Lipchick BC,Wolff DW,Roll MV,Wang J,Liu S,Bakin AV,Kandel ES,Lee AH,Nikiforov MA

    更新日期:2018-10-02 00:00:00

  • Interferon Regulatory Factors IRF1 and IRF7 Directly Regulate Gene Expression in Bats in Response to Viral Infection.

    abstract::Bat cells and tissue have elevated basal expression levels of antiviral genes commonly associated with interferon alpha (IFNα) signaling. Here, we show Interferon Regulatory Factor 1 (IRF1), 3, and 7 levels are elevated in most bat tissues and that, basally, IRFs contribute to the expression of type I IFN ligands and ...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Irving AT,Zhang Q,Kong PS,Luko K,Rozario P,Wen M,Zhu F,Zhou P,Ng JHJ,Sobota RM,Wang LF

    更新日期:2020-11-03 00:00:00

  • Organ size control is dominant over Rb family inactivation to restrict proliferation in vivo.

    abstract::In mammals, a cell's decision to divide is thought to be under the control of the Rb/E2F pathway. We previously found that inactivation of the Rb family of cell cycle inhibitors (Rb, p107, and p130) in quiescent liver progenitors leads to uncontrolled division and cancer initiation. Here, we show that, in contrast, de...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Ehmer U,Zmoos AF,Auerbach RK,Vaka D,Butte AJ,Kay MA,Sage J

    更新日期:2014-07-24 00:00:00

  • 3' UTR-dependent, miR-92-mediated restriction of Tis21 expression maintains asymmetric neural stem cell division to ensure proper neocortex size.

    abstract::Mammalian neocortex size primarily reflects the number and mode of divisions of neural stem and progenitor cells. Cortical stem cells (apical progenitors) switching from symmetric divisions, which expand their population, to asymmetric divisions, which generate downstream neuronal progenitors (basal progenitors), star...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Fei JF,Haffner C,Huttner WB

    更新日期:2014-04-24 00:00:00

  • Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis.

    abstract::The quest to extend healthspan via pharmacological means is becoming increasingly urgent, both from a health and economic perspective. Here we show that lithium, a drug approved for human use, promotes longevity and healthspan. We demonstrate that lithium extends lifespan in female and male Drosophila, when administer...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Castillo-Quan JI,Li L,Kinghorn KJ,Ivanov DK,Tain LS,Slack C,Kerr F,Nespital T,Thornton J,Hardy J,Bjedov I,Partridge L

    更新日期:2016-04-19 00:00:00

  • A Disease-Causing Single Amino Acid Deletion in the Coiled-Coil Domain of RAD50 Impairs MRE11 Complex Functions in Yeast and Humans.

    abstract::The MRE11-RAD50-NBS1 complex plays a central role in response to DNA double-strand breaks. Here, we identify a patient with bone marrow failure and developmental defects caused by biallelic RAD50 mutations. One of the mutations creates a null allele, whereas the other (RAD50E1035Δ) leads to the loss of a single residu...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Chansel-Da Cruz M,Hohl M,Ceppi I,Kermasson L,Maggiorella L,Modesti M,de Villartay JP,Ileri T,Cejka P,Petrini JHJ,Revy P

    更新日期:2020-12-29 00:00:00

  • Atg5 Is Essential for the Development and Survival of Innate Lymphocytes.

    abstract::Autophagy is an essential cellular survival mechanism that is required for adaptive lymphocyte development; however, its role in innate lymphoid cell (ILC) development remains unknown. Furthermore, the conditions that promote lymphocyte autophagy during homeostasis are poorly understood. Here, we demonstrate that Atg5...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: O'Sullivan TE,Geary CD,Weizman OE,Geiger TL,Rapp M,Dorn GW 2nd,Overholtzer M,Sun JC

    更新日期:2016-05-31 00:00:00

  • High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML.

    abstract::Bromodomain and extra-terminal domain (BET) family inhibitors offer an approach to treating hematological malignancies. We used precision nuclear run-on transcription sequencing (PRO-seq) to create high-resolution maps of active RNA polymerases across the genome in t(8;21) acute myeloid leukemia (AML), as these polyme...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Zhao Y,Liu Q,Acharya P,Stengel KR,Sheng Q,Zhou X,Kwak H,Fischer MA,Bradner JE,Strickland SA,Mohan SR,Savona MR,Venters BJ,Zhou MM,Lis JT,Hiebert SW

    更新日期:2016-08-16 00:00:00

  • A Tonoplast P3B-ATPase Mediates Fusion of Two Types of Vacuoles in Petal Cells.

    abstract::It is known that plant cells can contain multiple distinct vacuoles; however, the abundance of multivacuolar cells and the mechanisms underlying vacuolar differentiation and communication among different types of vacuoles remain unknown. PH1 and PH5 are tonoplast P-ATPases that form a heteromeric pump that hyper-acidi...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Faraco M,Li Y,Li S,Spelt C,Di Sansebastiano GP,Reale L,Ferranti F,Verweij W,Koes R,Quattrocchio FM

    更新日期:2017-06-20 00:00:00

  • The Halastavi árva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism.

    abstract::Dicistrovirus intergenic region internal ribosomal entry sites (IGR IRESs) do not require initiator tRNA, an AUG codon, or initiation factors and jumpstart translation from the middle of the elongation cycle via formation of IRES/80S complexes resembling the pre-translocation state. eEF2 then translocates the [codon-a...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Abaeva IS,Vicens Q,Bochler A,Soufari H,Simonetti A,Pestova TV,Hashem Y,Hellen CUT

    更新日期:2020-12-08 00:00:00

  • Pressure-Driven Mitochondrial Transfer Pipeline Generates Mammalian Cells of Desired Genetic Combinations and Fates.

    abstract::Generating mammalian cells with desired mitochondrial DNA (mtDNA) sequences is enabling for studies of mitochondria, disease modeling, and potential regenerative therapies. MitoPunch, a high-throughput mitochondrial transfer device, produces cells with specific mtDNA-nuclear DNA (nDNA) combinations by transferring iso...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Patananan AN,Sercel AJ,Wu TH,Ahsan FM,Torres A Jr,Kennedy SAL,Vandiver A,Collier AJ,Mehrabi A,Van Lew J,Zakin L,Rodriguez N,Sixto M,Tadros W,Lazar A,Sieling PA,Nguyen TL,Dawson ER,Braas D,Golovato J,Cisneros L,V

    更新日期:2020-12-29 00:00:00

  • Non-acylated Wnts Can Promote Signaling.

    abstract::Wnts are a family of 19 extracellular ligands that regulate cell fate, proliferation, and migration during metazoan embryogenesis and throughout adulthood. Wnts are acylated post-translationally at a conserved serine and bind the extracellular cysteine-rich domain (CRD) of Frizzled (FZD) seven-pass transmembrane recep...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Speer KF,Sommer A,Tajer B,Mullins MC,Klein PS,Lemmon MA

    更新日期:2019-01-22 00:00:00

  • Constitutional chromothripsis rearrangements involve clustered double-stranded DNA breaks and nonhomologous repair mechanisms.

    abstract::Chromothripsis represents a novel phenomenon in the structural variation landscape of cancer genomes. Here, we analyze the genomes of ten patients with congenital disease who were preselected to carry complex chromosomal rearrangements with more than two breakpoints. The rearrangements displayed unanticipated complexi...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Kloosterman WP,Tavakoli-Yaraki M,van Roosmalen MJ,van Binsbergen E,Renkens I,Duran K,Ballarati L,Vergult S,Giardino D,Hansson K,Ruivenkamp CA,Jager M,van Haeringen A,Ippel EF,Haaf T,Passarge E,Hochstenbach R,Menten B,

    更新日期:2012-06-28 00:00:00

  • Bone Morphogenic Proteins Are Immunoregulatory Cytokines Controlling FOXP3+ Treg Cells.

    abstract::Bone morphogenic proteins (BMPs) are members of the transforming growth factor β (TGF-β) cytokine family promoting differentiation, homeostasis, and self-renewal of multiple tissues. We show that signaling through the bone morphogenic protein receptor 1α (BMPR1α) sustains expression of FOXP3 in Treg cells in periphera...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Browning LM,Miller C,Kuczma M,Pietrzak M,Jing Y,Rempala G,Muranski P,Ignatowicz L,Kraj P

    更新日期:2020-10-06 00:00:00

  • NKX2-1 Is Required in the Embryonic Septum for Cholinergic System Development, Learning, and Memory.

    abstract::The transcription factor NKX2-1 is best known for its role in the specification of subsets of cortical, striatal, and pallidal neurons. We demonstrate through genetic fate mapping and intersectional focal septal deletion that NKX2-1 is selectively required in the embryonic septal neuroepithelium for the development of...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Magno L,Barry C,Schmidt-Hieber C,Theodotou P,Häusser M,Kessaris N

    更新日期:2017-08-15 00:00:00

  • Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity.

    abstract::The translation initiation repressor 4E-BP2 is deamidated in the brain on asparagines N99/N102 during early postnatal brain development. This post-translational modification enhances 4E-BP2 association with Raptor, a central component of mTORC1 and alters the kinetics of excitatory synaptic transmission. We show that ...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Kouloulia S,Hallin EI,Simbriger K,Amorim IS,Lach G,Amvrosiadis T,Chalkiadaki K,Kampaite A,Truong VT,Hooshmandi M,Jafarnejad SM,Skehel P,Kursula P,Khoutorsky A,Gkogkas CG

    更新日期:2019-12-10 00:00:00

  • WRNIP1 Is Recruited to DNA Interstrand Crosslinks and Promotes Repair.

    abstract::The Fanconi anemia (FA) pathway repairs DNA interstrand crosslinks (ICLs). Many FA proteins are recruited to ICLs in a timely fashion so that coordinated repair can occur. However, the mechanism of this process is poorly understood. Here, we report the purification of a FANCD2-containing protein complex with multiple ...

    journal_title:Cell reports

    pub_type: 杂志文章


    authors: Socha A,Yang D,Bulsiewicz A,Yaprianto K,Kupculak M,Liang CC,Hadjicharalambous A,Wu R,Gygi SP,Cohn MA

    更新日期:2020-07-07 00:00:00