A Positive Twist to the Centromeric Nucleosome.

abstract：:APPL1- and RAB5-positive signaling endosomes play a crucial role in the activation of AKT in response to extracellular stimuli. Myosin VI (MYO6) and two of its cargo adaptor proteins, GIPC and TOM1/TOM1L2, localize to these peripheral endosomes and mediate endosome association with cortical actin filaments. Loss of MY...

journal_title：Cell reports

authors： Masters TA,Tumbarello DA,Chibalina MV,Buss F

更新日期：2017-06-06 00:00:00

abstract：:MicroRNA (miRNA) transfer via exosomes may mediate cell-to-cell communication. Interestingly, specific miRNAs are enriched in exosomes in a cell-type-dependent fashion. However, the mechanisms whereby miRNAs are sorted to exosomes and the significance of miRNA transfer to acceptor cells are unclear. We used macrophage...

journal_title：Cell reports

authors： Squadrito ML,Baer C,Burdet F,Maderna C,Gilfillan GD,Lyle R,Ibberson M,De Palma M

更新日期：2014-09-11 00:00:00

abstract：:Sustained canonical Wnt signaling requires the inhibition of glycogen synthase kinase 3 (GSK3) activity by sequestration of GSK3 inside multivesicular endosomes (MVEs). Here, we show that Wnt signaling is increased by the lysosomal inhibitor chloroquine, which causes accumulation of MVEs. A similar MVE expansion and i...

journal_title：Cell reports

authors： Dobrowolski R,Vick P,Ploper D,Gumper I,Snitkin H,Sabatini DD,De Robertis EM

更新日期：2012-11-29 00:00:00

abstract：:Amino acid hydroxylation is a post-translational modification that regulates intra- and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate- (2OG) dependent enzymes and, although the biochemistry is well understood, until now only a few substrates have been descr...

journal_title：Cell reports

authors： Rodriguez J,Pilkington R,Garcia Munoz A,Nguyen LK,Rauch N,Kennedy S,Monsefi N,Herrero A,Taylor CT,von Kriegsheim A

更新日期：2016-03-22 00:00:00

abstract：:Neutrophil polarity relies on local, mutual inhibition to segregate incompatible signaling circuits to the leading and trailing edges. Mutual inhibition alone should lead to cells having strong fronts and weak backs or vice versa. However, analysis of cell-to-cell variation in human neutrophils revealed that back pola...

journal_title：Cell reports

authors： Wang Y,Ku CJ,Zhang ER,Artyukhin AB,Weiner OD,Wu LF,Altschuler SJ

更新日期：2013-05-30 00:00:00

abstract：:Recent studies have shown that lysines can be posttranslationally modified by various types of acylations. However, except for acetylation, very little is known about their scope and cellular distribution. We mapped thousands of succinylation sites in bacteria (E. coli), yeast (S. cerevisiae), human (HeLa) cells, and ...

journal_title：Cell reports

authors： Weinert BT,Schölz C,Wagner SA,Iesmantavicius V,Su D,Daniel JA,Choudhary C

更新日期：2013-08-29 00:00:00

abstract：:The hair follicle (HF) is a complex miniorgan that serves as an ideal model system to study stem cell (SC) interactions with the niche during growth and regeneration. Dermal papilla (DP) cells are required for SC activation during the adult hair cycle, but signal exchange between niche and SC precursors/transit-amplif...

journal_title：Cell reports

authors： Rezza A,Wang Z,Sennett R,Qiao W,Wang D,Heitman N,Mok KW,Clavel C,Yi R,Zandstra P,Ma'ayan A,Rendl M

更新日期：2016-03-29 00:00:00

abstract：:Microbes have shown a remarkable ability in evading the killing actions of antimicrobial agents, such that treatment of bacterial infections represents once more an urgent global challenge. Understanding the initial bacterial response to antimicrobials may reveal intrinsic tolerance mechanisms to antibiotics and sugge...

journal_title：Cell reports

authors： Zampieri M,Zimmermann M,Claassen M,Sauer U

更新日期：2017-05-09 00:00:00

abstract：:Recent reports suggest that botulinum neurotoxin (BoNT) A, which is widely used clinically to inhibit neurotransmission, can spread within networks of neurons to have distal effects, but this remains controversial. Moreover, it is not known whether other members of this toxin family are transferred between neurons. He...

journal_title：Cell reports

authors： Bomba-Warczak E,Vevea JD,Brittain JM,Figueroa-Bernier A,Tepp WH,Johnson EA,Yeh FL,Chapman ER

更新日期：2016-08-16 00:00:00

abstract：:DC-SIGN+ monocyte-derived dendritic cells (mo-DCs) play important roles in bacterial infections and inflammatory diseases, but the factors regulating their differentiation and proinflammatory status remain poorly defined. Here, we identify a microRNA, miR-181a, and a molecular mechanism that simultaneously regulate th...

journal_title：Cell reports

authors： Lim CX,Lee B,Geiger O,Passegger C,Beitzinger M,Romberger J,Stracke A,Högenauer C,Stift A,Stoiber H,Poidinger M,Zebisch A,Meister G,Williams A,Flavell RA,Henao-Mejia J,Strobl H

更新日期：2020-03-17 00:00:00

abstract：:Transcription factors often activate and repress different target genes in the same cell. How activation and repression are encoded by different arrangements of transcription factor binding sites in cis-regulatory elements is poorly understood. We investigated how sites for the transcription factor CRX encode both act...

journal_title：Cell reports

authors： White MA,Kwasnieski JC,Myers CA,Shen SQ,Corbo JC,Cohen BA

更新日期：2016-10-25 00:00:00

abstract：:Animal nervous systems remodel following stress. Although global stress-dependent changes are well documented, contributions of individual neuron remodeling events to animal behavior modification are challenging to study. In response to environmental insults, C. elegans become stress-resistant dauers. Dauer entry indu...

journal_title：Cell reports

authors： Lee IH,Procko C,Lu Y,Shaham S

更新日期：2021-01-12 00:00:00

abstract：:Whole-body regeneration relies on the re-establishment of body axes for patterning of new tissue. Wnt signaling is required to correctly regenerate tissues along the primary axis in many animals. However, the causal mechanisms that first launch Wnt signaling during regeneration are poorly characterized. We use the aco...

journal_title：Cell reports

authors： Ramirez AN,Loubet-Senear K,Srivastava M

更新日期：2020-09-01 00:00:00

abstract：:A major challenge in biology is determining how evolutionarily novel characters originate; however, mechanistic explanations for the origin of new characters are almost completely unknown. The evolution of pregnancy is an excellent system in which to study the origin of novelties because mammals preserve stages in the...

journal_title：Cell reports

authors： Lynch VJ,Nnamani MC,Kapusta A,Brayer K,Plaza SL,Mazur EC,Emera D,Sheikh SZ,Grützner F,Bauersachs S,Graf A,Young SL,Lieb JD,DeMayo FJ,Feschotte C,Wagner GP

更新日期：2015-02-03 00:00:00

abstract：:The ability of cells to stably maintain their fate is governed by specific transcription regulators. Here, we show that the Scalloped (Sd) and Nervous fingers-1 (Nerfin-1) transcription factors physically and functionally interact to maintain medulla neuron fate in the Drosophila melanogaster CNS. Using Targeted DamID...

journal_title：Cell reports

authors： Vissers JHA,Froldi F,Schröder J,Papenfuss AT,Cheng LY,Harvey KF

更新日期：2018-11-06 00:00:00

abstract：:Activation of the transcription factor NF-κB is essential for innate immune function and requires strict regulation. The micronutrient zinc modulates proper host defense, and zinc deficiency is associated with elevated inflammation and worse outcomes in response to bacterial infection and sepsis. Previous studies sugg...

journal_title：Cell reports

authors： Liu MJ,Bao S,Gálvez-Peralta M,Pyle CJ,Rudawsky AC,Pavlovicz RE,Killilea DW,Li C,Nebert DW,Wewers MD,Knoell DL

更新日期：2013-02-21 00:00:00

abstract：:Translation of mRNAs in dendrites mediates synaptic plasticity, the probable cellular basis of learning and memory. Coordination of translational inhibitory and stimulatory mechanisms, as well as dendritic transport of mRNA, is necessary to ensure proper control of this local translation. Here, we find that the deaden...

journal_title：Cell reports

authors： McFleder RL,Mansur F,Richter JD

更新日期：2017-07-18 00:00:00

abstract：:Eukaryotic DNA replication licensing is a prerequisite for, and plays a role in, regulating genome duplication that occurs exactly once per cell cycle. ORC (origin recognition complex) binds to and marks replication origins throughout the cell cycle and loads other replication-initiation proteins onto replication orig...

journal_title：Cell reports

authors： Amin A,Wu R,Cheung MH,Scott JF,Wang Z,Zhou Z,Liu C,Zhu G,Wong CK,Yu Z,Liang C

更新日期：2020-03-10 00:00:00

abstract：:Transgenic zebrafish embryos expressing tissue-specific green fluorescent protein (GFP) can provide an unlimited supply of primary embryonic cells. Agents that promote the differentiation of these cells may be beneficial for therapeutics. We report a high-throughput approach for screening small molecules that regulate...

journal_title：Cell reports

authors： Huang H,Lindgren A,Wu X,Liu NA,Lin S

更新日期：2012-09-27 00:00:00

abstract：:Endosomal sorting complexes required for transport (ESCRT) drive cell surface receptor degradation resulting in attenuation of oncogenic signaling and pointing to a tumor suppressor function. Here, we show that loss of function of an ESCRT protein (HD-PTP encoded by the PTPN23 gene, located on the tumor suppressor gen...

journal_title：Cell reports

authors： Manteghi S,Gingras MC,Kharitidi D,Galarneau L,Marques M,Yan M,Cencic R,Robert F,Paquet M,Witcher M,Pelletier J,Pause A

更新日期：2016-05-31 00:00:00

abstract：:Many autoimmune and infectious diseases are characterized by the formation of granulomas which are inflammatory lesions that consist of spatially organized immune cells. These sites protect the host and control pathogens like Mycobacterium tuberculosis (Mtb), but are highly inflammatory and cause pathology. Using baci...

journal_title：Cell reports

authors： Harding JS,Herbath M,Chen Y,Rayasam A,Ritter A,Csoka B,Hasko G,Michael IP,Fabry Z,Nagy A,Sandor M

更新日期：2019-05-14 00:00:00

abstract：:Hepatocyte nuclear factor 4α (HNF4α) is a dimeric transcription factor that controls as much as 60% of all liver genes. However, how it achieves such broad functional diversity is unknown. Here, we show that inflammation and immune pathway genes are differentially regulated in an isoform-dependent manner, confirming t...

journal_title：Cell reports

authors： Ko HL,Zhuo Z,Ren EC

更新日期：2019-03-05 00:00:00

abstract：:Immunoglobulin M (IgM) memory cells undergo differentiation in germinal centers following antigen challenge, but the full effector cell potential of these cells is unknown. We monitored the differentiation of enhanced yellow fluorescent protein (eYFP)-labeled CD11c+ and CD11cneg T-bet+ IgM memory cells after their tra...

journal_title：Cell reports

authors： Kenderes KJ,Levack RC,Papillion AM,Cabrera-Martinez B,Dishaw LM,Winslow GM

更新日期：2018-07-24 00:00:00

abstract：:Genetic differences between humans and in vivo model systems, including mice and nonhuman primates, make it difficult to predict the efficacy of immunoglobulin G (IgG) activity in humans and understand the molecular and cellular mechanisms underlying that activity. To bridge this gap, we established a small-animal mod...

journal_title：Cell reports

authors： Lux A,Seeling M,Baerenwaldt A,Lehmann B,Schwab I,Repp R,Meidenbauer N,Mackensen A,Hartmann A,Heidkamp G,Dudziak D,Nimmerjahn F

更新日期：2014-04-10 00:00:00

abstract：:The quality of mitochondria in skeletal muscle is essential for maintaining metabolic homeostasis during adaptive stress responses. However, the precise control mechanism of muscle mitochondrial quality and its physiological impacts remain unclear. Here, we demonstrate that FUNDC1, a mediator of mitophagy, plays a cri...

journal_title：Cell reports

authors： Fu T,Xu Z,Liu L,Guo Q,Wu H,Liang X,Zhou D,Xiao L,Liu L,Liu Y,Zhu MS,Chen Q,Gan Z

更新日期：2018-05-01 00:00:00

abstract：:Allergic asthma is a highly prevalent airway disease triggered by hyperresponsiveness to inhaled allergens. Interferon regulatory factor 7 (IRF7) has been shown to be highly expressed in nasal aspirates from children with asthma. Type 2 innate lymphoid cells (ILC2s) represent the major player in allergic airway inflam...

journal_title：Cell reports

authors： He J,Yang Q,Xiao Q,Lei A,Li X,Zhou P,Liu T,Zhang L,Shi K,Yang Q,Dong J,Zhou J

更新日期：2019-11-26 00:00:00

abstract：:G-protein-coupled receptors (GPCRs) constitute the largest superfamily of cell-surface signaling proteins. However, mechanisms underlying their surface targeting and sorting are poorly understood. Here, we screen the Rab family of small GTPases in the surface transport of multiple GPCRs. We find that manipulation of R...

journal_title：Cell reports

authors： Li C,Wei Z,Fan Y,Huang W,Su Y,Li H,Dong Z,Fukuda M,Khater M,Wu G

更新日期：2017-10-24 00:00:00

abstract：:In vivo experimental evidence indicates that acute neuronal activation increases Aβ release from presynaptic terminals, whereas long-term effects of chronic synaptic activation on Aβ pathology remain unclear. To address this issue, we adopted optogenetics and transduced stabilized step-function opsin, a channelrhodops...

journal_title：Cell reports

authors： Yamamoto K,Tanei ZI,Hashimoto T,Wakabayashi T,Okuno H,Naka Y,Yizhar O,Fenno LE,Fukayama M,Bito H,Cirrito JR,Holtzman DM,Deisseroth K,Iwatsubo T

更新日期：2015-05-12 00:00:00

abstract：:Wiskott-Aldrich syndrome protein (WASp) is a main cytoskeletal regulator in B cells. WASp-interacting protein (WIP) binds to and stabilizes WASp but also interacts with actin. Using mice with a mutated actin binding domain of WIP (WIPΔABD), we here investigated the role of WIP binding to actin during B cell activation...

journal_title：Cell reports

authors： Keppler SJ,Burbage M,Gasparrini F,Hartjes L,Aggarwal S,Massaad MJ,Geha RS,Bruckbauer A,Batista FD

更新日期：2018-07-17 00:00:00

abstract：:In mammalian skin, Merkel cells are mechanoreceptor cells that are required for the perception of gentle touch. Recent evidence indicates that mature Merkel cells descend from the proliferative layer of skin epidermis; however, the stem cell niche for Merkel cell homeostasis has not been reported. Here, we provide gen...

journal_title：Cell reports

authors： Doucet YS,Woo SH,Ruiz ME,Owens DM

更新日期：2013-06-27 00:00:00