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Signaling Networks among Stem Cell Precursors, Transit-Amplifying Progenitors, and their Niche in Developing Hair Follicles.

Abstract：

:The hair follicle (HF) is a complex miniorgan that serves as an ideal model system to study stem cell (SC) interactions with the niche during growth and regeneration. Dermal papilla (DP) cells are required for SC activation during the adult hair cycle, but signal exchange between niche and SC precursors/transit-amplifying cell (TAC) progenitors that regulates HF morphogenetic growth is largely unknown. Here we use six transgenic reporters to isolate 14 major skin and HF cell populations. With next-generation RNA sequencing, we characterize their transcriptomes and define unique molecular signatures. SC precursors, TACs, and the DP niche express a plethora of ligands and receptors. Signaling interaction network analysis reveals a bird's-eye view of pathways implicated in epithelial-mesenchymal interactions. Using a systematic tissue-wide approach, this work provides a comprehensive platform, linked to an interactive online database, to identify and further explore the SC/TAC/niche crosstalk regulating HF growth.

journal_name

Cell Rep

journal_title

Cell reports

authors

Rezza A,Wang Z,Sennett R,Qiao W,Wang D,Heitman N,Mok KW,Clavel C,Yi R,Zandstra P,Ma'ayan A,Rendl M

doi

10.1016/j.celrep.2016.02.078

subject

Has Abstract

pub_date

2016-03-29 00:00:00

pages

3001-18

issue

12

issn

2211-1247

pii

S2211-1247(16)30213-3

journal_volume

14

pub_type

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